Fresolimumab

A4DAB120 | Phase-I
TGFB
G4 / None
Cambridge Antibody Technology Baylor College of Medicine Genzyme Corporation Sanofi Genzyme
Phase-I
Whole mAb
GC-1008 GC1008
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IMGT PubChem (135281361) PubChem (160687956) PubChem (252166476) PubChem (347911330) PubChem (464013587) PubChem (468575045) PubChem (472220980) PubChem (472385904) PubChem (481155555) PubChem (505596123) Thera-SAbDab YAbS
Avg A4D Score
-0.6565
Score Range
-0.67 to -0.64
Structures
10
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB120_4kxz_N_M 4kxz 100% -0.6554 6.5 4.0 0.1806 -0.7588
A4DAB120_4kxz_H_L 4kxz 100% -0.6571 6.5 4.0 0.1514 -0.7571
A4DAB120_3eo0_B_A 3eo0 100% -0.6366 7.0 4.0 0.1794 -0.7378
A4DAB120_3eo1_H_G 3eo1 100% -0.6484 6.5 4.0 0.1386 -0.7471
A4DAB120_3eo1_E_D 3eo1 100% -0.6698 6.5 4.0 0.1834 -0.7768
A4DAB120_4kxz_Q_P 4kxz 100% -0.6584 6.5 4.0 0.2021 -0.7666
A4DAB120_3eo1_K_J 3eo1 100% -0.6711 6.5 4.0 0.1854 -0.7785
A4DAB120_4kxz_J_I 4kxz 100% -0.666 6.5 4.0 0.1942 -0.7744
A4DAB120_3eo1_B_A 3eo1 100% -0.6521 6.5 4.0 0.1432 -0.7518
A4DAB120_3eo0_D_C 3eo0 100% -0.65 7.0 4.0 0.1974 -0.7551