Ripertamab / 2osl

A4DAB225_2osl_H_L | Source PDB: 2osl | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6466
Max Score
1.7486
Min Score
-3.73
Total Score
-282.56
Score CDR
-0.3035
Score non-CDR
-0.6879

Calculation Parameters

Chain Sequence(s) QVQLQQPGAELVKPGASVKMSCKASGYTFTSYNMHWVKQTPGRGLEWIGAIYPGNGDTSYNQKFKGKATLTADKSSSTAYMQLSSLTSEDSAVYYCARSTYYGGDWYFNVWGAGTTVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCQIVLSQSPAILSASPGEKVTMTCRASSSVSYIHWFQQKPGSSPKPWIYATSNLASGVPVRFSGSGSGTSYSLTISRVEAEDAATYYCQQWTSNPPTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.73
Maximum Score 1.7486
Average Score -0.6466
Total Score -282.5644

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q H -1.2912 Soluble
2 V H -0.5160 Soluble
3 Q H -1.4610 Soluble
4 L H 0.0000 Buried
5 Q H -1.9077 Soluble
6 Q H -1.1594 Soluble
7 P H -0.8896 Soluble
8 G H -0.8189 Soluble
9 A H -0.7999 Soluble
11 E H -0.8774 Soluble
12 L H -0.3599 Soluble
13 V H 0.0000 Buried
14 K H -1.8518 Soluble
15 P H -1.2262 Soluble
16 G H -1.1429 Soluble
17 A H -0.9507 Soluble
18 S H -1.1371 Soluble
19 V H 0.0000 Buried
20 K H -1.9297 Soluble
21 M H 0.0000 Buried
22 S H -0.8782 Soluble
23 C H 0.0000 Buried
24 K H -1.7074 Soluble
25 A H 0.0000 Buried
26 S H -1.0857 Soluble
27 G H -0.7923 Soluble
28 Y H -0.2331 Soluble
29 T H -0.2255 Soluble
30 F H 0.0000 Buried
35 T H -0.7774 Soluble
36 S H -0.2163 Soluble
37 Y H 0.2973 Aggregation-prone
38 N H -0.4411 Soluble
39 M H 0.0000 Buried
40 H H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 K H 0.0000 Buried
44 Q H -0.6504 Soluble
45 T H 0.0000 Buried
46 P H -1.0649 Soluble
47 G H -1.6046 Soluble
48 R H -2.3585 Soluble
49 G H -1.4748 Soluble
50 L H 0.0000 Buried
51 E H -0.9281 Soluble
52 W H 0.0000 Buried
53 I H 0.0000 Buried
54 G H 0.0000 Buried
55 A H 0.0000 Buried
56 I H 0.0000 Buried
57 Y H -0.8478 Soluble
58 P H 0.0000 Buried
59 G H -1.5659 Soluble
62 N H -2.1543 Soluble
63 G H -2.2061 Soluble
64 D H -2.4487 Soluble
65 T H -1.1685 Soluble
66 S H -0.8510 Soluble
67 Y H -1.1288 Soluble
68 N H -2.0644 Soluble
69 Q H -2.9570 Soluble
70 K H -2.9100 Soluble
71 F H 0.0000 Buried
72 K H -2.7833 Soluble
74 G H -1.8843 Soluble
75 K H -1.6168 Soluble
76 A H 0.0000 Buried
77 T H -0.8543 Soluble
78 L H 0.0000 Buried
79 T H -0.6981 Soluble
80 A H -1.3731 Soluble
81 D H -2.0189 Soluble
82 K H -2.4156 Soluble
83 S H -1.3987 Soluble
84 S H -1.2854 Soluble
85 S H -1.3900 Soluble
86 T H 0.0000 Buried
87 A H 0.0000 Buried
88 Y H -0.5978 Soluble
89 M H 0.0000 Buried
90 Q H -1.3566 Soluble
91 L H 0.0000 Buried
92 S H -0.9070 Soluble
93 S H -0.8695 Soluble
94 L H 0.0000 Buried
95 T H -1.2328 Soluble
96 S H -1.3992 Soluble
97 E H -1.9610 Soluble
98 D H 0.0000 Buried
99 S H -0.7000 Soluble
100 A H -0.2815 Soluble
101 V H 0.1687 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 R H 0.0000 Buried
107 S H 0.0000 Buried
108 T H 0.0000 Buried
109 Y H 1.7486 Aggregation-prone
110 Y H 1.6469 Aggregation-prone
111 G H 0.3805 Aggregation-prone
112A G H -0.0040 Soluble
112 D H 0.5455 Aggregation-prone
113 W H 1.0798 Aggregation-prone
114 Y H 0.0000 Buried
115 F H 0.0000 Buried
116 N H -0.2234 Soluble
117 V H -0.2016 Soluble
118 W H -0.3758 Soluble
119 G H 0.0000 Buried
120 A H -0.4647 Soluble
121 G H -0.3441 Soluble
122 T H 0.0000 Buried
123 T H -0.2411 Soluble
124 V H 0.0000 Buried
125 T H -0.5994 Soluble
126 V H 0.0000 Buried
127 S H -0.6586 Soluble
128 A H -0.6072 Soluble
129 A H -0.4329 Soluble
130 S H -0.6703 Soluble
131 T H -0.8294 Soluble
132 K H -1.4278 Soluble
133 G H -1.4737 Soluble
134 P H 0.0000 Buried
135 S H -0.3828 Soluble
136 V H 0.0000 Buried
137 F H 0.0000 Buried
138 P H -1.1355 Soluble
139 L H 0.0000 Buried
140 A H -1.0058 Soluble
141 P H 0.0000 Buried
142 S H -0.5379 Soluble
143 S H -0.4763 Soluble
144 K H -0.7448 Soluble
145 S H -0.5362 Soluble
146 T H -0.6827 Soluble
147 S H -0.7562 Soluble
148 G H -0.9879 Soluble
149 G H -0.8911 Soluble
150 T H -0.6126 Soluble
151 A H 0.0000 Buried
152 A H 0.0000 Buried
153 L H 0.0000 Buried
154 G H 0.0000 Buried
155 C H 0.0000 Buried
156 L H 0.0000 Buried
157 V H 0.0000 Buried
158 K H 0.0000 Buried
159 D H -0.4195 Soluble
160 Y H 0.0000 Buried
161 F H 0.0000 Buried
162 P H 0.0000 Buried
163 E H -0.5667 Soluble
164 P H -0.9519 Soluble
165 V H 0.0000 Buried
166 T H -0.7605 Soluble
167 V H -0.2766 Soluble
168 S H -0.3907 Soluble
169 W H 0.0000 Buried
170 N H -0.7358 Soluble
171 S H -0.6507 Soluble
172 G H -0.5118 Soluble
173 A H -0.2438 Soluble
174 L H 0.0053 Aggregation-prone
175 T H -0.1721 Soluble
176 S H -0.1707 Soluble
177 G H -0.1765 Soluble
178 V H 0.1783 Aggregation-prone
179 H H -0.3380 Soluble
180 T H 0.0296 Aggregation-prone
181 F H 0.0000 Buried
182 P H -0.2704 Soluble
183 A H 0.4382 Aggregation-prone
184 V H 0.6120 Aggregation-prone
185 L H 1.4739 Aggregation-prone
186 Q H 0.3850 Aggregation-prone
187 S H -0.0415 Soluble
188 S H -0.2164 Soluble
189 G H 0.0413 Aggregation-prone
190 L H 0.1570 Aggregation-prone
191 Y H 0.4568 Aggregation-prone
192 S H 0.0000 Buried
193 L H 0.0000 Buried
194 S H 0.0000 Buried
195 S H 0.0000 Buried
196 V H 0.0000 Buried
197 V H 0.0000 Buried
198 T H -0.1366 Soluble
199 V H 0.0000 Buried
200 P H -0.5228 Soluble
201 S H -0.6141 Soluble
202 S H -0.6440 Soluble
203 S H -0.6281 Soluble
204 L H -0.7924 Soluble
205 G H -0.9549 Soluble
206 T H -0.8012 Soluble
207 Q H -1.1756 Soluble
208 T H -1.1609 Soluble
209 Y H 0.0000 Buried
210 I H -1.2228 Soluble
211 C H 0.0000 Buried
212 N H -1.5208 Soluble
213 V H 0.0000 Buried
214 N H -2.1625 Soluble
215 H H 0.0000 Buried
216 K H -2.8076 Soluble
217 P H -1.6905 Soluble
218 S H -1.8999 Soluble
219 N H -2.5989 Soluble
220 T H -2.1877 Soluble
221 K H -2.8306 Soluble
222 V H -1.7316 Soluble
223 D H -2.5781 Soluble
224 K H -2.2216 Soluble
225 K H -2.6105 Soluble
226 V H 0.0000 Buried
227 E H -2.5764 Soluble
228 P H -1.5855 Soluble
229 K H -1.1636 Soluble
230 S H -0.4542 Soluble
231 C H 0.1096 Aggregation-prone
1 Q L -1.2094 Soluble
2 I L 0.1129 Aggregation-prone
3 V L 1.1868 Aggregation-prone
4 L L 0.0000 Buried
5 S L -0.3337 Soluble
6 Q L -0.2714 Soluble
7 S L -0.1652 Soluble
8 P L 0.3703 Aggregation-prone
9 A L 0.6312 Aggregation-prone
10 I L 1.6591 Aggregation-prone
11 L L 0.6750 Aggregation-prone
12 S L -0.3222 Soluble
13 A L 0.0000 Buried
14 S L -1.9030 Soluble
15 P L -2.0966 Soluble
16 G L -2.1112 Soluble
17 E L -2.9772 Soluble
18 K L -3.0393 Soluble
19 V L -1.3349 Soluble
20 T L -0.3695 Soluble
21 M L 0.0000 Buried
22 T L -0.5093 Soluble
23 C L 0.0000 Buried
24 R L -1.1387 Soluble
25 A L -0.2810 Soluble
26 S L -0.1210 Soluble
27 S L -0.4162 Soluble
28 S L -0.6151 Soluble
29 V L 0.0000 Buried
37 S L -0.2493 Soluble
38 Y L 0.1873 Aggregation-prone
39 I L 0.0000 Buried
40 H L 0.0000 Buried
41 W L 0.0000 Buried
42 F L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L -0.9431 Soluble
45 K L -1.4669 Soluble
46 P L -1.0932 Soluble
47 G L -0.7437 Soluble
48 S L -0.7810 Soluble
49 S L -0.5872 Soluble
50 P L 0.0000 Buried
51 K L -1.3827 Soluble
52 P L -0.5646 Soluble
53 W L -0.2654 Soluble
54 I L 0.0000 Buried
55 Y L 0.3534 Aggregation-prone
56 A L 0.0263 Aggregation-prone
57 T L -0.1637 Soluble
65 S L -0.3639 Soluble
66 N L -0.3776 Soluble
67 L L 0.4514 Aggregation-prone
68 A L 0.0000 Buried
69 S L -0.4202 Soluble
70 G L -0.2883 Soluble
71 V L 0.0000 Buried
72 P L 0.6580 Aggregation-prone
74 V L 1.4095 Aggregation-prone
75 R L -0.2878 Soluble
76 F L 0.0000 Buried
77 S L 0.0513 Aggregation-prone
78 G L -0.3429 Soluble
79 S L -0.5897 Soluble
80 G L -0.7478 Soluble
83 S L -0.6746 Soluble
84 G L -0.6594 Soluble
85 T L -0.8296 Soluble
86 S L -0.9680 Soluble
87 Y L 0.0000 Buried
88 S L -0.5124 Soluble
89 L L 0.0000 Buried
90 T L -0.6892 Soluble
91 I L 0.0000 Buried
92 S L -1.8048 Soluble
93 R L -2.9471 Soluble
94 V L 0.0000 Buried
95 E L -2.4176 Soluble
96 A L -2.1329 Soluble
97 E L -2.4522 Soluble
98 D L 0.0000 Buried
99 A L -1.5852 Soluble
100 A L 0.0000 Buried
101 T L 0.0000 Buried
102 Y L 0.0000 Buried
103 Y L -0.3018 Soluble
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 Q L 0.0000 Buried
107 W L 0.0460 Aggregation-prone
108 T L -0.4186 Soluble
109 S L -1.0034 Soluble
114 N L -1.7059 Soluble
115 P L -1.5813 Soluble
116 P L 0.0000 Buried
117 T L -0.2003 Soluble
118 F L 0.0000 Buried
119 G L 0.0000 Buried
120 G L -0.8341 Soluble
121 G L -0.2849 Soluble
122 T L 0.0000 Buried
123 K L -0.2149 Soluble
124 L L 0.0000 Buried
125 E L -0.8189 Soluble
126 I L 0.0000 Buried
127 K L -1.7172 Soluble
128 R L -1.0254 Soluble
129 T L 0.1459 Aggregation-prone
130 V L 1.1793 Aggregation-prone
131 A L 0.2855 Aggregation-prone
132 A L 0.0098 Aggregation-prone
133 P L 0.0000 Buried
134 S L -0.1905 Soluble
135 V L 0.0000 Buried
136 F L 0.0000 Buried
137 I L 0.0000 Buried
138 F L 0.0000 Buried
139 P L -0.4220 Soluble
140 P L -0.7623 Soluble
141 S L -1.5532 Soluble
142 D L -2.6205 Soluble
143 E L -2.3011 Soluble
144 Q L 0.0000 Buried
145 L L -1.7035 Soluble
146 K L -2.5703 Soluble
147 S L -1.5695 Soluble
148 G L -1.0632 Soluble
149 T L -0.8442 Soluble
150 A L 0.0000 Buried
151 S L 0.0000 Buried
152 V L 0.0000 Buried
153 V L 0.0000 Buried
154 C L 0.0000 Buried
155 L L 0.0000 Buried
156 L L 0.0000 Buried
157 N L 0.0000 Buried
158 N L -0.8466 Soluble
159 F L 0.0000 Buried
160 Y L 0.0000 Buried
161 P L -1.4506 Soluble
162 R L -2.6731 Soluble
163 E L -3.0085 Soluble
164 A L -2.2586 Soluble
165 K L -2.4078 Soluble
166 V L -1.2531 Soluble
167 Q L -0.5214 Soluble
168 W L 0.0000 Buried
169 K L -0.4793 Soluble
170 V L 0.0000 Buried
171 D L -1.9549 Soluble
172 N L -1.5783 Soluble
173 A L -0.2454 Soluble
174 L L 0.6847 Aggregation-prone
175 Q L -0.5076 Soluble
176 S L -0.8516 Soluble
177 G L -1.3934 Soluble
178 N L -1.7712 Soluble
179 S L -1.5898 Soluble
180 Q L -1.7608 Soluble
181 E L -1.9110 Soluble
182 S L -0.9239 Soluble
183 V L -0.5395 Soluble
184 T L -0.8886 Soluble
185 E L -2.1717 Soluble
186 Q L 0.0000 Buried
187 D L -2.3121 Soluble
188 S L -2.4035 Soluble
189 K L -2.6587 Soluble
190 D L -1.8117 Soluble
191 S L 0.0000 Buried
192 T L 0.0000 Buried
193 Y L 0.0000 Buried
194 S L 0.0000 Buried
195 L L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 T L -0.7460 Soluble
199 L L 0.0000 Buried
200 T L -0.4315 Soluble
201 L L -0.7181 Soluble
202 S L -1.0181 Soluble
203 K L -2.0541 Soluble
204 A L -1.7640 Soluble
205 D L -2.3847 Soluble
206 Y L 0.0000 Buried
207 E L -3.7300 Soluble
208 K L -3.6648 Soluble
209 H L -3.1384 Soluble
210 K L -3.3258 Soluble
211 V L -1.6487 Soluble
212 Y L 0.0000 Buried
213 A L 0.0000 Buried
214 C L 0.0000 Buried
215 E L -0.6580 Soluble
216 V L 0.0000 Buried
217 T L -1.1978 Soluble
218 H L 0.0000 Buried
219 Q L -1.5762 Soluble
220 G L -0.2320 Soluble
221 L L -0.1544 Soluble
222 S L -0.4370 Soluble
223 S L -0.4056 Soluble
224 P L -0.5373 Soluble
225 V L 0.1229 Aggregation-prone
226 T L -0.2717 Soluble
227 K L -0.4397 Soluble
228 S L -0.4693 Soluble
229 F L -0.7200 Soluble
230 N L -1.7323 Soluble
231 R L -2.4997 Soluble
232 G L -2.1499 Soluble
233 E L -2.0183 Soluble
234 C L -0.4604 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.7058 2.6312 CSV PDB
4.5 -0.7416 2.6237 CSV PDB
5.0 -0.7833 2.6165 CSV PDB
5.5 -0.8208 2.6149 CSV PDB
6.0 -0.8421 2.6289 CSV PDB
6.5 -0.8379 2.6708 CSV PDB
7.0 -0.8086 2.7421 CSV PDB
7.5 -0.763 2.8317 CSV PDB
8.0 -0.709 2.9291 CSV PDB
8.5 -0.6498 3.0291 CSV PDB
9.0 -0.586 3.1295 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH