Nivolumab

A4DAB182 | Cancer | Approved
PDCD1/CD279/PD1
G4 / IgG4
Aduro BioTech AIO Studien gGmbH Australian and New Zealand Urogenital and Prostate Cancer Group Barbara Ann Karmanos Cancer Institute Bavarian Nordic Big Ten Cancer Research Consortium Bristol-Myers Squibb Canadian Cancer Trials Group Celleron Therapeutics Clatterbridge Cancer Centre NHS Foundation Trust Clovis Oncology Curie Institute Daiichi Sankyo Company Dana-Farber Cancer Institute Duke University Medical Center Eisai Inc Eli Lilly Emory University European Thoracic Oncology Platform Exelixis Frontier Science foundation Grupo Espanol Multidisciplinar de Melanoma H. Lee Moffitt Cancer Center and Research Institute Hellenic Genitourinary Cancer Group Hoosier Cancer Research Network HOVON Foundation Incyte Corporation Intergroupe Francophone de Cancerologie Thoracique Janssen Biotech Janssen Research & Development Kansai Medical University Kyoto Breast Cancer Research Network M. D. Anderson Cancer Center Massachusetts General Hospital Medarex Nantes University Hospital National Cancer Center (Tokyo) National Cancer Centre (Singapore) National Cancer Institute (USA) Nektar Therapeutics Neon Therapeutics Netherlands Cancer Institute Northwestern University Ono Pharmaceutical Pharmacyclics PrECOG Seattle Genetics Sidney Kimmel Cancer Center Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Syneos Health The University of Montreal Hospital Research Center UNICANCER University College London University of Liverpool University of Pittsburgh University of Texas M. D. Anderson Cancer Center Vanderbilt-Ingram Cancer Center Zucero Therapeutics
Approved
Whole mAb
BMS-936558 BMS936558 BMS 936558 MDX-1106 MDX1106 MDX 1106 ONO-4538 ONO4538 ONO 4538 OPDIVO OPDUALAG (combination of Nivolumab and Relatlimab)
['6', '5.5-6.5']
IMGT PubChem (135341610) PubChem (160698453) PubChem (178103907) PubChem (347910393) PubChem (349494907) PubChem (354355034) PubChem (384647092) PubChem (385327549) PubChem (387061103) PubChem (469753496) PubChem (472217544) PubChem (472403414) PubChem (475546929) PubChem (481101762) PubChem (481155336) PubChem (488222681) PubChem (496156066) PubChem (496739869) PubChem (498214778) PubChem (508644823) PubChem (513259915) PubChem (519875309) Thera-SAbDab YAbS
Avg A4D Score
-0.7559
Score Range
-0.78 to -0.71
Structures
4
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB182_5ggq_H_L 5ggq 100% -0.7717 6.5 4.0 -0.8002 -0.7687
A4DAB182_5ggr_H_L 5ggr 100% -0.7582 6.5 4.0 -0.7577 -0.7583
A4DAB182_5ggr_A_B 5ggr 100% -0.7101 6.5 4.0 -0.6554 -0.7158
A4DAB182_5wt9_H_L 5wt9 100% -0.7834 6.5 4.0 -0.7754 -0.7843