Upanovimab / 7cyp

A4DAB283_7cyp_G_F | Source PDB: 7cyp | Chains: G, F | Done
96.95
Yes
10 Å
Yes
Avg A4D Score
-0.4921
Max Score
2.2259
Min Score
-3.3631
Total Score
-112.68
Score CDR
-0.0922
Score non-CDR
-0.6067

Calculation Parameters

Chain Sequence(s) VKLVESGGGLVKPGGSLRLSCAASGFTFTNYGMSWVRQAPGKRLEWVAEISSGGSYTYYPDTVTGRFTISRDNAKNTLYLQMNSLRAEDTAVYYCARFRYGGGGTVDYWGQGTLVTVSSIVLTQSPTLSLSPGERATLSCRASESVDNYGISFMNWFQQKPGQAPRLLIYAASNQGSGIPSRFSGSGSGTDFSLTISSLEPEDFAVYFCQQSKEVPRIFGQGTKVEILK input.pdb
Selected Chain(s) G (Heavy), F (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.3631
Maximum Score 2.2259
Average Score -0.4921
Total Score -112.6848

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
2 V G 0.2823 Aggregation-prone
3 K G -1.0775 Soluble
4 L G 0.0000 Buried
5 V G 0.4371 Aggregation-prone
6 E G 0.0000 Buried
7 S G -0.3271 Soluble
8 G G -0.3842 Soluble
9 G G 0.2214 Aggregation-prone
11 G G 0.5875 Aggregation-prone
12 L G 1.4954 Aggregation-prone
13 V G 0.2498 Aggregation-prone
14 K G -1.5169 Soluble
15 P G -1.6023 Soluble
16 G G -1.2800 Soluble
17 G G -1.2533 Soluble
18 S G -1.4676 Soluble
19 L G -1.0273 Soluble
20 R G -2.0243 Soluble
21 L G 0.0000 Buried
22 S G -0.6319 Soluble
23 C G 0.0000 Buried
24 A G -0.2706 Soluble
25 A G -0.6419 Soluble
26 S G -0.5022 Soluble
27 G G -0.6150 Soluble
28 F G -0.3288 Soluble
29 T G -0.5706 Soluble
30 F G 0.0000 Buried
35 T G -1.2458 Soluble
36 N G -1.1736 Soluble
37 Y G -0.5027 Soluble
38 G G -0.3482 Soluble
39 M G 0.0000 Buried
40 S G 0.0000 Buried
41 W G 0.0000 Buried
42 V G 0.0000 Buried
43 R G -0.8723 Soluble
44 Q G -1.2922 Soluble
45 A G 0.0000 Buried
46 P G -1.5279 Soluble
47 G G -1.8226 Soluble
48 K G -3.2770 Soluble
49 R G -3.3631 Soluble
50 L G 0.0000 Buried
51 E G -1.9918 Soluble
52 W G 0.0000 Buried
53 V G 0.0000 Buried
54 A G 0.0000 Buried
55 E G 0.0000 Buried
56 I G 0.0000 Buried
57 S G -0.1065 Soluble
58 S G -0.5747 Soluble
59 G G -0.8947 Soluble
62 G G -0.5524 Soluble
63 S G -0.0313 Soluble
64 Y G 0.9394 Aggregation-prone
65 T G 0.7061 Aggregation-prone
66 Y G 1.0400 Aggregation-prone
67 Y G 0.2016 Aggregation-prone
68 P G -0.3553 Soluble
69 D G -1.1358 Soluble
70 T G -0.0606 Soluble
71 V G 0.9064 Aggregation-prone
72 T G -0.4202 Soluble
74 G G -0.7879 Soluble
75 R G -1.8543 Soluble
76 F G 0.0000 Buried
77 T G -1.0558 Soluble
78 I G 0.0000 Buried
79 S G -0.6041 Soluble
80 R G -1.4116 Soluble
81 D G -2.0625 Soluble
82 N G -2.3734 Soluble
83 A G -1.7496 Soluble
84 K G -2.5163 Soluble
85 N G -1.9483 Soluble
86 T G 0.0000 Buried
87 L G 0.0000 Buried
88 Y G -0.6019 Soluble
89 L G 0.0000 Buried
90 Q G -1.6133 Soluble
91 M G 0.0000 Buried
92 N G -1.6851 Soluble
93 S G -0.9947 Soluble
94 L G 0.0000 Buried
95 R G -1.8573 Soluble
96 A G -1.6015 Soluble
97 E G -2.0890 Soluble
98 D G 0.0000 Buried
99 T G -0.2584 Soluble
100 A G 0.0000 Buried
101 V G 0.5797 Aggregation-prone
102 Y G 0.0000 Buried
103 Y G 0.0000 Buried
104 C G 0.0000 Buried
105 A G 0.0000 Buried
106 R G 0.0000 Buried
107 F G -0.0818 Soluble
108 R G -0.4246 Soluble
109 Y G 0.3697 Aggregation-prone
110 G G -0.2561 Soluble
111 G G -0.4945 Soluble
112 G G -0.6527 Soluble
113 G G 0.0000 Buried
114 T G 0.0000 Buried
115 V G 0.0000 Buried
116 D G 0.0011 Aggregation-prone
117 Y G 0.2550 Aggregation-prone
118 W G 0.0000 Buried
119 G G 0.0000 Buried
120 Q G -1.1725 Soluble
121 G G 0.0000 Buried
122 T G 0.0000 Buried
123 L G 1.3856 Aggregation-prone
124 V G 0.0000 Buried
125 T G 0.3050 Aggregation-prone
126 V G 0.0000 Buried
127 S G -0.7527 Soluble
128 S G -0.4228 Soluble
2 I F 0.6069 Aggregation-prone
3 V F 1.1985 Aggregation-prone
4 L F 0.0000 Buried
5 T F -0.7516 Soluble
6 Q F 0.0000 Buried
7 S F -0.6882 Soluble
8 P F -0.4419 Soluble
10 T F -0.3910 Soluble
11 L F -0.1753 Soluble
12 S F -0.0387 Soluble
13 L F -0.3201 Soluble
14 S F -0.6331 Soluble
15 P F -1.4918 Soluble
16 G F -1.5458 Soluble
17 E F -2.1015 Soluble
18 R F -2.4547 Soluble
19 A F 0.0000 Buried
20 T F -0.6533 Soluble
21 L F 0.0000 Buried
22 S F -0.8601 Soluble
23 C F 0.0000 Buried
24 R F -2.0279 Soluble
25 A F 0.0000 Buried
26 S F -0.7192 Soluble
27 E F -1.5270 Soluble
28 S F -0.2836 Soluble
29 V F 0.5267 Aggregation-prone
30 D F 0.0000 Buried
31 N F 0.8865 Aggregation-prone
34 Y F 1.6088 Aggregation-prone
35 G F 1.0827 Aggregation-prone
36 I F 2.2259 Aggregation-prone
37 S F 0.8585 Aggregation-prone
38 F F 0.3688 Aggregation-prone
39 M F 0.0000 Buried
40 N F 0.0000 Buried
41 W F 0.0000 Buried
42 F F 0.0000 Buried
43 Q F 0.0000 Buried
44 Q F -1.3145 Soluble
45 K F -1.7527 Soluble
46 P F -1.2901 Soluble
47 G F -1.5621 Soluble
48 Q F -2.2125 Soluble
49 A F -1.4027 Soluble
50 P F 0.0000 Buried
51 R F -0.7684 Soluble
52 L F 0.0000 Buried
53 L F 0.0000 Buried
54 I F 0.0000 Buried
55 Y F -0.2947 Soluble
56 A F 0.0000 Buried
57 A F 0.0000 Buried
65 S F -0.8708 Soluble
66 N F -1.1998 Soluble
67 Q F -0.8827 Soluble
68 G F -0.8423 Soluble
69 S F -0.6062 Soluble
70 G F -0.6438 Soluble
71 I F -0.5653 Soluble
72 P F -0.5121 Soluble
74 S F -0.6233 Soluble
75 R F -1.1469 Soluble
76 F F 0.0000 Buried
77 S F -0.8648 Soluble
78 G F -0.6326 Soluble
79 S F -0.7136 Soluble
80 G F -0.5268 Soluble
83 S F -0.3395 Soluble
84 G F 0.2311 Aggregation-prone
85 T F -0.8042 Soluble
86 D F -1.2363 Soluble
87 F F 0.0000 Buried
88 S F -0.7047 Soluble
89 L F 0.0000 Buried
90 T F -0.8764 Soluble
91 I F 0.0000 Buried
92 S F -1.7249 Soluble
93 S F -1.7274 Soluble
94 L F 0.0000 Buried
95 E F -1.9406 Soluble
96 P F -1.6769 Soluble
97 E F -2.3447 Soluble
98 D F -1.9420 Soluble
99 F F -1.1134 Soluble
100 A F 0.0000 Buried
101 V F -0.6264 Soluble
102 Y F 0.0000 Buried
103 F F 0.0000 Buried
104 C F 0.0000 Buried
105 Q F 0.0000 Buried
106 Q F 0.0000 Buried
107 S F -0.8389 Soluble
108 K F -1.6612 Soluble
109 E F -1.2512 Soluble
114 V F 0.6883 Aggregation-prone
115 P F 0.2243 Aggregation-prone
116 R F -0.1604 Soluble
117 I F 0.0042 Aggregation-prone
118 F F 0.0000 Buried
119 G F 0.0000 Buried
120 Q F -1.7845 Soluble
121 G F -1.2719 Soluble
122 T F 0.0000 Buried
123 K F -0.6447 Soluble
124 V F 0.0000 Buried
125 E F -0.7977 Soluble
126 I F -0.5221 Soluble
127 L F 0.4535 Aggregation-prone
128 K F -0.8962 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.5881 3.1416 CSV PDB
4.5 -0.6223 3.1416 CSV PDB
5.0 -0.664 3.1416 CSV PDB
5.5 -0.7042 3.1416 CSV PDB
6.0 -0.7332 3.1416 CSV PDB
6.5 -0.7435 3.1416 CSV PDB
7.0 -0.7336 3.1416 CSV PDB
7.5 -0.7096 3.1415 CSV PDB
8.0 -0.6782 3.1414 CSV PDB
8.5 -0.6426 3.1409 CSV PDB
9.0 -0.6039 3.1395 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH