Domagrozumab

A4DAB088 | Phase-II
MSTN/GDF8/GDF-8
G1 / None
Kennedy Krieger Institute Pfizer
Phase-II
Whole mAb
PF 6252616 PF6252616 PF-06252616 PF06252616
—
Avg A4D Score
-0.6355
Score Range
-0.66 to -0.62
Structures
4
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB088_5f3h_C_D 5f3h 99% -0.6384 6.5 4.0 -0.2071 -0.6873
A4DAB088_5f3h_E_F 5f3h 99% -0.66 6.5 4.0 -0.229 -0.7089
A4DAB088_5f3h_G_H 5f3h 99% -0.6282 6.5 4.0 -0.1334 -0.6848
A4DAB088_5f3h_A_B 5f3h 99% -0.6155 6.5 4.0 -0.1337 -0.6706