Tarperprumig

A4DAB283 | Phase-II
ALB;CFP
non-canonical / None
Alexion Pharmaceuticals
Phase-II
Whole mAb
ALXN-1820 ALXN1820 ALXN 1820
—
Avg A4D Score
-0.5043
Score Range
-0.54 to -0.44
Structures
8
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB283_7cyh_E_D 7cyh 96% -0.5401 6.5 4.0 -0.2079 -0.6352
A4DAB283_7cyp_E_D 7cyp 96% -0.5112 6.5 4.0 -0.0919 -0.6313
A4DAB283_7cwt_E_D 7cwt 96% -0.5439 6.5 9.0 -0.1416 -0.6591
A4DAB283_7e5s_R_O 7e5s 96% -0.5026 6.5 9.0 -0.0074 -0.6444
A4DAB283_7cwt_I_J 7cwt 96% -0.4352 6.5 9.0 -0.0164 -0.5552
A4DAB283_7cyp_G_F 7cyp 96% -0.4921 6.5 4.0 -0.0922 -0.6067
A4DAB283_7cyp_I_H 7cyp 96% -0.5233 6.5 4.0 -0.0898 -0.6475
A4DAB283_7cwt_G_F 7cwt 96% -0.4863 6.5 4.0 -0.1186 -0.5917