Dacetuzumab

A4DAB078 | Phase-II
TNFRSF5/CD40
G1 / None
Seattle Genetics
Phase-II
Whole mAb
huS2C6 PRO 64553 PRO-64553 PRO64553 RG 3636 RG3636 RG-3636 SGN 14 SGN14 SGN-14 SGN-40 SGN40
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IMGT PubChem (135323347) PubChem (160666624) PubChem (347911348) PubChem (349991504) PubChem (464013582) PubChem (468575037) PubChem (472220376) PubChem (472398106) PubChem (481155346) PubChem (498125441) PubChem (505580875) Thera-SAbDab YAbS
Avg A4D Score
-0.7165
Score Range
-0.74 to -0.68
Structures
4
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB078_8yx9_E_F 8yx9 100% -0.7253 6.5 9.0 -0.4767 -0.7553
A4DAB078_8yx9_B_C 8yx9 100% -0.6821 6.0 9.0 -0.3826 -0.7181
A4DAB078_8yx9_G_I 8yx9 100% -0.7373 6.5 9.0 -0.4814 -0.7683
A4DAB078_8yx9_H_L 8yx9 100% -0.7212 6.0 9.0 -0.4657 -0.7519