Zinlirvimab / 8dok

A4DAB308_8dok_O_P | Source PDB: 8dok | Chains: O, P | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.4707
Max Score
2.6245
Min Score
-2.9729
Total Score
-110.62
Score CDR
-0.161
Score non-CDR
-0.5817

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTVSLSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTVLG input.pdb
Selected Chain(s) O (Heavy), P (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -2.9729
Maximum Score 2.6245
Average Score -0.4707
Total Score -110.6216

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q O -1.6063 Soluble
2 V O -1.2704 Soluble
3 Q O -2.0197 Soluble
4 L O -1.7154 Soluble
5 Q O -2.1107 Soluble
6 E O -1.7741 Soluble
7 S O -0.9595 Soluble
8 G O -0.6516 Soluble
9 P O -0.1924 Soluble
11 G O 0.1502 Aggregation-prone
12 L O 0.5409 Aggregation-prone
13 V O 0.0000 Buried
14 K O -2.1353 Soluble
15 P O -1.6120 Soluble
16 S O -1.6750 Soluble
17 E O -2.5085 Soluble
18 T O -1.6108 Soluble
19 L O 0.0000 Buried
20 S O -0.8021 Soluble
21 V O 0.0000 Buried
22 T O 0.0000 Buried
23 C O 0.0000 Buried
24 S O 0.0000 Buried
25 V O 0.0000 Buried
26 S O -1.3208 Soluble
27 G O -1.3391 Soluble
28 D O -1.3281 Soluble
29 S O -1.3303 Soluble
30 M O 0.0000 Buried
35 N O -2.0504 Soluble
36 N O -1.2589 Soluble
37 Y O -1.0501 Soluble
38 Y O -1.1383 Soluble
39 W O 0.0000 Buried
40 T O 0.0000 Buried
41 W O 0.0000 Buried
42 I O 0.0000 Buried
43 R O 0.0000 Buried
44 Q O -0.8820 Soluble
45 S O -0.9603 Soluble
46 P O -1.1063 Soluble
47 G O -1.5229 Soluble
48 K O -2.3063 Soluble
49 G O -1.5948 Soluble
50 L O 0.0000 Buried
51 E O -0.7855 Soluble
52 W O 0.0000 Buried
53 I O 0.0000 Buried
54 G O 0.0000 Buried
55 Y O 0.0000 Buried
56 I O 0.0000 Buried
57 S O -1.3978 Soluble
58 D O 0.0000 Buried
59 R O -2.9729 Soluble
63 E O -2.9571 Soluble
64 S O -1.6362 Soluble
65 A O -0.4115 Soluble
66 T O 0.1321 Aggregation-prone
67 Y O -0.0620 Soluble
68 N O -0.5956 Soluble
69 P O -0.8577 Soluble
70 S O -0.8503 Soluble
71 L O 0.0000 Buried
72 N O -1.6284 Soluble
74 S O -0.7241 Soluble
75 R O -0.6863 Soluble
76 V O 0.0000 Buried
77 V O 1.3978 Aggregation-prone
78 I O 0.2491 Aggregation-prone
79 S O -0.4979 Soluble
80 R O -1.3616 Soluble
81 D O -2.1052 Soluble
82 T O -1.6975 Soluble
83 S O -1.6368 Soluble
84 K O -2.5025 Soluble
85 N O -2.0494 Soluble
86 Q O -1.8477 Soluble
87 L O 0.0000 Buried
88 S O -0.5702 Soluble
89 L O 0.0000 Buried
90 K O -0.6410 Soluble
91 L O 0.0000 Buried
92 N O -1.1316 Soluble
93 S O -1.3552 Soluble
94 V O 0.0000 Buried
95 T O -0.7402 Soluble
96 P O -0.4659 Soluble
97 A O -0.0862 Soluble
98 D O 0.0000 Buried
99 T O 0.0000 Buried
100 A O 0.0000 Buried
101 V O -0.1870 Soluble
102 Y O 0.0000 Buried
103 Y O 0.0000 Buried
104 C O 0.0000 Buried
105 A O 0.0000 Buried
106 T O 0.0000 Buried
107 A O 0.0000 Buried
108 R O -2.3205 Soluble
109 R O -1.8797 Soluble
110 G O -0.9674 Soluble
111 Q O -0.0983 Soluble
111A R O 0.6707 Aggregation-prone
111B I O 2.3448 Aggregation-prone
111C Y O 1.9639 Aggregation-prone
111D G O 1.7937 Aggregation-prone
111E V O 2.6245 Aggregation-prone
111F V O 2.4699 Aggregation-prone
112G S O 1.4465 Aggregation-prone
112F F O 2.2540 Aggregation-prone
112E G O 1.2730 Aggregation-prone
112D E O 1.3507 Aggregation-prone
112C F O 1.7267 Aggregation-prone
112B F O 0.6864 Aggregation-prone
112A Y O 0.5380 Aggregation-prone
112 Y O -0.0973 Soluble
113 Y O 0.0000 Buried
114 S O 0.0000 Buried
115 M O 0.0000 Buried
116 D O -1.4971 Soluble
117 V O -0.7496 Soluble
118 W O 0.0000 Buried
119 G O 0.0000 Buried
120 K O -2.7099 Soluble
121 G O -1.5164 Soluble
122 T O -0.8051 Soluble
123 T O -0.0146 Soluble
124 V O 0.0000 Buried
125 T O 0.0798 Aggregation-prone
126 V O -0.3956 Soluble
127 S O -0.4868 Soluble
11 L P 1.1200 Aggregation-prone
12 S P 0.5287 Aggregation-prone
13 V P 0.9631 Aggregation-prone
14 A P 0.9626 Aggregation-prone
15 L P 1.1066 Aggregation-prone
16 G P -0.4331 Soluble
17 E P -1.3995 Soluble
18 T P -0.9164 Soluble
19 A P -0.7167 Soluble
20 R P -1.3898 Soluble
21 I P -0.0846 Soluble
22 S P -0.9415 Soluble
23 C P -1.1359 Soluble
24 G P -1.1593 Soluble
25 R P -1.6017 Soluble
26 Q P -1.8206 Soluble
27 A P -0.7488 Soluble
28 L P 0.1788 Aggregation-prone
29 G P 0.1728 Aggregation-prone
36 S P 0.5526 Aggregation-prone
37 R P 0.0000 Buried
38 A P 0.0000 Buried
39 V P 0.0000 Buried
40 Q P 0.0000 Buried
41 W P 0.0000 Buried
42 Y P 0.0000 Buried
43 Q P 0.0000 Buried
44 H P 0.0000 Buried
45 R P -1.2164 Soluble
46 P P -1.4138 Soluble
47 G P -1.7275 Soluble
48 Q P -2.0680 Soluble
49 A P -0.9241 Soluble
50 P P 0.0000 Buried
51 I P 1.1322 Aggregation-prone
52 L P 0.0000 Buried
53 L P 0.0000 Buried
54 I P 0.0000 Buried
55 Y P -0.3664 Soluble
56 N P -1.1822 Soluble
57 N P 0.0000 Buried
65 Q P -2.2893 Soluble
66 D P -2.5367 Soluble
67 R P -2.4092 Soluble
68 P P -1.3493 Soluble
69 S P -0.8029 Soluble
70 G P -0.6811 Soluble
71 I P -0.6672 Soluble
72 P P -1.3871 Soluble
74 E P -2.3576 Soluble
75 R P -1.5201 Soluble
76 F P 0.0000 Buried
77 S P -1.3083 Soluble
78 G P -1.5883 Soluble
79 T P -1.0663 Soluble
80 P P -1.0940 Soluble
81 D P -0.3721 Soluble
81A I P 0.7731 Aggregation-prone
82 N P 0.0304 Aggregation-prone
83 F P 1.1837 Aggregation-prone
84 G P -0.2181 Soluble
85 T P -0.8084 Soluble
86 R P -1.8991 Soluble
87 A P 0.0000 Buried
88 T P 0.0000 Buried
89 L P 0.0000 Buried
90 T P -0.9356 Soluble
91 I P 0.0000 Buried
92 S P -0.3877 Soluble
93 G P -0.4360 Soluble
94 V P -0.0095 Soluble
95 E P -0.5621 Soluble
96 A P -0.4857 Soluble
97 G P -0.8971 Soluble
98 D P 0.0000 Buried
99 E P -0.9847 Soluble
100 A P 0.0000 Buried
101 D P -1.2280 Soluble
102 Y P 0.0000 Buried
103 Y P 0.0000 Buried
104 C P 0.0000 Buried
105 H P 0.0000 Buried
106 M P 0.0000 Buried
107 W P 0.0000 Buried
108 D P 0.0000 Buried
109 S P -0.3143 Soluble
110 R P -1.6368 Soluble
112 S P -0.7623 Soluble
113 G P -0.1731 Soluble
114 F P 0.9208 Aggregation-prone
115 S P 0.4863 Aggregation-prone
116 W P 0.3387 Aggregation-prone
117 S P -0.1898 Soluble
118 F P 0.0000 Buried
119 G P -0.8081 Soluble
120 G P -1.1035 Soluble
121 A P -0.7629 Soluble
122 T P -0.6498 Soluble
123 R P -1.0740 Soluble
124 L P 0.0000 Buried
125 T P 0.5568 Aggregation-prone
126 V P 1.3305 Aggregation-prone
127 L P 1.7678 Aggregation-prone
128 G P 0.3946 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.335 4.4457 CSV PDB
4.5 -0.3664 4.4164 CSV PDB
5.0 -0.4058 4.3772 CSV PDB
5.5 -0.4455 4.3349 CSV PDB
6.0 -0.4772 4.2959 CSV PDB
6.5 -0.4958 4.2668 CSV PDB
7.0 -0.5005 4.2506 CSV PDB
7.5 -0.4957 4.2438 CSV PDB
8.0 -0.4856 4.2414 CSV PDB
8.5 -0.4724 4.2406 CSV PDB
9.0 -0.4561 4.2403 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH