Paridiprubart / 4r7n

A4DAB203_4r7n_O_P | Source PDB: 4r7n | Chains: O, P | Done
96
Yes
10 Å
Yes
Avg A4D Score
-0.7126
Max Score
1.7761
Min Score
-3.8308
Total Score
-305.71
Score CDR
-0.1573
Score non-CDR
-0.7777

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSDTLSLTCAVSGYPIRFGYSWHWIRQPPGKGLEWMGYIHYSGYTDFNPSLKTRITISRDTSKNQFSLKLSSVTAVDTAVYYCARKDSGNYFPYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPEIVLTQSPDFQSVTPKEKVTITCRASQSISDHLHWYQQKPDQSPKLLIKYASHAISGVPSRFSGSGSGTDFTLTINSLEAEDAATYYCQQGYDFPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR input.pdb
Selected Chain(s) O (Heavy), P (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.8308
Maximum Score 1.7761
Average Score -0.7126
Total Score -305.7081

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q O -1.4305 Soluble
2 V O -0.9350 Soluble
3 Q O -1.7040 Soluble
4 L O -1.1635 Soluble
5 Q O -1.8033 Soluble
6 E O 0.0000 Buried
7 S O -0.8683 Soluble
8 G O -0.6329 Soluble
9 P O -0.5762 Soluble
11 G O -0.5442 Soluble
12 L O -0.3441 Soluble
13 V O 0.0000 Buried
14 K O -2.2648 Soluble
15 P O -1.5809 Soluble
16 S O -1.4777 Soluble
17 D O -2.1320 Soluble
18 T O -1.4200 Soluble
19 L O 0.0000 Buried
20 S O -0.7327 Soluble
21 L O 0.0000 Buried
22 T O -0.7552 Soluble
23 C O 0.0000 Buried
24 A O -1.0492 Soluble
25 V O 0.0000 Buried
26 S O -1.0444 Soluble
27 G O -0.9772 Soluble
28 Y O -0.1402 Soluble
29 P O -0.1330 Soluble
30 I O 0.0000 Buried
31 R O -0.8477 Soluble
35 F O 1.2006 Aggregation-prone
36 G O 0.7199 Aggregation-prone
37 Y O 0.7049 Aggregation-prone
38 S O 0.0000 Buried
39 W O 0.0000 Buried
40 H O 0.0000 Buried
41 W O 0.0000 Buried
42 I O 0.0000 Buried
43 R O 0.0000 Buried
44 Q O 0.0000 Buried
45 P O -0.5891 Soluble
46 P O -1.1686 Soluble
47 G O -1.6625 Soluble
48 K O -2.2507 Soluble
49 G O -1.4046 Soluble
50 L O 0.0000 Buried
51 E O -0.8349 Soluble
52 W O 0.0000 Buried
53 M O 0.0000 Buried
54 G O 0.0000 Buried
55 Y O 0.0000 Buried
56 I O 0.0000 Buried
57 H O 0.3962 Aggregation-prone
58 Y O 0.5652 Aggregation-prone
59 S O 0.3176 Aggregation-prone
63 G O 0.0620 Aggregation-prone
64 Y O 1.0872 Aggregation-prone
65 T O 0.3429 Aggregation-prone
66 D O -0.2740 Soluble
67 F O -0.3524 Soluble
68 N O 0.0000 Buried
69 P O -0.8884 Soluble
70 S O -0.6933 Soluble
71 L O 0.0000 Buried
72 K O -1.4070 Soluble
74 T O -0.8650 Soluble
75 R O -0.9966 Soluble
76 I O 0.0000 Buried
77 T O -0.8072 Soluble
78 I O 0.0000 Buried
79 S O -0.6541 Soluble
80 R O -1.3620 Soluble
81 D O -1.7691 Soluble
82 T O -1.4776 Soluble
83 S O -1.6616 Soluble
84 K O -2.2986 Soluble
85 N O -1.8762 Soluble
86 Q O -1.5206 Soluble
87 F O 0.0000 Buried
88 S O -0.7071 Soluble
89 L O 0.0000 Buried
90 K O -1.2432 Soluble
91 L O 0.0000 Buried
92 S O -1.0187 Soluble
93 S O -1.1320 Soluble
94 V O 0.0000 Buried
95 T O -0.0464 Soluble
96 A O 0.6288 Aggregation-prone
97 V O 1.7761 Aggregation-prone
98 D O 0.0000 Buried
99 T O 0.6402 Aggregation-prone
100 A O 0.0000 Buried
101 V O 0.1073 Aggregation-prone
102 Y O 0.0000 Buried
103 Y O 0.0000 Buried
104 C O 0.0000 Buried
105 A O 0.0000 Buried
106 R O 0.0000 Buried
107 K O -0.1541 Soluble
108 D O 0.0000 Buried
109 S O -0.2752 Soluble
110 G O -0.4179 Soluble
113 N O -0.3849 Soluble
114 Y O 0.0190 Aggregation-prone
115 F O 0.0000 Buried
116 P O 0.0965 Aggregation-prone
117 Y O 0.1355 Aggregation-prone
118 W O -0.5325 Soluble
119 G O 0.0000 Buried
120 Q O -2.1935 Soluble
121 G O -1.2633 Soluble
122 T O -0.4569 Soluble
123 L O 0.1344 Aggregation-prone
124 V O 0.0000 Buried
125 T O 0.0078 Aggregation-prone
126 V O 0.0000 Buried
127 S O -0.6640 Soluble
128 S O -0.8572 Soluble
129 A O -0.5832 Soluble
130 S O -0.6791 Soluble
131 T O -0.6734 Soluble
132 K O -1.4327 Soluble
133 G O -1.4089 Soluble
134 P O -0.9348 Soluble
135 S O -0.6356 Soluble
136 V O -0.2030 Soluble
137 F O 0.0845 Aggregation-prone
138 P O -0.4912 Soluble
139 L O -0.3494 Soluble
140 A O -0.7252 Soluble
141 P O -0.6899 Soluble
142 S O -0.6880 Soluble
143 S O -1.5197 Soluble
144 K O -2.2147 Soluble
145 S O -1.4899 Soluble
146 T O -1.0461 Soluble
147 S O -1.2134 Soluble
148 G O -1.0993 Soluble
149 G O -0.9588 Soluble
150 T O -0.6327 Soluble
151 A O -0.4124 Soluble
152 A O 0.0000 Buried
153 L O 0.0000 Buried
154 G O 0.0000 Buried
155 C O 0.0000 Buried
156 L O 0.2339 Aggregation-prone
157 V O 0.0000 Buried
158 K O -0.8664 Soluble
159 D O -1.3299 Soluble
160 Y O 0.0000 Buried
161 F O -0.7412 Soluble
162 P O 0.0000 Buried
163 E O -0.4023 Soluble
164 P O -0.4455 Soluble
165 V O -0.1904 Soluble
166 T O -0.4481 Soluble
167 V O 0.1562 Aggregation-prone
168 S O -0.3720 Soluble
169 W O 0.0000 Buried
170 N O -0.7474 Soluble
171 S O -0.6458 Soluble
172 G O -0.6297 Soluble
173 A O -0.2412 Soluble
174 L O -0.0070 Soluble
175 T O -0.1801 Soluble
176 S O -0.3642 Soluble
177 G O -0.5791 Soluble
178 V O 0.1974 Aggregation-prone
179 H O -0.2463 Soluble
180 T O -0.0911 Soluble
181 F O 0.0000 Buried
182 P O -0.0863 Soluble
183 A O 0.4378 Aggregation-prone
184 V O 0.6996 Aggregation-prone
185 L O 1.3158 Aggregation-prone
186 Q O -0.2665 Soluble
187 S O -0.3897 Soluble
188 S O -0.5255 Soluble
189 G O -0.5599 Soluble
190 L O -0.5039 Soluble
191 Y O -0.0336 Soluble
192 S O 0.0000 Buried
193 L O 0.0521 Aggregation-prone
194 S O 0.1338 Aggregation-prone
195 S O 0.0000 Buried
196 V O 0.0000 Buried
197 V O 0.0000 Buried
198 T O -0.1242 Soluble
199 V O 0.0000 Buried
200 P O -0.3615 Soluble
201 S O -0.5170 Soluble
202 S O -0.6542 Soluble
203 S O -0.6574 Soluble
204 L O -0.8634 Soluble
205 G O -1.1241 Soluble
206 T O -0.8881 Soluble
207 Q O -1.5350 Soluble
208 T O -1.3172 Soluble
209 Y O -0.8075 Soluble
210 I O -1.1719 Soluble
211 C O 0.0000 Buried
212 N O -1.6073 Soluble
213 V O 0.0000 Buried
214 N O -1.7525 Soluble
215 H O 0.0000 Buried
216 K O -2.6496 Soluble
217 P O -1.6471 Soluble
218 S O -1.8432 Soluble
219 N O -2.5627 Soluble
220 T O -1.9969 Soluble
221 K O -2.6960 Soluble
222 V O -1.5990 Soluble
223 D O -2.6830 Soluble
224 K O -2.1308 Soluble
225 R O -2.7074 Soluble
226 V O 0.0000 Buried
227 E O -2.5055 Soluble
228 P O -1.2204 Soluble
1 E P -1.5366 Soluble
2 I P -0.1555 Soluble
3 V P 0.8292 Aggregation-prone
4 L P 0.0000 Buried
5 T P -0.7270 Soluble
6 Q P 0.0000 Buried
7 S P -1.1454 Soluble
8 P P -0.8978 Soluble
9 D P -1.5952 Soluble
10 F P 0.0151 Aggregation-prone
11 Q P -0.2213 Soluble
12 S P -0.2733 Soluble
13 V P -1.0133 Soluble
14 T P -1.5968 Soluble
15 P P -2.2339 Soluble
16 K P -3.4048 Soluble
17 E P -3.8052 Soluble
18 K P -3.4609 Soluble
19 V P 0.0000 Buried
20 T P -0.8795 Soluble
21 I P 0.0000 Buried
22 T P -1.0321 Soluble
23 C P 0.0000 Buried
24 R P -2.2340 Soluble
25 A P 0.0000 Buried
26 S P -0.8394 Soluble
27 Q P -1.6182 Soluble
28 S P -1.4193 Soluble
29 I P 0.0000 Buried
36 S P -1.2737 Soluble
37 D P -1.7652 Soluble
38 H P -0.9179 Soluble
39 L P 0.0000 Buried
40 H P 0.0000 Buried
41 W P 0.0000 Buried
42 Y P 0.0000 Buried
43 Q P 0.0000 Buried
44 Q P -1.4605 Soluble
45 K P -2.2403 Soluble
46 P P -2.0542 Soluble
47 D P -2.9553 Soluble
48 Q P -2.7847 Soluble
49 S P -1.6640 Soluble
50 P P 0.0000 Buried
51 K P -1.2355 Soluble
52 L P -0.2556 Soluble
53 L P 0.0000 Buried
54 I P 0.0000 Buried
55 K P -0.1472 Soluble
56 Y P 0.0047 Aggregation-prone
57 A P 0.0000 Buried
65 S P -0.7908 Soluble
66 H P -0.7968 Soluble
67 A P -0.3258 Soluble
68 I P 0.0404 Aggregation-prone
69 S P -0.3232 Soluble
70 G P -0.3889 Soluble
71 V P -0.1637 Soluble
72 P P -0.5538 Soluble
74 S P -0.8704 Soluble
75 R P -1.6989 Soluble
76 F P 0.0000 Buried
77 S P -0.8815 Soluble
78 G P -0.6308 Soluble
79 S P -0.8314 Soluble
80 G P -1.0497 Soluble
83 S P -1.2865 Soluble
84 G P -1.5795 Soluble
85 T P -1.8246 Soluble
86 D P -2.0195 Soluble
87 F P 0.0000 Buried
88 T P -0.7473 Soluble
89 L P 0.0000 Buried
90 T P -0.9722 Soluble
91 I P 0.0000 Buried
92 N P -3.0603 Soluble
93 S P -3.0565 Soluble
94 L P 0.0000 Buried
95 E P -2.5658 Soluble
96 A P -2.4441 Soluble
97 E P -2.9832 Soluble
98 D P -1.4681 Soluble
99 A P -1.4104 Soluble
100 A P 0.0000 Buried
101 T P -0.6740 Soluble
102 Y P 0.0000 Buried
103 Y P 0.0000 Buried
104 C P 0.0000 Buried
105 Q P 0.0000 Buried
106 Q P 0.0000 Buried
107 G P 0.0000 Buried
108 Y P 0.0285 Aggregation-prone
109 D P -1.0032 Soluble
114 F P -0.1280 Soluble
115 P P -0.3545 Soluble
116 L P 0.0000 Buried
117 T P -0.1574 Soluble
118 F P 0.0000 Buried
119 G P 0.0000 Buried
120 G P -1.1283 Soluble
121 G P -1.1591 Soluble
122 T P 0.0000 Buried
123 K P -0.9904 Soluble
124 V P 0.0000 Buried
125 E P 0.0000 Buried
126 I P -0.7733 Soluble
127 K P -0.8145 Soluble
128 R P -1.1047 Soluble
129 T P 0.1629 Aggregation-prone
130 V P 1.1335 Aggregation-prone
131 A P 0.3040 Aggregation-prone
132 A P 0.1957 Aggregation-prone
133 P P 0.0000 Buried
134 S P -0.1457 Soluble
135 V P 0.0000 Buried
136 F P 0.2033 Aggregation-prone
137 I P 0.0000 Buried
138 F P 0.0000 Buried
139 P P -0.6830 Soluble
140 P P -0.5444 Soluble
141 S P 0.0000 Buried
142 D P -2.5557 Soluble
143 E P -2.4409 Soluble
144 Q P 0.0000 Buried
145 L P -1.9331 Soluble
146 K P -2.4137 Soluble
147 S P -1.3931 Soluble
148 G P -1.1502 Soluble
149 T P -0.8319 Soluble
150 A P 0.0000 Buried
151 S P -0.0413 Soluble
152 V P 0.0000 Buried
153 V P 0.1187 Aggregation-prone
154 C P 0.0000 Buried
155 L P 0.0000 Buried
156 L P 0.0000 Buried
157 N P -0.4309 Soluble
158 N P -0.6384 Soluble
159 F P 0.0000 Buried
160 Y P 0.0000 Buried
161 P P -1.1548 Soluble
162 R P -1.9258 Soluble
163 E P -2.5807 Soluble
164 A P -1.9459 Soluble
165 K P -2.0497 Soluble
166 V P -0.9094 Soluble
167 Q P -0.2954 Soluble
168 W P 0.0000 Buried
169 K P -0.3712 Soluble
170 V P 0.0000 Buried
171 D P -1.8627 Soluble
172 N P -1.5248 Soluble
173 A P -0.2657 Soluble
174 L P 0.6822 Aggregation-prone
175 Q P -0.4463 Soluble
176 S P -0.7976 Soluble
177 G P -1.3865 Soluble
178 N P -1.6695 Soluble
179 S P -1.7890 Soluble
180 Q P -2.4787 Soluble
181 E P -2.0288 Soluble
182 S P 0.0000 Buried
183 V P 0.5588 Aggregation-prone
184 T P -0.0700 Soluble
185 E P -1.3130 Soluble
186 Q P -1.6336 Soluble
187 D P -2.1766 Soluble
188 S P -2.7692 Soluble
189 K P -3.2695 Soluble
190 D P -3.0581 Soluble
191 S P -2.3697 Soluble
192 T P 0.0000 Buried
193 Y P -0.5847 Soluble
194 S P 0.0000 Buried
195 L P 0.0000 Buried
196 S P -0.3197 Soluble
197 S P 0.0000 Buried
198 T P -0.8970 Soluble
199 L P 0.0000 Buried
200 T P -0.6066 Soluble
201 L P -0.8467 Soluble
202 S P -1.2111 Soluble
203 K P -2.1074 Soluble
204 A P -1.8558 Soluble
205 D P -3.0770 Soluble
206 Y P 0.0000 Buried
207 E P -3.7728 Soluble
208 K P -3.8308 Soluble
209 H P -3.2421 Soluble
210 K P -3.2133 Soluble
211 V P -1.5394 Soluble
212 Y P 0.0000 Buried
213 A P 0.0000 Buried
214 C P 0.0000 Buried
215 E P -0.5061 Soluble
216 V P 0.0000 Buried
217 T P -1.1172 Soluble
218 H P 0.0000 Buried
219 Q P -1.2879 Soluble
220 G P -0.2858 Soluble
221 L P -0.2858 Soluble
222 S P -0.4345 Soluble
223 S P -0.3911 Soluble
224 P P -0.4775 Soluble
225 V P 0.1195 Aggregation-prone
226 T P -0.3039 Soluble
227 K P -0.5924 Soluble
228 S P -0.6027 Soluble
229 F P -1.3425 Soluble
230 N P -2.4744 Soluble
231 R P -2.6370 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.7081 2.8097 CSV PDB
4.5 -0.7533 2.8125 CSV PDB
5.0 -0.807 2.8174 CSV PDB
5.5 -0.8582 2.823 CSV PDB
6.0 -0.8939 2.8272 CSV PDB
6.5 -0.9058 2.8292 CSV PDB
7.0 -0.8953 2.83 CSV PDB
7.5 -0.8701 2.8302 CSV PDB
8.0 -0.8363 2.8301 CSV PDB
8.5 -0.7958 2.8296 CSV PDB
9.0 -0.7477 2.828 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH