Zinlirvimab / 4fq2

A4DAB308_4fq2_H_L | Source PDB: 4fq2 | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6032
Max Score
2.5171
Min Score
-3.4992
Total Score
-264.2
Score CDR
-0.2646
Score non-CDR
-0.659

Calculation Parameters

Chain Sequence(s) QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTVSSASTKGPSVFPLAPSSKTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCLSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTEC input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.4992
Maximum Score 2.5171
Average Score -0.6032
Total Score -264.2003

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q H -1.6876 Soluble
2 V H -1.3190 Soluble
3 Q H -1.9265 Soluble
4 L H 0.0000 Buried
5 Q H -1.5074 Soluble
6 E H 0.0000 Buried
7 S H -0.6873 Soluble
8 G H -0.3290 Soluble
9 P H -0.4184 Soluble
11 G H 0.0000 Buried
12 L H -0.3335 Soluble
13 V H 0.0000 Buried
14 K H -2.1288 Soluble
15 P H -1.6135 Soluble
16 S H -1.6781 Soluble
17 E H -2.4125 Soluble
18 T H -1.8468 Soluble
19 L H 0.0000 Buried
20 S H -0.9650 Soluble
21 V H 0.0000 Buried
22 T H -0.5694 Soluble
23 C H 0.0000 Buried
24 S H -1.1317 Soluble
25 V H 0.0000 Buried
26 S H -1.4189 Soluble
27 G H -1.5221 Soluble
28 D H -1.8312 Soluble
29 S H -1.4290 Soluble
30 M H 0.0000 Buried
35 N H -2.4126 Soluble
36 N H -2.0018 Soluble
37 Y H -1.0599 Soluble
38 Y H -0.7043 Soluble
39 W H 0.0000 Buried
40 T H 0.0000 Buried
41 W H 0.0000 Buried
42 I H 0.0000 Buried
43 R H 0.0000 Buried
44 Q H -0.9047 Soluble
45 S H 0.0000 Buried
46 P H -1.0512 Soluble
47 G H -1.5089 Soluble
48 K H -2.3097 Soluble
49 G H -1.5581 Soluble
50 L H 0.0000 Buried
51 E H -0.9114 Soluble
52 W H 0.0000 Buried
53 I H 0.0000 Buried
54 G H 0.0000 Buried
55 Y H 0.1845 Aggregation-prone
56 I H 0.0000 Buried
57 S H -1.7901 Soluble
58 D H -3.0466 Soluble
59 R H -3.4992 Soluble
63 E H -3.2157 Soluble
64 S H -1.9793 Soluble
65 A H -0.6367 Soluble
66 T H 0.2408 Aggregation-prone
67 Y H 0.2219 Aggregation-prone
68 N H 0.0000 Buried
69 P H -0.7593 Soluble
70 S H -0.8156 Soluble
71 L H 0.0000 Buried
72 N H -1.5743 Soluble
74 S H -0.9060 Soluble
75 R H -1.0741 Soluble
76 V H 0.0000 Buried
77 V H 0.4631 Aggregation-prone
78 I H 0.0000 Buried
79 S H -0.8039 Soluble
80 R H -1.7462 Soluble
81 D H -1.7249 Soluble
82 T H -1.6203 Soluble
83 S H -1.4686 Soluble
84 K H -2.3252 Soluble
85 N H -1.9412 Soluble
86 Q H -1.5240 Soluble
87 L H 0.0000 Buried
88 S H -0.5657 Soluble
89 L H 0.0000 Buried
90 K H -1.2852 Soluble
91 L H 0.0000 Buried
92 N H -1.6059 Soluble
93 S H -1.4187 Soluble
94 V H 0.0000 Buried
95 T H -0.8758 Soluble
96 P H -0.5382 Soluble
97 A H -0.1349 Soluble
98 D H 0.0000 Buried
99 T H -0.0927 Soluble
100 A H 0.0000 Buried
101 V H -0.0667 Soluble
102 Y H 0.0000 Buried
103 Y H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 T H 0.0000 Buried
107 A H 0.0000 Buried
108 R H -1.2479 Soluble
109 R H -1.3638 Soluble
