Gevokizumab / 4g6m

A4DAB129_4g6m_H_L | Source PDB: 4g6m | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.7373
Max Score
1.0991
Min Score
-3.5528
Total Score
-319.25
Score CDR
—
Score non-CDR
—

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSQTLSLTCSFSGFSLSTSGMGVGWIRQPSGKGLEWLAHIWWDGDESYNPSLKSRLTISKDTSKNQVSLKITSVTAADTAVYFCARNRYDPPWFVDWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPDIQMTQSTSSLSASVGDRVTITCRASQDISNYLSWYQQKPGKAVKLLIYYTSKLHSGVPSRFSGSGSGTDYTLTISSLQQEDFATYFCLQGKMLPWTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.5528
Maximum Score 1.0991
Average Score -0.7373
Total Score -319.2479

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q H -1.4456 Soluble
2 V H -1.0670 Soluble
3 Q H -1.8430 Soluble
4 L H 0.0000 Buried
5 Q H -1.3236 Soluble
6 E H 0.0000 Buried
7 S H -0.5475 Soluble
8 G H -0.4889 Soluble
9 P H -0.4002 Soluble
11 G H -0.3894 Soluble
12 L H -0.3219 Soluble
13 V H 0.0000 Buried
14 K H -1.9664 Soluble
15 P H -1.2748 Soluble
16 S H -1.1660 Soluble
17 Q H -1.5711 Soluble
18 T H -1.1740 Soluble
19 L H 0.0000 Buried
20 S H -0.8580 Soluble
21 L H 0.0000 Buried
22 T H -0.7389 Soluble
23 C H 0.0000 Buried
24 S H -1.3267 Soluble
25 F H 0.0000 Buried
26 S H -1.3317 Soluble
27 G H -1.0260 Soluble
28 F H -0.4867 Soluble
29 S H -0.3067 Soluble
30 L H 0.0000 Buried
31 S H -0.7322 Soluble
34 T H -0.4153 Soluble
35 S H -0.3733 Soluble
36 G H 0.0000 Buried
37 M H 0.0000 Buried
38 G H 0.0000 Buried
39 V H 0.0000 Buried
40 G H 0.0000 Buried
41 W H 0.0000 Buried
42 I H 0.0000 Buried
43 R H 0.0000 Buried
44 Q H -0.7516 Soluble
45 P H -0.8438 Soluble
46 S H -0.9620 Soluble
47 G H -1.4399 Soluble
48 K H -2.3610 Soluble
49 G H -1.6065 Soluble
50 L H 0.0000 Buried
51 E H -0.8666 Soluble
52 W H 0.0000 Buried
53 L H 0.0000 Buried
54 A H 0.0000 Buried
55 H H 0.0000 Buried
56 I H 0.0000 Buried
57 W H -1.5554 Soluble
58 W H -1.0711 Soluble
59 D H -2.3762 Soluble
63 G H -2.3070 Soluble
64 D H -3.0111 Soluble
65 E H -2.5697 Soluble
66 S H -1.1759 Soluble
67 Y H -0.6683 Soluble
68 N H 0.0000 Buried
69 P H -1.0090 Soluble
70 S H -0.7512 Soluble
71 L H 0.0000 Buried
72 K H -1.9440 Soluble
74 S H -1.2324 Soluble
75 R H -1.3132 Soluble
76 L H 0.0000 Buried
77 T H -1.1255 Soluble
78 I H 0.0000 Buried
79 S H -1.5255 Soluble
80 K H -1.9662 Soluble
81 D H -2.3861 Soluble
82 T H -1.7936 Soluble
83 S H -1.7567 Soluble
84 K H -2.7626 Soluble
85 N H -2.4443 Soluble
86 Q H -2.1293 Soluble
87 V H 0.0000 Buried
88 S H -0.9833 Soluble
89 L H 0.0000 Buried
90 K H -1.3820 Soluble
91 I H 0.0000 Buried
92 T H -0.9097 Soluble
93 S H -0.9114 Soluble
94 V H 0.0000 Buried
95 T H -0.5203 Soluble
96 A H -0.2185 Soluble
97 A H 0.0509 Aggregation-prone
98 D H 0.0000 Buried
99 T H 0.0805 Aggregation-prone
100 A H 0.0000 Buried
101 V H 0.2063 Aggregation-prone
102 Y H 0.0000 Buried
103 F H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 R H -0.4391 Soluble
107 N H 0.0000 Buried
108 R H -0.5018 Soluble
109 Y H 0.0816 Aggregation-prone
110 D H -1.3951 Soluble
112 P H -0.7031 Soluble
113 P H 0.0000 Buried
114 W H 0.1596 Aggregation-prone
115 F H 0.0000 Buried
116 V H -0.0127 Soluble
117 D H -0.7221 Soluble
118 W H 0.0000 Buried
119 G H 0.0000 Buried
120 Q H -1.9336 Soluble
121 G H 0.0000 Buried
122 T H -0.2663 Soluble
123 L H 0.0871 Aggregation-prone
124 V H 0.0000 Buried
125 T H 0.0000 Buried
126 V H 0.0000 Buried
127 S H -0.6979 Soluble
128 S H -0.7933 Soluble
129 A H -0.5127 Soluble
130 S H -0.6165 Soluble
131 T H -0.7530 Soluble
132 K H -1.2119 Soluble
133 G H -1.3731 Soluble
134 P H 0.0000 Buried
135 S H -0.5953 Soluble
136 V H 0.0000 Buried
137 F H 0.0000 Buried
138 P H -1.2177 Soluble
139 L H 0.0000 Buried
140 A H -0.8579 Soluble
141 P H 0.0000 Buried
142 S H -0.9818 Soluble
143 S H -1.2013 Soluble
144 K H -1.9388 Soluble
145 S H -1.1078 Soluble
146 T H -0.9589 Soluble
147 S H -0.9442 Soluble
148 G H -0.8102 Soluble
149 G H -0.6275 Soluble
150 T H -0.4350 Soluble
151 A H 0.0000 Buried
152 A H 0.0000 Buried
153 L H 0.0000 Buried
154 G H 0.0000 Buried
155 C H 0.0000 Buried
156 L H 0.0000 Buried
157 V H 0.0000 Buried
158 K H 0.0000 Buried
159 D H -0.3849 Soluble
160 Y H 0.0000 Buried
161 F H 0.0000 Buried
162 P H 0.0000 Buried
163 E H -0.4044 Soluble
164 P H -0.6620 Soluble
165 V H -0.6586 Soluble
166 T H -0.5996 Soluble
167 V H -0.1129 Soluble
168 S H -0.3360 Soluble
169 W H 0.0000 Buried
170 N H -0.7665 Soluble
171 S H -0.6414 Soluble
172 G H -0.5655 Soluble
173 A H -0.2469 Soluble
174 L H -0.0318 Soluble
175 T H -0.1796 Soluble
176 S H -0.2082 Soluble
177 G H -0.2731 Soluble
178 V H 0.1364 Aggregation-prone
179 H H -0.3157 Soluble
180 T H 0.0449 Aggregation-prone
181 F H 0.0000 Buried
182 P H -0.3066 Soluble
183 A H 0.2721 Aggregation-prone
184 V H 0.5527 Aggregation-prone
185 L H 1.0991 Aggregation-prone
186 Q H 0.2312 Aggregation-prone
187 S H -0.0970 Soluble
188 S H -0.2378 Soluble
189 G H 0.0238 Aggregation-prone
190 L H 0.1028 Aggregation-prone
191 Y H 0.4009 Aggregation-prone
192 S H 0.0000 Buried
193 L H 0.0000 Buried
194 S H 0.0000 Buried
195 S H 0.0000 Buried
196 V H 0.0000 Buried
197 V H 0.0000 Buried
198 T H -0.1381 Soluble
199 V H 0.0000 Buried
200 P H -0.5548 Soluble
201 S H -0.6297 Soluble
202 S H -0.7261 Soluble
203 S H -0.6942 Soluble
204 L H -0.9077 Soluble
205 G H -1.0828 Soluble
206 T H -0.7105 Soluble
207 Q H -1.1852 Soluble
208 T H -1.1668 Soluble
209 Y H 0.0000 Buried
210 I H -1.3389 Soluble
211 C H 0.0000 Buried
212 N H -1.3395 Soluble
213 V H 0.0000 Buried
214 N H -1.9659 Soluble
215 H H 0.0000 Buried
216 K H -2.7556 Soluble
217 P H -1.6387 Soluble
218 S H -1.8353 Soluble
219 N H -2.5951 Soluble
220 T H -2.0458 Soluble
221 K H -2.6471 Soluble
222 V H -1.5376 Soluble
223 D H -2.2276 Soluble
224 K H -2.1239 Soluble
225 R H -2.6791 Soluble
226 V H 0.0000 Buried
227 E H -2.5679 Soluble
228 P H -1.2325 Soluble
1 D L -2.0225 Soluble
2 I L 0.0000 Buried
3 Q L -2.1852 Soluble
4 M L 0.0000 Buried
5 T L -1.4293 Soluble
6 Q L 0.0000 Buried
7 S L -0.7522 Soluble
8 T L -0.4866 Soluble
9 S L -0.7328 Soluble
10 S L -0.5054 Soluble
11 L L -0.1081 Soluble
12 S L -0.5323 Soluble
13 A L -0.9385 Soluble
14 S L -1.1514 Soluble
15 V L -0.8404 Soluble
16 G L -1.2256 Soluble
17 D L -1.9345 Soluble
18 R L -2.4295 Soluble
19 V L 0.0000 Buried
20 T L -0.6357 Soluble
21 I L 0.0000 Buried
22 T L -0.7253 Soluble
23 C L 0.0000 Buried
24 R L -2.7598 Soluble
25 A L 0.0000 Buried
26 S L -2.1939 Soluble
27 Q L -2.7343 Soluble
28 D L -2.8089 Soluble
29 I L 0.0000 Buried
36 S L -1.0212 Soluble
37 N L -0.6796 Soluble
38 Y L -0.2457 Soluble
39 L L 0.0000 Buried
40 S L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L -1.1155 Soluble
45 K L -1.8059 Soluble
46 P L -1.5229 Soluble
47 G L -1.8450 Soluble
48 K L -2.5314 Soluble
49 A L -1.7959 Soluble
50 V L 0.0000 Buried
51 K L -1.2124 Soluble
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L 0.2757 Aggregation-prone
56 Y L 0.5160 Aggregation-prone
57 T L 0.0000 Buried
65 S L -0.6742 Soluble
66 K L -1.0556 Soluble
67 L L -0.2521 Soluble
68 H L -0.4709 Soluble
69 S L -0.5234 Soluble
70 G L -0.5711 Soluble
71 V L 0.0000 Buried
72 P L -0.3902 Soluble
74 S L -0.4496 Soluble
75 R L -0.8488 Soluble
76 F L 0.0000 Buried
77 S L -0.5162 Soluble
78 G L -0.4044 Soluble
79 S L -0.7139 Soluble
80 G L -0.9978 Soluble
83 S L -1.2012 Soluble
84 G L -1.7083 Soluble
85 T L -2.1283 Soluble
86 D L -2.1011 Soluble
87 Y L 0.0000 Buried
88 T L -0.6657 Soluble
89 L L 0.0000 Buried
90 T L -0.6249 Soluble
91 I L 0.0000 Buried
92 S L -1.3663 Soluble
93 S L -1.3374 Soluble
94 L L 0.0000 Buried
95 Q L -1.1820 Soluble
96 Q L -2.0973 Soluble
97 E L -2.3104 Soluble
98 D L 0.0000 Buried
99 F L -1.3012 Soluble
100 A L 0.0000 Buried
101 T L -0.8314 Soluble
102 Y L 0.0000 Buried
103 F L 0.0000 Buried
104 C L 0.0000 Buried
105 L L 0.0000 Buried
106 Q L 0.0000 Buried
107 G L -0.4065 Soluble
108 K L -1.2326 Soluble
109 M L -0.1854 Soluble
114 L L 0.4669 Aggregation-prone
115 P L 0.0000 Buried
116 W L 0.0000 Buried
117 T L -0.7346 Soluble
118 F L 0.0000 Buried
119 G L 0.0000 Buried
120 Q L -1.7768 Soluble
121 G L 0.0000 Buried
122 T L 0.0000 Buried
123 K L -1.2432 Soluble
124 L L 0.0000 Buried
125 E L -1.0195 Soluble
126 I L 0.0000 Buried
127 K L -1.2451 Soluble
128 R L -0.9494 Soluble
129 T L -0.1106 Soluble
130 V L 0.2160 Aggregation-prone
131 A L 0.0620 Aggregation-prone
132 A L -0.1496 Soluble
133 P L 0.0000 Buried
134 S L -0.1752 Soluble
135 V L 0.0000 Buried
136 F L 0.1237 Aggregation-prone
137 I L 0.1363 Aggregation-prone
138 F L 0.0000 Buried
139 P L -0.5493 Soluble
140 P L 0.0000 Buried
141 S L -1.7175 Soluble
142 D L -3.0360 Soluble
143 E L -3.1684 Soluble
144 Q L 0.0000 Buried
145 L L -2.2558 Soluble
146 K L -2.8623 Soluble
147 S L -1.7612 Soluble
148 G L -1.2251 Soluble
149 T L -1.0491 Soluble
150 A L 0.0000 Buried
151 S L 0.0000 Buried
152 V L 0.0000 Buried
153 V L 0.0000 Buried
154 C L 0.0000 Buried
155 L L 0.0000 Buried
156 L L 0.0000 Buried
157 N L 0.0000 Buried
158 N L -0.9718 Soluble
159 F L 0.0000 Buried
160 Y L 0.0000 Buried
161 P L -1.7687 Soluble
162 R L -2.8617 Soluble
163 E L -3.1840 Soluble
164 A L -2.3550 Soluble
165 K L -2.2791 Soluble
166 V L -1.2699 Soluble
167 Q L -0.7085 Soluble
168 W L 0.0000 Buried
169 K L -0.7510 Soluble
170 V L 0.0000 Buried
171 D L -2.0421 Soluble
172 N L -1.6083 Soluble
173 A L -0.4185 Soluble
174 L L 0.3881 Aggregation-prone
175 Q L -0.2559 Soluble
176 S L -0.4656 Soluble
177 G L -0.8861 Soluble
178 N L -0.7928 Soluble
179 S L -0.9910 Soluble
180 Q L -1.1644 Soluble
181 E L -1.4439 Soluble
182 S L -0.7768 Soluble
183 V L -0.7435 Soluble
184 T L -1.1822 Soluble
185 E L -2.2736 Soluble
186 Q L 0.0000 Buried
187 D L -2.1052 Soluble
188 S L -2.2748 Soluble
189 K L -2.6432 Soluble
190 D L -1.9924 Soluble
191 S L 0.0000 Buried
192 T L 0.0000 Buried
193 Y L 0.0000 Buried
194 S L 0.0000 Buried
195 L L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 T L -0.5347 Soluble
199 L L 0.0000 Buried
200 T L -0.4420 Soluble
201 L L -0.6880 Soluble
202 S L -1.0785 Soluble
203 K L -2.0347 Soluble
204 A L -1.8574 Soluble
205 D L -2.6058 Soluble
206 Y L 0.0000 Buried
207 E L -3.2718 Soluble
208 K L -3.5469 Soluble
209 H L -3.1697 Soluble
210 K L -3.5528 Soluble
211 V L -1.8163 Soluble
212 Y L 0.0000 Buried
213 A L 0.0000 Buried
214 C L 0.0000 Buried
215 E L -0.7677 Soluble
216 V L 0.0000 Buried
217 T L -1.2328 Soluble
218 H L 0.0000 Buried
219 Q L -1.7292 Soluble
220 G L -0.4351 Soluble
221 L L -0.2141 Soluble
222 S L -0.4429 Soluble
223 S L -0.4203 Soluble
224 P L -0.5550 Soluble
225 V L -0.0224 Soluble
226 T L -0.4154 Soluble
227 K L -0.4783 Soluble
228 S L -0.6004 Soluble
229 F L -1.2352 Soluble
230 N L -2.7001 Soluble
231 R L -2.9839 Soluble
232 G L -2.5440 Soluble
233 E L -2.7232 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.8401 1.7542 CSV PDB
4.5 -0.8829 1.7542 CSV PDB
5.0 -0.9314 1.7542 CSV PDB
5.5 -0.9755 1.7542 CSV PDB
6.0 -1.0039 1.7542 CSV PDB
6.5 -1.0084 1.7542 CSV PDB
7.0 -0.9903 1.7542 CSV PDB
7.5 -0.9577 1.7542 CSV PDB
8.0 -0.9172 1.7542 CSV PDB
8.5 -0.8701 1.8335 CSV PDB
9.0 -0.8159 1.9187 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH