Global Registry
A4D-Ab
Crovalimab
A4DAB076
|
Cardiovascular / hemostasis disorders
|
Approved
Target
C5
Isotype / Subclass
G1 / IgG1
Company
Chugai Pharmaceutical
Roche
Clinical Status
Approved
Format
Whole mAb
Synonyms
CH 7092230
CH7092230
CH-7092230
RG 6107
RG-6107
RG6107
RO 7092230
RO-7112689
RO7112689
SKY 59
SKY-59
SKY59
pH Formulation
5.8
IMGT
PubChem (381128162)
PubChem (440234576)
PubChem (472418753)
PubChem (480403257)
PubChem (481988122)
PubChem (483123338)
PubChem (505575202)
PubChem (508534419)
Thera-SAbDab
YAbS
Avg A4D Score
-0.6993
Score Range
-0.71 to -0.69
Structures
2
Show Structure Profiles
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity
Associated Structural Profiles
Level 2
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Column Filters
Min Seq. Identity (%)
0
Min Avg A4D Score
-5.0
Max Avg A4D Score
2.0
Min pH (min agg. prop.)
0.0
Max pH (max agg. prop.)
14.0
Reset Filters
Structure ID
Source PDB
Seq. Identity
Avg. A4D Score
pH (Min Agg.)
pH (Max Agg.)
Score CDR
Score non-CDR
A4DAB076_5b71_D_C
5b71
100%
-0.6935
6.5
4.0
-0.3177
-0.7459
A4DAB076_5b71_B_A
5b71
100%
-0.7051
6.5
4.0
-0.2955
-0.7614