Cosfroviximab / 5kem

A4DAB073_5kem_D_E | Source PDB: 5kem | Chains: D, E | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6022
Max Score
1.1102
Min Score
-2.7651
Total Score
-137.3
Score CDR
-0.4934
Score non-CDR
-0.632

Calculation Parameters

Chain Sequence(s) DVKLLESGGGLVQPGGSLKLSCAASGFSLSTSGVGVGWFRQPSGKGLEWLALIWWDDDKYYNPSLKSQLSISKDFSRNQVFLKISNVDIADTATYYCARRDPFGYDNAMGYWGQGTSVTVSDIVMTQSPLSLSTSVGDRVSLTCKASQNVGTAVAWYQQKPGQSPKLLIYSASNRYTGVPDRFTGSGSGTDFTLTISNMQSEDLADYFCQQYSSYPLTFGAGTKLELR input.pdb
Selected Chain(s) D (Heavy), E (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -2.7651
Maximum Score 1.1102
Average Score -0.6022
Total Score -137.3048

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 D D -2.0857 Soluble
2 V D -1.3764 Soluble
3 K D -1.8455 Soluble
4 L D 0.0000 Buried
5 L D -0.3955 Soluble
6 E D 0.0000 Buried
7 S D -0.7241 Soluble
8 G D -0.8431 Soluble
9 G D -0.6108 Soluble
11 G D 0.3345 Aggregation-prone
12 L D 1.1102 Aggregation-prone
13 V D 0.0000 Buried
14 Q D -1.0602 Soluble
15 P D -0.8208 Soluble
16 G D -1.4993 Soluble
17 G D -1.4258 Soluble
18 S D -1.3928 Soluble
19 L D -1.2390 Soluble
20 K D -2.1219 Soluble
21 L D 0.0000 Buried
22 S D -0.7084 Soluble
23 C D 0.0000 Buried
24 A D -0.7293 Soluble
25 A D 0.0000 Buried
26 S D -1.1825 Soluble
27 G D -1.0338 Soluble
28 F D -0.6657 Soluble
29 S D -0.2241 Soluble
30 L D -0.0908 Soluble
31 S D 0.1519 Aggregation-prone
34 T D -0.1690 Soluble
35 S D -0.3762 Soluble
36 G D -0.5865 Soluble
37 V D -0.1452 Soluble
38 G D -0.5501 Soluble
39 V D 0.0000 Buried
40 G D 0.0000 Buried
41 W D 0.0000 Buried
42 F D 0.0000 Buried
43 R D 0.0000 Buried
44 Q D 0.0000 Buried
45 P D -0.6810 Soluble
46 S D -0.9228 Soluble
47 G D -1.6876 Soluble
48 K D -2.1571 Soluble
49 G D -1.2680 Soluble
50 L D -0.3705 Soluble
51 E D -0.7738 Soluble
52 W D 0.0000 Buried
53 L D 0.0000 Buried
54 A D 0.0000 Buried
55 L D -0.3200 Soluble
56 I D 0.0000 Buried
57 W D -1.0230 Soluble
58 W D -0.8556 Soluble
59 D D -2.5147 Soluble
63 D D -2.7651 Soluble
64 D D -2.0372 Soluble
65 K D -1.6604 Soluble
66 Y D -0.7276 Soluble
67 Y D 0.0000 Buried
68 N D -0.7057 Soluble
69 P D -0.7732 Soluble
70 S D -0.6233 Soluble
71 L D -0.4834 Soluble
72 K D -1.2943 Soluble
74 S D -0.9931 Soluble
75 Q D -1.4972 Soluble
76 L D 0.0000 Buried
77 S D -1.1125 Soluble
78 I D 0.0000 Buried
79 S D -0.8861 Soluble
80 K D -0.5673 Soluble
81 D D -0.6044 Soluble
82 F D -0.0660 Soluble
83 S D -0.8398 Soluble
84 R D -1.8853 Soluble
85 N D -1.1066 Soluble
86 Q D -0.8253 Soluble
87 V D 0.0000 Buried
88 F D -0.6996 Soluble
89 L D 0.0000 Buried
90 K D -1.7884 Soluble
91 I D -1.5674 Soluble
92 S D -1.7541 Soluble
93 N D -1.8844 Soluble
94 V D -1.2449 Soluble
95 D D -1.0717 Soluble
96 I D 0.8676 Aggregation-prone
97 A D 0.3939 Aggregation-prone
98 D D -0.1834 Soluble
99 T D 0.2793 Aggregation-prone
100 A D 0.0000 Buried
101 T D -0.4430 Soluble
102 Y D 0.0000 Buried
103 Y D 0.0320 Aggregation-prone
104 C D 0.0000 Buried
105 A D 0.0000 Buried
106 R D -0.7554 Soluble
107 R D -1.1619 Soluble
108 D D -1.7469 Soluble
109 P D -0.6648 Soluble
110 F D 0.1501 Aggregation-prone
111 G D 0.0909 Aggregation-prone
112A Y D 1.0462 Aggregation-prone
112 D D 0.2079 Aggregation-prone
113 N D -0.2056 Soluble
114 A D 0.0000 Buried
115 M D -0.3744 Soluble
116 G D 0.0000 Buried
117 Y D -0.4533 Soluble
118 W D -0.4560 Soluble
119 G D -0.4515 Soluble
120 Q D -0.9816 Soluble
121 G D -0.8191 Soluble
122 T D -0.5843 Soluble
123 S D -0.2381 Soluble
124 V D 0.0000 Buried
125 T D 0.6187 Aggregation-prone
126 V D 0.4836 Aggregation-prone
127 S D 0.0611 Aggregation-prone
1 D E -1.2987 Soluble
2 I E 0.0000 Buried
3 V E 1.0723 Aggregation-prone
4 M E 0.3527 Aggregation-prone
5 T E -0.2660 Soluble
6 Q E -0.3622 Soluble
7 S E -0.1083 Soluble
8 P E 0.3641 Aggregation-prone
9 L E 1.0033 Aggregation-prone
10 S E 0.2316 Aggregation-prone
11 L E -0.0422 Soluble
12 S E -0.8799 Soluble
13 T E 0.0000 Buried
14 S E -0.4582 Soluble
15 V E 0.3221 Aggregation-prone
16 G E -0.9521 Soluble
17 D E -1.7866 Soluble
18 R E -2.6437 Soluble
19 V E -1.3603 Soluble
20 S E -0.7121 Soluble
21 L E 0.0000 Buried
22 T E -0.6745 Soluble
23 C E 0.0000 Buried
24 K E -1.7071 Soluble
25 A E -0.8341 Soluble
26 S E -0.8128 Soluble
27 Q E -1.5479 Soluble
28 N E -2.0334 Soluble
29 V E 0.0000 Buried
36 G E -0.9998 Soluble
37 T E -0.4913 Soluble
38 A E -0.2671 Soluble
39 V E 0.0000 Buried
40 A E 0.0000 Buried
41 W E 0.0000 Buried
42 Y E 0.0000 Buried
43 Q E -0.8745 Soluble
44 Q E -1.4799 Soluble
45 K E -1.9037 Soluble
46 P E -1.3315 Soluble
47 G E -1.3989 Soluble
48 Q E -2.0596 Soluble
49 S E -1.3806 Soluble
50 P E -1.2099 Soluble
51 K E -1.4250 Soluble
52 L E 0.0000 Buried
53 L E 0.0000 Buried
54 I E 0.0000 Buried
55 Y E -0.5963 Soluble
56 S E -0.5107 Soluble
57 A E 0.0000 Buried
65 S E -1.0536 Soluble
66 N E -1.7359 Soluble
67 R E -1.8216 Soluble
68 Y E 0.0000 Buried
69 T E -0.5861 Soluble
70 G E -0.9180 Soluble
71 V E -0.9794 Soluble
72 P E -1.3238 Soluble
74 D E -2.2092 Soluble
75 R E -1.8220 Soluble
76 F E 0.0000 Buried
77 T E -1.0422 Soluble
78 G E 0.0000 Buried
79 S E -0.7241 Soluble
80 G E -0.9388 Soluble
83 S E -1.2584 Soluble
84 G E 0.0000 Buried
85 T E -1.6144 Soluble
86 D E -2.0372 Soluble
87 F E 0.0000 Buried
88 T E -0.6875 Soluble
89 L E 0.0000 Buried
90 T E -0.6177 Soluble
91 I E 0.0000 Buried
92 S E -2.0596 Soluble
93 N E -2.2040 Soluble
94 M E 0.0000 Buried
95 Q E -1.2577 Soluble
96 S E -0.9009 Soluble
97 E E -2.0315 Soluble
98 D E -1.3586 Soluble
99 L E -1.0756 Soluble
100 A E 0.0000 Buried
101 D E -0.5006 Soluble
102 Y E 0.0000 Buried
103 F E 0.0775 Aggregation-prone
104 C E 0.0000 Buried
105 Q E 0.0000 Buried
106 Q E 0.0000 Buried
107 Y E 0.2198 Aggregation-prone
108 S E -0.3365 Soluble
109 S E 0.1429 Aggregation-prone
114 Y E 0.3925 Aggregation-prone
115 P E 0.2395 Aggregation-prone
116 L E 0.0000 Buried
117 T E 0.4837 Aggregation-prone
118 F E 0.5346 Aggregation-prone
119 G E 0.0000 Buried
120 A E 0.0736 Aggregation-prone
121 G E -0.0823 Soluble
122 T E 0.0000 Buried
123 K E -0.4525 Soluble
124 L E 0.0000 Buried
125 E E -1.2064 Soluble
126 L E -0.3734 Soluble
127 R E -1.5643 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.503 3.0728 CSV PDB
4.5 -0.5536 2.8895 CSV PDB
5.0 -0.609 2.6914 CSV PDB
5.5 -0.6612 2.4881 CSV PDB
6.0 -0.7019 2.3305 CSV PDB
6.5 -0.7264 2.3452 CSV PDB
7.0 -0.7369 2.3664 CSV PDB
7.5 -0.7386 2.3911 CSV PDB
8.0 -0.734 2.4172 CSV PDB
8.5 -0.7214 2.4437 CSV PDB
9.0 -0.6971 2.4702 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH