Bevacizumab

A4DAB044 | Cancer | Approved
VEGFA
G1 / IgG1
All Ireland Cooperative Oncology Research Group ARCAGY/GINECO Group Austrian Breast & Colorectal Cancer Study Group Bayer Beth Israel Deaconess Medical Center Breast Cancer Research Foundation Brigham and Women's Hospital Bristol-Myers Squibb Cancer and Leukemia Group B Cancer Research UK Chugai Pharmaceutical Cincinnati Children's Hospital Medical Center Dana-Farber Cancer Institute Duke University European Organisation for Research and Treatment of Cancer European Thoracic Oncology Platform Genentech Hackensack University Medical Center Hoosier Cancer Research Network Indiana University School of Medicine Japan Breast Cancer Research Group M. D. Anderson Cancer Center Massachusetts General Hospital Medical University of South Carolina Melanoma Research Foundation Breakthrough Consortium Memorial Sloan-Kettering Cancer Center National Cancer Institute (USA) National Comprehensive Cancer Network NCIC Clinical Trials Group North Central Cancer Treatment Group NSABP Foundation Ohio State University Medical Center Peter MacCallum Cancer Centre Roche Royal Marsden NHS Foundation Trust Sanofi Sarcoma Alliance for Research through Collaboration SCRI Development Innovations South Eastern European Research Oncology Group Spanish Cooperative Group for Digestive Tumour Therapy Spanish Lung Cancer Group Stanford University School of Medicine SWOG The Catalan Institute of Oncology UNICANCER University College London University of Alabama at Birmingham University of Arkansas System University of California Davis University of Iowa University of Oklahoma University of Tennessee University of Texas M. D. Anderson Cancer Center US Oncology Research West German Study Group Xijing Hospital
Approved
Whole mAb
12-IgG1 rhuMAb-VEGF AVASTIN
6.2
IMGT PubChem (46504473) PubChem (50067187) PubChem (103771315) PubChem (135329020) PubChem (178103377) PubChem (329976976) PubChem (348480209) PubChem (350080043) PubChem (387061165) PubChem (440790697) PubChem (441072526) PubChem (445537291) PubChem (468769596) PubChem (469690934) PubChem (472217546) PubChem (472423468) PubChem (475546928) PubChem (481101539) PubChem (481152874) PubChem (485726125) PubChem (488297021) PubChem (496156058) PubChem (508644795) PubChem (513259655) PubChem (519821651) Thera-SAbDab YAbS
Avg A4D Score
-0.6784
Score Range
-0.71 to -0.64
Structures
8
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB044_1bj1_K_J 1bj1 100% -0.6424 6.5 4.0 -0.171 -0.7042
A4DAB044_1cz8_Y_X 1cz8 97% -0.6636 6.5 4.0 -0.0974 -0.7379
A4DAB044_1bj1_H_L 1bj1 100% -0.6886 6.5 4.0 -0.1696 -0.7567
A4DAB044_6bft_H_L 6bft 98% -0.7047 6.5 4.0 -0.3845 -0.7469
A4DAB044_6bft_A_B 6bft 98% -0.713 6.5 4.0 -0.3946 -0.754
A4DAB044_1cz8_H_L 1cz8 97% -0.6603 6.5 4.0 -0.0949 -0.7345
A4DAB044_7v5n_B_A 7v5n 100% -0.6788 6.5 4.0 -0.3101 -0.7267
A4DAB044_7v5n_F_E 7v5n 100% -0.6761 6.5 4.0 -0.2723 -0.7296