Calculation Parameters
| Chain Sequence(s) |
QVQLVQSGVEVKKPGASVKVSCKASGYTFTNYYMYWVRQAPGQGLEWMGGINPSNGGTNFNEKFKNRVTLTTDSSTTTAYMELKSLQFDDTAVYYCARRDYRFDMGFDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSEIVLTQSPATLSLSPGERATLSCRASKGVSTSGYSYLHWYQQKPGQAPRLLIYLASYLESGVPARFSGSGSGTDFTLTISSLEPEDFAVYYCQHSRDLPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
input.pdb
|
| Selected Chain(s) | B (Heavy), A (Light) |
| Distance of Aggregation | 10 Å |
| FoldX Energy Minimization | Yes |
| pH Calculations | Yes |
| Downloads | Download all data (.tar.gz) |
Aggrescan4D Profile
Per-Residue A4D Scores
Download CSVResidues with A4D score > 0.0 are highlighted as aggregation-prone.
| Index | Residue | Chain | A4D Score | Classification |
|---|---|---|---|---|
| 1 | Q | B | -1.4733 | Soluble |
| 2 | V | B | -0.8281 | Soluble |
| 3 | Q | B | -1.1278 | Soluble |
| 4 | L | B | 0.0000 | Buried |
| 5 | V | B | 0.3982 | Aggregation-prone |
| 6 | Q | B | 0.0000 | Buried |
| 7 | S | B | -0.4405 | Soluble |
| 8 | G | B | -0.6627 | Soluble |
| 9 | V | B | -0.5382 | Soluble |
| 11 | E | B | -0.9060 | Soluble |
| 12 | V | B | -0.5528 | Soluble |
| 13 | K | B | -1.2896 | Soluble |
| 14 | K | B | -1.9646 | Soluble |
| 15 | P | B | -1.3091 | Soluble |
| 16 | G | B | -1.2140 | Soluble |
| 17 | A | B | -1.3266 | Soluble |
| 18 | S | B | -1.5053 | Soluble |
| 19 | V | B | 0.0000 | Buried |
| 20 | K | B | -1.8139 | Soluble |
| 21 | V | B | 0.0000 | Buried |
| 22 | S | B | -0.4298 | Soluble |
| 23 | C | B | 0.0000 | Buried |
| 24 | K | B | -0.6617 | Soluble |
| 25 | A | B | 0.0000 | Buried |
| 26 | S | B | -0.8098 | Soluble |
| 27 | G | B | -1.0155 | Soluble |
| 28 | Y | B | -0.4275 | Soluble |
| 29 | T | B | -0.1930 | Soluble |
| 30 | F | B | 0.0000 | Buried |
| 35 | T | B | -0.3596 | Soluble |
| 36 | N | B | -0.5526 | Soluble |
| 37 | Y | B | 0.0181 | Aggregation-prone |
| 38 | Y | B | 0.0629 | Aggregation-prone |
| 39 | M | B | 0.0000 | Buried |
| 40 | Y | B | 0.0597 | Aggregation-prone |
| 41 | W | B | 0.0000 | Buried |
| 42 | V | B | 0.0000 | Buried |
| 43 | R | B | 0.0000 | Buried |
| 44 | Q | B | -0.6356 | Soluble |
| 45 | A | B | -1.0248 | Soluble |
| 46 | P | B | -1.0986 | Soluble |
| 47 | G | B | -1.2264 | Soluble |
| 48 | Q | B | -1.7522 | Soluble |
| 49 | G | B | -1.1139 | Soluble |
| 50 | L | B | 0.0000 | Buried |
| 51 | E | B | -0.5340 | Soluble |
| 52 | W | B | 0.0000 | Buried |
| 53 | M | B | 0.0000 | Buried |
| 54 | G | B | 0.0000 | Buried |
| 55 | G | B | 0.0000 | Buried |
| 56 | I | B | 0.0000 | Buried |
| 57 | N | B | 0.0000 | Buried |
| 58 | P | B | -0.7763 | Soluble |
| 59 | S | B | -0.9726 | Soluble |
| 62 | N | B | -1.6781 | Soluble |
| 63 | G | B | -1.2139 | Soluble |
| 64 | G | B | -1.1823 | Soluble |
| 65 | T | B | -0.9552 | Soluble |
| 66 | N | B | -1.4638 | Soluble |
| 67 | F | B | -1.6463 | Soluble |
| 68 | N | B | -2.0751 | Soluble |
| 69 | E | B | -3.5114 | Soluble |
| 70 | K | B | -3.2827 | Soluble |
| 71 | F | B | 0.0000 | Buried |
| 72 | K | B | -3.6737 | Soluble |
| 74 | N | B | -2.8545 | Soluble |
| 75 | R | B | -2.2073 | Soluble |
| 76 | V | B | 0.0000 | Buried |
| 77 | T | B | -0.9513 | Soluble |
| 78 | L | B | 0.0000 | Buried |
| 79 | T | B | -0.3549 | Soluble |
| 80 | T | B | -0.6809 | Soluble |
| 81 | D | B | -1.0063 | Soluble |
| 82 | S | B | -0.7351 | Soluble |
| 83 | S | B | -0.5606 | Soluble |
| 84 | T | B | -0.6085 | Soluble |
| 85 | T | B | -0.6505 | Soluble |
| 86 | T | B | 0.0000 | Buried |
| 87 | A | B | 0.0000 | Buried |
| 88 | Y | B | -0.5295 | Soluble |
| 89 | M | B | 0.0000 | Buried |
| 90 | E | B | -1.3281 | Soluble |
| 91 | L | B | 0.0000 | Buried |
| 92 | K | B | -1.7202 | Soluble |
| 93 | S | B | -1.3930 | Soluble |
| 94 | L | B | 0.0000 | Buried |
| 95 | Q | B | -0.9153 | Soluble |
| 96 | F | B | 0.3456 | Aggregation-prone |
| 97 | D | B | -1.1181 | Soluble |
| 98 | D | B | 0.0000 | Buried |
| 99 | T | B | -0.2832 | Soluble |
| 100 | A | B | 0.0000 | Buried |
| 101 | V | B | 0.1190 | Aggregation-prone |
| 102 | Y | B | 0.0000 | Buried |
| 103 | Y | B | 0.0000 | Buried |
| 104 | C | B | 0.0000 | Buried |
| 105 | A | B | 0.0000 | Buried |
| 106 | R | B | 0.0000 | Buried |
| 107 | R | B | -0.0679 | Soluble |
| 108 | D | B | -0.2350 | Soluble |
| 109 | Y | B | 0.1017 | Aggregation-prone |
| 110 | R | B | -1.1954 | Soluble |
| 111 | F | B | -0.1016 | Soluble |
| 112 | D | B | 0.0289 | Aggregation-prone |
| 113 | M | B | 0.2376 | Aggregation-prone |
| 114 | G | B | 0.0000 | Buried |
| 115 | F | B | 0.0000 | Buried |
| 116 | D | B | -0.2159 | Soluble |
| 117 | Y | B | 0.1783 | Aggregation-prone |
| 118 | W | B | -0.1327 | Soluble |
| 119 | G | B | 0.0000 | Buried |
| 120 | Q | B | -1.2605 | Soluble |
| 121 | G | B | -0.6514 | Soluble |
| 122 | T | B | 0.0000 | Buried |
| 123 | T | B | -0.1989 | Soluble |
| 124 | V | B | 0.0000 | Buried |
| 125 | T | B | 0.0000 | Buried |
| 126 | V | B | 0.0000 | Buried |
| 127 | S | B | -0.6378 | Soluble |
| 128 | S | B | -0.7076 | Soluble |
| 129 | A | B | -0.5334 | Soluble |
| 130 | S | B | -0.5917 | Soluble |
| 131 | T | B | -0.5895 | Soluble |
| 132 | K | B | -1.2685 | Soluble |
| 133 | G | B | -1.5042 | Soluble |
| 134 | P | B | 0.0000 | Buried |
| 135 | S | B | -0.5601 | Soluble |
| 136 | V | B | 0.0000 | Buried |
| 137 | F | B | 0.0000 | Buried |
| 138 | P | B | -0.9386 | Soluble |
| 139 | L | B | 0.0000 | Buried |
| 140 | A | B | -0.0908 | Soluble |
| 141 | P | B | -0.2225 | Soluble |
| 142 | C | B | -0.5605 | Soluble |
| 143 | S | B | -0.8446 | Soluble |
| 144 | R | B | -1.3962 | Soluble |
| 145 | S | B | -1.1861 | Soluble |
| 146 | T | B | -1.1749 | Soluble |
| 147 | S | B | -1.3722 | Soluble |
| 148 | E | B | -1.9692 | Soluble |
| 149 | S | B | -1.0871 | Soluble |
| 150 | T | B | -0.7228 | Soluble |
| 151 | A | B | 0.0000 | Buried |
| 152 | A | B | 0.0000 | Buried |
| 153 | L | B | 0.0000 | Buried |
| 154 | G | B | 0.0000 | Buried |
| 155 | C | B | 0.0000 | Buried |
| 156 | L | B | 0.0000 | Buried |
| 157 | V | B | 0.0000 | Buried |
| 158 | K | B | -0.3319 | Soluble |
| 159 | D | B | -0.5198 | Soluble |
| 160 | Y | B | 0.0000 | Buried |
| 161 | F | B | -0.2587 | Soluble |
| 162 | P | B | 0.0000 | Buried |
| 163 | E | B | -0.6092 | Soluble |
| 164 | P | B | -0.6662 | Soluble |
| 165 | V | B | 0.0000 | Buried |
| 166 | T | B | -0.6300 | Soluble |
| 167 | V | B | -0.3691 | Soluble |
| 168 | S | B | -0.4585 | Soluble |
| 169 | W | B | 0.0000 | Buried |
| 170 | N | B | -1.0095 | Soluble |
| 171 | S | B | -0.7615 | Soluble |
| 172 | G | B | -0.5707 | Soluble |
| 173 | A | B | -0.2431 | Soluble |
| 174 | L | B | -0.0630 | Soluble |
| 175 | T | B | -0.1743 | Soluble |
| 176 | S | B | -0.1821 | Soluble |
| 177 | G | B | -0.2044 | Soluble |
| 178 | V | B | 0.1797 | Aggregation-prone |
| 179 | H | B | -0.2975 | Soluble |
| 180 | T | B | 0.0113 | Aggregation-prone |
| 181 | F | B | 0.0000 | Buried |
| 182 | P | B | -0.4175 | Soluble |
| 183 | A | B | 0.0969 | Aggregation-prone |
| 184 | V | B | 0.3383 | Aggregation-prone |
| 185 | L | B | 1.0238 | Aggregation-prone |
| 186 | Q | B | 0.1759 | Aggregation-prone |
| 187 | S | B | -0.1164 | Soluble |
| 188 | S | B | -0.2619 | Soluble |
| 189 | G | B | 0.0086 | Aggregation-prone |
| 190 | L | B | 0.0796 | Aggregation-prone |
| 191 | Y | B | 0.3489 | Aggregation-prone |
| 192 | S | B | 0.0000 | Buried |
| 193 | L | B | 0.0000 | Buried |
| 194 | S | B | 0.0000 | Buried |
| 195 | S | B | 0.0000 | Buried |
| 196 | V | B | 0.0000 | Buried |
| 197 | V | B | 0.0000 | Buried |
| 198 | T | B | -0.1158 | Soluble |
| 199 | V | B | 0.0000 | Buried |
| 200 | P | B | -0.5782 | Soluble |
| 201 | S | B | -0.8688 | Soluble |
| 202 | S | B | -0.5195 | Soluble |
| 203 | S | B | -0.6812 | Soluble |
| 204 | L | B | -0.6112 | Soluble |
| 205 | G | B | -0.6465 | Soluble |
| 206 | T | B | -0.7785 | Soluble |
| 207 | K | B | -1.3688 | Soluble |
| 208 | T | B | -1.2930 | Soluble |
| 209 | Y | B | 0.0000 | Buried |
| 210 | T | B | 0.0000 | Buried |
| 211 | C | B | 0.0000 | Buried |
| 212 | N | B | -1.6511 | Soluble |
| 213 | V | B | 0.0000 | Buried |
| 214 | D | B | -1.9029 | Soluble |
| 215 | H | B | 0.0000 | Buried |
| 216 | K | B | -2.8006 | Soluble |
| 217 | P | B | -1.5881 | Soluble |
| 218 | S | B | -1.8104 | Soluble |
| 219 | N | B | -2.5555 | Soluble |
| 220 | T | B | -2.0789 | Soluble |
| 221 | K | B | -2.6805 | Soluble |
| 222 | V | B | -1.7526 | Soluble |
| 223 | D | B | -2.6750 | Soluble |
| 224 | K | B | -2.2205 | Soluble |
| 225 | R | B | -2.5084 | Soluble |
| 226 | V | B | -1.2646 | Soluble |
| 227 | E | B | -1.2657 | Soluble |
| 228 | S | B | -1.3475 | Soluble |
| 229 | K | B | -1.3892 | Soluble |
| 230 | Y | B | 0.6023 | Aggregation-prone |
| 231 | G | B | -0.1914 | Soluble |
| 232 | P | B | -0.4116 | Soluble |
| 233 | P | B | -0.4003 | Soluble |
| 234 | C | B | -0.0021 | Soluble |
| 235 | P | B | 0.0729 | Aggregation-prone |
| 236 | P | B | 0.1932 | Aggregation-prone |
| 237 | C | B | 0.6256 | Aggregation-prone |
| 238 | E | B | -1.1605 | Soluble |
| 239 | F | B | 1.2380 | Aggregation-prone |
| 240 | L | B | 1.1429 | Aggregation-prone |
| 241 | G | B | 0.1956 | Aggregation-prone |
| 242 | G | B | -0.0784 | Soluble |
| 243 | P | B | -0.1860 | Soluble |
| 244 | S | B | 0.0087 | Aggregation-prone |
| 245 | V | B | 0.0000 | Buried |
| 246 | F | B | 1.5121 | Aggregation-prone |
| 247 | L | B | 0.0000 | Buried |
| 248 | F | B | 1.2308 | Aggregation-prone |
| 249 | P | B | -0.1349 | Soluble |
| 250 | P | B | -1.3283 | Soluble |
| 251 | K | B | -2.7488 | Soluble |
| 252 | P | B | -2.5482 | Soluble |
| 253 | K | B | -2.9632 | Soluble |
| 254 | D | B | -2.5971 | Soluble |
| 255 | T | B | -0.7168 | Soluble |
| 256 | L | B | 1.5440 | Aggregation-prone |
| 257 | M | B | 2.2430 | Aggregation-prone |
| 258 | I | B | 2.0283 | Aggregation-prone |
| 259 | S | B | 0.3145 | Aggregation-prone |
| 260 | R | B | -0.9236 | Soluble |
| 261 | T | B | -0.6686 | Soluble |
| 262 | P | B | -1.0581 | Soluble |
| 263 | E | B | -0.9020 | Soluble |
| 264 | V | B | 0.0000 | Buried |
| 265 | T | B | 0.1561 | Aggregation-prone |
| 266 | C | B | 0.0000 | Buried |
| 267 | V | B | 0.9135 | Aggregation-prone |
| 268 | V | B | 0.0000 | Buried |
| 269 | V | B | 0.1056 | Aggregation-prone |
| 270 | D | B | -0.6223 | Soluble |
| 271 | V | B | 0.0000 | Buried |
| 272 | S | B | -1.7004 | Soluble |
| 273 | Q | B | -2.6580 | Soluble |
| 274 | E | B | -3.1633 | Soluble |
| 275 | D | B | -2.6320 | Soluble |
| 276 | P | B | -2.7210 | Soluble |
| 277 | E | B | -2.7847 | Soluble |
| 278 | V | B | -1.6996 | Soluble |
| 279 | Q | B | -1.5107 | Soluble |
| 280 | F | B | -0.7167 | Soluble |
| 281 | N | B | -0.8945 | Soluble |
| 282 | W | B | 0.0000 | Buried |
| 283 | Y | B | -0.6213 | Soluble |
| 284 | V | B | 0.0000 | Buried |
| 285 | D | B | -1.1571 | Soluble |
| 286 | G | B | -0.5825 | Soluble |
| 287 | V | B | 0.4904 | Aggregation-prone |
| 288 | E | B | -0.7599 | Soluble |
| 289 | V | B | -0.7414 | Soluble |
| 290 | H | B | -1.8841 | Soluble |
| 291 | N | B | -2.1396 | Soluble |
| 292 | A | B | -1.8184 | Soluble |
| 293 | K | B | -2.3854 | Soluble |
| 294 | T | B | -1.7848 | Soluble |
| 295 | K | B | -2.2450 | Soluble |
| 296 | P | B | -2.1782 | Soluble |
| 297 | R | B | -3.5997 | Soluble |
| 298 | E | B | -3.7602 | Soluble |
| 299 | E | B | -3.2945 | Soluble |
| 300 | Q | B | -1.9696 | Soluble |
| 301 | F | B | -0.2788 | Soluble |
| 302 | N | B | -1.0195 | Soluble |
| 303 | S | B | -1.0518 | Soluble |
| 304 | T | B | -1.5094 | Soluble |
| 305 | Y | B | -2.3144 | Soluble |
| 306 | R | B | -2.0353 | Soluble |
| 307 | V | B | 0.0000 | Buried |
| 308 | V | B | -0.8204 | Soluble |
| 309 | S | B | 0.0000 | Buried |
| 310 | V | B | 0.0000 | Buried |
| 311 | L | B | 0.0000 | Buried |
| 312 | T | B | -0.5288 | Soluble |
| 313 | V | B | -0.0983 | Soluble |
| 314 | L | B | -0.1764 | Soluble |
| 315 | H | B | -1.2672 | Soluble |
| 316 | Q | B | -1.4389 | Soluble |
| 317 | D | B | 0.0000 | Buried |
| 318 | W | B | -0.4383 | Soluble |
| 319 | L | B | -0.4385 | Soluble |
| 320 | N | B | 0.0000 | Buried |
| 321 | G | B | -1.3481 | Soluble |
| 322 | K | B | 0.0000 | Buried |
| 323 | E | B | -1.6529 | Soluble |
| 324 | Y | B | 0.0000 | Buried |
| 325 | K | B | -1.2733 | Soluble |
| 326 | C | B | 0.0000 | Buried |
| 327 | K | B | -1.0413 | Soluble |
| 328 | V | B | 0.0000 | Buried |
| 329 | S | B | -1.1373 | Soluble |
| 330 | N | B | 0.0000 | Buried |
| 331 | K | B | -2.7114 | Soluble |
| 332 | G | B | -2.0384 | Soluble |
| 333 | L | B | -0.8353 | Soluble |
| 334 | P | B | -0.7569 | Soluble |
| 335 | S | B | -0.5672 | Soluble |
| 336 | S | B | -0.6637 | Soluble |
| 337 | I | B | -0.6896 | Soluble |
| 338 | E | B | -1.4124 | Soluble |
| 339 | K | B | -0.7999 | Soluble |
| 340 | T | B | -0.6551 | Soluble |
| 341 | I | B | -0.2506 | Soluble |
| 342 | S | B | -0.9278 | Soluble |
| 343 | K | B | -1.3673 | Soluble |
| 344 | A | B | -1.1521 | Soluble |
| 345 | K | B | -2.1338 | Soluble |
| 346 | G | B | -1.5602 | Soluble |
| 347 | Q | B | -1.7346 | Soluble |
| 348 | P | B | -1.6865 | Soluble |
| 349 | R | B | -1.9372 | Soluble |
| 350 | E | B | -2.8338 | Soluble |
| 351 | P | B | 0.0000 | Buried |
| 352 | Q | B | -1.4426 | Soluble |
| 353 | V | B | 0.0000 | Buried |
| 354 | Y | B | 0.4480 | Aggregation-prone |
| 355 | T | B | 0.2701 | Aggregation-prone |
| 356 | L | B | 0.5823 | Aggregation-prone |
| 357 | P | B | -0.1372 | Soluble |
| 358 | P | B | -0.8327 | Soluble |
| 359 | S | B | -1.4127 | Soluble |
| 360 | Q | B | -2.2590 | Soluble |
| 361 | E | B | -2.8475 | Soluble |
| 362 | E | B | -2.4760 | Soluble |
| 363 | M | B | -2.1813 | Soluble |
| 364 | T | B | -2.0570 | Soluble |
| 365 | K | B | -3.1119 | Soluble |
| 366 | N | B | -2.9464 | Soluble |
| 367 | Q | B | -2.6944 | Soluble |
| 368 | V | B | 0.0000 | Buried |
| 369 | S | B | -0.6392 | Soluble |
| 370 | L | B | 0.0000 | Buried |
| 371 | T | B | 0.1395 | Aggregation-prone |
| 372 | C | B | 0.0000 | Buried |
| 373 | L | B | 0.5169 | Aggregation-prone |
| 374 | V | B | 0.0000 | Buried |
| 375 | K | B | -0.5848 | Soluble |
| 376 | G | B | -1.1562 | Soluble |
| 377 | F | B | 0.0000 | Buried |
| 378 | Y | B | 0.0000 | Buried |
| 379 | P | B | -1.3296 | Soluble |
| 380 | S | B | -0.7333 | Soluble |
| 381 | D | B | -1.9182 | Soluble |
| 382 | I | B | -0.8452 | Soluble |
| 383 | A | B | -0.1070 | Soluble |
| 384 | V | B | -0.2608 | Soluble |
| 385 | E | B | -1.2722 | Soluble |
| 386 | W | B | 0.0000 | Buried |
| 387 | E | B | -1.6257 | Soluble |
| 388 | S | B | 0.0000 | Buried |
| 389 | N | B | -1.8035 | Soluble |
| 390 | G | B | -1.7241 | Soluble |
| 391 | Q | B | -2.1155 | Soluble |
| 392 | P | B | -1.8003 | Soluble |
| 393 | E | B | -1.7875 | Soluble |
| 394 | N | B | -2.1303 | Soluble |
| 395 | N | B | -1.7531 | Soluble |
| 396 | Y | B | -1.5870 | Soluble |
| 397 | K | B | -2.1307 | Soluble |
| 398 | T | B | -0.9545 | Soluble |
| 399 | T | B | -0.2430 | Soluble |
| 400 | P | B | -0.0792 | Soluble |
| 401 | P | B | 0.4444 | Aggregation-prone |
| 402 | V | B | 1.4820 | Aggregation-prone |
| 403 | L | B | 0.8698 | Aggregation-prone |
| 404 | D | B | -0.3042 | Soluble |
| 405 | S | B | -0.8675 | Soluble |
| 406 | D | B | -1.6774 | Soluble |
| 407 | G | B | 0.0000 | Buried |
| 408 | S | B | 0.0000 | Buried |
| 409 | F | B | 0.2366 | Aggregation-prone |
| 410 | F | B | 0.6546 | Aggregation-prone |
| 411 | L | B | 0.0000 | Buried |
| 412 | Y | B | 0.4958 | Aggregation-prone |
| 413 | S | B | 0.0000 | Buried |
| 414 | R | B | -1.2706 | Soluble |
| 415 | L | B | 0.0000 | Buried |
| 416 | T | B | -1.2207 | Soluble |
| 417 | V | B | 0.0000 | Buried |
| 418 | D | B | -2.5770 | Soluble |
| 419 | K | B | -2.7644 | Soluble |
| 420 | S | B | -2.2125 | Soluble |
| 421 | R | B | -2.0418 | Soluble |
| 422 | W | B | 0.0000 | Buried |
| 423 | Q | B | -2.3748 | Soluble |
| 424 | Q | B | -2.1747 | Soluble |
| 425 | G | B | -1.4182 | Soluble |
| 426 | N | B | -0.9993 | Soluble |
| 427 | V | B | -0.3055 | Soluble |
| 428 | F | B | 0.0000 | Buried |
| 429 | S | B | 0.0000 | Buried |
| 430 | C | B | 0.0000 | Buried |
| 431 | S | B | 0.0000 | Buried |
| 432 | V | B | 0.0000 | Buried |
| 433 | M | B | -0.6844 | Soluble |
| 434 | H | B | 0.0000 | Buried |
| 435 | E | B | -2.6942 | Soluble |
| 436 | A | B | -2.0918 | Soluble |
| 437 | L | B | -1.9434 | Soluble |
| 438 | H | B | -2.1288 | Soluble |
| 439 | N | B | -2.1797 | Soluble |
| 440 | H | B | -2.1513 | Soluble |
| 441 | Y | B | -0.8140 | Soluble |
| 442 | T | B | -0.9141 | Soluble |
| 443 | Q | B | -1.1876 | Soluble |
| 444 | K | B | -1.4956 | Soluble |
| 445 | S | B | -0.7985 | Soluble |
| 446 | L | B | 0.0000 | Buried |
| 447 | S | B | -0.2970 | Soluble |
| 448 | L | B | -0.3886 | Soluble |
| 449 | S | B | -0.2711 | Soluble |
| 1 | E | A | -1.5326 | Soluble |
| 2 | I | A | 0.0000 | Buried |
| 3 | V | A | 0.6984 | Aggregation-prone |
| 4 | L | A | 0.0000 | Buried |
| 5 | T | A | -0.4409 | Soluble |
| 6 | Q | A | -0.5033 | Soluble |
| 7 | S | A | -0.6983 | Soluble |
| 8 | P | A | -0.4194 | Soluble |
| 9 | A | A | -0.5044 | Soluble |
| 10 | T | A | -0.6369 | Soluble |
| 11 | L | A | -0.4493 | Soluble |
| 12 | S | A | -0.6892 | Soluble |
| 13 | L | A | -1.1303 | Soluble |
| 14 | S | A | -1.5610 | Soluble |
| 15 | P | A | -1.8587 | Soluble |
| 16 | G | A | -1.8454 | Soluble |
| 17 | E | A | -2.5393 | Soluble |
| 18 | R | A | -2.8113 | Soluble |
| 19 | A | A | 0.0000 | Buried |
| 20 | T | A | -0.6590 | Soluble |
| 21 | L | A | 0.0000 | Buried |
| 22 | S | A | -0.7960 | Soluble |
| 23 | C | A | 0.0000 | Buried |
| 24 | R | A | -1.9997 | Soluble |
| 25 | A | A | 0.0000 | Buried |
| 26 | S | A | -1.1648 | Soluble |
| 27 | K | A | -2.4151 | Soluble |
| 28 | G | A | -1.7300 | Soluble |
| 29 | V | A | 0.0000 | Buried |
| 30 | S | A | -0.6796 | Soluble |
| 31 | T | A | -0.3988 | Soluble |
| 34 | S | A | -0.3047 | Soluble |
| 35 | G | A | -0.3243 | Soluble |
| 36 | Y | A | 0.0622 | Aggregation-prone |
| 37 | S | A | -0.2425 | Soluble |
| 38 | Y | A | -0.3337 | Soluble |
| 39 | L | A | 0.0000 | Buried |
| 40 | H | A | 0.0000 | Buried |
| 41 | W | A | 0.0000 | Buried |
| 42 | Y | A | 0.0000 | Buried |
| 43 | Q | A | 0.0000 | Buried |
| 44 | Q | A | 0.0000 | Buried |
| 45 | K | A | -1.6287 | Soluble |
| 46 | P | A | -1.3911 | Soluble |
| 47 | G | A | -1.5864 | Soluble |
| 48 | Q | A | -2.0016 | Soluble |
| 49 | A | A | -1.2072 | Soluble |
| 50 | P | A | 0.0000 | Buried |
| 51 | R | A | -0.9879 | Soluble |
| 52 | L | A | 0.0000 | Buried |
| 53 | L | A | 0.0000 | Buried |
| 54 | I | A | 0.0000 | Buried |
| 55 | Y | A | 0.5117 | Aggregation-prone |
| 56 | L | A | 0.0000 | Buried |
| 57 | A | A | 0.0000 | Buried |
| 65 | S | A | 0.2106 | Aggregation-prone |
| 66 | Y | A | 0.9223 | Aggregation-prone |
| 67 | L | A | 0.7528 | Aggregation-prone |
| 68 | E | A | -0.0611 | Soluble |
| 69 | S | A | -0.3519 | Soluble |
| 70 | G | A | -0.5424 | Soluble |
| 71 | V | A | 0.0000 | Buried |
| 72 | P | A | -0.2565 | Soluble |
| 74 | A | A | -0.2119 | Soluble |
| 75 | R | A | -0.7661 | Soluble |
| 76 | F | A | 0.0000 | Buried |
| 77 | S | A | -0.1539 | Soluble |
| 78 | G | A | -0.0898 | Soluble |
| 79 | S | A | -0.6372 | Soluble |
| 80 | G | A | -1.1304 | Soluble |
| 83 | S | A | -0.9976 | Soluble |
| 84 | G | A | -1.1775 | Soluble |
| 85 | T | A | -1.8368 | Soluble |
| 86 | D | A | -2.3474 | Soluble |
| 87 | F | A | 0.0000 | Buried |
| 88 | T | A | -0.7785 | Soluble |
| 89 | L | A | 0.0000 | Buried |
| 90 | T | A | -0.6824 | Soluble |
| 91 | I | A | 0.0000 | Buried |
| 92 | S | A | -1.6849 | Soluble |
| 93 | S | A | -1.8434 | Soluble |
| 94 | L | A | 0.0000 | Buried |
| 95 | E | A | -2.1746 | Soluble |
| 96 | P | A | -2.1494 | Soluble |
| 97 | E | A | -2.3048 | Soluble |
| 98 | D | A | 0.0000 | Buried |
| 99 | F | A | -1.4414 | Soluble |
| 100 | A | A | 0.0000 | Buried |
| 101 | V | A | -0.7405 | Soluble |
| 102 | Y | A | 0.0000 | Buried |
| 103 | Y | A | 0.0000 | Buried |
| 104 | C | A | 0.0000 | Buried |
| 105 | Q | A | 0.0000 | Buried |
| 106 | H | A | 0.0000 | Buried |
| 107 | S | A | -0.7045 | Soluble |
| 108 | R | A | -1.7682 | Soluble |
| 109 | D | A | -1.4995 | Soluble |
| 114 | L | A | -0.3222 | Soluble |
| 115 | P | A | -0.8981 | Soluble |
| 116 | L | A | 0.0000 | Buried |
| 117 | T | A | -0.1258 | Soluble |
| 118 | F | A | 0.2308 | Aggregation-prone |
| 119 | G | A | 0.0000 | Buried |
| 120 | G | A | -0.6690 | Soluble |
| 121 | G | A | -0.8173 | Soluble |
| 122 | T | A | 0.0000 | Buried |
| 123 | K | A | -1.6154 | Soluble |
| 124 | V | A | 0.0000 | Buried |
| 125 | E | A | -1.4347 | Soluble |
| 126 | I | A | 0.0000 | Buried |
| 127 | K | A | -1.2158 | Soluble |
| 128 | R | A | -1.0796 | Soluble |
| 129 | T | A | -0.0739 | Soluble |
| 130 | V | A | 0.4160 | Aggregation-prone |
| 131 | A | A | -0.0417 | Soluble |
| 132 | A | A | -0.1218 | Soluble |
| 133 | P | A | 0.0000 | Buried |
| 134 | S | A | -0.1816 | Soluble |
| 135 | V | A | 0.0000 | Buried |
| 136 | F | A | 0.0591 | Aggregation-prone |
| 137 | I | A | 0.0418 | Aggregation-prone |
| 138 | F | A | 0.0000 | Buried |
| 139 | P | A | -0.2077 | Soluble |
| 140 | P | A | 0.0000 | Buried |
| 141 | S | A | -1.5815 | Soluble |
| 142 | D | A | -2.9825 | Soluble |
| 143 | E | A | -3.0728 | Soluble |
| 144 | Q | A | 0.0000 | Buried |
| 145 | L | A | -2.4014 | Soluble |
| 146 | K | A | -2.8835 | Soluble |
| 147 | S | A | -1.8410 | Soluble |
| 148 | G | A | -1.3221 | Soluble |
| 149 | T | A | -0.9436 | Soluble |
| 150 | A | A | 0.0000 | Buried |
| 151 | S | A | 0.0000 | Buried |
| 152 | V | A | 0.0000 | Buried |
| 153 | V | A | 0.0000 | Buried |
| 154 | C | A | 0.0000 | Buried |
| 155 | L | A | 0.0000 | Buried |
| 156 | L | A | 0.0000 | Buried |
| 157 | N | A | 0.0000 | Buried |
| 158 | N | A | -0.8202 | Soluble |
| 159 | F | A | 0.0000 | Buried |
| 160 | Y | A | 0.0000 | Buried |
| 161 | P | A | -1.6771 | Soluble |
| 162 | R | A | -3.0716 | Soluble |
| 163 | E | A | -3.2226 | Soluble |
| 164 | A | A | -2.2602 | Soluble |
| 165 | K | A | -2.2098 | Soluble |
| 166 | V | A | 0.0000 | Buried |
| 167 | Q | A | -0.7118 | Soluble |
| 168 | W | A | 0.0000 | Buried |
| 169 | K | A | -0.6835 | Soluble |
| 170 | V | A | 0.0000 | Buried |
| 171 | D | A | -1.6036 | Soluble |
| 172 | N | A | -1.4218 | Soluble |
| 173 | A | A | -0.2812 | Soluble |
| 174 | L | A | 0.6146 | Aggregation-prone |
| 175 | Q | A | -0.1344 | Soluble |
| 176 | S | A | -0.4178 | Soluble |
| 177 | G | A | -0.8521 | Soluble |
| 178 | N | A | -0.7560 | Soluble |
| 179 | S | A | -1.0883 | Soluble |
| 180 | Q | A | -1.3005 | Soluble |
| 181 | E | A | -1.9385 | Soluble |
| 182 | S | A | -1.0088 | Soluble |
| 183 | V | A | -0.8314 | Soluble |
| 184 | T | A | -1.1590 | Soluble |
| 185 | E | A | -2.3067 | Soluble |
| 186 | Q | A | 0.0000 | Buried |
| 187 | D | A | -1.9972 | Soluble |
| 188 | S | A | -2.3108 | Soluble |
| 189 | K | A | -2.6069 | Soluble |
| 190 | D | A | -1.7897 | Soluble |
| 191 | S | A | 0.0000 | Buried |
| 192 | T | A | 0.0000 | Buried |
| 193 | Y | A | -1.2941 | Soluble |
| 194 | S | A | 0.0000 | Buried |
| 195 | L | A | 0.0000 | Buried |
| 196 | S | A | 0.0000 | Buried |
| 197 | S | A | 0.0000 | Buried |
| 198 | T | A | -0.6074 | Soluble |
| 199 | L | A | 0.0000 | Buried |
| 200 | T | A | -0.3064 | Soluble |
| 201 | L | A | -0.6737 | Soluble |
| 202 | S | A | -1.0962 | Soluble |
| 203 | K | A | -2.1507 | Soluble |
| 204 | A | A | -1.8887 | Soluble |
| 205 | D | A | -2.4897 | Soluble |
| 206 | Y | A | 0.0000 | Buried |
| 207 | E | A | -3.3066 | Soluble |
| 208 | K | A | -3.3996 | Soluble |
| 209 | H | A | -2.5338 | Soluble |
| 210 | K | A | -2.3787 | Soluble |
| 211 | V | A | -0.8734 | Soluble |
| 212 | Y | A | 0.0000 | Buried |
| 213 | A | A | 0.0000 | Buried |
| 214 | C | A | 0.0000 | Buried |
| 215 | E | A | -0.8752 | Soluble |
| 216 | V | A | 0.0000 | Buried |
| 217 | T | A | -1.1685 | Soluble |
| 218 | H | A | 0.0000 | Buried |
| 219 | Q | A | -1.5810 | Soluble |
| 220 | G | A | -0.4092 | Soluble |
| 221 | L | A | -0.2614 | Soluble |
| 222 | S | A | -0.5004 | Soluble |
| 223 | S | A | -0.4156 | Soluble |
| 224 | P | A | -0.4966 | Soluble |
| 225 | V | A | -0.0058 | Soluble |
| 226 | T | A | -0.4444 | Soluble |
| 227 | K | A | -0.6072 | Soluble |
| 228 | S | A | -0.5282 | Soluble |
| 229 | F | A | 0.0000 | Buried |
| 230 | N | A | -1.3864 | Soluble |
| 231 | R | A | -1.8655 | Soluble |
| 232 | G | A | -1.6698 | Soluble |
| 233 | E | A | -2.0519 | Soluble |
| 234 | C | A | -0.5923 | Soluble |
3D Structure — colored by A4D score
pH-Dependent Aggregation Profiles
A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.
| pH | Avg A4D Score | Max A4D Score | Downloads |
|---|---|---|---|
| 4.0 | -0.6771 | 4.9116 | CSV PDB |
| 4.5 | -0.7292 | 4.87 | CSV PDB |
| 5.0 | -0.7921 | 4.8088 | CSV PDB |
| 5.5 | -0.852 | 4.7383 | CSV PDB |
| 6.0 | -0.8936 | 4.6693 | CSV PDB |
| 6.5 | -0.9056 | 4.6592 | CSV PDB |
| 7.0 | -0.8886 | 4.6592 | CSV PDB |
| 7.5 | -0.8534 | 4.6592 | CSV PDB |
| 8.0 | -0.8092 | 4.6591 | CSV PDB |
| 8.5 | -0.7592 | 4.6587 | CSV PDB |
| 9.0 | -0.7039 | 4.6576 | CSV PDB |