Epcoritamab / 6y92

A4DAB106_6y92_H_L | Source PDB: 6y92 | Chains: H, L | Done
98.25
Yes
10 Å
Yes
Avg A4D Score
-0.702
Max Score
1.5785
Min Score
-3.7066
Total Score
-299.77
Score CDR
-0.1958
Score non-CDR
-0.7677

Calculation Parameters

Chain Sequence(s) EVQLVESGGGLVQPGRSLRLSCAASGFTFNDYAMHWVRQAPGKGLEWVSTISWNSGSIGYADSVKGRFTISRDNAKKSLYLQMNSLRAEDTALYYCAKDIQYGNYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPEIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPITFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.7066
Maximum Score 1.5785
Average Score -0.702
Total Score -299.7741

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E H -1.8593 Soluble
2 V H -0.8305 Soluble
3 Q H -1.0827 Soluble
4 L H 0.0000 Buried
5 V H 0.9824 Aggregation-prone
6 E H 0.1257 Aggregation-prone
7 S H -0.5505 Soluble
8 G H -1.0926 Soluble
9 G H -0.7748 Soluble
11 G H 0.0655 Aggregation-prone
12 L H 1.2057 Aggregation-prone
13 V H -0.0981 Soluble
14 Q H -1.1150 Soluble
15 P H -0.8546 Soluble
16 G H -1.4455 Soluble
17 R H -2.3065 Soluble
18 S H -1.8044 Soluble
19 L H -1.3803 Soluble
20 R H -2.0611 Soluble
21 L H -1.0708 Soluble
22 S H -0.3272 Soluble
23 C H 0.0000 Buried
24 A H -0.0725 Soluble
25 A H 0.0000 Buried
26 S H -0.6396 Soluble
27 G H -0.7036 Soluble
28 F H -0.1007 Soluble
29 T H -0.6931 Soluble
30 F H 0.0000 Buried
35 N H -2.2583 Soluble
36 D H -1.8087 Soluble
37 Y H -0.3322 Soluble
38 A H 0.0000 Buried
39 M H 0.0000 Buried
40 H H 0.0191 Aggregation-prone
41 W H 0.0000 Buried
42 V H 0.0330 Aggregation-prone
43 R H 0.0000 Buried
44 Q H -0.8789 Soluble
45 A H -1.3777 Soluble
46 P H -1.0176 Soluble
47 G H -1.4567 Soluble
48 K H -2.4095 Soluble
49 G H -1.6432 Soluble
50 L H -0.9503 Soluble
51 E H -1.0341 Soluble
52 W H -0.3795 Soluble
53 V H 0.0000 Buried
54 S H 0.0000 Buried
55 T H 0.3826 Aggregation-prone
56 I H 0.0000 Buried
57 S H -0.1320 Soluble
58 W H -0.5224 Soluble
59 N H -1.6078 Soluble
62 S H -0.5596 Soluble
63 G H -0.5844 Soluble
64 S H -0.0360 Soluble
65 I H 0.9208 Aggregation-prone
66 G H 0.4675 Aggregation-prone
67 Y H -0.0934 Soluble
68 A H -0.9753 Soluble
69 D H -2.1131 Soluble
70 S H -1.5750 Soluble
71 V H 0.0000 Buried
72 K H -2.4963 Soluble
74 G H -1.5702 Soluble
75 R H -1.5865 Soluble
76 F H -0.9096 Soluble
77 T H -0.3630 Soluble
78 I H 0.2041 Aggregation-prone
79 S H -0.4912 Soluble
80 R H -1.3812 Soluble
81 D H -2.3001 Soluble
82 N H -2.6585 Soluble
83 A H -2.0127 Soluble
84 K H -2.5326 Soluble
85 K H -2.1116 Soluble
86 S H -1.2360 Soluble
87 L H 0.0000 Buried
88 Y H -0.1142 Soluble
89 L H 0.0000 Buried
90 Q H -1.0506 Soluble
91 M H -1.1482 Soluble
92 N H -1.9516 Soluble
93 S H -0.7401 Soluble
94 L H 0.0478 Aggregation-prone
95 R H -0.5400 Soluble
96 A H -0.8431 Soluble
97 E H -2.0303 Soluble
98 D H -1.7728 Soluble
99 T H -0.7945 Soluble
100 A H -0.3723 Soluble
101 L H 0.1740 Aggregation-prone
102 Y H 0.0000 Buried
103 Y H 0.0842 Aggregation-prone
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 K H 0.0000 Buried
107 D H 0.0000 Buried
108 I H 1.0750 Aggregation-prone
109 Q H 0.9273 Aggregation-prone
110 Y H 1.1265 Aggregation-prone
111 G H -0.0573 Soluble
111A N H -0.2731 Soluble
112A Y H 1.2454 Aggregation-prone
112 Y H 1.5785 Aggregation-prone
113 Y H 1.1140 Aggregation-prone
114 G H 0.3424 Aggregation-prone
115 M H 0.1021 Aggregation-prone
116 D H -0.6810 Soluble
117 V H -0.2378 Soluble
118 W H -0.2514 Soluble
119 G H -0.4473 Soluble
120 Q H -1.1860 Soluble
121 G H -0.5819 Soluble
122 T H -0.4435 Soluble
123 T H 0.1170 Aggregation-prone
124 V H 0.4440 Aggregation-prone
125 T H 0.0921 Aggregation-prone
126 V H 0.4182 Aggregation-prone
127 S H 0.0784 Aggregation-prone
128 S H -0.3775 Soluble
129 A H -0.4473 Soluble
130 S H -0.6617 Soluble
131 T H -1.0685 Soluble
132 K H -2.0366 Soluble
133 G H -1.6200 Soluble
134 P H -0.9855 Soluble
135 S H -0.3240 Soluble
136 V H -0.0972 Soluble
137 F H -0.1787 Soluble
138 P H -0.7136 Soluble
139 L H -0.1283 Soluble
140 A H -0.7380 Soluble
141 P H 0.0000 Buried
142 G H -0.5887 Soluble
143 G H -0.6329 Soluble
144 T H -0.5029 Soluble
145 A H -0.3094 Soluble
146 A H 0.0967 Aggregation-prone
147 L H 0.0000 Buried
148 G H 0.0000 Buried
149 C H 0.0000 Buried
150 L H 0.3710 Aggregation-prone
151 V H 0.0000 Buried
152 K H -0.3787 Soluble
153 D H -0.7406 Soluble
154 Y H 0.0000 Buried
155 F H -0.9667 Soluble
156 P H -1.1417 Soluble
157 E H -1.8444 Soluble
158 P H -1.3958 Soluble
159 V H -0.5109 Soluble
160 T H -0.2947 Soluble
161 V H 0.2445 Aggregation-prone
162 S H 0.2081 Aggregation-prone
163 W H 0.0000 Buried
164 N H -0.1606 Soluble
165 S H -0.3208 Soluble
166 G H -0.4018 Soluble
167 A H -0.0980 Soluble
168 L H 0.4655 Aggregation-prone
169 T H 0.3330 Aggregation-prone
170 S H 0.2508 Aggregation-prone
171 G H 0.4621 Aggregation-prone
172 V H 1.5465 Aggregation-prone
173 H H 0.6367 Aggregation-prone
174 T H 0.2185 Aggregation-prone
175 F H -0.0015 Soluble
176 P H 0.0584 Aggregation-prone
177 A H 0.4455 Aggregation-prone
178 V H 0.7566 Aggregation-prone
179 L H 1.2600 Aggregation-prone
180 Q H 0.2526 Aggregation-prone
181 S H -0.1001 Soluble
182 S H -0.1391 Soluble
183 G H 0.2523 Aggregation-prone
184 L H 0.4823 Aggregation-prone
185 Y H 0.5822 Aggregation-prone
186 S H 0.4182 Aggregation-prone
187 L H 0.2413 Aggregation-prone
188 S H 0.1432 Aggregation-prone
189 S H 0.0000 Buried
190 V H 0.5715 Aggregation-prone
191 V H 0.0000 Buried
192 T H 0.0950 Aggregation-prone
193 V H 0.0000 Buried
194 P H -0.4700 Soluble
195 S H -0.6359 Soluble
196 S H -0.5357 Soluble
197 S H -0.6276 Soluble
198 L H -0.7944 Soluble
199 G H -1.0604 Soluble
200 T H -0.8598 Soluble
201 Q H -1.2395 Soluble
202 T H -0.8763 Soluble
203 Y H -0.4681 Soluble
204 I H -0.3660 Soluble
205 C H -0.3532 Soluble
206 N H -0.9787 Soluble
207 V H 0.0000 Buried
208 N H -1.3930 Soluble
209 H H 0.0000 Buried
210 K H -2.7628 Soluble
211 P H -1.7533 Soluble
212 S H -1.9620 Soluble
213 N H -2.5125 Soluble
214 T H -2.0152 Soluble
215 K H -2.3963 Soluble
216 V H -1.3329 Soluble
217 D H -2.0272 Soluble
218 K H -2.4035 Soluble
219 K H -1.9023 Soluble
220 V H 0.0000 Buried
221 E H -2.3285 Soluble
222 P H -1.2591 Soluble
1 E L -1.4352 Soluble
2 I L -0.1629 Soluble
3 V L 1.1821 Aggregation-prone
4 L L 0.3038 Aggregation-prone
5 T L -0.1925 Soluble
6 Q L -0.7579 Soluble
7 S L -0.5208 Soluble
8 P L -0.4634 Soluble
9 A L -0.6869 Soluble
10 T L -0.6029 Soluble
11 L L -0.1104 Soluble
12 S L -0.2883 Soluble
13 L L -0.7635 Soluble
14 S L -1.2795 Soluble
15 P L -1.1029 Soluble
16 G L -1.7889 Soluble
17 E L -2.7397 Soluble
18 R L -2.7148 Soluble
19 A L -1.1652 Soluble
20 T L -0.4101 Soluble
21 L L 0.0000 Buried
22 S L -0.7312 Soluble
23 C L 0.0000 Buried
24 R L -1.4275 Soluble
25 A L -0.7229 Soluble
26 S L -0.7035 Soluble
27 Q L -1.3865 Soluble
28 S L -1.0130 Soluble
29 V L -0.7489 Soluble
36 S L -0.5225 Soluble
37 S L -0.4569 Soluble
38 Y L 0.1480 Aggregation-prone
39 L L 0.0450 Aggregation-prone
40 A L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L -0.7242 Soluble
45 K L -1.2897 Soluble
46 P L -1.0870 Soluble
47 G L -1.2937 Soluble
48 Q L -1.9145 Soluble
49 A L -1.1912 Soluble
50 P L -0.8214 Soluble
51 R L -0.7657 Soluble
52 L L -0.1734 Soluble
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 Y L -0.2210 Soluble
56 D L -0.4501 Soluble
57 A L -0.8478 Soluble
65 S L -1.0804 Soluble
66 N L -1.6008 Soluble
67 R L -1.6501 Soluble
68 A L -0.8083 Soluble
69 T L -0.5532 Soluble
70 G L -0.2884 Soluble
71 I L 0.0507 Aggregation-prone
72 P L -0.5348 Soluble
74 A L -1.1096 Soluble
75 R L -1.8216 Soluble
76 F L -0.8257 Soluble
77 S L -0.6776 Soluble
78 G L -0.7222 Soluble
79 S L -0.9154 Soluble
80 G L -1.1734 Soluble
83 S L -1.1071 Soluble
84 G L -1.3615 Soluble
85 T L -1.7262 Soluble
86 D L -2.3245 Soluble
87 F L 0.0000 Buried
88 T L -0.7063 Soluble
89 L L 0.0000 Buried
90 T L -0.8298 Soluble
91 I L -0.7269 Soluble
92 S L -1.4342 Soluble
93 S L -0.8768 Soluble
94 L L -0.4056 Soluble
95 E L -1.8352 Soluble
96 P L -1.6251 Soluble
97 E L -2.2985 Soluble
98 D L -1.4156 Soluble
99 F L -0.3090 Soluble
100 A L -0.7469 Soluble
101 V L 0.0000 Buried
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 Q L 0.0000 Buried
107 R L -0.1618 Soluble
108 S L -0.5870 Soluble
109 N L -0.9702 Soluble
114 W L 0.3169 Aggregation-prone
115 P L -0.2129 Soluble
116 I L 0.1927 Aggregation-prone
117 T L 0.3415 Aggregation-prone
118 F L 0.1669 Aggregation-prone
119 G L 0.0000 Buried
120 Q L -1.5240 Soluble
121 G L -1.4062 Soluble
122 T L 0.0000 Buried
123 R L -1.6040 Soluble
124 L L -0.4507 Soluble
125 E L -0.5074 Soluble
126 I L -0.4113 Soluble
127 K L -1.3341 Soluble
128 R L -1.2881 Soluble
129 T L -0.3375 Soluble
130 V L 0.2355 Aggregation-prone
131 A L -0.1896 Soluble
132 A L -0.3724 Soluble
133 P L -0.5578 Soluble
134 S L -0.2779 Soluble
135 V L 0.4764 Aggregation-prone
136 F L 0.4699 Aggregation-prone
137 I L 0.4738 Aggregation-prone
138 F L 0.4506 Aggregation-prone
139 P L -0.6165 Soluble
140 P L -0.6859 Soluble
141 S L -1.5394 Soluble
142 D L -2.9107 Soluble
143 E L -2.8532 Soluble
144 Q L 0.0000 Buried
145 L L -2.0569 Soluble
146 K L -2.9531 Soluble
147 S L -1.8794 Soluble
148 G L -1.4223 Soluble
149 T L -0.8867 Soluble
150 A L 0.0000 Buried
151 S L 0.2499 Aggregation-prone
152 V L 0.4211 Aggregation-prone
153 V L 0.5449 Aggregation-prone
154 C L 0.0000 Buried
155 L L 0.4176 Aggregation-prone
156 L L 0.0000 Buried
157 N L -0.8835 Soluble
158 N L -1.1397 Soluble
159 F L 0.0000 Buried
160 Y L -1.1030 Soluble
161 P L -1.6898 Soluble
162 R L -2.7559 Soluble
163 E L -2.9286 Soluble
164 A L -2.1478 Soluble
165 K L -1.9271 Soluble
166 V L -0.6850 Soluble
167 Q L -0.6022 Soluble
168 W L 0.0000 Buried
169 K L -0.5701 Soluble
170 V L -0.5128 Soluble
171 D L -0.9985 Soluble
172 N L -1.2901 Soluble
173 A L -0.1322 Soluble
174 L L 0.6450 Aggregation-prone
175 Q L -0.6570 Soluble
176 S L -0.9663 Soluble
177 G L -1.5588 Soluble
178 N L -1.9767 Soluble
179 S L -1.9371 Soluble
180 Q L -1.9787 Soluble
181 E L -1.4393 Soluble
182 S L -0.3474 Soluble
183 V L -0.4698 Soluble
184 T L -1.2373 Soluble
185 E L -2.6971 Soluble
186 Q L -3.1856 Soluble
187 D L -3.7036 Soluble
188 S L -2.7598 Soluble
189 K L -3.3522 Soluble
190 D L -3.4301 Soluble
191 S L -3.0172 Soluble
192 T L -2.3026 Soluble
193 Y L -1.8179 Soluble
194 S L 0.0000 Buried
195 L L -0.2429 Soluble
196 S L 0.0923 Aggregation-prone
197 S L -0.3664 Soluble
198 T L -0.4142 Soluble
199 L L -0.4740 Soluble
200 T L -0.3014 Soluble
201 L L -0.2220 Soluble
202 S L -0.9952 Soluble
203 K L -2.1523 Soluble
204 A L -1.8977 Soluble
205 D L -2.3555 Soluble
206 Y L -2.5483 Soluble
207 E L -3.7066 Soluble
208 K L -3.4913 Soluble
209 H L -2.7169 Soluble
210 K L -2.7886 Soluble
211 V L -0.9152 Soluble
212 Y L 0.0000 Buried
213 A L 0.0000 Buried
214 C L 0.0000 Buried
215 E L -0.3932 Soluble
216 V L 0.0000 Buried
217 T L -0.6422 Soluble
218 H L -1.2669 Soluble
219 Q L -1.3025 Soluble
220 G L -0.8140 Soluble
221 L L -0.3504 Soluble
222 S L -0.4121 Soluble
223 S L -0.1506 Soluble
224 P L 0.3656 Aggregation-prone
225 V L 1.2774 Aggregation-prone
226 T L 0.2165 Aggregation-prone
227 K L -0.4413 Soluble
228 S L -0.7574 Soluble
229 F L -1.0767 Soluble
230 N L -2.2083 Soluble
231 R L -2.8570 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.5142 3.5094 CSV PDB
4.5 -0.565 3.4749 CSV PDB
5.0 -0.6275 3.4226 CSV PDB
5.5 -0.6901 3.3612 CSV PDB
6.0 -0.7403 3.3002 CSV PDB
6.5 -0.7681 3.2494 CSV PDB
7.0 -0.772 3.2169 CSV PDB
7.5 -0.7585 3.2015 CSV PDB
8.0 -0.7346 3.1957 CSV PDB
8.5 -0.7034 3.1937 CSV PDB
9.0 -0.665 3.193 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH