Paridiprubart / 4r7d

A4DAB203_4r7d_G_H | Source PDB: 4r7d | Chains: G, H | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6224
Max Score
1.7506
Min Score
-4.0489
Total Score
-250.18
Score CDR
-0.2224
Score non-CDR
-0.6728

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSDTLSLTCAVSGYSITGGYSWHWIRQPPGKGLEWMGYIHYSGYTDFNPSLKTRITISRDTSKNQFSLKLSSVTAVDTAVYYCARKDPSDAFPYWGQGTLVTVSSASTKGPSVFPLAPTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTTYICNVNHKPEIVLTQSPDFQSVTPKEKVTITCRASQSISDHLHWYQQKPDQSPKLLIKYASHAISGVPSRFSGSGSGTDFTLTINSLEAEDAATYYCQQGHSFPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG input.pdb
Selected Chain(s) G (Heavy), H (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -4.0489
Maximum Score 1.7506
Average Score -0.6224
Total Score -250.1848

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q G -1.4765 Soluble
2 V G 0.0000 Buried
3 Q G -1.8766 Soluble
4 L G 0.0000 Buried
5 Q G -1.8729 Soluble
6 E G 0.0000 Buried
7 S G -0.8052 Soluble
8 G G -0.4679 Soluble
9 P G -0.3757 Soluble
11 G G -0.4142 Soluble
12 L G -0.3321 Soluble
13 V G 0.0000 Buried
14 K G -2.0395 Soluble
15 P G -1.5879 Soluble
16 S G -1.6016 Soluble
17 D G -2.4661 Soluble
18 T G -1.5735 Soluble
19 L G 0.0000 Buried
20 S G -0.8179 Soluble
21 L G 0.0000 Buried
22 T G -0.7129 Soluble
23 C G 0.0000 Buried
24 A G -1.2744 Soluble
25 V G 0.0000 Buried
26 S G -1.2116 Soluble
27 G G -0.8692 Soluble
28 Y G -0.1196 Soluble
29 S G -0.2333 Soluble
30 I G 0.0000 Buried
31 T G -0.1952 Soluble
35 G G -0.1964 Soluble
36 G G 0.1371 Aggregation-prone
37 Y G 0.3089 Aggregation-prone
38 S G 0.0000 Buried
39 W G 0.0000 Buried
40 H G 0.0000 Buried
41 W G 0.0000 Buried
42 I G 0.0000 Buried
43 R G 0.0000 Buried
44 Q G -0.7086 Soluble
45 P G -0.5246 Soluble
46 P G -0.7623 Soluble
47 G G -1.4791 Soluble
48 K G -2.2362 Soluble
49 G G -1.3527 Soluble
50 L G 0.0000 Buried
51 E G -0.8335 Soluble
52 W G 0.0000 Buried
53 M G 0.0000 Buried
54 G G 0.0000 Buried
55 Y G 0.1693 Aggregation-prone
56 I G 0.0000 Buried
57 H G 0.3708 Aggregation-prone
58 Y G 0.5845 Aggregation-prone
59 S G 0.3270 Aggregation-prone
63 G G 0.3659 Aggregation-prone
64 Y G 1.1022 Aggregation-prone
65 T G 0.3690 Aggregation-prone
66 D G -0.2705 Soluble
67 F G -0.4102 Soluble
68 N G -0.7460 Soluble
69 P G -0.9331 Soluble
70 S G -0.7033 Soluble
71 L G 0.0000 Buried
72 K G -1.4096 Soluble
74 T G -0.8768 Soluble
75 R G -0.9883 Soluble
76 I G 0.0000 Buried
77 T G -0.6956 Soluble
78 I G 0.0000 Buried
79 S G -0.5246 Soluble
80 R G -1.2864 Soluble
81 D G -1.6683 Soluble
82 T G -1.3253 Soluble
83 S G -1.4439 Soluble
84 K G -2.3301 Soluble
85 N G -1.5907 Soluble
86 Q G -1.5220 Soluble
87 F G 0.0000 Buried
88 S G -0.6151 Soluble
89 L G 0.0000 Buried
90 K G -0.9972 Soluble
91 L G 0.0000 Buried
92 S G -1.1271 Soluble
93 S G -1.2267 Soluble
94 V G 0.0000 Buried
95 T G -0.0934 Soluble
96 A G 0.6664 Aggregation-prone
97 V G 1.7506 Aggregation-prone
98 D G 0.0000 Buried
99 T G 0.6326 Aggregation-prone
100 A G 0.0000 Buried
101 V G -0.0002 Soluble
102 Y G 0.0000 Buried
103 Y G 0.0000 Buried
104 C G 0.0000 Buried
105 A G 0.0000 Buried
106 R G 0.0000 Buried
107 K G -0.2584 Soluble
108 D G -0.4693 Soluble
109 P G -0.4690 Soluble
110 S G 0.0000 Buried
113 D G -0.6388 Soluble
114 A G 0.0000 Buried
115 F G 0.0000 Buried
116 P G -0.2593 Soluble
117 Y G -0.2363 Soluble
118 W G -0.7378 Soluble
119 G G 0.0000 Buried
120 Q G -2.1414 Soluble
121 G G -1.1931 Soluble
122 T G -0.3735 Soluble
123 L G 0.1782 Aggregation-prone
124 V G 0.0000 Buried
125 T G 0.0324 Aggregation-prone
126 V G 0.0000 Buried
127 S G -0.5990 Soluble
128 S G -0.7163 Soluble
129 A G -0.5389 Soluble
130 S G -0.6798 Soluble
131 T G -0.8848 Soluble
132 K G -1.6211 Soluble
133 G G -1.5610 Soluble
134 P G -0.7344 Soluble
135 S G -0.3746 Soluble
136 V G 0.1033 Aggregation-prone
137 F G 0.0000 Buried
138 P G -0.4305 Soluble
139 L G 0.0000 Buried
140 A G -0.0689 Soluble
141 P G -0.1320 Soluble
142 T G -0.0620 Soluble
143 A G 0.0060 Aggregation-prone
144 A G 0.0000 Buried
145 L G 0.3193 Aggregation-prone
146 G G 0.0000 Buried
147 C G 0.0000 Buried
148 L G 0.0000 Buried
149 V G 0.0000 Buried
150 K G 0.0000 Buried
151 D G -0.5139 Soluble
152 Y G 0.0000 Buried
153 F G 0.0000 Buried
154 P G 0.0000 Buried
155 E G -0.7204 Soluble
156 P G -0.9061 Soluble
157 V G 0.0000 Buried
158 T G -0.7667 Soluble
159 V G -0.2221 Soluble
160 S G -0.0290 Soluble
161 W G 0.0000 Buried
162 N G 0.3324 Aggregation-prone
163 S G -0.1872 Soluble
164 G G -0.1117 Soluble
165 A G 0.6713 Aggregation-prone
166 L G 1.4027 Aggregation-prone
167 T G 0.4325 Aggregation-prone
168 S G 0.0437 Aggregation-prone
169 G G -0.3208 Soluble
170 V G 0.1602 Aggregation-prone
171 H G -0.4014 Soluble
172 T G -0.1887 Soluble
173 F G 0.0000 Buried
174 P G -0.3056 Soluble
175 A G 0.3811 Aggregation-prone
176 V G 0.7123 Aggregation-prone
177 L G 1.2687 Aggregation-prone
178 Q G 0.2494 Aggregation-prone
179 S G -0.0610 Soluble
180 S G -0.2013 Soluble
181 G G 0.1317 Aggregation-prone
182 L G 0.0895 Aggregation-prone
183 Y G 0.5530 Aggregation-prone
184 S G 0.0000 Buried
185 L G 0.0000 Buried
186 S G 0.0000 Buried
187 S G 0.0000 Buried
188 V G 0.0000 Buried
189 V G 0.0000 Buried
190 T G -0.2154 Soluble
191 T G 0.9489 Aggregation-prone
192 Y G 1.7096 Aggregation-prone
193 I G 1.1646 Aggregation-prone
194 C G 0.5358 Aggregation-prone
195 N G -0.3338 Soluble
196 V G -0.4296 Soluble
197 N G -1.7721 Soluble
198 H G -1.8979 Soluble
199 K G -2.3434 Soluble
200 P G -1.6457 Soluble
1 E H -1.3192 Soluble
2 I H -0.0890 Soluble
3 V H 0.8343 Aggregation-prone
4 L H 0.0000 Buried
5 T H -0.7127 Soluble
6 Q H 0.0000 Buried
7 S H -0.9267 Soluble
8 P H -0.6621 Soluble
9 D H -1.3319 Soluble
10 F H 0.4211 Aggregation-prone
11 Q H -0.1520 Soluble
12 S H -0.3442 Soluble
13 V H -1.3856 Soluble
14 T H -1.9882 Soluble
15 P H -2.3621 Soluble
16 K H -3.5378 Soluble
17 E H -3.8668 Soluble
18 K H -3.1279 Soluble
19 V H 0.0000 Buried
20 T H -0.6032 Soluble
21 I H 0.0000 Buried
22 T H -0.9161 Soluble
23 C H 0.0000 Buried
24 R H -2.1830 Soluble
25 A H -1.1398 Soluble
26 S H -0.9536 Soluble
27 Q H -1.6574 Soluble
28 S H -1.5036 Soluble
29 I H 0.0000 Buried
36 S H -1.2322 Soluble
37 D H -1.6500 Soluble
38 H H -1.0652 Soluble
39 L H 0.0000 Buried
40 H H 0.0000 Buried
41 W H 0.0000 Buried
42 Y H 0.0000 Buried
43 Q H 0.0000 Buried
44 Q H 0.0000 Buried
45 K H -2.1410 Soluble
46 P H -2.0417 Soluble
47 D H -2.8822 Soluble
48 Q H -2.7360 Soluble
49 S H -1.6586 Soluble
50 P H 0.0000 Buried
51 K H -1.3845 Soluble
52 L H 0.0000 Buried
53 L H 0.0000 Buried
54 I H 0.0000 Buried
55 K H -0.6131 Soluble
56 Y H -0.5482 Soluble
57 A H 0.0000 Buried
65 S H -0.9438 Soluble
66 H H -1.0095 Soluble
67 A H -0.4389 Soluble
68 I H -0.1972 Soluble
69 S H -0.2709 Soluble
70 G H -0.3910 Soluble
71 V H -0.0789 Soluble
72 P H -0.2699 Soluble
74 S H -0.5452 Soluble
75 R H -1.2009 Soluble
76 F H 0.0000 Buried
77 S H -0.6568 Soluble
78 G H -0.5575 Soluble
79 S H -0.8810 Soluble
80 G H -1.0261 Soluble
83 S H -1.3584 Soluble
84 G H -1.4069 Soluble
85 T H -1.7570 Soluble
86 D H -2.0387 Soluble
87 F H 0.0000 Buried
88 T H -0.7168 Soluble
89 L H 0.0000 Buried
90 T H -0.7091 Soluble
91 I H 0.0000 Buried
92 N H -2.4899 Soluble
93 S H -2.7661 Soluble
94 L H 0.0000 Buried
95 E H -2.6752 Soluble
96 A H -2.5831 Soluble
97 E H -2.7917 Soluble
98 D H 0.0000 Buried
99 A H -1.6124 Soluble
100 A H 0.0000 Buried
101 T H -0.6758 Soluble
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 Q H 0.0000 Buried
106 Q H 0.0000 Buried
107 G H -0.5038 Soluble
108 H H -0.6680 Soluble
109 S H -0.2083 Soluble
114 F H 0.3856 Aggregation-prone
115 P H -0.1235 Soluble
116 L H 0.0000 Buried
117 T H 0.0911 Aggregation-prone
118 F H 0.2634 Aggregation-prone
119 G H 0.0000 Buried
120 G H -0.9733 Soluble
121 G H 0.0000 Buried
122 T H 0.0000 Buried
123 K H -0.9743 Soluble
124 V H 0.0000 Buried
125 E H -0.8330 Soluble
126 I H 0.0000 Buried
127 K H -1.6133 Soluble
128 R H -0.8674 Soluble
129 T H 0.0607 Aggregation-prone
130 V H 0.7811 Aggregation-prone
131 A H 0.1668 Aggregation-prone
132 A H -0.0749 Soluble
133 P H 0.0000 Buried
134 S H -0.1127 Soluble
135 V H 0.0000 Buried
136 F H 0.1244 Aggregation-prone
137 I H 0.1178 Aggregation-prone
138 F H 0.0000 Buried
139 P H -0.8132 Soluble
140 P H -0.9916 Soluble
141 S H 0.0000 Buried
142 D H -2.8579 Soluble
143 E H -2.7673 Soluble
144 Q H 0.0000 Buried
145 L H -1.9912 Soluble
146 K H -2.6293 Soluble
147 S H -1.6739 Soluble
148 G H -1.4178 Soluble
149 T H -0.9500 Soluble
150 A H 0.0000 Buried
151 S H 0.0000 Buried
152 V H 0.0000 Buried
153 V H 0.0000 Buried
154 C H 0.0000 Buried
155 L H 0.0000 Buried
156 L H 0.0000 Buried
157 N H -0.4592 Soluble
158 N H -1.0017 Soluble
159 F H 0.0000 Buried
160 Y H 0.0000 Buried
161 P H -1.7392 Soluble
162 R H -3.2429 Soluble
163 E H -3.2711 Soluble
164 A H -2.3959 Soluble
165 K H -2.4672 Soluble
166 V H -1.0486 Soluble
167 Q H -0.6477 Soluble
168 W H 0.0000 Buried
169 K H -0.6568 Soluble
170 V H 0.0000 Buried
171 D H -2.2147 Soluble
172 N H -1.6572 Soluble
173 A H -0.2675 Soluble
174 L H 0.7664 Aggregation-prone
175 Q H -0.0608 Soluble
176 S H -0.5141 Soluble
177 G H -0.9400 Soluble
178 N H -0.8654 Soluble
179 S H -1.0939 Soluble
180 Q H -1.3664 Soluble
181 E H -1.4462 Soluble
182 S H -0.7898 Soluble
183 V H -0.7763 Soluble
184 T H 0.0000 Buried
185 E H -2.4036 Soluble
186 Q H 0.0000 Buried
187 D H -2.0752 Soluble
188 S H -2.4778 Soluble
189 K H -2.8324 Soluble
190 D H -2.1598 Soluble
191 S H 0.0000 Buried
192 T H 0.0000 Buried
193 Y H 0.0000 Buried
194 S H 0.0000 Buried
195 L H 0.0000 Buried
196 S H 0.0000 Buried
197 S H 0.0000 Buried
198 T H -0.5953 Soluble
199 L H 0.0000 Buried
200 T H -0.6141 Soluble
201 L H -1.0555 Soluble
202 S H -1.3895 Soluble
203 K H -2.3255 Soluble
204 A H -2.0935 Soluble
205 D H -3.1306 Soluble
206 Y H 0.0000 Buried
207 E H -4.0489 Soluble
208 K H -3.8263 Soluble
209 H H -3.6987 Soluble
210 K H -3.6896 Soluble
211 V H -2.2465 Soluble
212 Y H 0.0000 Buried
213 A H -0.7556 Soluble
214 C H 0.0000 Buried
215 E H -0.9003 Soluble
216 V H 0.0000 Buried
217 T H -1.2249 Soluble
218 H H 0.0000 Buried
219 Q H -1.7222 Soluble
220 G H -0.3494 Soluble
221 L H -0.2333 Soluble
222 S H -0.4702 Soluble
223 S H -0.4228 Soluble
224 P H -0.5373 Soluble
225 V H 0.0443 Aggregation-prone
226 T H -0.4661 Soluble
227 K H -0.6942 Soluble
228 S H -0.8332 Soluble
229 F H -1.2328 Soluble
230 N H -2.6033 Soluble
231 R H -2.9779 Soluble
232 G H -1.6792 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.5832 3.1144 CSV PDB
4.5 -0.6233 2.9157 CSV PDB
5.0 -0.6705 2.7473 CSV PDB
5.5 -0.7142 2.7473 CSV PDB
6.0 -0.7428 2.7473 CSV PDB
6.5 -0.7492 2.7473 CSV PDB
7.0 -0.7348 2.7473 CSV PDB
7.5 -0.7069 2.7473 CSV PDB
8.0 -0.6715 2.7473 CSV PDB
8.5 -0.6303 2.7473 CSV PDB
9.0 -0.5829 2.7473 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH