Quilizumab

A4DAB215 | Phase-II
IGHE
G1 / None
Genentech
Phase-II
Whole mAb
MEMP-1972A MEMP1972A MEMP 1972A RG-7449 RG7449 RG 7449
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IMGT PubChem (160698538) PubChem (310264776) PubChem (381126678) PubChem (404772614) PubChem (472401245) PubChem (474488746) PubChem (474489074) PubChem (505867784) Thera-SAbDab YAbS
Avg A4D Score
-0.6604
Score Range
-0.67 to -0.64
Structures
4
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB215_3hr5_H_L 3hr5 100% -0.6433 6.5 9.0 -0.1571 -0.7046
A4DAB215_3hr5_J_Q 3hr5 100% -0.6696 6.5 4.0 -0.1562 -0.7343
A4DAB215_3hr5_B_A 3hr5 100% -0.6626 6.5 9.0 -0.1752 -0.724
A4DAB215_3hr5_I_P 3hr5 100% -0.666 6.5 9.0 -0.1303 -0.7333