Lorigerlimab / 6rp8

A4DAB158_6rp8_h_l | Source PDB: 6rp8 | Chains: h, l | Done
97.35
Yes
10 Å
Yes
Avg A4D Score
-0.692
Max Score
2.1475
Min Score
-3.9895
Total Score
-292.74
Score CDR
-0.1115
Score non-CDR
-0.7629

Calculation Parameters

Chain Sequence(s) QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYTMHWVRQAPGKGLEWVTFISYDGNNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAIYYCARTGWLGPFDYWGQGTLVTVSSASTKGPSVFPLAPSTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPEIVLTQSPGTLSLSPGERATLSCRASQSVGSSYLAWYQQKPGQAPRLLIYGAFSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR input.pdb
Selected Chain(s) h (Heavy), l (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.9895
Maximum Score 2.1475
Average Score -0.692
Total Score -292.737

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q h -1.3989 Soluble
2 V h -0.6687 Soluble
3 Q h -0.9887 Soluble
4 L h 0.0000 Buried
5 V h 0.3956 Aggregation-prone
6 E h 0.0000 Buried
7 S h -0.4546 Soluble
8 G h -0.8639 Soluble
9 G h -0.2491 Soluble
11 G h 0.1447 Aggregation-prone
12 V h 0.6983 Aggregation-prone
13 V h -0.4661 Soluble
14 Q h -1.2630 Soluble
15 P h -2.0510 Soluble
16 G h -2.1267 Soluble
17 R h -2.6094 Soluble
18 S h -2.0556 Soluble
19 L h -1.4461 Soluble
20 R h -2.1833 Soluble
21 L h 0.0000 Buried
22 S h -0.5005 Soluble
23 C h 0.0000 Buried
24 A h -0.2582 Soluble
25 A h 0.0000 Buried
26 S h -0.8526 Soluble
27 G h -0.9861 Soluble
28 F h -0.3770 Soluble
29 T h -0.1824 Soluble
30 F h 0.0000 Buried
35 S h -0.5121 Soluble
36 S h 0.0572 Aggregation-prone
37 Y h 0.0000 Buried
38 T h 0.2613 Aggregation-prone
39 M h 0.0000 Buried
40 H h 0.0000 Buried
41 W h 0.0000 Buried
42 V h 0.0000 Buried
43 R h 0.0000 Buried
44 Q h -0.6456 Soluble
45 A h -1.0282 Soluble
46 P h -0.8706 Soluble
47 G h -1.4822 Soluble
48 K h -2.3809 Soluble
49 G h -1.5703 Soluble
50 L h 0.0000 Buried
51 E h -1.0006 Soluble
52 W h 0.0000 Buried
53 V h 0.0000 Buried
54 T h 0.0000 Buried
55 F h 0.2337 Aggregation-prone
56 I h 0.0000 Buried
57 S h -0.6249 Soluble
58 Y h -0.1785 Soluble
59 D h -1.9260 Soluble
62 G h -1.6801 Soluble
63 N h -2.0195 Soluble
64 N h -1.3652 Soluble
65 K h -0.6774 Soluble
66 Y h 0.0633 Aggregation-prone
67 Y h -0.6187 Soluble
68 A h -1.2487 Soluble
69 D h -2.4030 Soluble
70 S h -1.7894 Soluble
71 V h 0.0000 Buried
72 K h -2.5456 Soluble
74 G h -1.7929 Soluble
75 R h -1.3613 Soluble
76 F h 0.0000 Buried
77 T h -0.8151 Soluble
78 I h 0.0000 Buried
79 S h -0.7901 Soluble
80 R h -0.9972 Soluble
81 D h -1.6769 Soluble
82 N h -1.6582 Soluble
83 S h -1.5128 Soluble
84 K h -2.3052 Soluble
85 N h -1.6962 Soluble
86 T h 0.0000 Buried
87 L h 0.0000 Buried
88 Y h -0.5020 Soluble
89 L h 0.0000 Buried
90 Q h -1.3927 Soluble
91 M h 0.0000 Buried
92 N h -1.9030 Soluble
93 S h -1.8077 Soluble
94 L h 0.0000 Buried
95 R h -3.0349 Soluble
96 A h -1.9018 Soluble
97 E h -2.4616 Soluble
98 D h 0.0000 Buried
99 T h -0.6191 Soluble
100 A h 0.0000 Buried
101 I h 0.5144 Aggregation-prone
102 Y h 0.0000 Buried
103 Y h 0.0000 Buried
104 C h 0.0000 Buried
105 A h 0.0000 Buried
106 R h 0.0000 Buried
107 T h 0.5667 Aggregation-prone
108 G h 1.0612 Aggregation-prone
109 W h 1.8306 Aggregation-prone
110 L h 2.1475 Aggregation-prone
113 G h 1.1187 Aggregation-prone
114 P h 0.0000 Buried
115 F h 0.0000 Buried
116 D h 0.0110 Aggregation-prone
117 Y h 0.0135 Aggregation-prone
118 W h -0.2586 Soluble
119 G h 0.0000 Buried
120 Q h -1.3161 Soluble
121 G h -0.3963 Soluble
122 T h 0.2055 Aggregation-prone
123 L h 0.9736 Aggregation-prone
124 V h 0.0000 Buried
125 T h -0.0647 Soluble
126 V h 0.0000 Buried
127 S h -0.7057 Soluble
128 S h -0.5877 Soluble
129 A h -0.3249 Soluble
130 S h -0.4396 Soluble
131 T h -0.7213 Soluble
132 K h -1.1788 Soluble
133 G h -1.3525 Soluble
134 P h 0.0000 Buried
135 S h -0.4234 Soluble
136 V h 0.0000 Buried
137 F h 0.0000 Buried
138 P h -1.2196 Soluble
139 L h 0.0000 Buried
140 A h -0.8230 Soluble
141 P h 0.0000 Buried
142 S h -0.3902 Soluble
143 T h -0.3096 Soluble
144 A h 0.0000 Buried
145 A h 0.0000 Buried
146 L h 0.0000 Buried
147 G h 0.0000 Buried
148 C h 0.0000 Buried
149 L h 0.0000 Buried
150 V h 0.0000 Buried
151 K h 0.0000 Buried
152 D h -0.3431 Soluble
153 Y h 0.0000 Buried
154 F h 0.0000 Buried
155 P h 0.0000 Buried
156 E h -0.7484 Soluble
157 P h -0.9579 Soluble
158 V h -0.7706 Soluble
159 T h -0.6231 Soluble
160 V h -0.2950 Soluble
161 S h -0.3129 Soluble
162 W h 0.0000 Buried
163 N h -0.7693 Soluble
164 S h -0.5355 Soluble
165 G h -0.3311 Soluble
166 A h -0.1447 Soluble
167 L h 0.0548 Aggregation-prone
168 T h -0.1198 Soluble
169 S h -0.1866 Soluble
170 G h -0.2402 Soluble
171 V h 0.1680 Aggregation-prone
172 H h -0.2886 Soluble
173 T h -0.1276 Soluble
174 F h 0.0000 Buried
175 P h -0.2532 Soluble
176 A h 0.2548 Aggregation-prone
177 V h 0.5332 Aggregation-prone
178 L h 1.2788 Aggregation-prone
179 Q h 0.2877 Aggregation-prone
180 S h -0.0064 Soluble
181 S h -0.1483 Soluble
182 G h 0.1045 Aggregation-prone
183 L h 0.1379 Aggregation-prone
184 Y h 0.4241 Aggregation-prone
185 S h 0.0000 Buried
186 L h 0.0000 Buried
187 S h 0.0000 Buried
188 S h 0.0000 Buried
189 V h 0.0000 Buried
190 V h 0.0000 Buried
191 T h -0.1766 Soluble
192 V h 0.0000 Buried
193 P h -0.5181 Soluble
194 S h -0.4419 Soluble
195 S h -0.5438 Soluble
196 S h -0.6479 Soluble
197 L h -0.8625 Soluble
198 G h -1.1271 Soluble
199 T h -0.8184 Soluble
200 Q h -1.4928 Soluble
201 T h -1.2613 Soluble
202 Y h 0.0000 Buried
203 I h -1.3022 Soluble
204 C h 0.0000 Buried
205 N h -1.3049 Soluble
206 V h 0.0000 Buried
207 N h -2.0599 Soluble
208 H h 0.0000 Buried
209 K h -2.8852 Soluble
210 P h -1.6248 Soluble
211 S h -1.8892 Soluble
212 N h -2.6393 Soluble
213 T h -2.1055 Soluble
214 K h -2.6233 Soluble
215 V h -1.3310 Soluble
216 D h -2.1754 Soluble
217 K h -1.8315 Soluble
218 R h -2.6230 Soluble
219 V h 0.0000 Buried
220 E h -2.5523 Soluble
221 P h -1.2120 Soluble
1 E l -1.4663 Soluble
2 I l -0.2312 Soluble
3 V l 0.7792 Aggregation-prone
4 L l 0.0000 Buried
5 T l -0.7807 Soluble
6 Q l 0.0000 Buried
7 S l -0.8331 Soluble
8 P l -0.4596 Soluble
9 G l -0.7681 Soluble
10 T l -0.2696 Soluble
11 L l -0.0907 Soluble
12 S l -0.3475 Soluble
13 L l -0.8816 Soluble
14 S l -1.4405 Soluble
15 P l -1.8763 Soluble
16 G l -2.1170 Soluble
17 E l -2.7859 Soluble
18 R l -3.1959 Soluble
19 A l 0.0000 Buried
20 T l -0.5580 Soluble
21 L l 0.0000 Buried
22 S l -1.0277 Soluble
23 C l 0.0000 Buried
24 R l -2.3779 Soluble
25 A l 0.0000 Buried
26 S l -1.0155 Soluble
27 Q l -1.7365 Soluble
28 S l -1.4289 Soluble
29 V l 0.0000 Buried
30 G l -0.4767 Soluble
36 S l 0.1076 Aggregation-prone
37 S l 0.5677 Aggregation-prone
38 Y l 0.8292 Aggregation-prone
39 L l 0.0000 Buried
40 A l 0.0000 Buried
41 W l 0.0000 Buried
42 Y l 0.0000 Buried
43 Q l 0.0000 Buried
44 Q l 0.0000 Buried
45 K l -1.6285 Soluble
46 P l -1.3969 Soluble
47 G l -1.4829 Soluble
48 Q l -2.2354 Soluble
49 A l -1.5584 Soluble
50 P l 0.0000 Buried
51 R l -1.9585 Soluble
52 L l 0.0000 Buried
53 L l 0.0000 Buried
54 I l 0.0000 Buried
55 Y l 0.7362 Aggregation-prone
56 G l 0.7787 Aggregation-prone
57 A l 0.0000 Buried
65 F l 1.2341 Aggregation-prone
66 S l 0.2094 Aggregation-prone
67 R l -0.9267 Soluble
68 A l -0.6275 Soluble
69 T l -0.5332 Soluble
70 G l -0.7692 Soluble
71 I l -0.9846 Soluble
72 P l -1.2382 Soluble
74 D l -2.3530 Soluble
75 R l -1.9890 Soluble
76 F l 0.0000 Buried
77 S l -0.4695 Soluble
78 G l 0.2379 Aggregation-prone
79 S l -0.1141 Soluble
80 G l -0.8463 Soluble
83 S l -1.0211 Soluble
84 G l -1.4090 Soluble
85 T l -2.0326 Soluble
86 D l -2.7815 Soluble
87 F l 0.0000 Buried
88 T l -0.6636 Soluble
89 L l 0.0000 Buried
90 T l -0.8235 Soluble
91 I l 0.0000 Buried
92 S l -2.3867 Soluble
93 R l -3.4659 Soluble
94 L l 0.0000 Buried
95 E l -2.4888 Soluble
96 P l -1.7566 Soluble
97 E l -2.2748 Soluble
98 D l 0.0000 Buried
99 F l -0.6031 Soluble
100 A l 0.0000 Buried
101 V l -0.0338 Soluble
102 Y l 0.0000 Buried
103 Y l 0.0000 Buried
104 C l 0.0000 Buried
105 Q l 0.0000 Buried
106 Q l 0.0000 Buried
107 Y l 0.0000 Buried
108 G l 0.0118 Aggregation-prone
109 S l -0.4923 Soluble
114 S l -0.4318 Soluble
115 P l -0.4819 Soluble
116 W l -0.0975 Soluble
117 T l -0.0489 Soluble
118 F l 0.1029 Aggregation-prone
119 G l 0.0000 Buried
120 Q l -1.4814 Soluble
121 G l -0.9838 Soluble
122 T l 0.0000 Buried
123 K l -0.3667 Soluble
124 V l 0.0000 Buried
125 E l 0.0000 Buried
126 I l -0.6087 Soluble
127 K l -1.1857 Soluble
128 R l -0.9077 Soluble
129 T l -0.0951 Soluble
130 V l 0.4386 Aggregation-prone
131 A l 0.0866 Aggregation-prone
132 A l -0.1706 Soluble
133 P l 0.0000 Buried
134 S l -0.2810 Soluble
135 V l 0.0000 Buried
136 F l 0.0740 Aggregation-prone
137 I l 0.1069 Aggregation-prone
138 F l 0.0000 Buried
139 P l -0.7112 Soluble
140 P l -0.9824 Soluble
141 S l -1.7165 Soluble
142 D l -3.0293 Soluble
143 E l -3.0996 Soluble
144 Q l 0.0000 Buried
145 L l -2.3775 Soluble
146 K l -2.8599 Soluble
147 S l -1.7541 Soluble
148 G l -1.2429 Soluble
149 T l -0.9523 Soluble
150 A l 0.0000 Buried
151 S l 0.0000 Buried
152 V l 0.0000 Buried
153 V l 0.0000 Buried
154 C l 0.0000 Buried
155 L l 0.0000 Buried
156 L l 0.0000 Buried
157 N l -0.3984 Soluble
158 N l -0.8144 Soluble
159 F l 0.0000 Buried
160 Y l 0.0000 Buried
161 P l -1.2111 Soluble
162 R l -1.9711 Soluble
163 E l -2.6768 Soluble
164 A l -2.0569 Soluble
165 K l -2.3742 Soluble
166 V l -1.1716 Soluble
167 Q l -0.8202 Soluble
168 W l 0.0000 Buried
169 K l -0.7168 Soluble
170 V l 0.0000 Buried
171 D l -2.0527 Soluble
172 N l -1.6510 Soluble
173 A l -0.4144 Soluble
174 L l 0.3564 Aggregation-prone
175 Q l -0.4609 Soluble
176 S l -0.7502 Soluble
177 G l -1.3528 Soluble
178 N l -1.6760 Soluble
179 S l -1.6642 Soluble
180 Q l -1.9049 Soluble
181 E l -1.7758 Soluble
182 S l -0.7430 Soluble
183 V l -0.2890 Soluble
184 T l -0.9077 Soluble
185 E l -2.0382 Soluble
186 Q l -1.6219 Soluble
187 D l -1.8187 Soluble
188 S l -1.7078 Soluble
189 K l -2.2776 Soluble
190 D l -1.8097 Soluble
191 S l -1.6930 Soluble
192 T l 0.0000 Buried
193 Y l 0.0000 Buried
194 S l 0.0000 Buried
195 L l 0.0000 Buried
196 S l 0.0000 Buried
197 S l 0.0000 Buried
198 T l -0.8534 Soluble
199 L l 0.0000 Buried
200 T l -0.7015 Soluble
201 L l -0.9678 Soluble
202 S l -1.2924 Soluble
203 K l -2.2901 Soluble
204 A l -2.1233 Soluble
205 D l -3.1019 Soluble
206 Y l 0.0000 Buried
207 E l -3.9895 Soluble
208 K l -3.7825 Soluble
209 H l -3.4423 Soluble
210 K l -3.5828 Soluble
211 V l -1.8724 Soluble
212 Y l 0.0000 Buried
213 A l 0.0000 Buried
214 C l 0.0000 Buried
215 E l -0.7372 Soluble
216 V l 0.0000 Buried
217 T l -1.1639 Soluble
218 H l 0.0000 Buried
219 Q l -1.4756 Soluble
220 G l -0.5038 Soluble
221 L l -0.2489 Soluble
222 S l -0.4632 Soluble
223 S l -0.4079 Soluble
224 P l -0.4844 Soluble
225 V l -0.0731 Soluble
226 T l -0.5005 Soluble
227 K l -0.6830 Soluble
228 S l -0.5295 Soluble
229 F l -1.1498 Soluble
230 N l -2.6279 Soluble
231 R l -3.1460 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6883 4.2962 CSV PDB
4.5 -0.734 4.2859 CSV PDB
5.0 -0.7874 4.2755 CSV PDB
5.5 -0.8393 4.265 CSV PDB
6.0 -0.8794 4.2546 CSV PDB
6.5 -0.8995 4.2443 CSV PDB
7.0 -0.8993 4.2344 CSV PDB
7.5 -0.8852 4.2258 CSV PDB
8.0 -0.8632 4.2195 CSV PDB
8.5 -0.8348 4.216 CSV PDB
9.0 -0.7995 4.2146 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH