Rituximab

A4DAB226 | Cancer | Approved
MS4A1/CD20
G1 / IgG1
Biogen Biogen Idec Cedars-Sinai Medical Center Chugai Pharmaceutical Genentech Hackensack University Medical Center Hoosier Cancer Research Network Janssen Research & Development M. D. Anderson Cancer Center Mayo Clinic Nagoya University Oregon Health & Science University Roche SCRI Development Innovations Takeda Oncology University of Gottingen University of Texas M. D. Anderson Cancer Center University of Tours Zenyaku Kogyo
Approved
Whole mAb
IDEC-102 IDEC102 IDEC 102 IDEC-C2B8 IDEC C2B8 RG 105 RG-105 RG105 Ristova Rituxan RO-452294 RO 452294 RO452294
6.5
IMGT PubChem (46505820) PubChem (50070184) PubChem (103771410) PubChem (135341754) PubChem (178103386) PubChem (319435463) PubChem (329976960) PubChem (348838049) PubChem (354355036) PubChem (365372203) PubChem (384647099) PubChem (385327556) PubChem (387061212) PubChem (441072531) PubChem (468746478) PubChem (469691030) PubChem (472186860) PubChem (472387480) PubChem (475546920) PubChem (481101830) PubChem (481155379) PubChem (488418835) PubChem (496156070) PubChem (496741027) PubChem (498150678) PubChem (508644831) PubChem (513259886) PubChem (519929088) Thera-SAbDab YAbS
Avg A4D Score
-0.6395
Score Range
-0.71 to -0.56
Structures
11
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB226_8vgn_H_L 8vgn 100% -0.5955 6.0 9.0 -0.2132 -0.6416
A4DAB226_2osl_A_B 2osl 100% -0.6719 6.0 9.0 -0.312 -0.7156
A4DAB226_8vgo_A_B 8vgo 98% -0.5644 6.0 9.0 -0.2059 -0.6074
A4DAB226_6vja_I_M 6vja 100% -0.7052 6.0 9.0 -0.2148 -0.7643
A4DAB226_8vgn_A_B 8vgn 100% -0.6033 6.0 9.0 -0.2087 -0.6508
A4DAB226_6y90_C_D 6y90 100% -0.6918 6.5 9.0 -0.2486 -0.7452
A4DAB226_4kaq_H_L 4kaq 100% -0.6261 6.5 9.0 -0.229 -0.6751
A4DAB226_6y90_H_L 6y90 100% -0.6861 6.0 9.0 -0.2485 -0.7388
A4DAB226_2osl_H_L 2osl 100% -0.6466 6.0 9.0 -0.3035 -0.6879
A4DAB226_8vgo_H_L 8vgo 98% -0.5706 6.0 9.0 -0.2087 -0.6141
A4DAB226_6vja_H_L 6vja 100% -0.6734 6.0 9.0 -0.2058 -0.7297