Andecaliximab

A4DAB017 | Skeletal disorders | Phase-III
MMP9/GELB
G4 / IgG4
Gilead Sciences
Phase-III
Whole mAb
GS-5745 GS5745
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IMGT PubChem (329968449) PubChem (336908661) PubChem (381127584) PubChem (472407955) PubChem (476262685) PubChem (476269288) PubChem (496735072) PubChem (500718489) Thera-SAbDab YAbS
Avg A4D Score
-0.6696
Score Range
-0.71 to -0.63
Structures
3
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB017_5th9_J_N 5th9 100% -0.6293 6.5 4.0 -0.0694 -0.7676
A4DAB017_5th9_H_L 5th9 100% -0.7056 6.5 4.0 -0.102 -0.7724
A4DAB017_5th9_I_M 5th9 100% -0.6738 6.5 4.0 -0.0902 -0.7383