Lorigerlimab

A4DAB158 | Phase-II
PDCD1/CD279/PD1;CTLA4/CD152
G4;G4 / None
MacroGenics
Phase-II
Bispecific Mixed scFv (scFv-CH2-CH3-scFv)
AEX1344 AEX-1344 AEX 1344 EXPASY MGD-019 MGD019 MGD 019 MGD19 MGD-19 MGD 19
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IMGT PubChem (443566461) PubChem (472419608) PubChem (476000871) PubChem (480403139) PubChem (481987997) Thera-SAbDab YAbS
Avg A4D Score
-0.6755
Score Range
-0.71 to -0.6
Structures
6
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB158_7elx_h_l 7elx 97% -0.6896 6.5 4.0 -0.1849 -0.751
A4DAB158_5tru_H_L 5tru 97% -0.7054 6.5 4.0 -0.1892 -0.7676
A4DAB158_7elx_H_L 7elx 97% -0.6754 7.0 4.0 -0.1751 -0.7364
A4DAB158_6jc2_H_L 6jc2 97% -0.6931 6.5 4.0 -0.1845 -0.7546
A4DAB158_5xj3_A_B 5xj3 97% -0.5972 7.0 4.0 -0.154 -0.7111
A4DAB158_6rp8_h_l 6rp8 97% -0.692 6.5 4.0 -0.1115 -0.7629