Pertuzumab / 6oge

A4DAB207_6oge_C_B | Source PDB: 6oge | Chains: C, B | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6873
Max Score
1.9166
Min Score
-3.6824
Total Score
-299.68
Score CDR
-0.1675
Score non-CDR
-0.7487

Calculation Parameters

Chain Sequence(s) EVQLVESGGGLVQPGGSLRLSCAASGFTFTDYTMDWVRQAPGKGLEWVADVNPNSGGSIYNQRFKGRFTLSVDRSKNTLYLQMNSLRAEDTAVYYCARNLGPSFYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDIQMTQSPSSLSASVGDRVTITCKASQDVSIGVAWYQQKPGKAPKLLIYSASYRYTGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYYIYPYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC input.pdb
Selected Chain(s) C (Heavy), B (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.6824
Maximum Score 1.9166
Average Score -0.6873
Total Score -299.6825

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E C -2.2652 Soluble
2 V C 0.0000 Buried
3 Q C -1.4253 Soluble
4 L C -0.1144 Soluble
5 V C 1.1218 Aggregation-prone
6 E C 0.1746 Aggregation-prone
7 S C -0.3804 Soluble
8 G C -0.5923 Soluble
9 G C -0.3752 Soluble
11 G C 0.0693 Aggregation-prone
12 L C 0.5215 Aggregation-prone
13 V C -0.2161 Soluble
14 Q C -1.4756 Soluble
15 P C -1.6980 Soluble
16 G C -1.2912 Soluble
17 G C -0.9420 Soluble
18 S C -0.9379 Soluble
19 L C -0.6771 Soluble
20 R C -1.5807 Soluble
21 L C 0.0000 Buried
22 S C -0.1443 Soluble
23 C C 0.0000 Buried
24 A C 0.0575 Aggregation-prone
25 A C -0.5197 Soluble
26 S C -0.9817 Soluble
27 G C -1.2807 Soluble
28 F C -0.6771 Soluble
29 T C -0.5594 Soluble
30 F C 0.0000 Buried
35 T C -1.5157 Soluble
36 D C -1.8435 Soluble
37 Y C -0.6254 Soluble
38 T C -0.5439 Soluble
39 M C 0.0000 Buried
40 D C 0.0000 Buried
41 W C 0.0000 Buried
42 V C 0.0000 Buried
43 R C 0.0000 Buried
44 Q C -0.6587 Soluble
45 A C -1.1217 Soluble
46 P C -0.9901 Soluble
47 G C -1.4520 Soluble
48 K C -2.3734 Soluble
49 G C -1.6581 Soluble
50 L C 0.0000 Buried
51 E C -0.8134 Soluble
52 W C 0.0000 Buried
53 V C 0.0000 Buried
54 A C 0.0000 Buried
55 D C 0.0000 Buried
56 V C 0.0000 Buried
57 N C -0.8933 Soluble
58 P C -1.6638 Soluble
59 N C -1.9893 Soluble
62 S C -1.0452 Soluble
63 G C -0.6624 Soluble
64 G C -0.2077 Soluble
65 S C 0.4178 Aggregation-prone
66 I C 0.9060 Aggregation-prone
67 Y C 0.0204 Aggregation-prone
68 N C 0.0000 Buried
69 Q C -2.5106 Soluble
70 R C -2.9233 Soluble
71 F C -2.0656 Soluble
72 K C -2.7460 Soluble
74 G C -1.8242 Soluble
75 R C -1.5502 Soluble
76 F C -0.7721 Soluble
77 T C -0.5766 Soluble
78 L C 0.0000 Buried
79 S C -0.4004 Soluble
80 V C -0.8245 Soluble
81 D C -1.7922 Soluble
82 R C -3.0202 Soluble
83 S C -2.1556 Soluble
84 K C -2.7518 Soluble
85 N C -2.2815 Soluble
86 T C -1.1042 Soluble
87 L C 0.0000 Buried
88 Y C -0.0402 Soluble
89 L C 0.0000 Buried
90 Q C -1.3046 Soluble
91 M C -0.9594 Soluble
92 N C -1.1039 Soluble
93 S C -1.1033 Soluble
94 L C -1.6853 Soluble
95 R C -2.6355 Soluble
96 A C -1.9303 Soluble
97 E C -2.3301 Soluble
98 D C 0.0000 Buried
99 T C -0.5589 Soluble
100 A C 0.0000 Buried
101 V C 0.2562 Aggregation-prone
102 Y C 0.0152 Aggregation-prone
103 Y C 0.0000 Buried
104 C C 0.0000 Buried
105 A C 0.0000 Buried
106 R C 0.0000 Buried
107 N C 0.0000 Buried
108 L C 0.2007 Aggregation-prone
109 G C 0.0000 Buried
110 P C -0.2991 Soluble
112 S C 0.1763 Aggregation-prone
113 F C 0.7600 Aggregation-prone
114 Y C 0.5031 Aggregation-prone
115 F C 0.0000 Buried
116 D C 0.0000 Buried
117 Y C -0.0549 Soluble
118 W C 0.0000 Buried
119 G C 0.0000 Buried
120 Q C -1.3806 Soluble
121 G C -0.5330 Soluble
122 T C -0.2511 Soluble
123 L C 0.3880 Aggregation-prone
124 V C 0.0000 Buried
125 T C 0.0961 Aggregation-prone
126 V C 0.0000 Buried
127 S C -0.7780 Soluble
128 S C -0.8479 Soluble
129 A C -0.4066 Soluble
130 S C -0.4638 Soluble
131 T C -0.7473 Soluble
132 K C -1.0142 Soluble
133 G C -1.1028 Soluble
134 P C -0.4370 Soluble
135 S C -0.0854 Soluble
136 V C 0.1350 Aggregation-prone
137 F C 0.0000 Buried
138 P C -0.8871 Soluble
139 L C 0.0000 Buried
140 A C -1.0706 Soluble
141 P C 0.0000 Buried
142 S C -1.4185 Soluble
143 S C -1.7230 Soluble
144 K C -2.1234 Soluble
145 S C -1.0841 Soluble
146 T C -0.7765 Soluble
147 S C -0.6958 Soluble
148 G C -0.9003 Soluble
149 G C -0.6713 Soluble
150 T C -0.4807 Soluble
151 A C 0.0000 Buried
152 A C 0.0108 Aggregation-prone
153 L C 0.0000 Buried
154 G C 0.0000 Buried
155 C C 0.0000 Buried
156 L C 0.0000 Buried
157 V C 0.0000 Buried
158 K C 0.0000 Buried
159 D C -0.1487 Soluble
160 Y C 0.0000 Buried
161 F C 0.0000 Buried
162 P C -0.6552 Soluble
163 E C -0.8624 Soluble
164 P C -0.7453 Soluble
165 V C -0.6249 Soluble
166 T C -0.6103 Soluble
167 V C -0.3780 Soluble
168 S C -0.3465 Soluble
169 W C 0.0000 Buried
170 N C -0.9626 Soluble
171 S C -0.6854 Soluble
172 G C -0.3871 Soluble
173 A C -0.1070 Soluble
174 L C 0.2681 Aggregation-prone
175 T C 0.0932 Aggregation-prone
176 S C -0.0383 Soluble
177 G C -0.1082 Soluble
178 V C 0.2569 Aggregation-prone
179 H C -0.0092 Soluble
180 T C -0.0105 Soluble
181 F C 0.0000 Buried
182 P C -0.1779 Soluble
183 A C 0.2816 Aggregation-prone
184 V C 0.6725 Aggregation-prone
185 L C 1.2300 Aggregation-prone
186 Q C 0.0636 Aggregation-prone
187 S C -0.3869 Soluble
188 S C -0.2361 Soluble
189 G C 0.0503 Aggregation-prone
190 L C 0.2917 Aggregation-prone
191 Y C 0.5131 Aggregation-prone
192 S C 0.3422 Aggregation-prone
193 L C 0.0000 Buried
194 S C 0.0000 Buried
195 S C 0.0000 Buried
196 V C 0.0000 Buried
197 V C 0.0000 Buried
198 T C -0.0808 Soluble
199 V C 0.0000 Buried
200 P C -0.5382 Soluble
201 S C -0.5716 Soluble
202 S C -0.6016 Soluble
203 S C -0.5171 Soluble
204 L C -0.6114 Soluble
205 G C -0.6465 Soluble
206 T C -0.6048 Soluble
207 Q C -0.8086 Soluble
208 T C -0.9972 Soluble
209 Y C -0.8892 Soluble
210 I C -1.1798 Soluble
211 C C 0.0000 Buried
212 N C -1.5884 Soluble
213 V C 0.0000 Buried
214 N C -2.1449 Soluble
215 H C 0.0000 Buried
216 K C -2.8820 Soluble
217 P C -1.7170 Soluble
218 S C -1.9844 Soluble
219 N C -2.7021 Soluble
220 T C -2.0593 Soluble
221 K C -2.7920 Soluble
222 V C -1.6250 Soluble
223 D C -2.6593 Soluble
224 K C -2.1874 Soluble
225 K C -2.5999 Soluble
226 V C 0.0000 Buried
227 E C -2.8134 Soluble
228 P C -2.0363 Soluble
229 K C -2.6545 Soluble
230 S C -1.4273 Soluble
231 C C -0.1392 Soluble
1 D B -1.9892 Soluble
2 I B 0.0000 Buried
3 Q B -2.3129 Soluble
4 M B 0.0000 Buried
5 T B -1.5500 Soluble
6 Q B -1.0911 Soluble
7 S B -0.5796 Soluble
8 P B -0.4861 Soluble
9 S B -0.8770 Soluble
10 S B -0.8487 Soluble
11 L B -0.4643 Soluble
12 S B -0.8164 Soluble
13 A B -0.5573 Soluble
14 S B -0.3291 Soluble
15 V B 0.8023 Aggregation-prone
16 G B -0.4443 Soluble
17 D B -1.1426 Soluble
18 R B -1.9646 Soluble
19 V B -0.7705 Soluble
20 T B -0.3443 Soluble
21 I B -0.2009 Soluble
22 T B -0.9092 Soluble
23 C B 0.0000 Buried
24 K B -3.0349 Soluble
25 A B 0.0000 Buried
26 S B -2.2679 Soluble
27 Q B -2.5552 Soluble
28 D B -2.3341 Soluble
29 V B 0.0000 Buried
36 S B -0.0109 Soluble
37 I B 1.9166 Aggregation-prone
38 G B 0.0000 Buried
39 V B 0.0000 Buried
40 A B 0.0000 Buried
41 W B 0.0000 Buried
42 Y B 0.0000 Buried
43 Q B 0.0000 Buried
44 Q B 0.0000 Buried
45 K B -2.1212 Soluble
46 P B -1.5596 Soluble
47 G B -1.6846 Soluble
48 K B -2.5333 Soluble
49 A B -1.6681 Soluble
50 P B 0.0000 Buried
51 K B -1.3960 Soluble
52 L B 0.0000 Buried
53 L B 0.0000 Buried
54 I B 0.0000 Buried
55 Y B 0.8644 Aggregation-prone
56 S B 0.9835 Aggregation-prone
57 A B 0.0000 Buried
65 S B 0.3657 Aggregation-prone
66 Y B 0.7023 Aggregation-prone
67 R B -0.5214 Soluble
68 Y B 0.0226 Aggregation-prone
69 T B -0.2313 Soluble
70 G B -0.5665 Soluble
71 V B -0.4605 Soluble
72 P B -0.5578 Soluble
74 S B -0.6980 Soluble
75 R B -0.9071 Soluble
76 F B 0.0000 Buried
77 S B -0.4460 Soluble
78 G B -0.1717 Soluble
79 S B -0.5345 Soluble
80 G B -0.8962 Soluble
83 S B -0.8950 Soluble
84 G B -1.3316 Soluble
85 T B -2.1488 Soluble
86 D B -2.6991 Soluble
87 F B 0.0000 Buried
88 T B -0.8069 Soluble
89 L B 0.0000 Buried
90 T B 0.0000 Buried
91 I B 0.0000 Buried
92 S B -1.2582 Soluble
93 S B -0.9075 Soluble
94 L B 0.0000 Buried
95 Q B -0.8157 Soluble
96 P B -0.9134 Soluble
97 E B -2.0889 Soluble
98 D B 0.0000 Buried
99 F B -0.6230 Soluble
100 A B 0.0000 Buried
101 T B -1.0468 Soluble
102 Y B 0.0000 Buried
103 Y B 0.0000 Buried
104 C B 0.0000 Buried
105 Q B 0.0000 Buried
106 Q B 0.0000 Buried
107 Y B 1.4962 Aggregation-prone
108 Y B 1.8328 Aggregation-prone
109 I B 1.0282 Aggregation-prone
114 Y B 1.1490 Aggregation-prone
115 P B 0.1403 Aggregation-prone
116 Y B 0.5205 Aggregation-prone
117 T B -0.4330 Soluble
118 F B 0.0000 Buried
119 G B 0.0000 Buried
120 Q B -1.8438 Soluble
121 G B -1.4284 Soluble
122 T B 0.0000 Buried
123 K B -1.4807 Soluble
124 V B -0.5713 Soluble
125 E B -0.8949 Soluble
126 I B -0.5178 Soluble
127 K B -1.4411 Soluble
128 R B -1.4407 Soluble
129 T B -0.3213 Soluble
130 V B 0.4603 Aggregation-prone
131 A B 0.3637 Aggregation-prone
132 A B 0.1896 Aggregation-prone
133 P B 0.0000 Buried
134 S B -0.0983 Soluble
135 V B 0.0000 Buried
136 F B 0.1360 Aggregation-prone
137 I B 0.0000 Buried
138 F B 0.0000 Buried
139 P B 0.0000 Buried
140 P B -0.2382 Soluble
141 S B -1.2191 Soluble
142 D B -2.1877 Soluble
143 E B -1.6622 Soluble
144 Q B 0.0000 Buried
145 L B -0.6422 Soluble
146 K B -1.8910 Soluble
147 S B -1.2414 Soluble
148 G B -0.9513 Soluble
149 T B -0.4104 Soluble
150 A B 0.0000 Buried
151 S B 0.0000 Buried
152 V B 0.0000 Buried
153 V B 0.0000 Buried
154 C B 0.0000 Buried
155 L B 0.0430 Aggregation-prone
156 L B 0.0000 Buried
157 N B 0.0000 Buried
158 N B -0.8070 Soluble
159 F B 0.0000 Buried
160 Y B 0.0000 Buried
161 P B -1.3578 Soluble
162 R B -2.0795 Soluble
163 E B -2.9879 Soluble
164 A B -2.2456 Soluble
165 K B -2.3522 Soluble
166 V B -1.3988 Soluble
167 Q B -1.1913 Soluble
168 W B 0.0000 Buried
169 K B -0.3134 Soluble
170 V B -0.5464 Soluble
171 D B -1.4552 Soluble
172 N B -1.2769 Soluble
173 A B -0.0979 Soluble
174 L B 0.6800 Aggregation-prone
175 Q B -0.4117 Soluble
176 S B -0.8345 Soluble
177 G B -1.3264 Soluble
178 N B -1.7597 Soluble
179 S B -1.7266 Soluble
180 Q B -1.8744 Soluble
181 E B -1.8022 Soluble
182 S B 0.0000 Buried
183 V B 0.1113 Aggregation-prone
184 T B -0.5985 Soluble
185 E B -1.9500 Soluble
186 Q B -1.9875 Soluble
187 D B -2.4166 Soluble
188 S B -2.0714 Soluble
189 K B -2.8918 Soluble
190 D B -2.9705 Soluble
191 S B 0.0000 Buried
192 T B -1.5956 Soluble
193 Y B 0.0000 Buried
194 S B 0.0000 Buried
195 L B 0.0935 Aggregation-prone
196 S B 0.0000 Buried
197 S B 0.0000 Buried
198 T B -0.8546 Soluble
199 L B 0.0000 Buried
200 T B -0.5678 Soluble
201 L B -0.5116 Soluble
202 S B -1.1826 Soluble
203 K B -1.8099 Soluble
204 A B -1.9084 Soluble
205 D B -2.1980 Soluble
206 Y B -2.5309 Soluble
207 E B -3.6666 Soluble
208 K B -3.5435 Soluble
209 H B -2.8787 Soluble
210 K B -3.4910 Soluble
211 V B -1.9275 Soluble
212 Y B 0.0000 Buried
213 A B 0.0000 Buried
214 C B 0.0000 Buried
215 E B -0.6692 Soluble
216 V B 0.0000 Buried
217 T B -0.9676 Soluble
218 H B -1.2360 Soluble
219 Q B -1.4885 Soluble
220 G B -0.1812 Soluble
221 L B 0.5623 Aggregation-prone
222 S B -0.1389 Soluble
223 S B -0.1470 Soluble
224 P B -0.2060 Soluble
225 V B 0.4859 Aggregation-prone
226 T B -0.1247 Soluble
227 K B -0.4774 Soluble
228 S B -0.5331 Soluble
229 F B 0.0000 Buried
230 N B -2.4358 Soluble
231 R B -3.6824 Soluble
232 G B -2.3618 Soluble
233 E B -2.6792 Soluble
234 C B -1.5991 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.7537 2.6414 CSV PDB
4.5 -0.7953 2.5904 CSV PDB
5.0 -0.8433 2.5349 CSV PDB
5.5 -0.8881 2.4776 CSV PDB
6.0 -0.9181 2.4199 CSV PDB
6.5 -0.9229 2.3621 CSV PDB
7.0 -0.9019 2.3046 CSV PDB
7.5 -0.8641 2.2484 CSV PDB
8.0 -0.8172 2.1958 CSV PDB
8.5 -0.7639 2.1518 CSV PDB
9.0 -0.7043 2.1219 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH