Trontinemab

A4DAB279 | Phase-II
APP Abeta 1-40/42;TFRC/CD71
G1;G1 / None
Roche
Phase-II
Bispecific Mixed Format with Domain Crossover
RG-6102 RG6102 RG 6102 RO 7126209 RO7126209 RO-7126209
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IMGT PubChem (461453731) PubChem (472420579) PubChem (476000870) PubChem (483558703) PubChem (483559431) PubChem (517688549) Thera-SAbDab YAbS
Avg A4D Score
-0.6953
Score Range
-0.7 to -0.69
Structures
2
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB279_5csz_A_B 5csz 100% -0.6911 6.5 4.0 -0.343 -0.7817
A4DAB279_5csz_H_L 5csz 100% -0.6995 6.5 4.0 -0.3347 -0.7944