Zinlirvimab / 6udk

A4DAB308_6udk_F_I | Source PDB: 6udk | Chains: F, I | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6344
Max Score
2.671
Min Score
-3.2509
Total Score
-150.35
Score CDR
-0.4672
Score non-CDR
-0.6936

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTVSSALSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTVLG input.pdb
Selected Chain(s) F (Heavy), I (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.2509
Maximum Score 2.671
Average Score -0.6344
Total Score -150.3455

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q F -1.8074 Soluble
2 V F -1.4101 Soluble
3 Q F -1.6069 Soluble
4 L F -1.2327 Soluble
5 Q F -1.9628 Soluble
6 E F -1.5238 Soluble
7 S F -1.1243 Soluble
8 G F -0.5888 Soluble
9 P F -0.1253 Soluble
11 G F 0.1828 Aggregation-prone
12 L F 1.0097 Aggregation-prone
13 V F -0.4208 Soluble
14 K F -1.8505 Soluble
15 P F -1.5810 Soluble
16 S F -1.9116 Soluble
17 E F -2.9173 Soluble
18 T F -2.0409 Soluble
19 L F 0.0000 Buried
20 S F -1.0484 Soluble
21 V F 0.0000 Buried
22 T F -0.8082 Soluble
23 C F 0.0000 Buried
24 S F -1.2660 Soluble
25 V F 0.0000 Buried
26 S F -1.5846 Soluble
27 G F -1.9309 Soluble
28 D F -2.6904 Soluble
29 S F -1.7751 Soluble
30 M F -1.7166 Soluble
35 N F -2.2779 Soluble
36 N F -2.4015 Soluble
37 Y F -1.6720 Soluble
38 Y F -1.0610 Soluble
39 W F 0.0000 Buried
40 T F 0.0000 Buried
41 W F 0.0000 Buried
42 I F 0.0000 Buried
43 R F 0.0000 Buried
44 Q F -0.9249 Soluble
45 S F -1.0695 Soluble
46 P F -1.1271 Soluble
47 G F -1.4841 Soluble
48 K F -2.2649 Soluble
49 G F -1.5105 Soluble
50 L F 0.0000 Buried
51 E F -1.0687 Soluble
52 W F 0.0000 Buried
53 I F 0.0000 Buried
54 G F 0.0000 Buried
55 Y F 0.0111 Aggregation-prone
56 I F 0.0000 Buried
57 S F -2.2981 Soluble
58 D F -3.0106 Soluble
59 R F -3.2509 Soluble
63 E F -3.1788 Soluble
64 S F -1.7777 Soluble
65 A F -0.5474 Soluble
66 T F -0.0369 Soluble
67 Y F 0.1207 Aggregation-prone
68 N F 0.0000 Buried
69 P F -0.6715 Soluble
70 S F -0.6787 Soluble
71 L F -0.8579 Soluble
72 N F -1.6151 Soluble
74 S F -1.1269 Soluble
75 R F -1.5554 Soluble
76 V F 0.0000 Buried
77 V F 0.0194 Aggregation-prone
78 I F 0.0000 Buried
79 S F -0.8214 Soluble
80 R F -1.4638 Soluble
81 D F -1.5947 Soluble
82 T F -1.5102 Soluble
83 S F -1.5361 Soluble
84 K F -2.5009 Soluble
85 N F -2.2804 Soluble
86 Q F -1.7474 Soluble
87 L F 0.0000 Buried
88 S F -0.7131 Soluble
89 L F 0.0000 Buried
90 K F -1.7109 Soluble
91 L F 0.0000 Buried
92 N F -2.4072 Soluble
93 S F -1.5617 Soluble
94 V F -1.3119 Soluble
95 T F -0.8413 Soluble
96 P F -0.6648 Soluble
97 A F -0.2941 Soluble
98 D F -0.5409 Soluble
99 T F -0.3385 Soluble
100 A F 0.0000 Buried
101 V F -0.2463 Soluble
102 Y F 0.0000 Buried
103 Y F 0.0000 Buried
104 C F 0.0000 Buried
105 A F 0.0000 Buried
106 T F 0.0000 Buried
107 A F 0.0000 Buried
108 R F -2.4358 Soluble
109 R F -2.3319 Soluble
110 G F -1.6163 Soluble
111 Q F -1.1646 Soluble
111A R F -0.5123 Soluble
111B I F 1.0181 Aggregation-prone
111C Y F 1.2884 Aggregation-prone
111D G F 1.1165 Aggregation-prone
111E V F 2.1238 Aggregation-prone
111F V F 2.6710 Aggregation-prone
112G S F 1.6272 Aggregation-prone
112F F F 2.2356 Aggregation-prone
112E G F 1.2625 Aggregation-prone
112D E F 0.8307 Aggregation-prone
112C F F 1.0959 Aggregation-prone
112B F F 0.5433 Aggregation-prone
112A Y F -0.0080 Soluble
112 Y F 0.0000 Buried
113 Y F 0.0000 Buried
114 S F -0.8580 Soluble
115 M F 0.0000 Buried
116 D F -0.2757 Soluble
117 V F 0.1322 Aggregation-prone
118 W F 0.0000 Buried
119 G F 0.0000 Buried
120 K F -2.3797 Soluble
121 G F -1.4887 Soluble
122 T F -0.8760 Soluble
123 T F -0.0722 Soluble
124 V F 0.0000 Buried
125 T F 0.0233 Aggregation-prone
126 V F 0.0000 Buried
127 S F -0.5171 Soluble
128 S F -0.7531 Soluble
129 A F -0.1795 Soluble
11 L I 0.9848 Aggregation-prone
12 S I 0.7198 Aggregation-prone
13 V I 0.4735 Aggregation-prone
14 A I 0.3797 Aggregation-prone
15 L I 0.2791 Aggregation-prone
16 G I -1.1409 Soluble
17 E I -1.8341 Soluble
18 T I -1.4171 Soluble
19 A I 0.0000 Buried
20 R I -1.8877 Soluble
21 I I 0.0000 Buried
22 S I -1.1977 Soluble
23 C I 0.0000 Buried
24 G I -1.3822 Soluble
25 R I -1.6520 Soluble
26 Q I -1.7215 Soluble
27 A I -0.7547 Soluble
28 L I 0.2903 Aggregation-prone
29 G I 0.1685 Aggregation-prone
36 S I 0.6222 Aggregation-prone
37 R I 0.0000 Buried
38 A I 0.0000 Buried
39 V I 0.0000 Buried
40 Q I 0.0000 Buried
41 W I 0.0000 Buried
42 Y I 0.0000 Buried
43 Q I -0.3257 Soluble
44 H I 0.0000 Buried
45 R I -1.8866 Soluble
46 P I -1.5220 Soluble
47 G I -1.6718 Soluble
48 Q I -2.1118 Soluble
49 A I -1.1918 Soluble
50 P I 0.0000 Buried
51 I I 0.5860 Aggregation-prone
52 L I 0.0000 Buried
53 L I 0.0000 Buried
54 I I 0.0000 Buried
55 Y I -0.7372 Soluble
56 N I -1.3679 Soluble
57 N I 0.0000 Buried
65 Q I -2.2474 Soluble
66 D I -2.3840 Soluble
67 R I -1.7750 Soluble
68 P I -0.6825 Soluble
69 S I -0.7353 Soluble
70 G I -0.7558 Soluble
71 I I -0.5984 Soluble
72 P I -1.3182 Soluble
74 E I -2.3244 Soluble
75 R I -1.6874 Soluble
76 F I 0.0000 Buried
77 S I -1.2772 Soluble
78 G I -1.2542 Soluble
79 T I -0.6052 Soluble
80 P I -0.2544 Soluble
81 D I 0.1794 Aggregation-prone
81A I I 1.6263 Aggregation-prone
82 N I 0.3787 Aggregation-prone
83 F I 1.4201 Aggregation-prone
84 G I 0.1215 Aggregation-prone
85 T I -0.5159 Soluble
86 R I -1.6843 Soluble
87 A I -1.3942 Soluble
88 T I -1.0782 Soluble
89 L I 0.0000 Buried
90 T I -0.9894 Soluble
91 I I 0.0000 Buried
92 S I -1.6089 Soluble
93 G I -1.2570 Soluble
94 V I 0.0000 Buried
95 E I -1.3654 Soluble
96 A I -0.4586 Soluble
97 G I -0.9895 Soluble
98 D I 0.0000 Buried
99 E I -1.8542 Soluble
100 A I 0.0000 Buried
101 D I -1.5973 Soluble
102 Y I 0.0000 Buried
103 Y I 0.0000 Buried
104 C I 0.0000 Buried
105 H I 0.0000 Buried
106 M I 0.0000 Buried
107 W I 0.0000 Buried
108 D I 0.0000 Buried
109 S I -0.5861 Soluble
110 R I -1.7556 Soluble
112 S I -0.8580 Soluble
113 G I -0.3671 Soluble
114 F I 0.7026 Aggregation-prone
115 S I 0.3361 Aggregation-prone
116 W I 0.0694 Aggregation-prone
117 S I -0.3745 Soluble
118 F I 0.0000 Buried
119 G I -0.9684 Soluble
120 G I -1.3724 Soluble
121 A I -1.1843 Soluble
122 T I -0.9020 Soluble
123 R I -1.8380 Soluble
124 L I 0.0000 Buried
125 T I -0.1929 Soluble
126 V I 0.0000 Buried
127 L I 1.4211 Aggregation-prone
128 G I 0.4244 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
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pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.5344 4.4337 CSV PDB
4.5 -0.5748 4.4013 CSV PDB
5.0 -0.6232 4.355 CSV PDB
5.5 -0.6714 4.3027 CSV PDB
6.0 -0.7113 4.253 CSV PDB
6.5 -0.7364 4.2192 CSV PDB
7.0 -0.7457 4.188 CSV PDB
7.5 -0.7437 4.1772 CSV PDB
8.0 -0.735 4.1732 CSV PDB
8.5 -0.7211 4.1719 CSV PDB
9.0 -0.7022 4.1715 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH