Tixagevimab / 7tcc

A4DAB270_7tcc_F_G | Source PDB: 7tcc | Chains: F, G | Done
95.26
Yes
10 Å
Yes
Avg A4D Score
-0.6923
Max Score
1.0451
Min Score
-3.05
Total Score
-159.22
Score CDR
-0.303
Score non-CDR
-0.8032

Calculation Parameters

Chain Sequence(s) MQLVQSGPEVKKPGTSVKVSCKASGFTFTSSAVQWVRQARGQRLEWIGWIVVGSGNTNYAQKFQERVTITRDMSTSTAYMELSSLRSEDTAVYYCAAPYCSGGSCFDGFDIWGQGTMVTVSSEIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGFPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGNSPWTFGQGTKVEIR input.pdb
Selected Chain(s) F (Heavy), G (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.05
Maximum Score 1.0451
Average Score -0.6923
Total Score -159.2246

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
2 M F 0.4253 Aggregation-prone
3 Q F -0.9262 Soluble
4 L F 0.0000 Buried
5 V F -0.3850 Soluble
6 Q F 0.0000 Buried
7 S F -0.7244 Soluble
8 G F -0.5171 Soluble
9 P F -0.2647 Soluble
11 E F -0.6645 Soluble
12 V F 0.2041 Aggregation-prone
13 K F -1.9235 Soluble
14 K F -2.6071 Soluble
15 P F -2.3207 Soluble
16 G F -1.8991 Soluble
17 T F -1.3551 Soluble
18 S F -1.2690 Soluble
19 V F -1.2508 Soluble
20 K F -1.7707 Soluble
21 V F 0.0000 Buried
22 S F -0.6215 Soluble
23 C F 0.0000 Buried
24 K F -1.4837 Soluble
25 A F 0.0000 Buried
26 S F -0.5483 Soluble
27 G F -0.1434 Soluble
28 F F 0.1226 Aggregation-prone
29 T F -0.1080 Soluble
30 F F 0.1435 Aggregation-prone
35 T F -0.1060 Soluble
36 S F -0.3826 Soluble
37 S F 0.0000 Buried
38 A F 0.1064 Aggregation-prone
39 V F 0.0000 Buried
40 Q F 0.0000 Buried
41 W F 0.0000 Buried
42 V F 0.0000 Buried
43 R F -0.8466 Soluble
44 Q F 0.0000 Buried
45 A F -1.7454 Soluble
46 R F -2.5525 Soluble
47 G F -2.0043 Soluble
48 Q F -2.3847 Soluble
49 R F -1.7346 Soluble
50 L F 0.0000 Buried
51 E F -1.6859 Soluble
52 W F 0.0000 Buried
53 I F 0.0000 Buried
54 G F 0.0000 Buried
55 W F -0.1223 Soluble
56 I F 0.0000 Buried
57 V F -0.0834 Soluble
58 V F 0.0000 Buried
59 G F -0.7493 Soluble
62 S F -1.0878 Soluble
63 G F -1.4499 Soluble
64 N F -1.8892 Soluble
65 T F -1.3728 Soluble
66 N F -1.7809 Soluble
67 Y F -1.6543 Soluble
68 A F 0.0000 Buried
69 Q F -2.5793 Soluble
70 K F -2.8536 Soluble
71 F F -2.3955 Soluble
72 Q F -3.0500 Soluble
74 E F -3.0360 Soluble
75 R F -1.9664 Soluble
76 V F 0.0000 Buried
77 T F -0.9561 Soluble
78 I F 0.0000 Buried
79 T F -0.6823 Soluble
80 R F -1.4308 Soluble
81 D F -0.7785 Soluble
82 M F 0.2400 Aggregation-prone
83 S F -0.0966 Soluble
84 T F -0.2992 Soluble
85 S F -0.4943 Soluble
86 T F 0.0000 Buried
87 A F 0.0000 Buried
88 Y F -0.6163 Soluble
89 M F 0.0000 Buried
90 E F -0.9279 Soluble
91 L F 0.0000 Buried
92 S F -1.1337 Soluble
93 S F -1.3168 Soluble
94 L F 0.0000 Buried
95 R F -2.9977 Soluble
96 S F -2.4071 Soluble
97 E F -2.6339 Soluble
98 D F -1.6783 Soluble
99 T F -1.0611 Soluble
100 A F 0.0000 Buried
101 V F -0.1701 Soluble
102 Y F 0.0000 Buried
103 Y F 0.0000 Buried
104 C F 0.0000 Buried
105 A F 0.0000 Buried
106 A F 0.0000 Buried
107 P F 0.0000 Buried
108 Y F 0.8427 Aggregation-prone
109 C F 0.0000 Buried
110 S F -0.3013 Soluble
111 G F -0.7523 Soluble
111A G F -0.6778 Soluble
112B S F -0.3273 Soluble
112A C F 0.2861 Aggregation-prone
112 F F 0.3446 Aggregation-prone
113 D F -0.2388 Soluble
114 G F 0.0000 Buried
115 F F 0.0000 Buried
116 D F -0.1632 Soluble
117 I F 0.1663 Aggregation-prone
118 W F -0.1965 Soluble
119 G F -0.6537 Soluble
120 Q F -0.9387 Soluble
121 G F -0.4985 Soluble
122 T F 0.0000 Buried
123 M F 0.3284 Aggregation-prone
124 V F 0.1232 Aggregation-prone
125 T F -0.3336 Soluble
126 V F -1.1409 Soluble
127 S F -0.5812 Soluble
128 S F -0.7435 Soluble
1 E G -0.8615 Soluble
2 I G 0.7024 Aggregation-prone
3 V G 1.0451 Aggregation-prone
4 L G 0.0000 Buried
5 T G 0.0541 Aggregation-prone
6 Q G -0.4829 Soluble
7 S G -0.5491 Soluble
8 P G -0.5951 Soluble
9 G G -0.8659 Soluble
10 T G -0.6270 Soluble
11 L G 0.0722 Aggregation-prone
12 S G 0.0160 Aggregation-prone
13 L G -0.0708 Soluble
14 S G -0.7614 Soluble
15 P G -1.3983 Soluble
16 G G -1.8319 Soluble
17 E G 0.0000 Buried
18 R G -2.1889 Soluble
19 A G -0.8038 Soluble
20 T G -0.4641 Soluble
21 L G 0.0000 Buried
22 S G 0.0000 Buried
23 C G 0.0000 Buried
24 R G -0.8070 Soluble
25 A G 0.0000 Buried
26 S G -0.8353 Soluble
27 Q G -1.6101 Soluble
28 S G -1.3595 Soluble
29 V G -0.6306 Soluble
30 S G -0.3169 Soluble
36 S G -0.1710 Soluble
37 S G 0.1141 Aggregation-prone
38 Y G 0.6265 Aggregation-prone
39 L G 0.0000 Buried
40 A G 0.0000 Buried
41 W G 0.0000 Buried
42 Y G 0.0000 Buried
43 Q G -0.5995 Soluble
44 Q G 0.0000 Buried
45 K G -1.9262 Soluble
46 P G -1.7601 Soluble
47 G G -1.8028 Soluble
48 Q G -2.0597 Soluble
49 A G 0.0000 Buried
50 P G 0.0000 Buried
51 R G -0.7962 Soluble
52 L G 0.0000 Buried
53 L G 0.0000 Buried
54 I G 0.0000 Buried
55 Y G -0.2416 Soluble
56 G G 0.0000 Buried
57 A G -0.4312 Soluble
65 S G -0.5369 Soluble
66 S G -1.0817 Soluble
67 R G -2.2458 Soluble
68 A G -1.1040 Soluble
69 T G -0.5202 Soluble
70 G G -0.7538 Soluble
71 F G -0.4418 Soluble
72 P G -1.3826 Soluble
74 D G -2.6673 Soluble
75 R G -2.9262 Soluble
76 F G -1.6299 Soluble
77 S G -1.1708 Soluble
78 G G -0.5021 Soluble
79 S G -0.5571 Soluble
80 G G -0.7973 Soluble
83 S G -0.8969 Soluble
84 G G -1.1510 Soluble
85 T G -1.0289 Soluble
86 D G -1.1477 Soluble
87 F G 0.0000 Buried
88 T G -0.4942 Soluble
89 L G 0.0000 Buried
90 T G -0.5549 Soluble
91 I G -0.9642 Soluble
92 S G -1.9313 Soluble
93 R G -2.9265 Soluble
94 L G -2.3545 Soluble
95 E G -2.9752 Soluble
96 P G -2.0635 Soluble
97 E G -2.4866 Soluble
98 D G -1.7723 Soluble
99 F G -0.9224 Soluble
100 A G -1.0714 Soluble
101 V G 0.0000 Buried
102 Y G -0.5181 Soluble
103 Y G 0.0000 Buried
104 C G 0.0000 Buried
105 Q G 0.0000 Buried
106 Q G 0.0000 Buried
107 Y G 0.0000 Buried
108 G G -0.6195 Soluble
109 N G -0.7367 Soluble
114 S G -0.8650 Soluble
115 P G -0.7976 Soluble
116 W G -0.2976 Soluble
117 T G 0.0000 Buried
118 F G 0.0000 Buried
119 G G 0.0000 Buried
120 Q G -0.5712 Soluble
121 G G -0.9813 Soluble
122 T G 0.0000 Buried
123 K G -1.6991 Soluble
124 V G -0.3306 Soluble
125 E G -0.2365 Soluble
126 I G 0.8698 Aggregation-prone
127 R G -0.9733 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.791 2.0899 CSV PDB
4.5 -0.8286 2.0246 CSV PDB
5.0 -0.8738 1.9264 CSV PDB
5.5 -0.9173 1.8112 CSV PDB
6.0 -0.9493 1.6973 CSV PDB
6.5 -0.9622 1.603 CSV PDB
7.0 -0.9549 1.5428 CSV PDB
7.5 -0.9334 1.5145 CSV PDB
8.0 -0.904 1.5039 CSV PDB
8.5 -0.8699 1.5003 CSV PDB
9.0 -0.8324 1.4992 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH