Zinlirvimab / 7ugn

A4DAB308_7ugn_M_P | Source PDB: 7ugn | Chains: M, P | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.5902
Max Score
3.0931
Min Score
-3.6238
Total Score
-139.88
Score CDR
-0.2787
Score non-CDR
-0.7006

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTVSSALSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTVLG input.pdb
Selected Chain(s) M (Heavy), P (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.6238
Maximum Score 3.0931
Average Score -0.5902
Total Score -139.8808

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q M -1.5256 Soluble
2 V M -1.0266 Soluble
3 Q M -1.6205 Soluble
4 L M -1.2471 Soluble
5 Q M -1.9259 Soluble
6 E M -1.4668 Soluble
7 S M -0.8999 Soluble
8 G M -0.4482 Soluble
9 P M 0.0048 Aggregation-prone
11 G M 0.4672 Aggregation-prone
12 L M 1.0659 Aggregation-prone
13 V M -0.4147 Soluble
14 K M -1.9205 Soluble
15 P M -1.6513 Soluble
16 S M -1.8215 Soluble
17 E M -2.6659 Soluble
18 T M -1.8265 Soluble
19 L M 0.0000 Buried
20 S M -0.7745 Soluble
21 V M 0.0000 Buried
22 T M -0.7662 Soluble
23 C M 0.0000 Buried
24 S M -1.2101 Soluble
25 V M 0.0000 Buried
26 S M -1.2494 Soluble
27 G M -1.3580 Soluble
28 D M -1.7436 Soluble
29 S M -1.2819 Soluble
30 M M 0.0000 Buried
35 N M -2.2140 Soluble
36 N M -2.2896 Soluble
37 Y M -1.4367 Soluble
38 Y M -1.1952 Soluble
39 W M 0.0000 Buried
40 T M 0.0000 Buried
41 W M 0.0000 Buried
42 I M 0.0000 Buried
43 R M 0.0000 Buried
44 Q M -1.1317 Soluble
45 S M -1.2036 Soluble
46 P M -1.1533 Soluble
47 G M -1.5412 Soluble
48 K M -2.4864 Soluble
49 G M -1.9031 Soluble
50 L M -1.3399 Soluble
51 E M -1.6632 Soluble
52 W M 0.0000 Buried
53 I M 0.0000 Buried
54 G M 0.0000 Buried
55 Y M 0.2434 Aggregation-prone
56 I M 0.0000 Buried
57 S M 0.0000 Buried
58 D M -3.5741 Soluble
59 R M -3.6238 Soluble
63 E M -3.4135 Soluble
64 S M -1.9441 Soluble
65 A M -0.6389 Soluble
66 T M -0.1001 Soluble
67 Y M 0.0348 Aggregation-prone
68 N M 0.0000 Buried
69 P M -0.5933 Soluble
70 S M -0.5876 Soluble
71 L M -0.7612 Soluble
72 N M -1.5323 Soluble
74 S M -0.9497 Soluble
75 R M -1.1025 Soluble
76 V M 0.0000 Buried
77 V M 0.4654 Aggregation-prone
78 I M 0.0000 Buried
79 S M -0.7810 Soluble
80 R M -1.7581 Soluble
81 D M -1.8373 Soluble
82 T M -1.4602 Soluble
83 S M -1.5535 Soluble
84 K M -2.3765 Soluble
85 N M -1.8708 Soluble
86 Q M -1.6400 Soluble
87 L M 0.0000 Buried
88 S M -0.5509 Soluble
89 L M 0.0000 Buried
90 K M -0.9188 Soluble
91 L M 0.0000 Buried
92 N M -1.7858 Soluble
93 S M -1.5970 Soluble
94 V M 0.0000 Buried
95 T M -0.9732 Soluble
96 P M -0.7400 Soluble
97 A M -0.3088 Soluble
98 D M -0.5333 Soluble
99 T M -0.3614 Soluble
100 A M 0.0000 Buried
101 V M -0.1650 Soluble
102 Y M 0.0000 Buried
103 Y M 0.0000 Buried
104 C M 0.0000 Buried
105 A M 0.0000 Buried
106 T M 0.0000 Buried
107 A M 0.0000 Buried
108 R M -2.7882 Soluble
109 R M -2.6976 Soluble
110 G M -1.6394 Soluble
111 Q M -0.7377 Soluble
111A R M 0.3579 Aggregation-prone
111B I M 2.2228 Aggregation-prone
111C Y M 2.1513 Aggregation-prone
111D G M 1.9048 Aggregation-prone
111E V M 2.7966 Aggregation-prone
111F V M 3.0931 Aggregation-prone
112G S M 1.7316 Aggregation-prone
112F F M 2.4103 Aggregation-prone
112E G M 1.4899 Aggregation-prone
112D E M 1.4169 Aggregation-prone
112C F M 1.7606 Aggregation-prone
112B F M 0.7610 Aggregation-prone
112A Y M 0.2343 Aggregation-prone
112 Y M -0.5131 Soluble
113 Y M -1.1250 Soluble
114 S M 0.0000 Buried
115 M M 0.0000 Buried
116 D M -0.5817 Soluble
117 V M 0.0937 Aggregation-prone
118 W M 0.0000 Buried
119 G M -1.3243 Soluble
120 K M -2.2575 Soluble
121 G M 0.0000 Buried
122 T M -0.7300 Soluble
123 T M -0.1518 Soluble
124 V M 0.0000 Buried
125 T M 0.0880 Aggregation-prone
126 V M 0.0000 Buried
127 S M -0.5247 Soluble
128 S M -0.6439 Soluble
129 A M -0.2028 Soluble
11 L P 0.8001 Aggregation-prone
12 S P 0.7148 Aggregation-prone
13 V P 0.0000 Buried
14 A P 0.1775 Aggregation-prone
15 L P -0.0281 Soluble
16 G P -1.2875 Soluble
17 E P -2.0116 Soluble
18 T P -1.3841 Soluble
19 A P 0.0000 Buried
20 R P -1.9160 Soluble
21 I P 0.0000 Buried
22 S P -1.2436 Soluble
23 C P -1.2895 Soluble
24 G P -1.9801 Soluble
25 R P -2.8139 Soluble
26 Q P -2.2952 Soluble
27 A P -0.8027 Soluble
28 L P 0.6924 Aggregation-prone
29 G P 0.4922 Aggregation-prone
36 S P 0.8530 Aggregation-prone
37 R P 0.0000 Buried
38 A P 0.0000 Buried
39 V P 0.0000 Buried
40 Q P 0.0000 Buried
41 W P 0.0000 Buried
42 Y P 0.0000 Buried
43 Q P 0.0000 Buried
44 H P 0.0000 Buried
45 R P -1.6624 Soluble
46 P P -1.4248 Soluble
47 G P -1.5796 Soluble
48 Q P -1.9758 Soluble
49 A P -1.0858 Soluble
50 P P 0.0000 Buried
51 I P 0.4818 Aggregation-prone
52 L P 0.0000 Buried
53 L P 0.0000 Buried
54 I P 0.0000 Buried
55 Y P -0.4481 Soluble
56 N P -0.9957 Soluble
57 N P 0.0000 Buried
65 Q P -2.1931 Soluble
66 D P -2.4245 Soluble
67 R P -1.8424 Soluble
68 P P -1.0013 Soluble
69 S P -0.6935 Soluble
70 G P -0.8199 Soluble
71 I P -0.6444 Soluble
72 P P -1.2229 Soluble
74 E P -2.1688 Soluble
75 R P -1.3673 Soluble
76 F P 0.0000 Buried
77 S P -1.3993 Soluble
78 G P -1.1273 Soluble
79 T P -0.7398 Soluble
80 P P -0.5426 Soluble
81 D P 0.2803 Aggregation-prone
81A I P 1.7331 Aggregation-prone
82 N P 0.4455 Aggregation-prone
83 F P 1.5253 Aggregation-prone
84 G P 0.0419 Aggregation-prone
85 T P -0.7629 Soluble
86 R P -2.2624 Soluble
87 A P -1.5232 Soluble
88 T P 0.0000 Buried
89 L P 0.0000 Buried
90 T P -0.9963 Soluble
91 I P 0.0000 Buried
92 S P -1.5886 Soluble
93 G P -1.3160 Soluble
94 V P 0.0000 Buried
95 E P -2.2947 Soluble
96 A P -1.1763 Soluble
97 G P -1.6176 Soluble
98 D P 0.0000 Buried
99 E P -2.6533 Soluble
100 A P 0.0000 Buried
101 D P -1.3865 Soluble
102 Y P 0.0000 Buried
103 Y P 0.0000 Buried
104 C P 0.0000 Buried
105 H P 0.0000 Buried
106 M P 0.0000 Buried
107 W P 0.0000 Buried
108 D P 0.0000 Buried
109 S P -0.3089 Soluble
110 R P -1.6237 Soluble
112 S P -0.8893 Soluble
113 G P -0.4773 Soluble
114 F P 0.6325 Aggregation-prone
115 S P 0.2864 Aggregation-prone
116 W P -0.0540 Soluble
117 S P -0.5212 Soluble
118 F P 0.0000 Buried
119 G P -1.2525 Soluble
120 G P -1.2397 Soluble
121 A P -0.8643 Soluble
122 T P -0.8471 Soluble
123 R P -1.8226 Soluble
124 L P 0.0000 Buried
125 T P -0.1652 Soluble
126 V P 0.5510 Aggregation-prone
127 L P 1.5141 Aggregation-prone
128 G P 0.5112 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
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pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.4452 4.5961 CSV PDB
4.5 -0.4843 4.5639 CSV PDB
5.0 -0.5338 4.5199 CSV PDB
5.5 -0.5853 4.4715 CSV PDB
6.0 -0.6296 4.4262 CSV PDB
6.5 -0.6598 4.3914 CSV PDB
7.0 -0.6737 4.3715 CSV PDB
7.5 -0.6749 4.3629 CSV PDB
8.0 -0.6686 4.3599 CSV PDB
8.5 -0.6571 4.3589 CSV PDB
9.0 -0.6405 4.3585 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH