Simaravibart / 7sbu

A4DAB240_7sbu_H_L | Source PDB: 7sbu | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.7062
Max Score
1.2967
Min Score
-3.8482
Total Score
-305.78
Score CDR
-0.3669
Score non-CDR
-0.7485

Calculation Parameters

Chain Sequence(s) VQLVQSGAEVKKPGSSVKVSCKASGGTFSSYTISWVRQAPGQGLEWMGRIIPILDRVMYAQKFQGRVTITADKSTSTAYMELSSLRSEDTAVYYCARRAIDSDTYVEQSHFDYWGQGTLVTVSSASTRGPSVFPLAPSSKSTGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCEIVMTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPSLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.8482
Maximum Score 1.2967
Average Score -0.7062
Total Score -305.7782

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
2 V H 1.2967 Aggregation-prone
3 Q H 0.0468 Aggregation-prone
4 L H 0.0000 Buried
5 V H 0.1917 Aggregation-prone
6 Q H 0.0000 Buried
7 S H -0.6242 Soluble
8 G H -0.6483 Soluble
9 A H -0.4028 Soluble
11 E H -0.8369 Soluble
12 V H -0.3185 Soluble
13 K H -1.3660 Soluble
14 K H -2.3184 Soluble
15 P H -1.9070 Soluble
16 G H -1.5745 Soluble
17 S H -1.2817 Soluble
18 S H -1.3766 Soluble
19 V H 0.0000 Buried
20 K H -2.0296 Soluble
21 V H 0.0000 Buried
22 S H -0.5434 Soluble
23 C H 0.0000 Buried
24 K H -0.9841 Soluble
25 A H 0.0000 Buried
26 S H -0.1674 Soluble
27 G H -0.8890 Soluble
28 G H -0.7153 Soluble
29 T H 0.0000 Buried
30 F H 0.0000 Buried
35 S H -0.5817 Soluble
36 S H -0.5981 Soluble
37 Y H -0.2195 Soluble
38 T H 0.0000 Buried
39 I H 0.0000 Buried
40 S H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 R H 0.0000 Buried
44 Q H -0.5457 Soluble
45 A H -1.0087 Soluble
46 P H -0.9970 Soluble
47 G H -1.2498 Soluble
48 Q H -1.7244 Soluble
49 G H -1.0699 Soluble
50 L H 0.0000 Buried
51 E H -0.7272 Soluble
52 W H 0.0000 Buried
53 M H 0.0000 Buried
54 G H 0.0000 Buried
55 R H -0.0438 Soluble
56 I H 0.0000 Buried
57 I H 0.0000 Buried
58 P H 0.0000 Buried
59 I H -0.2297 Soluble
62 L H -0.6882 Soluble
63 D H -2.1963 Soluble
64 R H -2.0928 Soluble
65 V H -0.3349 Soluble
66 M H 0.0910 Aggregation-prone
67 Y H -0.4278 Soluble
68 A H 0.0000 Buried
69 Q H -2.7003 Soluble
70 K H -2.9178 Soluble
71 F H 0.0000 Buried
72 Q H -2.2637 Soluble
74 G H -1.5655 Soluble
75 R H -1.2399 Soluble
76 V H 0.0000 Buried
77 T H -0.5593 Soluble
78 I H 0.0000 Buried
79 T H -0.7075 Soluble
80 A H -1.0044 Soluble
81 D H -1.7508 Soluble
82 K H -2.2367 Soluble
83 S H -1.3152 Soluble
84 T H -1.2062 Soluble
85 S H -1.5338 Soluble
86 T H 0.0000 Buried
87 A H 0.0000 Buried
88 Y H -0.4400 Soluble
89 M H 0.0000 Buried
90 E H -1.3933 Soluble
91 L H 0.0000 Buried
92 S H -1.0135 Soluble
93 S H -1.1328 Soluble
94 L H 0.0000 Buried
95 R H -2.4836 Soluble
96 S H -2.0088 Soluble
97 E H -2.3052 Soluble
98 D H 0.0000 Buried
99 T H -0.7992 Soluble
100 A H 0.0000 Buried
101 V H 0.3017 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 R H 0.0000 Buried
107 R H 0.0000 Buried
108 A H -0.3090 Soluble
109 I H 0.0000 Buried
110 D H -1.2689 Soluble
111 S H -1.0916 Soluble
111A D H -1.8126 Soluble
111B T H -0.4602 Soluble
112C Y H 0.6107 Aggregation-prone
112B V H 1.1347 Aggregation-prone
112A E H 0.1144 Aggregation-prone
112 Q H -0.4786 Soluble
113 S H -0.1078 Soluble
114 H H -0.3897 Soluble
115 F H 0.0000 Buried
116 D H -0.7017 Soluble
117 Y H 0.2036 Aggregation-prone
118 W H -0.1165 Soluble
119 G H 0.0000 Buried
120 Q H -1.1739 Soluble
121 G H -0.4849 Soluble
122 T H 0.0000 Buried
123 L H -0.0089 Soluble
124 V H 0.0000 Buried
125 T H 0.0000 Buried
126 V H 0.0000 Buried
127 S H -1.0756 Soluble
128 S H -1.1089 Soluble
129 A H -0.6830 Soluble
130 S H -0.7485 Soluble
131 T H -0.8490 Soluble
132 R H -1.7328 Soluble
133 G H -1.5822 Soluble
134 P H -0.6835 Soluble
135 S H -0.4298 Soluble
136 V H 0.0000 Buried
137 F H -0.7005 Soluble
138 P H -1.0715 Soluble
139 L H 0.0000 Buried
140 A H -1.2965 Soluble
141 P H 0.0000 Buried
142 S H -0.9969 Soluble
143 S H -0.7848 Soluble
144 K H -0.9233 Soluble
145 S H 0.0000 Buried
146 T H -0.6098 Soluble
147 G H -0.7940 Soluble
148 G H -0.8873 Soluble
149 T H -0.5857 Soluble
150 A H 0.0000 Buried
151 A H 0.0000 Buried
152 L H 0.0000 Buried
153 G H 0.0000 Buried
154 C H 0.0000 Buried
155 L H 0.0000 Buried
156 V H 0.0000 Buried
157 K H 0.0000 Buried
158 D H -0.5672 Soluble
159 Y H 0.0000 Buried
160 F H 0.0000 Buried
161 P H 0.0000 Buried
162 E H -0.4586 Soluble
163 P H -0.7262 Soluble
164 V H -0.4470 Soluble
165 T H -0.5024 Soluble
166 V H -0.2058 Soluble
167 S H -0.3940 Soluble
168 W H 0.0000 Buried
169 N H -0.7627 Soluble
170 S H -0.6842 Soluble
171 G H -0.5343 Soluble
172 A H -0.2483 Soluble
173 L H 0.0458 Aggregation-prone
174 T H -0.1374 Soluble
175 S H -0.1293 Soluble
176 G H -0.1284 Soluble
177 V H 0.2318 Aggregation-prone
178 H H -0.3148 Soluble
179 T H -0.1874 Soluble
180 F H 0.0000 Buried
181 P H -0.5050 Soluble
182 A H 0.1377 Aggregation-prone
183 V H 0.4610 Aggregation-prone
184 L H 1.0927 Aggregation-prone
185 Q H 0.0774 Aggregation-prone
186 S H -0.2836 Soluble
187 S H -0.2101 Soluble
188 G H 0.0161 Aggregation-prone
189 L H -0.0289 Soluble
190 Y H 0.3016 Aggregation-prone
191 S H 0.0000 Buried
192 L H 0.0000 Buried
193 S H 0.0000 Buried
194 S H 0.0000 Buried
195 V H 0.0000 Buried
196 V H 0.0000 Buried
197 T H -0.1058 Soluble
198 V H 0.0000 Buried
199 P H -0.6664 Soluble
200 S H -0.7127 Soluble
201 S H -0.6389 Soluble
202 S H -0.7195 Soluble
203 L H -0.8038 Soluble
204 G H -1.0009 Soluble
205 T H -0.7899 Soluble
206 Q H -1.4020 Soluble
207 T H -1.1890 Soluble
208 Y H 0.0000 Buried
209 I H -1.2200 Soluble
210 C H 0.0000 Buried
211 N H -1.5254 Soluble
212 V H 0.0000 Buried
213 N H -1.7885 Soluble
214 H H 0.0000 Buried
215 K H -2.7175 Soluble
216 P H -1.7972 Soluble
217 S H -1.9526 Soluble
218 N H -2.5960 Soluble
219 T H -2.0939 Soluble
220 K H -2.6416 Soluble
221 V H -1.5881 Soluble
222 D H -2.5157 Soluble
223 K H -1.9658 Soluble
224 R H -2.6552 Soluble
225 V H 0.0000 Buried
226 E H -2.8674 Soluble
227 P H -2.0754 Soluble
228 K H -2.0669 Soluble
229 S H -0.8845 Soluble
230 C H 0.2455 Aggregation-prone
1 E L -1.6995 Soluble
2 I L -0.1833 Soluble
3 V L 0.9186 Aggregation-prone
4 M L 0.0000 Buried
5 T L -0.5725 Soluble
6 Q L -0.6830 Soluble
7 S L -0.6980 Soluble
8 P L -0.3296 Soluble
9 A L -0.2587 Soluble
10 T L -0.1747 Soluble
11 L L -0.1460 Soluble
12 S L -0.5794 Soluble
13 L L -1.1987 Soluble
14 S L -1.7129 Soluble
15 P L -2.0266 Soluble
16 G L -2.2096 Soluble
17 E L -3.2037 Soluble
18 R L -3.0838 Soluble
19 A L 0.0000 Buried
20 T L -0.7262 Soluble
21 L L 0.0000 Buried
22 S L -0.8672 Soluble
23 C L 0.0000 Buried
24 R L -2.3075 Soluble
25 A L -1.1581 Soluble
26 S L -0.9101 Soluble
27 Q L -1.6099 Soluble
28 S L -1.1439 Soluble
29 V L 0.0000 Buried
36 S L -0.4385 Soluble
37 S L -0.0886 Soluble
38 Y L 0.6287 Aggregation-prone
39 L L 0.0000 Buried
40 A L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L -0.3256 Soluble
44 Q L 0.0000 Buried
45 K L -1.4521 Soluble
46 P L -1.4442 Soluble
47 G L -1.3529 Soluble
48 Q L -1.9348 Soluble
49 A L -1.0560 Soluble
50 P L 0.0000 Buried
51 S L -0.3795 Soluble
52 L L -0.0592 Soluble
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L -0.8657 Soluble
56 D L -1.2615 Soluble
57 A L 0.0000 Buried
65 S L -1.3153 Soluble
66 N L -2.0174 Soluble
67 R L -1.6218 Soluble
68 A L -0.9294 Soluble
69 T L -0.5296 Soluble
70 G L -0.5002 Soluble
71 I L -0.2415 Soluble
72 P L -0.3182 Soluble
74 A L -0.3237 Soluble
75 R L -0.8016 Soluble
76 F L 0.0000 Buried
77 S L -0.6936 Soluble
78 G L 0.0000 Buried
79 S L -0.9113 Soluble
80 G L -1.1586 Soluble
83 S L -0.9853 Soluble
84 G L -1.0411 Soluble
85 T L -1.7611 Soluble
86 D L -2.1743 Soluble
87 F L 0.0000 Buried
88 T L -0.7637 Soluble
89 L L 0.0000 Buried
90 T L -0.5966 Soluble
91 I L 0.0000 Buried
92 S L -1.5474 Soluble
93 S L -2.0888 Soluble
94 L L 0.0000 Buried
95 E L -2.4498 Soluble
96 P L -1.7248 Soluble
97 E L -2.3536 Soluble
98 D L 0.0000 Buried
99 F L -0.7108 Soluble
100 A L 0.0000 Buried
101 V L -0.0543 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 Q L 0.0000 Buried
107 P L 0.3118 Aggregation-prone
116 L L 0.2781 Aggregation-prone
117 T L 0.1301 Aggregation-prone
118 F L 0.0000 Buried
119 G L 0.0000 Buried
120 G L -0.6345 Soluble
121 G L -0.5990 Soluble
122 T L 0.0000 Buried
123 K L -0.4805 Soluble
124 V L 0.0000 Buried
125 E L 0.0000 Buried
126 I L -0.8700 Soluble
127 K L -1.6734 Soluble
128 R L -1.1517 Soluble
129 T L 0.0757 Aggregation-prone
130 V L 0.9233 Aggregation-prone
131 A L 0.2317 Aggregation-prone
132 A L 0.0084 Aggregation-prone
133 P L 0.0000 Buried
134 S L -0.1419 Soluble
135 V L -0.1484 Soluble
136 F L 0.0000 Buried
137 I L 0.0000 Buried
138 F L 0.0000 Buried
139 P L -0.8021 Soluble
140 P L 0.0000 Buried
141 S L 0.0000 Buried
142 D L -2.9686 Soluble
143 E L -3.0273 Soluble
144 Q L 0.0000 Buried
145 L L -2.1551 Soluble
146 K L -2.8970 Soluble
147 S L -1.8211 Soluble
148 G L -1.4706 Soluble
149 T L -1.2347 Soluble
150 A L 0.0000 Buried
151 S L 0.0000 Buried
152 V L 0.0000 Buried
153 V L 0.0000 Buried
154 C L 0.0000 Buried
155 L L 0.0000 Buried
156 L L 0.0000 Buried
157 N L 0.0000 Buried
158 N L -0.9735 Soluble
159 F L 0.0000 Buried
160 Y L 0.0000 Buried
161 P L -1.5812 Soluble
162 R L -2.8230 Soluble
163 E L -3.1017 Soluble
164 A L -2.2268 Soluble
165 K L -2.4289 Soluble
166 V L -1.0838 Soluble
167 Q L -0.6412 Soluble
168 W L 0.0000 Buried
169 K L -0.5031 Soluble
170 V L 0.0000 Buried
171 D L -1.8426 Soluble
172 N L -1.2616 Soluble
173 A L -0.2090 Soluble
174 L L 0.7152 Aggregation-prone
175 Q L -0.4008 Soluble
176 S L -0.7575 Soluble
177 G L -1.3686 Soluble
178 N L -1.7776 Soluble
179 S L -1.5663 Soluble
180 Q L -1.5201 Soluble
181 E L -2.0949 Soluble
182 S L -1.0594 Soluble
183 V L -1.1368 Soluble
184 T L -1.2401 Soluble
185 E L -2.3034 Soluble
186 Q L -1.9454 Soluble
187 D L -2.0851 Soluble
188 S L -2.0009 Soluble
189 K L -2.3768 Soluble
190 D L -1.9736 Soluble
191 S L -1.9170 Soluble
192 T L 0.0000 Buried
193 Y L 0.0000 Buried
194 S L 0.0000 Buried
195 L L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 T L -0.7422 Soluble
199 L L 0.0000 Buried
200 T L -0.6888 Soluble
201 L L -0.8522 Soluble
202 S L -1.0586 Soluble
203 K L -2.1286 Soluble
204 A L -1.8592 Soluble
205 D L -2.3801 Soluble
206 Y L 0.0000 Buried
207 E L -3.8482 Soluble
208 K L -3.6050 Soluble
209 H L -3.3369 Soluble
210 K L -3.5518 Soluble
211 V L -1.9859 Soluble
212 Y L 0.0000 Buried
213 A L 0.0000 Buried
214 C L 0.0000 Buried
215 E L -0.6659 Soluble
216 V L 0.0000 Buried
217 T L -1.2023 Soluble
218 H L 0.0000 Buried
219 Q L -1.4183 Soluble
220 G L -0.3066 Soluble
221 L L -0.1995 Soluble
222 S L -0.4893 Soluble
223 S L -0.4283 Soluble
224 P L -0.5822 Soluble
225 V L 0.0531 Aggregation-prone
226 T L -0.3850 Soluble
227 K L -0.7152 Soluble
228 S L -0.9434 Soluble
229 F L 0.0000 Buried
230 N L -2.5697 Soluble
231 R L -2.9979 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
Load structure to view sequence…
Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.7376 1.6285 CSV PDB
4.5 -0.7844 1.5122 CSV PDB
5.0 -0.8402 1.4662 CSV PDB
5.5 -0.8947 1.4416 CSV PDB
6.0 -0.9362 1.4468 CSV PDB
6.5 -0.9553 1.4799 CSV PDB
7.0 -0.9504 1.5381 CSV PDB
7.5 -0.9288 1.6139 CSV PDB
8.0 -0.8974 1.6981 CSV PDB
8.5 -0.8588 1.7848 CSV PDB
9.0 -0.8141 1.8695 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH