Zinlirvimab / 8czz

A4DAB308_8czz_M_N | Source PDB: 8czz | Chains: M, N | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.5492
Max Score
3.4887
Min Score
-2.9412
Total Score
-129.07
Score CDR
-0.146
Score non-CDR
-0.6938

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTVSLSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTVLG input.pdb
Selected Chain(s) M (Heavy), N (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -2.9412
Maximum Score 3.4887
Average Score -0.5492
Total Score -129.0692

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q M -1.6023 Soluble
2 V M -1.1236 Soluble
3 Q M -1.8943 Soluble
4 L M -1.4051 Soluble
5 Q M -2.0264 Soluble
6 E M -1.3776 Soluble
7 S M -0.8298 Soluble
8 G M -0.4581 Soluble
9 P M -0.0313 Soluble
11 G M 0.3077 Aggregation-prone
12 L M 1.0434 Aggregation-prone
13 V M 0.0000 Buried
14 K M -1.8923 Soluble
15 P M -1.5412 Soluble
16 S M -1.7890 Soluble
17 E M -2.6843 Soluble
18 T M -1.9361 Soluble
19 L M 0.0000 Buried
20 S M -0.7695 Soluble
21 V M 0.0000 Buried
22 T M -1.0312 Soluble
23 C M 0.0000 Buried
24 S M -1.3163 Soluble
25 V M 0.0000 Buried
26 S M -1.4972 Soluble
27 G M -1.2725 Soluble
28 D M -1.4403 Soluble
29 S M -1.0951 Soluble
30 M M -1.3408 Soluble
35 N M -2.2469 Soluble
36 N M -1.8510 Soluble
37 Y M -1.3099 Soluble
38 Y M -1.2636 Soluble
39 W M 0.0000 Buried
40 T M 0.0000 Buried
41 W M 0.0000 Buried
42 I M 0.0000 Buried
43 R M 0.0000 Buried
44 Q M 0.0000 Buried
45 S M -1.0576 Soluble
46 P M -1.1925 Soluble
47 G M -1.5196 Soluble
48 K M -2.1402 Soluble
49 G M -1.4309 Soluble
50 L M 0.0000 Buried
51 E M -0.6262 Soluble
52 W M 0.0000 Buried
53 I M 0.0000 Buried
54 G M 0.0000 Buried
55 Y M 0.0000 Buried
56 I M 0.0000 Buried
57 S M -1.3912 Soluble
58 D M 0.0000 Buried
59 R M -2.9412 Soluble
63 E M -2.9071 Soluble
64 S M -1.5329 Soluble
65 A M -0.3795 Soluble
66 T M 0.0018 Aggregation-prone
67 Y M 0.0910 Aggregation-prone
68 N M 0.0000 Buried
69 P M -0.8195 Soluble
70 S M -0.6566 Soluble
71 L M -0.6983 Soluble
72 N M -1.4606 Soluble
74 S M -0.8179 Soluble
75 R M -0.9456 Soluble
76 V M 0.0000 Buried
77 V M 0.2433 Aggregation-prone
78 I M 0.0000 Buried
79 S M -0.8439 Soluble
80 R M -1.6517 Soluble
81 D M -1.6210 Soluble
82 T M -1.4687 Soluble
83 S M -1.3970 Soluble
84 K M -2.3410 Soluble
85 N M -1.8055 Soluble
86 Q M -1.6469 Soluble
87 L M 0.0000 Buried
88 S M -0.6042 Soluble
89 L M 0.0000 Buried
90 K M -1.4920 Soluble
91 L M 0.0000 Buried
92 N M -2.1548 Soluble
93 S M -1.7773 Soluble
94 V M 0.0000 Buried
95 T M -0.8140 Soluble
96 P M -0.2647 Soluble
97 A M -0.0645 Soluble
98 D M 0.0000 Buried
99 T M -0.1294 Soluble
100 A M 0.0000 Buried
101 V M 0.0000 Buried
102 Y M 0.0000 Buried
103 Y M 0.0000 Buried
104 C M 0.0000 Buried
105 A M 0.0000 Buried
106 T M 0.0000 Buried
107 A M 0.0000 Buried
108 R M -2.0812 Soluble
109 R M -1.4884 Soluble
110 G M -1.0772 Soluble
111 Q M -0.2587 Soluble
111A R M 0.5087 Aggregation-prone
111B I M 2.8620 Aggregation-prone
111C Y M 2.4116 Aggregation-prone
111D G M 2.3068 Aggregation-prone
111E V M 3.3824 Aggregation-prone
111F V M 3.4887 Aggregation-prone
112G S M 1.9483 Aggregation-prone
112F F M 2.6869 Aggregation-prone
112E G M 1.8836 Aggregation-prone
112D E M 1.7748 Aggregation-prone
112C F M 2.1818 Aggregation-prone
112B F M 0.9992 Aggregation-prone
112A Y M 0.6085 Aggregation-prone
112 Y M 0.0000 Buried
113 Y M 0.0000 Buried
114 S M -0.7845 Soluble
115 M M 0.0000 Buried
116 D M -0.8156 Soluble
117 V M -0.3638 Soluble
118 W M 0.0000 Buried
119 G M 0.0000 Buried
120 K M -2.5015 Soluble
121 G M -1.4890 Soluble
122 T M -0.9103 Soluble
123 T M -0.0021 Soluble
124 V M 0.0000 Buried
125 T M 0.2211 Aggregation-prone
126 V M 0.0183 Aggregation-prone
127 S M -0.2627 Soluble
11 L N 1.1067 Aggregation-prone
12 S N 0.5543 Aggregation-prone
13 V N 1.1007 Aggregation-prone
14 A N 0.8358 Aggregation-prone
15 L N 1.1076 Aggregation-prone
16 G N -0.6642 Soluble
17 E N -1.3431 Soluble
18 T N -0.9407 Soluble
19 A N -1.0489 Soluble
20 R N -1.6521 Soluble
21 I N 0.0000 Buried
22 S N -1.2625 Soluble
23 C N 0.0000 Buried
24 G N -1.8209 Soluble
25 R N -2.7079 Soluble
26 Q N -2.3765 Soluble
27 A N -1.1190 Soluble
28 L N -0.4490 Soluble
29 G N -0.1466 Soluble
36 S N 0.5431 Aggregation-prone
37 R N 0.0000 Buried
38 A N 0.0000 Buried
39 V N 0.0000 Buried
40 Q N 0.0000 Buried
41 W N 0.0000 Buried
42 Y N 0.0000 Buried
43 Q N -0.6759 Soluble
44 H N -1.7160 Soluble
45 R N -2.4200 Soluble
46 P N -1.6624 Soluble
47 G N -1.8636 Soluble
48 Q N -2.4045 Soluble
49 A N -1.5236 Soluble
50 P N 0.0000 Buried
51 I N 0.0275 Aggregation-prone
52 L N 0.0000 Buried
53 L N 0.0000 Buried
54 I N 0.0000 Buried
55 Y N -0.6401 Soluble
56 N N -1.3119 Soluble
57 N N -1.4221 Soluble
65 Q N -2.3045 Soluble
66 D N -2.0665 Soluble
67 R N -2.8331 Soluble
68 P N -1.5989 Soluble
69 S N -1.0381 Soluble
70 G N -1.0824 Soluble
71 I N 0.0000 Buried
72 P N -1.6580 Soluble
74 E N -2.7065 Soluble
75 R N -1.3551 Soluble
76 F N 0.0000 Buried
77 S N -1.2390 Soluble
78 G N -1.0060 Soluble
79 T N -0.5825 Soluble
80 P N -0.6922 Soluble
81 D N -0.4305 Soluble
81A I N 1.3154 Aggregation-prone
82 N N 0.2628 Aggregation-prone
83 F N 1.3202 Aggregation-prone
84 G N -0.0962 Soluble
85 T N -0.6171 Soluble
86 R N -1.4763 Soluble
87 A N -1.1927 Soluble
88 T N -0.9042 Soluble
89 L N 0.0000 Buried
90 T N -0.9446 Soluble
91 I N 0.0000 Buried
92 S N -1.2934 Soluble
93 G N -1.1007 Soluble
94 V N -1.0748 Soluble
95 E N -1.9825 Soluble
96 A N -1.4305 Soluble
97 G N -1.7635 Soluble
98 D N 0.0000 Buried
99 E N -2.8580 Soluble
100 A N -2.0906 Soluble
101 D N 0.0000 Buried
102 Y N 0.0000 Buried
103 Y N 0.0000 Buried
104 C N 0.0000 Buried
105 H N 0.0000 Buried
106 M N 0.0000 Buried
107 W N 0.0000 Buried
108 D N 0.0000 Buried
109 S N -0.7002 Soluble
110 R N -1.8114 Soluble
112 S N -0.9341 Soluble
113 G N -0.2728 Soluble
114 F N 0.6584 Aggregation-prone
115 S N 0.4628 Aggregation-prone
116 W N 0.6202 Aggregation-prone
117 S N -0.0640 Soluble
118 F N 0.0000 Buried
119 G N -0.7414 Soluble
120 G N -1.2305 Soluble
121 A N -0.6554 Soluble
122 T N -0.9250 Soluble
123 R N -1.9750 Soluble
124 L N 0.0000 Buried
125 T N 0.0875 Aggregation-prone
126 V N 0.8426 Aggregation-prone
127 L N 1.9550 Aggregation-prone
128 G N 0.7147 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.4536 4.7923 CSV PDB
4.5 -0.4813 4.7838 CSV PDB
5.0 -0.5179 4.7726 CSV PDB
5.5 -0.5556 4.7605 CSV PDB
6.0 -0.5865 4.7495 CSV PDB
6.5 -0.6047 4.7414 CSV PDB
7.0 -0.6083 4.7369 CSV PDB
7.5 -0.5997 4.735 CSV PDB
8.0 -0.5838 4.7344 CSV PDB
8.5 -0.5638 4.7342 CSV PDB
9.0 -0.541 4.7341 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH