Carlumab

A4DAB058 | Phase-II

Target CCL2/MCP1

Isotype / Subclass G1 / None

Company

MorphoSys Janssen Biotech

Clinical Status Phase-II

Format Whole mAb

Synonyms

CNTO-888 CNTO888

pH Formulation —

IMGT PubChem (135350336) PubChem (160698790) PubChem (347911366) PubChem (472397238) PubChem (472435521) PubChem (472440369) PubChem (481155504) PubChem (498124491) PubChem (505570407) Thera-SAbDab YAbS

Avg A4D Score

-0.6651

Score Range

-0.67 to -0.66

Structures

Avg. A4D Score per Structure

pH at Min / Max Aggregation Propensity

Structure ID	Source PDB	Seq. Identity	Avg. A4D Score	pH (Min Agg.)	pH (Max Agg.)	Score CDR	Score non-CDR
A4DAB058_4dn3_H_L	4dn3	99%	-0.6567	6.5	4.0	0.0368	-0.745
A4DAB058_4dn4_H_L	4dn4	99%	-0.6735	6.5	4.0	-0.0222	-0.756

Carlumab

Avg. A4D Score per Structure

pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2