Galegenimab / 7sjn

A4DAB122_7sjn_D_E | Source PDB: 7sjn | Chains: D, E | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.716
Max Score
1.2966
Min Score
-3.1306
Total Score
-159.66
Score CDR
-0.7722
Score non-CDR
-0.7018

Calculation Parameters

Chain Sequence(s) EVQLVQSGAEVKKPGASVKVSCKASGYKFTDSEMHWVRQAPGQGLEWIGGVDPETEGAAYNQKFKGRATITRDTSTSTAYLELSSLRSEDTAVYYCTRGYDYDYALDYWGQGTLVTVDIQMTQSPSSLSASVGDRVTITCRASSSVEFIHWYQQKPGKAPKPLISATSNLASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQWSSAPWTFGQGTKVEIK input.pdb
Selected Chain(s) D (Heavy), E (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.1306
Maximum Score 1.2966
Average Score -0.716
Total Score -159.6627

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E D -2.1052 Soluble
2 V D -1.4329 Soluble
3 Q D -1.0370 Soluble
4 L D 0.0000 Buried
5 V D 0.6201 Aggregation-prone
6 Q D -0.1286 Soluble
7 S D -0.6815 Soluble
8 G D -0.5134 Soluble
9 A D -0.0138 Soluble
11 E D -0.6236 Soluble
12 V D 0.7647 Aggregation-prone
13 K D -1.0251 Soluble
14 K D -1.9420 Soluble
15 P D -1.7184 Soluble
16 G D -1.5896 Soluble
17 A D -1.0529 Soluble
18 S D -0.9291 Soluble
19 V D 0.0000 Buried
20 K D -2.1012 Soluble
21 V D 0.0000 Buried
22 S D -0.5488 Soluble
23 C D 0.0000 Buried
24 K D -0.6872 Soluble
25 A D 0.0000 Buried
26 S D -1.0971 Soluble
27 G D -1.5889 Soluble
28 Y D -1.5337 Soluble
29 K D -2.3723 Soluble
30 F D 0.0000 Buried
35 T D -2.3007 Soluble
36 D D -2.7565 Soluble
37 S D 0.0000 Buried
38 E D -1.7849 Soluble
39 M D 0.0000 Buried
40 H D 0.0000 Buried
41 W D 0.0000 Buried
42 V D 0.0000 Buried
43 R D 0.0000 Buried
44 Q D -0.5421 Soluble
45 A D -1.0870 Soluble
46 P D -1.0267 Soluble
47 G D -1.3140 Soluble
48 Q D -1.8427 Soluble
49 G D -1.3349 Soluble
50 L D -0.6519 Soluble
51 E D -0.6726 Soluble
52 W D 0.0000 Buried
53 I D 0.0000 Buried
54 G D 0.0000 Buried
55 G D -0.3656 Soluble
56 V D 0.0000 Buried
57 D D -2.7001 Soluble
58 P D -2.7678 Soluble
59 E D -3.1306 Soluble
62 T D -2.2603 Soluble
63 E D -2.7976 Soluble
64 G D -1.6737 Soluble
65 A D -0.5971 Soluble
66 A D -0.3990 Soluble
67 Y D -0.6824 Soluble
68 N D 0.0000 Buried
69 Q D -2.8063 Soluble
70 K D -3.0393 Soluble
71 F D -1.9512 Soluble
72 K D -2.7455 Soluble
74 G D -1.7532 Soluble
75 R D -1.3537 Soluble
76 A D 0.0000 Buried
77 T D -0.3651 Soluble
78 I D -0.1058 Soluble
79 T D -0.7149 Soluble
80 R D -1.3851 Soluble
81 D D -1.2650 Soluble
82 T D -0.9428 Soluble
83 S D -0.6068 Soluble
84 T D -0.7003 Soluble
85 S D -0.9980 Soluble
86 T D -0.6664 Soluble
87 A D 0.0000 Buried
88 Y D -0.4251 Soluble
89 L D 0.0000 Buried
90 E D -0.9112 Soluble
91 L D 0.0000 Buried
92 S D -1.0193 Soluble
93 S D -1.1814 Soluble
94 L D 0.0000 Buried
95 R D -2.7883 Soluble
96 S D -2.1323 Soluble
97 E D -2.4740 Soluble
98 D D 0.0000 Buried
99 T D -0.6949 Soluble
100 A D 0.0000 Buried
101 V D 0.4502 Aggregation-prone
102 Y D 0.0000 Buried
103 Y D -0.0182 Soluble
104 C D 0.0000 Buried
105 T D 0.0000 Buried
106 R D -0.3186 Soluble
107 G D 0.2722 Aggregation-prone
108 Y D 0.7841 Aggregation-prone
109 D D 0.7142 Aggregation-prone
110 Y D 1.2966 Aggregation-prone
112 D D 0.4806 Aggregation-prone
113 Y D 1.0860 Aggregation-prone
114 A D 0.2859 Aggregation-prone
115 L D 0.0000 Buried
116 D D -0.9445 Soluble
117 Y D -0.5128 Soluble
118 W D -0.5712 Soluble
119 G D 0.0000 Buried
120 Q D -0.9883 Soluble
121 G D -0.0863 Soluble
122 T D 0.0000 Buried
123 L D 1.1024 Aggregation-prone
124 V D 0.0000 Buried
125 T D 0.3162 Aggregation-prone
126 V D -0.9740 Soluble
1 D E -2.5222 Soluble
2 I E -1.2479 Soluble
3 Q E -1.9852 Soluble
4 M E 0.0000 Buried
5 T E -1.2574 Soluble
6 Q E 0.0000 Buried
7 S E -0.8511 Soluble
8 P E -0.6245 Soluble
9 S E -0.8620 Soluble
10 S E -0.8117 Soluble
11 L E -0.6066 Soluble
12 S E -0.8077 Soluble
13 A E -0.6346 Soluble
14 S E -0.4241 Soluble
15 V E 0.6511 Aggregation-prone
16 G E -0.5238 Soluble
17 D E -1.3976 Soluble
18 R E -2.1637 Soluble
19 V E 0.0000 Buried
20 T E -0.5465 Soluble
21 I E 0.0000 Buried
22 T E -0.9183 Soluble
23 C E 0.0000 Buried
24 R E -2.0334 Soluble
25 A E -1.3088 Soluble
26 S E -1.1043 Soluble
27 S E -1.0106 Soluble
28 S E -1.0361 Soluble
29 V E -0.8739 Soluble
37 E E -1.8057 Soluble
38 F E -0.8921 Soluble
39 I E 0.0000 Buried
40 H E 0.0000 Buried
41 W E 0.0000 Buried
42 Y E 0.0000 Buried
43 Q E -1.0470 Soluble
44 Q E -1.5394 Soluble
45 K E -1.9749 Soluble
46 P E -1.3429 Soluble
47 G E -1.7912 Soluble
48 K E -2.6910 Soluble
49 A E -1.7807 Soluble
50 P E 0.0000 Buried
51 K E -1.7608 Soluble
52 P E 0.0000 Buried
53 L E -0.3987 Soluble
54 I E 0.0000 Buried
55 S E -0.0500 Soluble
56 A E 0.0000 Buried
57 T E -0.7727 Soluble
65 S E -0.7451 Soluble
66 N E -1.0502 Soluble
67 L E -0.0964 Soluble
68 A E -0.2719 Soluble
69 S E -0.5249 Soluble
70 G E -0.4033 Soluble
71 V E -0.0756 Soluble
72 P E -0.3887 Soluble
74 S E -0.4944 Soluble
75 R E -0.7324 Soluble
76 F E 0.0000 Buried
77 S E -0.5640 Soluble
78 G E -0.5899 Soluble
79 S E -0.7580 Soluble
80 G E -1.0710 Soluble
83 S E -1.3202 Soluble
84 G E -1.3021 Soluble
85 T E -1.6199 Soluble
86 D E -2.0024 Soluble
87 F E 0.0000 Buried
88 T E -0.5966 Soluble
89 L E 0.0000 Buried
90 T E -0.8957 Soluble
91 I E 0.0000 Buried
92 S E -1.1704 Soluble
93 S E -0.8584 Soluble
94 L E 0.0000 Buried
95 Q E -0.5660 Soluble
96 P E -0.5896 Soluble
97 E E -1.5164 Soluble
98 D E 0.0000 Buried
99 F E -0.2645 Soluble
100 A E 0.0000 Buried
101 T E -0.7807 Soluble
102 Y E 0.0000 Buried
103 Y E 0.0000 Buried
104 C E 0.0000 Buried
105 Q E 0.0000 Buried
106 Q E 0.0000 Buried
107 W E 0.1329 Aggregation-prone
108 S E -0.2789 Soluble
109 S E -0.4435 Soluble
114 A E -0.3250 Soluble
115 P E -0.7989 Soluble
116 W E -0.1821 Soluble
117 T E -0.5989 Soluble
118 F E 0.0000 Buried
119 G E 0.0000 Buried
120 Q E -1.7764 Soluble
121 G E -1.1654 Soluble
122 T E 0.0000 Buried
123 K E -1.1003 Soluble
124 V E 0.0000 Buried
125 E E -0.7695 Soluble
126 I E -0.3508 Soluble
127 K E -1.3321 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.6489 2.1069 CSV PDB
4.5 -0.7036 1.988 CSV PDB
5.0 -0.7687 1.8479 CSV PDB
5.5 -0.8323 1.699 CSV PDB
6.0 -0.8812 1.547 CSV PDB
6.5 -0.906 1.4795 CSV PDB
7.0 -0.9063 1.4551 CSV PDB
7.5 -0.8888 1.4455 CSV PDB
8.0 -0.8598 1.4422 CSV PDB
8.5 -0.8219 1.4968 CSV PDB
9.0 -0.7762 1.7617 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH