Prezalumab

A4DAB212 | Phase-II
ICOSLG
G2 / None
Amgen MedImmune
Phase-II
Whole mAb
AMG-557 AMG557 AMG 557 B7RP-1 MEDI-5872 MEDI 5872 MEDI5872
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IMGT PubChem (160709221) PubChem (381127586) PubChem (472409526) PubChem (474488758) PubChem (474489160) PubChem (498152194) Thera-SAbDab YAbS
Avg A4D Score
-0.7146
Score Range
-0.73 to -0.7
Structures
2
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB212_6x4t_D_F 6x4t 100% -0.7036 6.5 4.0 -0.1875 -0.7676
A4DAB212_6x4t_B_E 6x4t 100% -0.7255 6.5 9.0 -0.372 -0.7691