Timigutuzumab

A4DAB266 | Approved
ERBB2/CD340/HER2
G1 / None
Roche
Approved
Whole mAb
GEXMab73 GEXMab-73 GEXMab 73
—
Avg A4D Score
-0.6964
Score Range
-0.76 to -0.59
Structures
60
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB266_4x4x_C_D 4x4x 99% -0.6715 7.5 4.0 -0.7576 -0.6507
A4DAB266_6my4_H_L 6my4 93% -0.6975 6.5 9.0 -0.4966 -0.7238
A4DAB266_8q6j_B_A 8q6j 100% -0.7468 6.5 4.0 -0.6281 -0.7612
A4DAB266_6oge_E_D 6oge 100% -0.6716 6.5 4.0 -0.6001 -0.6802
A4DAB266_4hkz_B_A 4hkz 100% -0.6936 6.5 4.0 -0.5284 -0.7139
A4DAB266_7t97_A_B 7t97 100% -0.685 6.5 4.0 -0.4901 -0.7088
A4DAB266_5xhg_B_A 5xhg 100% -0.7279 6.5 4.0 -0.5465 -0.7504
A4DAB266_7t97_H_L 7t97 100% -0.6974 6.5 9.0 -0.5216 -0.7189
A4DAB266_5tdp_D_C 5tdp 98% -0.6842 6.5 4.0 -0.5283 -0.7035
A4DAB266_1fve_D_C 1fve 99% -0.7307 6.5 4.0 -0.5117 -0.7571
A4DAB266_7t97_C_D 7t97 100% -0.7171 6.5 4.0 -0.59 -0.7327
A4DAB266_4x4x_A_B 4x4x 99% -0.5887 7.0 4.0 -0.4712 -0.6199
A4DAB266_1fvc_D_C 1fvc 100% -0.6803 7.0 4.0 -0.5869 -0.7046
A4DAB266_6mxs_A_B 6mxs 93% -0.6864 6.5 9.0 -0.3031 -0.7373
A4DAB266_5tdn_B_A 5tdn 98% -0.6985 6.5 9.0 -0.458 -0.7581
A4DAB266_5xhg_D_C 5xhg 100% -0.7411 6.5 9.0 -0.5824 -0.7605
A4DAB266_8tjf_H_L 8tjf 100% -0.725 6.5 9.0 -0.6158 -0.7386
A4DAB266_5tdo_D_C 5tdo 98% -0.7017 6.5 4.0 -0.4691 -0.7306
A4DAB266_5tdp_B_A 5tdp 98% -0.7026 6.5 4.0 -0.4534 -0.7595
A4DAB266_3be1_H_L 3be1 94% -0.6949 6.5 4.0 -0.4862 -0.723
A4DAB266_6mh2_D_C 6mh2 100% -0.7079 6.5 9.0 -0.3715 -0.7883
A4DAB266_7t99_C_D 7t99 100% -0.7118 6.5 9.0 -0.5096 -0.7365
A4DAB266_6bi0_H_L 6bi0 100% -0.665 6.5 4.0 -0.4606 -0.6905
A4DAB266_6bhz_I_M 6bhz 100% -0.6908 6.5 4.0 -0.3959 -0.7545
A4DAB266_6my5_H_L 6my5 93% -0.6873 6.5 9.0 -0.3826 -0.7272
A4DAB266_6my4_A_B 6my4 93% -0.7028 6.5 9.0 -0.4355 -0.7379
A4DAB266_6bi2_I_M 6bi2 100% -0.723 6.5 4.0 -0.6091 -0.7372
A4DAB266_7t99_A_B 7t99 100% -0.7136 6.5 4.0 -0.5064 -0.739
A4DAB266_5tdn_D_C 5tdn 98% -0.6936 6.5 4.0 -0.4911 -0.719
A4DAB266_1n8z_B_A 1n8z 100% -0.73 6.5 4.0 -0.5916 -0.7468
A4DAB266_6bgt_B_A 6bgt 99% -0.7087 6.5 4.0 -0.6086 -0.7213
A4DAB266_8pwh_B_A 8pwh 100% -0.764 6.5 4.0 -0.6357 -0.7796
A4DAB266_7t99_H_L 7t99 100% -0.6693 6.5 9.0 -0.4992 -0.6901
A4DAB266_7t98_H_L 7t98 99% -0.6558 6.5 9.0 -0.4857 -0.6766
A4DAB266_8ti4_H_L 8ti4 100% -0.7255 6.5 9.0 -0.578 -0.7437
A4DAB266_6dn0_C_D 6dn0 98% -0.5897 8.0 4.0 -0.5312 -0.6042
A4DAB266_7t98_A_B 7t98 99% -0.6412 6.5 4.0 -0.5006 -0.6583
A4DAB266_7mn8_D_C 7mn8 100% -0.717 6.5 4.0 -0.6291 -0.7277
A4DAB266_6my5_A_B 6my5 93% -0.6835 6.5 9.0 -0.4036 -0.7203
A4DAB266_1fve_B_A 1fve 99% -0.7416 6.5 4.0 -0.676 -0.7496
A4DAB266_7t99_E_F 7t99 100% -0.6745 6.5 9.0 -0.468 -0.6998
A4DAB266_5xhf_B_A 5xhf 100% -0.7254 6.5 4.0 -0.5376 -0.7487
A4DAB266_5tdn_B_A 5tdn 98% -0.6985 6.5 9.0 -0.458 -0.7581
A4DAB266_6dn0_A_B 6dn0 98% -0.5998 8.5 4.0 -0.5229 -0.6201
A4DAB266_6bi2_H_L 6bi2 100% -0.7158 6.5 9.0 -0.5269 -0.7389
A4DAB266_6bi0_I_M 6bi0 100% -0.6809 6.5 4.0 -0.4386 -0.7357
A4DAB266_5tdn_D_C 5tdn 98% -0.6936 6.5 4.0 -0.4911 -0.719
A4DAB266_6mh2_B_A 6mh2 100% -0.6968 6.5 4.0 -0.428 -0.7577
A4DAB266_6mxs_H_L 6mxs 93% -0.6769 6.5 4.0 -0.2621 -0.7322
A4DAB266_6mxr_A_B 6mxr 93% -0.6987 6.5 9.0 -0.3547 -0.7442
A4DAB266_3bdy_H_L 3bdy 94% -0.7086 6.5 4.0 -0.5726 -0.7268
A4DAB266_1fvc_B_A 1fvc 100% -0.661 6.5 4.0 -0.5827 -0.6812
A4DAB266_1fvd_B_A 1fvd 98% -0.7277 6.5 4.0 -0.5832 -0.7451
A4DAB266_4ub0_H_L 4ub0 100% -0.7448 6.5 4.0 -0.6186 -0.7603
A4DAB266_5tdo_B_A 5tdo 98% -0.6747 6.5 9.0 -0.4406 -0.7324
A4DAB266_1fvd_D_C 1fvd 98% -0.7552 6.5 4.0 -0.5605 -0.7787
A4DAB266_5xhf_D_C 5xhf 100% -0.7168 6.5 4.0 -0.6094 -0.7299
A4DAB266_7t97_E_F 7t97 100% -0.687 6.5 9.0 -0.5446 -0.7044
A4DAB266_6bhz_H_L 6bhz 100% -0.696 6.5 4.0 -0.4897 -0.7208
A4DAB266_6mxr_H_L 6mxr 93% -0.6875 6.5 4.0 -0.3478 -0.7326