Pertuzumab

A4DAB207 | Cancer | Approved
ERBB2/CD340/HER2
G1 / IgG1
Chugai Pharmaceutical Dana-Farber Cancer Institute FONDAZIONE DEL PIEMONTE PER L'ONCOLOGIA IRCC DI CANDIOLO Genentech International Breast Cancer Study Group Japan Breast Cancer Research Group Medica Scientia Innovation Research Roche West German Study Group
Approved
Whole mAb
R-1273 R1273 R 1273 RG-1273 RG 1273 RG1273 RO-4368451 RO4368451 RO 4368451
6
IMGT PubChem (50069677) PubChem (135348342) PubChem (136926963) PubChem (178101741) PubChem (329976972) PubChem (347910348) PubChem (349020482) PubChem (354355049) PubChem (384647098) PubChem (385327555) PubChem (387061213) PubChem (441080425) PubChem (468817967) PubChem (472218185) PubChem (472422729) PubChem (472677715) PubChem (481101798) PubChem (481155407) PubChem (486341070) PubChem (488414453) PubChem (496156077) PubChem (498137358) PubChem (505187042) PubChem (508644828) PubChem (513260811) PubChem (519908957) Thera-SAbDab YAbS
Avg A4D Score
-0.6744
Score Range
-0.71 to -0.63
Structures
17
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB207_8pwh_D_C 8pwh 100% -0.6786 6.5 9.0 -0.1398 -0.7422
A4DAB207_4llu_C_D 4llu 100% -0.6905 6.0 9.0 -0.1957 -0.7504
A4DAB207_1l7i_H_L 1l7i 100% -0.691 6.5 4.0 -0.2476 -0.7433
A4DAB207_6oge_C_B 6oge 100% -0.6873 6.5 9.0 -0.1675 -0.7487
A4DAB207_5vsh_H_L 5vsh 98% -0.6619 6.5 4.0 -0.2181 -0.7155
A4DAB207_4lly_C_D 4lly 98% -0.6976 6.0 9.0 -0.2449 -0.752
A4DAB207_5vsh_E_F 5vsh 98% -0.6687 6.5 9.0 -0.2398 -0.721
A4DAB207_4lly_A_B 4lly 98% -0.6793 6.0 9.0 -0.2143 -0.7351
A4DAB207_5vsh_C_D 5vsh 98% -0.6422 6.5 9.0 -0.2052 -0.6953
A4DAB207_4llw_C_D 4llw 99% -0.6745 6.5 9.0 -0.2087 -0.7313
A4DAB207_1s78_D_C 1s78 100% -0.7056 6.5 4.0 -0.1865 -0.7668
A4DAB207_9l1s_C_B 9l1s 99% -0.6783 6.5 4.0 -0.06 -0.7512
A4DAB207_8q6j_D_C 8q6j 100% -0.6572 6.5 9.0 -0.1468 -0.7174
A4DAB207_5vsh_A_B 5vsh 98% -0.6486 6.5 4.0 -0.1837 -0.7048
A4DAB207_4llw_A_B 4llw 99% -0.631 6.0 9.0 -0.1663 -0.6882
A4DAB207_1s78_F_E 1s78 100% -0.6834 6.5 9.0 -0.2279 -0.7371
A4DAB207_4llu_A_B 4llu 100% -0.6899 6.0 9.0 -0.2225 -0.7458