Zinlirvimab / 6udj

A4DAB308_6udj_K_L | Source PDB: 6udj | Chains: K, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.5555
Max Score
2.3718
Min Score
-3.5322
Total Score
-131.65
Score CDR
-0.3398
Score non-CDR
-0.6319

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTVSSALSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTVLG input.pdb
Selected Chain(s) K (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.5322
Maximum Score 2.3718
Average Score -0.5555
Total Score -131.6454

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q K -1.7543 Soluble
2 V K -1.3854 Soluble
3 Q K -1.8911 Soluble
4 L K -1.4307 Soluble
5 Q K -1.9381 Soluble
6 E K -1.3502 Soluble
7 S K -0.8360 Soluble
8 G K -0.4226 Soluble
9 P K 0.0244 Aggregation-prone
11 G K 0.3192 Aggregation-prone
12 L K 1.0419 Aggregation-prone
13 V K -0.4137 Soluble
14 K K -1.9147 Soluble
15 P K -1.6522 Soluble
16 S K -1.8487 Soluble
17 E K -2.7284 Soluble
18 T K -2.1643 Soluble
19 L K 0.0000 Buried
20 S K -0.8554 Soluble
21 V K 0.0000 Buried
22 T K -0.7473 Soluble
23 C K 0.0000 Buried
24 S K -1.0827 Soluble
25 V K -1.3169 Soluble
26 S K -1.6408 Soluble
27 G K -1.9563 Soluble
28 D K -2.6542 Soluble
29 S K -1.6807 Soluble
30 M K 0.0000 Buried
35 N K -2.3540 Soluble
36 N K -2.1955 Soluble
37 Y K -1.2944 Soluble
38 Y K -1.1445 Soluble
39 W K 0.0000 Buried
40 T K 0.0000 Buried
41 W K 0.0000 Buried
42 I K 0.0000 Buried
43 R K -0.4307 Soluble
44 Q K -0.8958 Soluble
45 S K -0.9690 Soluble
46 P K -1.0867 Soluble
47 G K -1.5004 Soluble
48 K K -2.2860 Soluble
49 G K -1.5372 Soluble
50 L K 0.0000 Buried
51 E K -0.9129 Soluble
52 W K 0.0000 Buried
53 I K 0.0000 Buried
54 G K 0.0000 Buried
55 Y K -0.0128 Soluble
56 I K 0.0000 Buried
57 S K -1.9883 Soluble
58 D K -3.5322 Soluble
59 R K -3.5024 Soluble
63 E K -3.4685 Soluble
64 S K -1.8785 Soluble
65 A K -0.5917 Soluble
66 T K -0.0706 Soluble
67 Y K 0.0519 Aggregation-prone
68 N K 0.0000 Buried
69 P K -0.6643 Soluble
70 S K -0.7488 Soluble
71 L K 0.0000 Buried
72 N K -1.7332 Soluble
74 S K -1.0719 Soluble
75 R K -1.3103 Soluble
76 V K 0.0000 Buried
77 V K 0.1974 Aggregation-prone
78 I K 0.0000 Buried
79 S K -0.7977 Soluble
80 R K 0.0000 Buried
81 D K -2.7300 Soluble
82 T K -1.8869 Soluble
83 S K -1.7116 Soluble
84 K K -2.5001 Soluble
85 N K -2.1403 Soluble
86 Q K -1.7050 Soluble
87 L K 0.0000 Buried
88 S K -0.6202 Soluble
89 L K 0.0000 Buried
90 K K -1.2983 Soluble
91 L K 0.0000 Buried
92 N K -2.3662 Soluble
93 S K -1.8742 Soluble
94 V K 0.0000 Buried
95 T K -0.9768 Soluble
96 P K -0.6551 Soluble
97 A K -0.2243 Soluble
98 D K -0.3342 Soluble
99 T K -0.2318 Soluble
100 A K 0.0000 Buried
101 V K -0.1631 Soluble
102 Y K 0.0000 Buried
103 Y K 0.0000 Buried
104 C K 0.0000 Buried
105 A K 0.0000 Buried
106 T K 0.0000 Buried
107 A K 0.0000 Buried
108 R K -1.5164 Soluble
109 R K -1.9033 Soluble
110 G K -1.1122 Soluble
111 Q K -0.5492 Soluble
111A R K -0.0247 Soluble
111B I K 1.4277 Aggregation-prone
111C Y K 1.0745 Aggregation-prone
111D G K 1.2928 Aggregation-prone
111E V K 2.3404 Aggregation-prone
111F V K 2.3718 Aggregation-prone
112G S K 1.4735 Aggregation-prone
112F F K 2.2645 Aggregation-prone
112E G K 1.2020 Aggregation-prone
112D E K 1.1145 Aggregation-prone
112C F K 1.2813 Aggregation-prone
112B F K 0.4378 Aggregation-prone
112A Y K 0.2233 Aggregation-prone
112 Y K 0.0000 Buried
113 Y K 0.0000 Buried
114 S K 0.0000 Buried
115 M K 0.0000 Buried
116 D K -0.1089 Soluble
117 V K 0.2070 Aggregation-prone
118 W K 0.0000 Buried
119 G K 0.0000 Buried
120 K K -2.2508 Soluble
121 G K 0.0000 Buried
122 T K -0.6808 Soluble
123 T K -0.1663 Soluble
124 V K 0.0000 Buried
125 T K 0.0673 Aggregation-prone
126 V K 0.0000 Buried
127 S K -0.5942 Soluble
128 S K -0.7161 Soluble
129 A K -0.1878 Soluble
11 L L 0.7104 Aggregation-prone
12 S L 0.6795 Aggregation-prone
13 V L 0.2421 Aggregation-prone
14 A L 0.1377 Aggregation-prone
15 L L 0.0916 Aggregation-prone
16 G L -1.0938 Soluble
17 E L -2.0717 Soluble
18 T L -1.4133 Soluble
19 A L 0.0000 Buried
20 R L -1.8800 Soluble
21 I L 0.0000 Buried
22 S L -1.2185 Soluble
23 C L 0.0000 Buried
24 G L -1.3278 Soluble
25 R L -1.4287 Soluble
26 Q L -1.6318 Soluble
27 A L -0.5024 Soluble
28 L L 0.7813 Aggregation-prone
29 G L 0.3270 Aggregation-prone
36 S L 0.6456 Aggregation-prone
37 R L 0.0000 Buried
38 A L 0.0000 Buried
39 V L 0.0000 Buried
40 Q L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L -0.4425 Soluble
44 H L 0.0000 Buried
45 R L -1.6510 Soluble
46 P L -1.1725 Soluble
47 G L -1.5262 Soluble
48 Q L -1.9056 Soluble
49 A L -1.1378 Soluble
50 P L 0.0000 Buried
51 I L 0.5381 Aggregation-prone
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L -0.6081 Soluble
56 N L -1.0388 Soluble
57 N L 0.0000 Buried
65 Q L -1.4290 Soluble
66 D L -1.3333 Soluble
67 R L -1.5790 Soluble
68 P L -0.7806 Soluble
69 S L -0.8117 Soluble
70 G L -0.8028 Soluble
71 I L -0.6732 Soluble
72 P L -1.2836 Soluble
74 E L -2.2304 Soluble
75 R L -1.4499 Soluble
76 F L 0.0000 Buried
77 S L -1.2124 Soluble
78 G L 0.0000 Buried
79 T L -0.5653 Soluble
80 P L -0.2446 Soluble
81 D L 0.2395 Aggregation-prone
81A I L 1.6809 Aggregation-prone
82 N L 0.4309 Aggregation-prone
83 F L 1.5040 Aggregation-prone
84 G L 0.0366 Aggregation-prone
85 T L -0.7005 Soluble
86 R L -2.1458 Soluble
87 A L 0.0000 Buried
88 T L 0.0000 Buried
89 L L 0.0000 Buried
90 T L -0.9117 Soluble
91 I L 0.0000 Buried
92 S L -1.5319 Soluble
93 G L -1.3193 Soluble
94 V L 0.0000 Buried
95 E L -1.9905 Soluble
96 A L -0.8326 Soluble
97 G L -1.1976 Soluble
98 D L 0.0000 Buried
99 E L -1.3213 Soluble
100 A L 0.0000 Buried
101 D L 0.0000 Buried
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 H L 0.0000 Buried
106 M L 0.0000 Buried
107 W L 0.0000 Buried
108 D L 0.0000 Buried
109 S L -0.4217 Soluble
110 R L -1.5609 Soluble
112 S L -0.8759 Soluble
113 G L -0.6026 Soluble
114 F L 0.3883 Aggregation-prone
115 S L 0.1869 Aggregation-prone
116 W L 0.0685 Aggregation-prone
117 S L -0.2862 Soluble
118 F L 0.0000 Buried
119 G L -0.6926 Soluble
120 G L -1.1874 Soluble
121 A L -1.0581 Soluble
122 T L -0.8500 Soluble
123 R L -1.7411 Soluble
124 L L 0.0000 Buried
125 T L 0.0764 Aggregation-prone
126 V L 0.1550 Aggregation-prone
127 L L 1.1534 Aggregation-prone
128 G L 0.4135 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
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pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.4295 4.4366 CSV PDB
4.5 -0.4663 4.4099 CSV PDB
5.0 -0.5125 4.3722 CSV PDB
5.5 -0.5596 4.3298 CSV PDB
6.0 -0.599 4.2892 CSV PDB
6.5 -0.6249 4.2573 CSV PDB
7.0 -0.6357 4.2382 CSV PDB
7.5 -0.6348 4.2298 CSV PDB
8.0 -0.6272 4.2267 CSV PDB
8.5 -0.6148 4.2257 CSV PDB
9.0 -0.5976 4.2254 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH