Zinlirvimab / 7ugq

A4DAB308_7ugq_M_P | Source PDB: 7ugq | Chains: M, P | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.5368
Max Score
2.3163
Min Score
-3.667
Total Score
-127.22
Score CDR
-0.3716
Score non-CDR
-0.5953

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTVSSALSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTVLG input.pdb
Selected Chain(s) M (Heavy), P (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.667
Maximum Score 2.3163
Average Score -0.5368
Total Score -127.2222

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q M -1.7106 Soluble
2 V M 0.0000 Buried
3 Q M -1.9918 Soluble
4 L M 0.0000 Buried
5 Q M -2.0229 Soluble
6 E M -1.3112 Soluble
7 S M -0.8143 Soluble
8 G M -0.4048 Soluble
9 P M -0.0600 Soluble
11 G M 0.4613 Aggregation-prone
12 L M 1.2785 Aggregation-prone
13 V M 0.0000 Buried
14 K M -0.7741 Soluble
15 P M -1.0719 Soluble
16 S M -1.2351 Soluble
17 E M -1.8024 Soluble
18 T M -1.3787 Soluble
19 L M 0.0000 Buried
20 S M -0.9091 Soluble
21 V M 0.0000 Buried
22 T M -0.6863 Soluble
23 C M 0.0000 Buried
24 S M -1.1991 Soluble
25 V M 0.0000 Buried
26 S M -1.5418 Soluble
27 G M -1.5816 Soluble
28 D M -2.0465 Soluble
29 S M -1.4021 Soluble
30 M M 0.0000 Buried
35 N M -2.3004 Soluble
36 N M -2.5562 Soluble
37 Y M -1.5399 Soluble
38 Y M -1.2464 Soluble
39 W M 0.0000 Buried
40 T M 0.0000 Buried
41 W M 0.0000 Buried
42 I M 0.0000 Buried
43 R M 0.0000 Buried
44 Q M 0.0000 Buried
45 S M 0.0000 Buried
46 P M -1.0929 Soluble
47 G M -1.4379 Soluble
48 K M -2.2159 Soluble
49 G M -1.4189 Soluble
50 L M 0.0000 Buried
51 E M -1.2040 Soluble
52 W M 0.0000 Buried
53 I M 0.0000 Buried
54 G M 0.0000 Buried
55 Y M 0.0680 Aggregation-prone
56 I M 0.0000 Buried
57 S M 0.0000 Buried
58 D M -3.6670 Soluble
59 R M -3.5773 Soluble
63 E M -3.3059 Soluble
64 S M 0.0000 Buried
65 A M -0.5338 Soluble
66 T M -0.2340 Soluble
67 Y M -0.2176 Soluble
68 N M 0.0000 Buried
69 P M -0.8373 Soluble
70 S M -0.9660 Soluble
71 L M 0.0000 Buried
72 N M -1.7332 Soluble
74 S M -1.0593 Soluble
75 R M -1.3621 Soluble
76 V M 0.0000 Buried
77 V M 0.1449 Aggregation-prone
78 I M 0.0000 Buried
79 S M -0.7802 Soluble
80 R M -1.6492 Soluble
81 D M -1.9831 Soluble
82 T M -1.6430 Soluble
83 S M -1.6175 Soluble
84 K M -2.3712 Soluble
85 N M -1.9040 Soluble
86 Q M -1.4845 Soluble
87 L M 0.0000 Buried
88 S M -0.6783 Soluble
89 L M 0.0000 Buried
90 K M -1.2441 Soluble
91 L M 0.0000 Buried
92 N M -1.5045 Soluble
93 S M -1.3300 Soluble
94 V M 0.0000 Buried
95 T M -0.6359 Soluble
96 P M -0.4730 Soluble
97 A M -0.1685 Soluble
98 D M -0.2663 Soluble
99 T M 0.0062 Aggregation-prone
100 A M 0.0000 Buried
101 V M -0.1881 Soluble
102 Y M 0.0000 Buried
103 Y M 0.0000 Buried
104 C M 0.0000 Buried
105 A M 0.0000 Buried
106 T M 0.0000 Buried
107 A M 0.0000 Buried
108 R M -2.7627 Soluble
109 R M -2.5939 Soluble
110 G M -1.5514 Soluble
111 Q M -0.6680 Soluble
111A R M 0.1115 Aggregation-prone
111B I M 1.6770 Aggregation-prone
111C Y M 1.4032 Aggregation-prone
111D G M 1.2402 Aggregation-prone
111E V M 2.0813 Aggregation-prone
111F V M 2.3163 Aggregation-prone
112G S M 1.3959 Aggregation-prone
112F F M 2.0879 Aggregation-prone
112E G M 1.0938 Aggregation-prone
112D E M 0.8955 Aggregation-prone
112C F M 1.3403 Aggregation-prone
112B F M 0.4756 Aggregation-prone
112A Y M 0.1858 Aggregation-prone
112 Y M -0.3531 Soluble
113 Y M 0.0000 Buried
114 S M 0.0000 Buried
115 M M 0.0000 Buried
116 D M -0.2786 Soluble
117 V M 0.0718 Aggregation-prone
118 W M 0.0000 Buried
119 G M 0.0000 Buried
120 K M -2.3684 Soluble
121 G M 0.0000 Buried
122 T M -0.8485 Soluble
123 T M -0.1694 Soluble
124 V M 0.0000 Buried
125 T M 0.3486 Aggregation-prone
126 V M 0.2134 Aggregation-prone
127 S M 0.0234 Aggregation-prone
128 S M -0.1948 Soluble
129 A M 0.0474 Aggregation-prone
11 L P 0.9671 Aggregation-prone
12 S P 0.6951 Aggregation-prone
13 V P 0.0000 Buried
14 A P 0.4104 Aggregation-prone
15 L P 0.1678 Aggregation-prone
16 G P -1.0769 Soluble
17 E P -1.7842 Soluble
18 T P -1.4001 Soluble
19 A P 0.0000 Buried
20 R P -1.7526 Soluble
21 I P 0.0000 Buried
22 S P -1.1278 Soluble
23 C P -0.9192 Soluble
24 G P -1.1655 Soluble
25 R P -1.5617 Soluble
26 Q P -1.8363 Soluble
27 A P -0.8831 Soluble
28 L P -0.0589 Soluble
29 G P 0.0037 Aggregation-prone
36 S P 0.0000 Buried
37 R P 0.0000 Buried
38 A P 0.0000 Buried
39 V P 0.0000 Buried
40 Q P 0.0000 Buried
41 W P 0.0000 Buried
42 Y P 0.0000 Buried
43 Q P -0.5131 Soluble
44 H P 0.0000 Buried
45 R P -1.9305 Soluble
46 P P -1.5808 Soluble
47 G P -1.7304 Soluble
48 Q P -2.2559 Soluble
49 A P -1.4801 Soluble
50 P P 0.0000 Buried
51 I P 0.4218 Aggregation-prone
52 L P 0.0000 Buried
53 L P 0.0000 Buried
54 I P 0.0000 Buried
55 Y P -0.7345 Soluble
56 N P -1.3937 Soluble
57 N P 0.0000 Buried
65 Q P -1.9017 Soluble
66 D P -2.0123 Soluble
67 R P -1.7388 Soluble
68 P P -0.8500 Soluble
69 S P -0.6971 Soluble
70 G P -0.5045 Soluble
71 I P -0.6667 Soluble
72 P P -1.3481 Soluble
74 E P -2.1566 Soluble
75 R P -1.6361 Soluble
76 F P 0.0000 Buried
77 S P -1.3171 Soluble
78 G P -1.0469 Soluble
79 T P -0.6881 Soluble
80 P P -0.3059 Soluble
81 D P 0.3784 Aggregation-prone
81A I P 1.7744 Aggregation-prone
82 N P 0.4570 Aggregation-prone
83 F P 1.4028 Aggregation-prone
84 G P -0.0873 Soluble
85 T P -0.6895 Soluble
86 R P -2.0371 Soluble
87 A P 0.0000 Buried
88 T P -1.0393 Soluble
89 L P 0.0000 Buried
90 T P -0.9825 Soluble
91 I P 0.0000 Buried
92 S P -1.6228 Soluble
93 G P -1.3743 Soluble
94 V P 0.0000 Buried
95 E P -2.0626 Soluble
96 A P -1.0451 Soluble
97 G P -1.4589 Soluble
98 D P 0.0000 Buried
99 E P -2.3026 Soluble
100 A P 0.0000 Buried
101 D P 0.0000 Buried
102 Y P 0.0000 Buried
103 Y P 0.0000 Buried
104 C P 0.0000 Buried
105 H P 0.0000 Buried
106 M P 0.0000 Buried
107 W P 0.0000 Buried
108 D P 0.0000 Buried
109 S P -0.5125 Soluble
110 R P -1.7763 Soluble
112 S P -0.9793 Soluble
113 G P -0.4902 Soluble
114 F P 0.6691 Aggregation-prone
115 S P 0.2970 Aggregation-prone
116 W P 0.0155 Aggregation-prone
117 S P -0.4431 Soluble
118 F P 0.0000 Buried
119 G P -0.7764 Soluble
120 G P -1.1561 Soluble
121 A P -1.0238 Soluble
122 T P -0.8892 Soluble
123 R P -1.8388 Soluble
124 L P 0.0000 Buried
125 T P -0.2526 Soluble
126 V P -0.0742 Soluble
127 L P 1.0389 Aggregation-prone
128 G P 0.2412 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.3914 4.298 CSV PDB
4.5 -0.4213 4.2716 CSV PDB
5.0 -0.46 4.2444 CSV PDB
5.5 -0.5015 4.2323 CSV PDB
6.0 -0.5392 4.2201 CSV PDB
6.5 -0.5666 4.208 CSV PDB
7.0 -0.5808 4.1962 CSV PDB
7.5 -0.5843 4.185 CSV PDB
8.0 -0.5813 4.1757 CSV PDB
8.5 -0.5741 4.1694 CSV PDB
9.0 -0.5635 4.1662 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH