Teneliximab / 5dmi

A4DAB260_5dmi_H_L | Source PDB: 5dmi | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.7277
Max Score
0.9549
Min Score
-3.3763
Total Score
-317.29
Score CDR
-0.309
Score non-CDR
-0.7807

Calculation Parameters

Chain Sequence(s) QIQLVQSGPELKKPGETVRISCKASGYAFTTTGMQWVQEMPGKGLKWIGWINTHSGVPKYVEDFKGRFAFSLETSANTAYLQISNLKNEDTATYFCVRSGNGNYDLAYFAYWGQGTLVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKDIVLTQSPATLSVTPGDRVSLSCRASQSISDYLHWYQQKSHESPRLLIKYASHSISGIPSRFSGSGSGSDFTLSINSVEPEDVGIYYCQHGHSFPWTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.3763
Maximum Score 0.9549
Average Score -0.7277
Total Score -317.2874

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q H -1.4651 Soluble
2 I H -0.9334 Soluble
3 Q H -1.2715 Soluble
4 L H 0.0000 Buried
5 V H 0.6465 Aggregation-prone
6 Q H 0.0000 Buried
7 S H -0.4885 Soluble
8 G H -0.7701 Soluble
9 P H -0.7856 Soluble
11 E H -1.1660 Soluble
12 L H -0.7368 Soluble
13 K H -1.9700 Soluble
14 K H -2.6944 Soluble
15 P H -2.6082 Soluble
16 G H -2.4828 Soluble
17 E H -2.5599 Soluble
18 T H -2.0411 Soluble
19 V H 0.0000 Buried
20 R H -1.9872 Soluble
21 I H 0.0000 Buried
22 S H -0.6753 Soluble
23 C H 0.0000 Buried
24 K H -1.2183 Soluble
25 A H 0.0000 Buried
26 S H -0.9277 Soluble
27 G H -0.9569 Soluble
28 Y H -0.5040 Soluble
29 A H -0.1545 Soluble
30 F H 0.0000 Buried
35 T H -0.5834 Soluble
36 T H -0.4407 Soluble
37 T H 0.0000 Buried
38 G H 0.0000 Buried
39 M H 0.0000 Buried
40 Q H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 Q H 0.0000 Buried
44 E H -0.9344 Soluble
45 M H -1.1966 Soluble
46 P H -0.9583 Soluble
47 G H -1.4218 Soluble
48 K H -2.2598 Soluble
49 G H -1.5544 Soluble
50 L H 0.0000 Buried
51 K H -1.4650 Soluble
52 W H 0.0000 Buried
53 I H 0.0000 Buried
54 G H 0.0000 Buried
55 W H 0.0000 Buried
56 I H 0.0000 Buried
57 N H -0.4084 Soluble
58 T H 0.0000 Buried
59 H H -1.0529 Soluble
62 S H -0.4757 Soluble
63 G H -0.2137 Soluble
64 V H 0.6404 Aggregation-prone
65 P H -0.1955 Soluble
66 K H -1.2016 Soluble
67 Y H -1.3826 Soluble
68 V H 0.0000 Buried
69 E H -3.2070 Soluble
70 D H -3.2119 Soluble
71 F H 0.0000 Buried
72 K H -3.0802 Soluble
74 G H -2.0401 Soluble
75 R H -1.7810 Soluble
76 F H 0.0000 Buried
77 A H -0.9547 Soluble
78 F H 0.0000 Buried
79 S H -0.4685 Soluble
80 L H -0.8061 Soluble
81 E H -1.5522 Soluble
82 T H -1.0684 Soluble
83 S H -0.7329 Soluble
84 A H -0.9578 Soluble
85 N H -1.2220 Soluble
86 T H 0.0000 Buried
87 A H 0.0000 Buried
88 Y H -0.7860 Soluble
89 L H 0.0000 Buried
90 Q H -1.3919 Soluble
91 I H 0.0000 Buried
92 S H -1.7453 Soluble
93 N H -2.5622 Soluble
94 L H 0.0000 Buried
95 K H -2.9475 Soluble
96 N H -3.0171 Soluble
97 E H -2.6807 Soluble
98 D H 0.0000 Buried
99 T H -1.0602 Soluble
100 A H 0.0000 Buried
101 T H -0.1399 Soluble
102 Y H 0.0000 Buried
103 F H 0.0000 Buried
104 C H 0.0000 Buried
105 V H 0.0000 Buried
106 R H 0.0000 Buried
107 S H 0.0000 Buried
108 G H 0.0000 Buried
109 N H -1.1019 Soluble
110 G H -0.6462 Soluble
111 N H -0.4695 Soluble
111A Y H 0.1903 Aggregation-prone
112A D H -1.0705 Soluble
112 L H -0.4300 Soluble
113 A H 0.0000 Buried
114 Y H 0.0488 Aggregation-prone
115 F H 0.0000 Buried
116 A H -0.0495 Soluble
117 Y H 0.1091 Aggregation-prone
118 W H -0.0632 Soluble
119 G H 0.0000 Buried
120 Q H -1.0638 Soluble
121 G H -0.5222 Soluble
122 T H 0.0000 Buried
123 L H -0.2075 Soluble
124 V H 0.0000 Buried
125 T H 0.0000 Buried
126 V H 0.0000 Buried
127 S H -1.1488 Soluble
128 A H -0.8081 Soluble
129 A H -0.5394 Soluble
130 S H -0.7201 Soluble
131 T H -0.8372 Soluble
132 K H -1.3150 Soluble
133 G H -1.3349 Soluble
134 P H -0.6098 Soluble
135 S H -0.4070 Soluble
136 V H 0.0000 Buried
137 F H 0.0000 Buried
138 P H -1.1382 Soluble
139 L H 0.0000 Buried
140 A H -1.1220 Soluble
141 P H 0.0000 Buried
142 S H -1.4234 Soluble
143 S H -1.4966 Soluble
144 K H -2.1041 Soluble
145 S H -1.2401 Soluble
146 T H -0.9759 Soluble
147 S H -0.5944 Soluble
148 G H -0.7934 Soluble
149 G H -0.8682 Soluble
150 T H -0.6386 Soluble
151 A H 0.0000 Buried
152 A H 0.0000 Buried
153 L H 0.0000 Buried
154 G H 0.0000 Buried
155 C H 0.0000 Buried
156 L H 0.0000 Buried
157 V H 0.0000 Buried
158 K H 0.0000 Buried
159 D H -0.5208 Soluble
160 Y H 0.0000 Buried
161 F H 0.0000 Buried
162 P H 0.0000 Buried
163 E H -0.4215 Soluble
164 P H -0.5720 Soluble
165 V H -0.4656 Soluble
166 T H -0.4832 Soluble
167 V H -0.1956 Soluble
168 S H -0.2406 Soluble
169 W H 0.0000 Buried
170 N H -0.6221 Soluble
171 S H -0.5305 Soluble
172 G H -0.4081 Soluble
173 A H -0.1270 Soluble
174 L H 0.0930 Aggregation-prone
175 T H -0.1317 Soluble
176 S H -0.1592 Soluble
177 G H -0.1699 Soluble
178 V H 0.1629 Aggregation-prone
179 H H -0.3044 Soluble
180 T H 0.0278 Aggregation-prone
181 F H 0.0000 Buried
182 P H -0.3129 Soluble
183 A H 0.2037 Aggregation-prone
184 V H 0.2279 Aggregation-prone
185 L H 0.8073 Aggregation-prone
186 Q H -0.0285 Soluble
187 S H -0.1912 Soluble
188 S H -0.3140 Soluble
189 G H -0.1018 Soluble
190 L H -0.0154 Soluble
191 Y H 0.3096 Aggregation-prone
192 S H 0.2455 Aggregation-prone
193 L H 0.0000 Buried
194 S H 0.0000 Buried
195 S H 0.0000 Buried
196 V H 0.0000 Buried
197 V H 0.0000 Buried
198 T H -0.2331 Soluble
199 V H 0.0000 Buried
200 P H -0.5528 Soluble
201 S H -0.8642 Soluble
202 S H -0.6626 Soluble
203 S H -0.7753 Soluble
204 L H 0.0000 Buried
205 G H -1.1348 Soluble
206 T H -0.8561 Soluble
207 Q H -1.4318 Soluble
208 T H -1.3441 Soluble
209 Y H 0.0000 Buried
210 I H -1.1678 Soluble
211 C H 0.0000 Buried
212 N H -1.1234 Soluble
213 V H 0.0000 Buried
214 N H -1.5963 Soluble
215 H H 0.0000 Buried
216 K H -2.6091 Soluble
217 P H -1.6197 Soluble
218 S H -1.7317 Soluble
219 N H -2.4064 Soluble
220 T H -1.9528 Soluble
221 K H -2.3724 Soluble
222 V H -1.1596 Soluble
223 D H -1.8159 Soluble
224 K H -1.7384 Soluble
225 K H -2.4692 Soluble
226 V H 0.0000 Buried
227 E H -2.8859 Soluble
228 P H -2.2359 Soluble
229 K H -2.5383 Soluble
1 D L -1.3100 Soluble
2 I L 0.0000 Buried
3 V L 0.9549 Aggregation-prone
4 L L 0.0000 Buried
5 T L -0.1727 Soluble
6 Q L 0.0000 Buried
7 S L -0.3885 Soluble
8 P L -0.2789 Soluble
9 A L -0.2059 Soluble
10 T L -0.3082 Soluble
11 L L -0.2720 Soluble
12 S L -0.5520 Soluble
13 V L -0.9305 Soluble
14 T L -1.2582 Soluble
15 P L -1.6731 Soluble
16 G L -1.6763 Soluble
17 D L -2.1934 Soluble
18 R L -2.7121 Soluble
19 V L 0.0000 Buried
20 S L -0.8323 Soluble
21 L L 0.0000 Buried
22 S L -0.6702 Soluble
23 C L 0.0000 Buried
24 R L -1.3187 Soluble
25 A L -0.6698 Soluble
26 S L -0.7547 Soluble
27 Q L -1.3250 Soluble
28 S L -1.3572 Soluble
29 I L 0.0000 Buried
36 S L -1.0073 Soluble
37 D L -1.0790 Soluble
38 Y L -0.1341 Soluble
39 L L 0.0000 Buried
40 H L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L 0.0000 Buried
45 K L -1.4034 Soluble
46 S L -1.4581 Soluble
47 H L -1.7973 Soluble
48 E L -1.8609 Soluble
49 S L -1.2017 Soluble
50 P L 0.0000 Buried
51 R L -0.6820 Soluble
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 K L -0.7078 Soluble
56 Y L -0.5115 Soluble
57 A L 0.0000 Buried
65 S L -0.9701 Soluble
66 H L -1.1454 Soluble
67 S L -0.7464 Soluble
68 I L -0.4115 Soluble
69 S L -0.3752 Soluble
70 G L -0.4541 Soluble
71 I L -0.2311 Soluble
72 P L -0.3118 Soluble
74 S L -0.5552 Soluble
75 R L -1.1012 Soluble
76 F L 0.0000 Buried
77 S L -0.6474 Soluble
78 G L -0.6168 Soluble
79 S L -0.9526 Soluble
80 G L -1.3015 Soluble
83 S L -1.2550 Soluble
84 G L -1.3489 Soluble
85 S L -1.7641 Soluble
86 D L -2.2981 Soluble
87 F L 0.0000 Buried
88 T L -0.7705 Soluble
89 L L 0.0000 Buried
90 S L -0.8893 Soluble
91 I L 0.0000 Buried
92 N L -2.0950 Soluble
93 S L -1.8782 Soluble
94 V L 0.0000 Buried
95 E L -2.1592 Soluble
96 P L -2.6368 Soluble
97 E L -3.0110 Soluble
98 D L 0.0000 Buried
99 V L 0.0000 Buried
100 G L 0.0000 Buried
101 I L 0.0394 Aggregation-prone
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 H L 0.0000 Buried
107 G L -0.1855 Soluble
108 H L -0.4848 Soluble
109 S L -0.1807 Soluble
114 F L 0.3250 Aggregation-prone
115 P L -0.2921 Soluble
116 W L 0.0000 Buried
117 T L -0.1741 Soluble
118 F L 0.0000 Buried
119 G L -0.2340 Soluble
120 G L -0.6668 Soluble
121 G L 0.0000 Buried
122 T L 0.0000 Buried
123 K L -0.5762 Soluble
124 L L 0.0000 Buried
125 E L -1.0848 Soluble
126 I L 0.0000 Buried
127 K L -1.0856 Soluble
128 R L -0.9205 Soluble
129 T L 0.1748 Aggregation-prone
130 V L 0.8676 Aggregation-prone
131 A L 0.3279 Aggregation-prone
132 A L 0.0191 Aggregation-prone
133 P L 0.0000 Buried
134 S L -0.3024 Soluble
135 V L 0.0000 Buried
136 F L 0.0000 Buried
137 I L 0.0182 Aggregation-prone
138 F L 0.0000 Buried
139 P L -0.4949 Soluble
140 P L 0.0000 Buried
141 S L -1.5125 Soluble
142 D L -2.7020 Soluble
143 E L -2.6391 Soluble
144 Q L 0.0000 Buried
145 L L -2.1064 Soluble
146 K L -2.7214 Soluble
147 S L -1.7074 Soluble
148 G L -1.2760 Soluble
149 T L -1.0056 Soluble
150 A L 0.0000 Buried
151 S L 0.0000 Buried
152 V L 0.0000 Buried
153 V L 0.0000 Buried
154 C L 0.0000 Buried
155 L L 0.0000 Buried
156 L L 0.0000 Buried
157 N L 0.0000 Buried
158 N L -0.9468 Soluble
159 F L 0.0000 Buried
160 Y L -1.0731 Soluble
161 P L -1.6480 Soluble
162 R L -3.2631 Soluble
163 E L -3.2785 Soluble
164 A L -2.3882 Soluble
165 K L -2.6460 Soluble
166 V L 0.0000 Buried
167 Q L -0.5603 Soluble
168 W L 0.0000 Buried
169 K L -0.4983 Soluble
170 V L 0.0000 Buried
171 D L -1.2955 Soluble
172 N L -1.2947 Soluble
173 A L -0.1599 Soluble
174 L L 0.7669 Aggregation-prone
175 Q L -0.3962 Soluble
176 S L -0.6447 Soluble
177 G L -1.4550 Soluble
178 N L -1.8792 Soluble
179 S L -1.8016 Soluble
180 Q L -2.1386 Soluble
181 E L -2.1171 Soluble
182 S L -0.8387 Soluble
183 V L -0.8610 Soluble
184 T L -1.1989 Soluble
185 E L -2.3948 Soluble
186 Q L 0.0000 Buried
187 D L -2.5694 Soluble
188 S L -2.8122 Soluble
189 K L -3.3704 Soluble
190 D L -3.1613 Soluble
191 S L 0.0000 Buried
192 T L 0.0000 Buried
193 Y L 0.0000 Buried
194 S L 0.0000 Buried
195 L L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 T L -0.9411 Soluble
199 L L 0.0000 Buried
200 T L -0.7699 Soluble
201 L L -0.8428 Soluble
202 S L -1.2326 Soluble
203 K L -2.1128 Soluble
204 A L -1.8746 Soluble
205 D L -2.3965 Soluble
206 Y L 0.0000 Buried
207 E L -3.2845 Soluble
208 K L -3.3763 Soluble
209 H L -2.7354 Soluble
210 K L -3.0041 Soluble
211 V L -1.0817 Soluble
212 Y L 0.0000 Buried
213 A L 0.0000 Buried
214 C L 0.0000 Buried
215 E L -0.7514 Soluble
216 V L 0.0000 Buried
217 T L -1.2270 Soluble
218 H L 0.0000 Buried
219 Q L -1.7045 Soluble
220 G L -0.3177 Soluble
221 L L -0.2212 Soluble
222 S L -0.4532 Soluble
223 S L -0.3961 Soluble
224 P L -0.5508 Soluble
225 V L 0.0730 Aggregation-prone
226 T L -0.3462 Soluble
227 K L -0.4967 Soluble
228 S L -0.3437 Soluble
229 F L -0.7824 Soluble
230 N L -1.8115 Soluble
231 R L -2.2199 Soluble
232 G L -2.0603 Soluble
233 E L -2.6698 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.7715 2.2052 CSV PDB
4.5 -0.816 2.0742 CSV PDB
5.0 -0.8688 1.914 CSV PDB
5.5 -0.9176 1.7488 CSV PDB
6.0 -0.9489 1.6002 CSV PDB
6.5 -0.9543 1.48 CSV PDB
7.0 -0.9362 1.3809 CSV PDB
7.5 -0.9034 1.288 CSV PDB
8.0 -0.8631 1.2299 CSV PDB
8.5 -0.8175 1.2876 CSV PDB
9.0 -0.7661 1.4443 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH