Galegenimab

A4DAB122 | Phase-II
HTRA1
G1 / None
Roche
Phase-II
Whole mAb
FHTR2163 FHTR-2163 RG-6147 RG6147 RO-7171009 RO7171009
—
Avg A4D Score
-0.7578
Score Range
-0.79 to -0.72
Structures
8
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB122_7sjn_D_E 7sjn 100% -0.716 7.0 4.0 -0.7722 -0.7018
A4DAB122_7sjo_E_F 7sjo 100% -0.7738 6.5 4.0 -0.7087 -0.7814
A4DAB122_7sjo_H_L 7sjo 100% -0.7841 6.5 4.0 -0.7416 -0.789
A4DAB122_7sjo_I_J 7sjo 100% -0.7865 6.5 4.0 -0.8505 -0.779
A4DAB122_7sjn_H_L 7sjn 100% -0.7679 7.0 4.0 -0.8291 -0.7524
A4DAB122_7sjn_F_G 7sjn 100% -0.7272 6.5 4.0 -0.7588 -0.7192
A4DAB122_7sjp_H_L 7sjp 100% -0.741 6.5 4.0 -0.741 -0.7409
A4DAB122_7sjm_H_L 7sjm 100% -0.766 6.5 4.0 -0.8578 -0.7552