Diridavumab / 4evn

A4DAB087_4evn_G_H | Source PDB: 4evn | Chains: G, H | Done
96.55
Yes
10 Å
Yes
Avg A4D Score
-0.6569
Max Score
3.2207
Min Score
-3.1731
Total Score
-285.1
Score CDR
-0.0033
Score non-CDR
-0.7478

Calculation Parameters

Chain Sequence(s) QVQLVESGAEVKKPGSSVKVSCKASGGPFRSYAISWVRQAPGQGPEWMGGIIPIFGTTKYAPKFQGRVTITADDFAGTVYMELSSLRSEDTAMYYCAKHMGYQVRETMDVWGKGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVSWYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSGTSATLGITGLQTGDEADYYCGTWDSSLSAYVVFGGGTKLTVLGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTE input.pdb
Selected Chain(s) G (Heavy), H (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.1731
Maximum Score 3.2207
Average Score -0.6569
Total Score -285.1029

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q G -1.4460 Soluble
2 V G -0.9708 Soluble
3 Q G -1.3460 Soluble
4 L G 0.0000 Buried
5 V G 0.5041 Aggregation-prone
6 E G -0.1134 Soluble
7 S G -0.4847 Soluble
8 G G -0.5085 Soluble
9 A G -0.3843 Soluble
11 E G -0.7557 Soluble
12 V G -0.2378 Soluble
13 K G -1.3290 Soluble
14 K G -2.2075 Soluble
15 P G -2.2300 Soluble
16 G G -1.6199 Soluble
17 S G -1.2402 Soluble
18 S G -1.1935 Soluble
19 V G 0.0000 Buried
20 K G -2.0275 Soluble
21 V G 0.0000 Buried
22 S G -0.5735 Soluble
23 C G 0.0000 Buried
24 K G -0.9340 Soluble
25 A G 0.0000 Buried
26 S G -0.7824 Soluble
27 G G -0.9375 Soluble
28 G G -0.4673 Soluble
29 P G 0.3893 Aggregation-prone
30 F G 1.9807 Aggregation-prone
35 R G 0.0000 Buried
36 S G 0.8924 Aggregation-prone
37 Y G 0.9628 Aggregation-prone
38 A G 0.0000 Buried
39 I G 0.0000 Buried
40 S G 0.0000 Buried
41 W G 0.0000 Buried
42 V G 0.0000 Buried
43 R G -0.4525 Soluble
44 Q G -0.7213 Soluble
45 A G -1.0596 Soluble
46 P G -0.8706 Soluble
47 G G -1.4492 Soluble
48 Q G -1.7622 Soluble
49 G G -1.2119 Soluble
50 P G 0.0000 Buried
51 E G -0.8045 Soluble
52 W G 0.0000 Buried
53 M G 0.0000 Buried
54 G G 0.0000 Buried
55 G G 0.0000 Buried
56 I G 0.0000 Buried
57 I G 1.1359 Aggregation-prone
58 P G 0.0000 Buried
59 I G 3.2207 Aggregation-prone
62 F G 2.8094 Aggregation-prone
63 G G 1.2206 Aggregation-prone
64 T G 0.5961 Aggregation-prone
65 T G -0.1356 Soluble
66 K G -0.7619 Soluble
67 Y G -0.8143 Soluble
68 A G 0.0000 Buried
69 P G -1.2528 Soluble
70 K G -2.2430 Soluble
71 F G 0.0000 Buried
72 Q G -2.1534 Soluble
74 G G -1.5451 Soluble
75 R G -1.5034 Soluble
76 V G 0.0000 Buried
77 T G -0.8640 Soluble
78 I G 0.0000 Buried
79 T G -0.4061 Soluble
80 A G -0.2296 Soluble
81 D G -0.5434 Soluble
82 D G 0.6503 Aggregation-prone
83 F G 1.7689 Aggregation-prone
84 A G 0.5067 Aggregation-prone
85 G G 0.0000 Buried
86 T G -0.2231 Soluble
87 V G 0.0000 Buried
88 Y G -0.6244 Soluble
89 M G 0.0000 Buried
90 E G -1.4081 Soluble
91 L G 0.0000 Buried
92 S G -1.2107 Soluble
93 S G -1.2520 Soluble
94 L G 0.0000 Buried
95 R G -3.0916 Soluble
96 S G -2.3815 Soluble
97 E G -2.5501 Soluble
98 D G 0.0000 Buried
99 T G -0.9994 Soluble
100 A G 0.0000 Buried
101 M G -0.0780 Soluble
102 Y G 0.0000 Buried
103 Y G 0.0000 Buried
104 C G 0.0000 Buried
105 A G 0.0000 Buried
106 K G -0.0628 Soluble
107 H G 0.0000 Buried
108 M G 0.2165 Aggregation-prone
109 G G 0.1450 Aggregation-prone
110 Y G 0.9285 Aggregation-prone
111 Q G -0.5704 Soluble
112A V G 0.0000 Buried
112 R G -1.9293 Soluble
113 E G -1.3353 Soluble
114 T G -0.6403 Soluble
115 M G 0.0000 Buried
116 D G -0.3464 Soluble
117 V G -0.2389 Soluble
118 W G 0.0000 Buried
119 G G 0.0000 Buried
120 K G -1.4684 Soluble
121 G G 0.0000 Buried
122 T G 0.0000 Buried
123 T G -0.1140 Soluble
124 V G 0.0000 Buried
125 T G -0.7923 Soluble
126 V G 0.0000 Buried
127 S G -1.2282 Soluble
128 S G -1.2251 Soluble
129 A G -0.7560 Soluble
130 S G -0.8219 Soluble
131 T G -0.8853 Soluble
132 K G -1.7858 Soluble
133 G G -1.7691 Soluble
134 P G -0.9706 Soluble
135 S G -0.4834 Soluble
136 V G 0.0000 Buried
137 F G 0.0000 Buried
138 P G -0.9650 Soluble
139 L G 0.0000 Buried
140 A G -1.0710 Soluble
141 P G 0.0000 Buried
142 S G -1.1275 Soluble
143 S G -1.2123 Soluble
144 K G -2.0146 Soluble
145 S G -1.1225 Soluble
146 T G -1.0382 Soluble
147 S G -0.9057 Soluble
148 G G -0.8955 Soluble
149 G G -0.9362 Soluble
150 T G -0.6325 Soluble
151 A G 0.0000 Buried
152 A G 0.0000 Buried
153 L G 0.0000 Buried
154 G G 0.0000 Buried
155 C G 0.0000 Buried
156 L G 0.0000 Buried
157 V G 0.0000 Buried
158 K G -0.6002 Soluble
159 D G -1.0565 Soluble
160 Y G 0.0000 Buried
161 F G 0.0000 Buried
162 P G 0.0000 Buried
163 E G -1.0905 Soluble
164 P G -1.0213 Soluble
165 V G -0.7848 Soluble
166 T G -0.6557 Soluble
167 V G -0.3869 Soluble
168 S G -0.3867 Soluble
169 W G 0.0000 Buried
170 N G -0.8498 Soluble
171 S G -0.7119 Soluble
172 G G -0.5424 Soluble
173 A G -0.2319 Soluble
174 L G 0.0637 Aggregation-prone
175 T G -0.1416 Soluble
176 S G -0.2460 Soluble
177 G G -0.3087 Soluble
178 V G 0.1388 Aggregation-prone
179 H G -0.2058 Soluble
180 T G -0.0575 Soluble
181 F G 0.0000 Buried
182 P G -0.2657 Soluble
183 A G -0.0354 Soluble
184 V G 0.0000 Buried
185 L G 0.9781 Aggregation-prone
186 Q G 0.0316 Aggregation-prone
187 S G -0.2170 Soluble
188 S G -0.3271 Soluble
189 G G -0.1453 Soluble
190 L G 0.0000 Buried
191 Y G -0.0777 Soluble
192 S G 0.0000 Buried
193 L G 0.0000 Buried
194 S G 0.0000 Buried
195 S G 0.0000 Buried
196 V G 0.0000 Buried
197 V G 0.0000 Buried
198 T G -0.1970 Soluble
199 V G 0.0000 Buried
200 P G -0.6505 Soluble
201 S G -0.7128 Soluble
202 S G -0.6623 Soluble
203 S G -0.6516 Soluble
204 L G -0.8500 Soluble
205 G G -1.0979 Soluble
206 T G -0.7186 Soluble
207 Q G -1.2596 Soluble
208 T G -1.1503 Soluble
209 Y G 0.0000 Buried
210 I G -1.3169 Soluble
211 C G 0.0000 Buried
212 N G -1.5295 Soluble
213 V G 0.0000 Buried
214 N G -1.9151 Soluble
215 H G 0.0000 Buried
216 K G -2.8272 Soluble
217 P G -1.8284 Soluble
218 S G -1.9589 Soluble
219 N G -2.6472 Soluble
220 T G -2.1152 Soluble
221 K G -2.6501 Soluble
222 V G -1.4650 Soluble
223 D G -2.5770 Soluble
224 K G -2.1109 Soluble
225 R G -2.7249 Soluble
226 V G 0.0000 Buried
227 E G -2.5522 Soluble
228 P G -1.2493 Soluble
3 V H 1.6160 Aggregation-prone
4 L H 0.0000 Buried
5 T H 0.0621 Aggregation-prone
6 Q H 0.0000 Buried
7 P H -0.4787 Soluble
8 P H -0.7007 Soluble
9 S H -0.6372 Soluble
11 V H -0.1998 Soluble
12 S H -0.1821 Soluble
13 A H 0.0000 Buried
14 A H -0.8053 Soluble
15 P H -1.4784 Soluble
16 G H -2.0325 Soluble
17 Q H -2.6083 Soluble
18 K H -2.5982 Soluble
19 V H 0.0000 Buried
20 T H -0.4704 Soluble
21 I H 0.0000 Buried
22 S H -0.2853 Soluble
23 C H 0.0000 Buried
24 S H -0.1570 Soluble
25 G H -0.0520 Soluble
26 S H -0.3916 Soluble
27 S H -0.8960 Soluble
28 S H -0.5534 Soluble
29 N H 0.0000 Buried
30 I H 0.0000 Buried
35 G H -1.0555 Soluble
36 N H -1.3520 Soluble
37 N H -0.7404 Soluble
38 Y H 0.0471 Aggregation-prone
39 V H 0.0000 Buried
40 S H 0.0000 Buried
41 W H 0.0000 Buried
42 Y H 0.0000 Buried
43 Q H 0.0000 Buried
44 Q H -0.5238 Soluble
45 L H -0.1864 Soluble
46 P H -0.5375 Soluble
47 G H -0.7529 Soluble
48 T H -0.7830 Soluble
49 A H -0.8826 Soluble
50 P H 0.0000 Buried
51 K H -0.7189 Soluble
52 L H 0.0000 Buried
53 L H 0.0000 Buried
54 I H 0.0000 Buried
55 Y H -1.1991 Soluble
56 D H -1.5965 Soluble
57 N H -1.5129 Soluble
65 N H -2.5266 Soluble
66 K H -2.8100 Soluble
67 R H -2.2596 Soluble
68 P H -1.1031 Soluble
69 S H -0.9244 Soluble
70 G H -0.8334 Soluble
71 I H -0.8871 Soluble
72 P H -1.2891 Soluble
74 D H -2.2089 Soluble
75 R H -1.5653 Soluble
76 F H 0.0000 Buried
77 S H -1.4640 Soluble
78 G H -1.4407 Soluble
79 S H -1.3138 Soluble
80 K H -1.0242 Soluble
83 S H -0.7722 Soluble
84 G H -0.9977 Soluble
85 T H -0.8684 Soluble
86 S H -0.6323 Soluble
87 A H 0.0000 Buried
88 T H -0.5334 Soluble
89 L H 0.0000 Buried
90 G H 0.0000 Buried
91 I H 0.0000 Buried
92 T H -1.9556 Soluble
93 G H -1.8961 Soluble
94 L H 0.0000 Buried
95 Q H -1.8516 Soluble
96 T H -0.9997 Soluble
97 G H -0.9144 Soluble
98 D H 0.0000 Buried
99 E H -0.7843 Soluble
100 A H 0.0000 Buried
101 D H -0.9690 Soluble
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 G H 0.0000 Buried
106 T H 0.0000 Buried
107 W H 0.0000 Buried
108 D H 0.0000 Buried
109 S H -0.3751 Soluble
110 S H 0.5365 Aggregation-prone
112 L H 1.4243 Aggregation-prone
113 S H 0.4548 Aggregation-prone
114 A H 0.1850 Aggregation-prone
115 Y H -0.0472 Soluble
116 V H 0.0000 Buried
117 V H 0.0000 Buried
118 F H 0.0000 Buried
119 G H 0.0000 Buried
120 G H -0.6832 Soluble
121 G H -0.9969 Soluble
122 T H 0.0000 Buried
123 K H -1.1126 Soluble
124 L H 0.0000 Buried
125 T H -0.2996 Soluble
126 V H 0.0000 Buried
127 L H 0.3760 Aggregation-prone
128 G H -0.5386 Soluble
129 Q H -1.0957 Soluble
130 P H -1.3880 Soluble
131 K H -2.5090 Soluble
132 A H -2.0524 Soluble
133 N H -2.1650 Soluble
134 P H 0.0000 Buried
135 T H -0.4965 Soluble
136 V H 0.0000 Buried
137 T H -0.6893 Soluble
138 L H 0.0000 Buried
139 F H 0.0000 Buried
140 P H -0.1581 Soluble
141 P H -0.5494 Soluble
142 S H -0.8221 Soluble
143 S H -1.3452 Soluble
144 E H -2.0219 Soluble
145 E H 0.0000 Buried
146 L H -2.0144 Soluble
147 Q H -2.2899 Soluble
148 A H -1.9110 Soluble
149 N H -2.7955 Soluble
150 K H -2.8856 Soluble
151 A H 0.0000 Buried
152 T H 0.0000 Buried
153 L H 0.0000 Buried
154 V H 0.0000 Buried
155 C H 0.0000 Buried
156 L H 0.0000 Buried
157 I H 0.0000 Buried
158 S H -0.8102 Soluble
159 D H -1.6791 Soluble
160 F H 0.0000 Buried
161 Y H 0.0000 Buried
162 P H -1.1947 Soluble
163 G H -1.1684 Soluble
164 A H -0.4684 Soluble
165 V H -0.3200 Soluble
166 T H -0.0516 Soluble
167 V H 0.1213 Aggregation-prone
168 A H -0.4668 Soluble
169 W H 0.0000 Buried
170 K H -1.0904 Soluble
171 A H -1.3239 Soluble
172 D H -1.6041 Soluble
173 G H -1.2000 Soluble
174 S H -0.7713 Soluble
175 P H -0.9575 Soluble
176 V H -0.8500 Soluble
177 K H -1.6610 Soluble
178 A H -0.8567 Soluble
179 G H -0.7224 Soluble
180 V H -0.4646 Soluble
181 E H -0.6439 Soluble
182 T H -0.4570 Soluble
183 T H -0.8443 Soluble
184 K H -1.7941 Soluble
185 P H -1.1779 Soluble
186 S H -1.3422 Soluble
187 K H -1.9884 Soluble
188 Q H -1.8149 Soluble
189 S H -1.6376 Soluble
190 N H -2.4143 Soluble
191 N H -2.6216 Soluble
192 K H -2.3690 Soluble
193 Y H 0.0000 Buried
194 A H 0.0000 Buried
195 A H 0.0000 Buried
196 S H 0.0000 Buried
197 S H 0.0000 Buried
198 Y H 0.0000 Buried
199 L H 0.0000 Buried
200 S H -0.7157 Soluble
201 L H 0.0000 Buried
202 T H -1.9794 Soluble
203 P H -2.5761 Soluble
204 E H -3.1731 Soluble
205 Q H -2.3813 Soluble
206 W H 0.0000 Buried
207 K H -3.0413 Soluble
208 S H -2.4788 Soluble
209 H H -2.3716 Soluble
210 R H -2.8401 Soluble
211 S H -1.8850 Soluble
212 Y H 0.0000 Buried
213 S H 0.0000 Buried
214 C H 0.0000 Buried
215 Q H -1.1437 Soluble
216 V H 0.0000 Buried
217 T H -0.8586 Soluble
218 H H 0.0000 Buried
219 E H -2.5111 Soluble
220 G H -1.3965 Soluble
221 S H -1.0889 Soluble
222 T H -1.0288 Soluble
223 V H -1.0617 Soluble
224 E H -2.1490 Soluble
225 K H -1.8610 Soluble
226 T H -1.2099 Soluble
227 V H 0.0000 Buried
228 A H -1.5549 Soluble
229 P H -1.6848 Soluble
230 T H -1.2273 Soluble
231 E H -2.1436 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6122 6.2337 CSV PDB
4.5 -0.6449 6.1621 CSV PDB
5.0 -0.682 6.0868 CSV PDB
5.5 -0.7144 6.0103 CSV PDB
6.0 -0.7316 5.9335 CSV PDB
6.5 -0.7251 5.857 CSV PDB
7.0 -0.6951 5.7815 CSV PDB
7.5 -0.6504 5.7163 CSV PDB
8.0 -0.5984 5.7163 CSV PDB
8.5 -0.5417 5.7163 CSV PDB
9.0 -0.4811 5.7163 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH