Pembrolizumab

A4DAB205 | Cancer | Approved
PDCD1/CD279/PD1
G4 / IgG4
Aduro BioTech AIO Studien gGmbH Amgen Augusta University Bayer BerGenBio Big Ten Cancer Research Consortium BioLineRx Canadian Cancer Trials Group Celgene Corporation Columbia University Dana-Farber Cancer Institute DNAtrix Duke University Eisai Co Ltd Eli Lilly Emory University Fox Chase Cancer Center Genexine Gilead Sciences H. Lee Moffitt Cancer Center and Research Institute Hoosier Cancer Research Network Icahn School of Medicine at Mount Sinai ImmunoGen Incyte Corporation Institut fuer Frauengesundheit Institute of Cancer Research M. D. Anderson Cancer Center Massachusetts General Hospital Mayo Clinic Memorial Sloan-Kettering Cancer Center Merck & Co Merck Sharp & Dohme National Cancer Center Hospital East National Cancer Institute (France) National Cancer Institute (USA) Netherlands Cancer Institute Northwestern University NYU Langone Medical Center Oslo University Hospital Plexxikon Providence Health & Services Royal Marsden NHS Foundation Trust Sarcoma Alliance for Research through Collaboration Sellas Life Sciences Group Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Spanish Breast Cancer Research Group Syndax Pharmaceuticals TG Therapeutics Inc University Health Network University of Alabama University of Birmingham University of California at Los Angeles University of California at San Francisco University of California San Diego University of Colorado at Denver University of Miami University of Pittsburgh University of Utah University of Washington Verastem Oncology Wakayama Medical University Washington University School of Medicine Yale University The Leukemia & Lymphoma Society
Approved
Whole mAb
MK-3475 MK3475 MK 3475 Keytruda Lambrolizumab SCH-900475 SCH900475 SCH 900475
5.5
IMGT PubChem (187051801) PubChem (194140938) PubChem (347910395) PubChem (354355033) PubChem (377483934) PubChem (384647091) PubChem (385327548) PubChem (387061105) PubChem (469499371) PubChem (469691028) PubChem (472217543) PubChem (472404427) PubChem (475546924) PubChem (481101797) PubChem (481155337) PubChem (488414049) PubChem (496740296) PubChem (498097597) PubChem (508644829) PubChem (519903473) Thera-SAbDab YAbS
Avg A4D Score
-0.6511
Score Range
-0.74 to -0.55
Structures
11
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB205_5dk3_B_A 5dk3 100% -0.7435 6.5 4.0 -0.4312 -0.7697
A4DAB205_8sjk_B_A 8sjk 100% -0.7406 6.5 4.0 -0.4731 -0.7638
A4DAB205_5jxe_G_F 5jxe 100% -0.7082 6.5 9.0 -0.4171 -0.7471
A4DAB205_5dk3_G_F 5dk3 100% -0.7295 6.5 4.0 -0.3694 -0.7598
A4DAB205_5b8c_B_A 5b8c 100% -0.5695 6.5 4.0 -0.513 -0.5855
A4DAB205_5ggs_C_D 5ggs 100% -0.6771 6.5 9.0 -0.449 -0.7073
A4DAB205_5b8c_E_D 5b8c 100% -0.5554 6.5 9.0 N/A N/A
A4DAB205_5ggs_A_B 5ggs 100% -0.6801 6.5 4.0 -0.4477 -0.7109
A4DAB205_5b8c_H_G 5b8c 100% -0.5456 6.5 9.0 -0.4195 -0.5813
A4DAB205_5jxe_D_C 5jxe 100% -0.6562 6.5 4.0 -0.4539 -0.6848
A4DAB205_5b8c_K_J 5b8c 100% -0.556 6.5 9.0 -0.5181 -0.5668