110 G H -0.7920 Soluble
111 Q H -0.1806 Soluble
111A R H 0.5508 Aggregation-prone
111B I H 2.2209 Aggregation-prone
111C Y H 1.4211 Aggregation-prone
111D G H 1.5295 Aggregation-prone
111E V H 2.5115 Aggregation-prone
111F V H 2.5171 Aggregation-prone
112G S H 1.4726 Aggregation-prone
112F F H 2.2073 Aggregation-prone
112E G H 1.2418 Aggregation-prone
112D E H 1.1448 Aggregation-prone
112C F H 1.6174 Aggregation-prone
112B F H 0.6648 Aggregation-prone
112A Y H 0.4852 Aggregation-prone
112 Y H 0.0000 Buried
113 Y H 0.0000 Buried
114 S H 0.0000 Buried
115 M H 0.0000 Buried
116 D H -0.7352 Soluble
117 V H -0.1065 Soluble
118 W H -0.5543 Soluble
119 G H 0.0000 Buried
120 K H -2.2848 Soluble
121 G H -1.2208 Soluble
122 T H -0.5013 Soluble
123 T H -0.0796 Soluble
124 V H 0.0000 Buried
125 T H -0.2733 Soluble
126 V H 0.0000 Buried
127 S H -0.7258 Soluble
128 S H -0.8081 Soluble
129 A H -0.5265 Soluble
130 S H -0.6649 Soluble
131 T H -0.7946 Soluble
132 K H -1.4185 Soluble
133 G H -1.5139 Soluble
134 P H 0.0000 Buried
135 S H -0.4647 Soluble
136 V H 0.0000 Buried
137 F H 0.0000 Buried
138 P H -1.0392 Soluble
139 L H 0.0000 Buried
140 A H -0.9398 Soluble
141 P H 0.0000 Buried
142 S H -0.7631 Soluble
143 S H -1.1152 Soluble
144 K H -1.7775 Soluble
145 T H -0.4633 Soluble
146 A H 0.0000 Buried
147 A H -0.0548 Soluble
148 L H 0.0000 Buried
149 G H 0.0000 Buried
150 C H 0.0000 Buried
151 L H 0.0000 Buried
152 V H 0.0000 Buried
153 K H -0.4431 Soluble
154 D H -0.6703 Soluble
155 Y H 0.0000 Buried
156 F H -0.2857 Soluble
157 P H 0.0000 Buried
158 E H -0.3302 Soluble
159 P H -0.6377 Soluble
160 V H 0.0000 Buried
161 T H -0.7033 Soluble
162 V H -0.4996 Soluble
163 S H -0.4257 Soluble
164 W H 0.0000 Buried
165 N H -0.6470 Soluble
166 S H -0.6057 Soluble
167 G H -0.5641 Soluble
168 A H -0.2230 Soluble
169 L H 0.0274 Aggregation-prone
170 T H -0.1938 Soluble
171 S H -0.2753 Soluble
172 G H -0.3513 Soluble
173 V H 0.1449 Aggregation-prone
174 H H -0.1336 Soluble
175 T H 0.0053 Aggregation-prone
176 F H 0.0000 Buried
177 P H -0.0834 Soluble
178 A H 0.2692 Aggregation-prone
179 V H 0.0000 Buried
180 L H 1.2399 Aggregation-prone
181 Q H 0.2210 Aggregation-prone
182 S H -0.1400 Soluble
183 S H -0.2016 Soluble
184 G H 0.0933 Aggregation-prone
185 L H 0.0995 Aggregation-prone
186 Y H 0.3363 Aggregation-prone
187 S H 0.0000 Buried
188 L H 0.0000 Buried
189 S H 0.0000 Buried
190 S H 0.0000 Buried
191 V H 0.1541 Aggregation-prone
192 V H 0.0000 Buried
193 T H -0.2064 Soluble
194 V H 0.0000 Buried
195 P H -0.4713 Soluble
196 S H -0.6734 Soluble
197 S H -0.4853 Soluble
198 S H -0.5424 Soluble
199 L H -0.8093 Soluble
200 G H -1.1483 Soluble
201 T H -0.8872 Soluble
202 Q H -1.2038 Soluble
203 T H -1.0905 Soluble
204 Y H 0.0000 Buried
205 I H -1.1006 Soluble
206 C H 0.0000 Buried
207 N H -1.4372 Soluble
208 V H 0.0000 Buried
209 N H -2.1403 Soluble
210 H H 0.0000 Buried
211 K H -1.9635 Soluble
212 P H -1.1944 Soluble
213 S H -1.6047 Soluble
214 N H -2.3111 Soluble
215 T H -2.1775 Soluble
216 K H -2.6717 Soluble
217 V H -1.6547 Soluble
218 D H -2.1238 Soluble
219 K H -1.9434 Soluble
220 R H -2.3194 Soluble
221 V H 0.0000 Buried
222 E H -2.5506 Soluble
223 P H -1.2325 Soluble
224 K H -0.7150 Soluble
225 S H -0.2862 Soluble
226 C H 0.3822 Aggregation-prone
11 L L 0.7514 Aggregation-prone
12 S L 0.6388 Aggregation-prone
13 V L -0.1275 Soluble
14 A L -0.3769 Soluble
15 L L -0.6603 Soluble
16 G L -1.5360 Soluble
17 E L -2.2882 Soluble
18 T L -1.6837 Soluble
19 A L 0.0000 Buried
20 R L -1.9216 Soluble
21 I L 0.0000 Buried
22 S L -1.0702 Soluble
23 C L 0.0000 Buried
24 G L -1.1972 Soluble
25 R L -1.2962 Soluble
26 Q L -1.4129 Soluble
27 A L -0.5710 Soluble
28 L L 0.3745 Aggregation-prone
29 G L -0.5550 Soluble
36 S L 0.0858 Aggregation-prone
37 R L 0.0000 Buried
38 A L 0.0000 Buried
39 V L 0.0000 Buried
40 Q L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L -0.2970 Soluble
44 H L 0.0000 Buried
45 R L -1.0927 Soluble
46 P L -1.1045 Soluble
47 G L -1.4802 Soluble
48 Q L -1.6914 Soluble
49 A L -1.0110 Soluble
50 P L 0.0000 Buried
51 I L 0.4455 Aggregation-prone
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L -0.7425 Soluble
56 N L -1.0605 Soluble
57 N L 0.0000 Buried
65 Q L -1.4692 Soluble
66 D L -1.5006 Soluble
67 R L -1.4746 Soluble
68 P L -0.9408 Soluble
69 S L -0.8233 Soluble
70 G L -0.8068 Soluble
71 I L -0.6918 Soluble
72 P L -1.3511 Soluble
74 E L -2.3018 Soluble
75 R L -1.5567 Soluble
76 F L 0.0000 Buried
77 S L -1.2269 Soluble
78 G L -0.8839 Soluble
79 T L -0.3424 Soluble
80 P L -0.2721 Soluble
81 D L -0.1330 Soluble
81A I L 1.2053 Aggregation-prone
82 N L 0.0884 Aggregation-prone
83 F L 1.4112 Aggregation-prone
84 G L 0.2215 Aggregation-prone
85 T L 0.0543 Aggregation-prone
86 R L -0.7288 Soluble
87 A L 0.0000 Buried
88 T L -0.8591 Soluble
89 L L 0.0000 Buried
90 T L -0.9741 Soluble
91 I L 0.0000 Buried
92 S L -1.6718 Soluble
93 G L -1.5096 Soluble
94 V L 0.0000 Buried
95 E L -2.0421 Soluble
96 A L -1.1016 Soluble
97 G L -1.1155 Soluble
98 D L 0.0000 Buried
99 E L 0.0000 Buried
100 A L 0.0000 Buried
101 D L -1.0553 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 H L 0.0000 Buried
106 M L 0.0000 Buried
107 W L 0.0000 Buried
108 D L 0.0000 Buried
109 S L -0.4427 Soluble
110 R L -1.6471 Soluble
112 S L -0.9273 Soluble
113 G L -0.5593 Soluble
114 F L 0.4763 Aggregation-prone
115 S L 0.0000 Buried
116 W L 0.1287 Aggregation-prone
117 S L -0.2689 Soluble
118 F L 0.0000 Buried
119 G L -0.6782 Soluble
120 G L -1.2314 Soluble
121 A L -1.1585 Soluble
122 T L -0.8637 Soluble
123 R L -1.6437 Soluble
124 L L 0.0000 Buried
125 T L 0.1468 Aggregation-prone
126 V L 0.0000 Buried
127 L L 0.5383 Aggregation-prone
128 G L -0.2242 Soluble
129 Q L -0.7467 Soluble
130 P L -1.1684 Soluble
131 K L -2.2126 Soluble
132 A L -1.2810 Soluble
133 A L -0.8149 Soluble
134 P L 0.0000 Buried
135 S L -0.3790 Soluble
136 V L 0.0000 Buried
137 T L -0.2173 Soluble
138 L L -0.1964 Soluble
139 F L 0.0000 Buried
140 P L 0.0592 Aggregation-prone
141 P L 0.0000 Buried
142 S L -1.0365 Soluble
143 S L -1.6262 Soluble
144 E L -2.4122 Soluble
145 E L 0.0000 Buried
146 L L -2.1271 Soluble
147 Q L -2.4127 Soluble
148 A L -1.9710 Soluble
149 N L -2.7591 Soluble
150 K L -2.7193 Soluble
151 A L 0.0000 Buried
152 T L 0.0000 Buried
153 L L 0.0000 Buried
154 V L 0.0000 Buried
155 C L 0.0000 Buried
156 L L 0.0000 Buried
157 I L 0.0000 Buried
158 S L -0.5270 Soluble
159 D L -1.0294 Soluble
160 F L 0.0000 Buried
161 Y L -1.0817 Soluble
162 P L -0.8605 Soluble
163 G L -0.5601 Soluble
164 A L -0.1324 Soluble
165 V L -0.0037 Soluble
166 T L -0.0716 Soluble
167 V L 0.2384 Aggregation-prone
168 A L -0.3056 Soluble
169 W L 0.0000 Buried
170 K L -0.8298 Soluble
171 A L 0.0000 Buried
172 D L -1.2131 Soluble
173 S L -0.8196 Soluble
174 S L -0.5588 Soluble
175 P L -0.8125 Soluble
176 V L -0.8174 Soluble
177 K L -1.6508 Soluble
178 A L -0.8298 Soluble
179 G L -0.6578 Soluble
180 V L -0.5143 Soluble
181 E L -0.4747 Soluble
182 T L -0.0047 Soluble
183 T L 0.0724 Aggregation-prone
184 T L 0.0580 Aggregation-prone
185 P L -0.2689 Soluble
186 S L -0.5723 Soluble
187 K L -1.2582 Soluble
188 Q L -1.2845 Soluble
189 S L -1.2157 Soluble
190 N L -1.6915 Soluble
191 N L -1.5132 Soluble
192 K L -1.4910 Soluble
193 Y L -0.7550 Soluble
194 A L 0.0000 Buried
195 A L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 Y L 0.0000 Buried
199 L L 0.0000 Buried
200 S L -0.5930 Soluble
201 L L -1.1540 Soluble
202 T L -1.8917 Soluble
203 P L -2.5147 Soluble
204 E L -3.1928 Soluble
205 Q L -2.3755 Soluble
206 W L 0.0000 Buried
207 K L -3.1020 Soluble
208 S L -2.3902 Soluble
209 H L -2.3484 Soluble
210 R L -2.6575 Soluble
211 S L -1.6831 Soluble
212 Y L 0.0000 Buried
213 S L 0.0000 Buried
214 C L 0.0000 Buried
215 Q L -0.6984 Soluble
216 V L 0.0000 Buried
217 T L -0.5635 Soluble
218 H L 0.0000 Buried
219 E L -2.3119 Soluble
220 G L -1.4437 Soluble
221 S L -0.9165 Soluble
222 T L -0.5482 Soluble
223 V L -0.2959 Soluble
224 E L -1.0960 Soluble
225 K L -1.0767 Soluble
226 T L -0.6311 Soluble
227 V L -0.5409 Soluble
228 A L -1.3340 Soluble
229 P L -1.4718 Soluble
230 T L -1.4671 Soluble
231 E L -1.6185 Soluble
232 C L -0.4236 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
Load structure to view sequence…
Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.5632 4.4474 CSV PDB
4.5 -0.6001 4.4236 CSV PDB
5.0 -0.6441 4.3986 CSV PDB
5.5 -0.6863 4.3731 CSV PDB
6.0 -0.7165 4.3475 CSV PDB
6.5 -0.7262 4.322 CSV PDB
7.0 -0.7145 4.2968 CSV PDB
7.5 -0.6883 4.2726 CSV PDB
8.0 -0.6545 4.2509 CSV PDB
8.5 -0.6158 4.2345 CSV PDB
9.0 -0.5734 4.2252 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH