Clesrovimab / 6ous

A4DAB067_6ous_O_P | Source PDB: 6ous | Chains: O, P | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.7301
Max Score
0.9889
Min Score
-3.5794
Total Score
-319.06
Score CDR
-0.665
Score non-CDR
-0.7393

Calculation Parameters

Chain Sequence(s) EVQLVESGGGLVRPGRSLRLSCTVSGFSFDDSAMSWVRQAPGKGLEWISFIKSKTYGGTKEYAASVKGRFTISRDDSKNIAYLQMNSLKTEDTAVYYCTRGAPYGGNSDYYYGLDVWGQGTTVTVSSASTKGPSVFPLAPSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDIQMTQSPSSLSASVGDRVTITCRTSQDVRGALAWYQQKPGKAPKLLIFDASSLETGVPSRFSGSGSGTVFTLTISSLQPEDFAAYYCQQFLDFPFTFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE input.pdb
Selected Chain(s) O (Heavy), P (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.5794
Maximum Score 0.9889
Average Score -0.7301
Total Score -319.0595

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E O -1.5980 Soluble
2 V O -0.2669 Soluble
3 Q O -0.8203 Soluble
4 L O 0.0000 Buried
5 V O 0.1816 Aggregation-prone
6 E O 0.0000 Buried
7 S O -0.5214 Soluble
8 G O -0.8097 Soluble
9 G O -0.4432 Soluble
11 G O 0.2966 Aggregation-prone
12 L O 0.7524 Aggregation-prone
13 V O 0.0000 Buried
14 R O -2.5266 Soluble
15 P O -2.2283 Soluble
16 G O -2.3550 Soluble
17 R O -2.8270 Soluble
18 S O -2.0327 Soluble
19 L O -1.5621 Soluble
20 R O -2.1653 Soluble
21 L O 0.0000 Buried
22 S O -0.5396 Soluble
23 C O 0.0000 Buried
24 T O -0.3437 Soluble
25 V O 0.0000 Buried
26 S O -0.4831 Soluble
27 G O -0.5717 Soluble
28 F O -0.3383 Soluble
29 S O -0.8291 Soluble
30 F O 0.0000 Buried
35 D O -2.6266 Soluble
36 D O -2.0550 Soluble
37 S O 0.0000 Buried
38 A O 0.0000 Buried
39 M O 0.0000 Buried
40 S O 0.0000 Buried
41 W O 0.0000 Buried
42 V O 0.0000 Buried
43 R O 0.0000 Buried
44 Q O -0.7680 Soluble
45 A O -1.2439 Soluble
46 P O -1.2277 Soluble
47 G O -1.4683 Soluble
48 K O -2.3076 Soluble
49 G O -1.5174 Soluble
50 L O 0.0000 Buried
51 E O -0.8018 Soluble
52 W O 0.0000 Buried
53 I O 0.0000 Buried
54 S O 0.0000 Buried
55 F O 0.0000 Buried
56 I O 0.0000 Buried
57 K O -1.4255 Soluble
58 S O 0.0000 Buried
59 K O -2.4386 Soluble
60 T O -1.5371 Soluble
61 Y O -0.7873 Soluble
62 G O -1.1193 Soluble
63 G O -1.2961 Soluble
64 T O -1.0722 Soluble
65 K O -1.3815 Soluble
66 E O -1.0832 Soluble
67 Y O -0.8404 Soluble
68 A O 0.0000 Buried
69 A O -0.8883 Soluble
70 S O -0.8831 Soluble
71 V O 0.0000 Buried
72 K O -2.0498 Soluble
74 G O -1.5080 Soluble
75 R O -1.3539 Soluble
76 F O 0.0000 Buried
77 T O -1.1126 Soluble
78 I O 0.0000 Buried
79 S O -0.5754 Soluble
80 R O -1.3607 Soluble
81 D O -1.6155 Soluble
82 D O -2.2051 Soluble
83 S O -1.7173 Soluble
84 K O -2.2706 Soluble
85 N O -1.9030 Soluble
86 I O -1.0064 Soluble
87 A O 0.0000 Buried
88 Y O -0.6660 Soluble
89 L O 0.0000 Buried
90 Q O -1.4375 Soluble
91 M O 0.0000 Buried
92 N O -1.7839 Soluble
93 S O -1.7822 Soluble
94 L O 0.0000 Buried
95 K O -2.6957 Soluble
96 T O -1.9820 Soluble
97 E O -2.3361 Soluble
98 D O 0.0000 Buried
99 T O -0.7202 Soluble
100 A O 0.0000 Buried
101 V O 0.0857 Aggregation-prone
102 Y O 0.0000 Buried
103 Y O 0.0000 Buried
104 C O 0.0000 Buried
105 T O 0.0000 Buried
106 R O -0.3094 Soluble
107 G O 0.0000 Buried
108 A O 0.0000 Buried
109 P O 0.0089 Aggregation-prone
110 Y O 0.9889 Aggregation-prone
111 G O -0.3346 Soluble
111A G O -1.0692 Soluble
111B N O -1.5093 Soluble
112C S O -0.4776 Soluble
112B D O -0.3026 Soluble
112A Y O 0.8764 Aggregation-prone
112 Y O 0.0000 Buried
113 Y O 0.0000 Buried
114 G O 0.0000 Buried
115 L O 0.0000 Buried
116 D O -0.5874 Soluble
117 V O -0.2845 Soluble
118 W O -0.4248 Soluble
119 G O 0.0000 Buried
120 Q O -1.4767 Soluble
121 G O 0.0000 Buried
122 T O -0.2498 Soluble
123 T O 0.0969 Aggregation-prone
124 V O 0.0000 Buried
125 T O 0.0000 Buried
126 V O 0.0000 Buried
127 S O 0.0000 Buried
128 S O -0.8738 Soluble
129 A O -0.5809 Soluble
130 S O -0.7981 Soluble
131 T O -0.8886 Soluble
132 K O -1.5341 Soluble
133 G O -1.4581 Soluble
134 P O 0.0000 Buried
135 S O -0.4578 Soluble
136 V O 0.0000 Buried
137 F O 0.0000 Buried
138 P O -1.0784 Soluble
139 L O 0.0000 Buried
140 A O -1.0134 Soluble
141 P O 0.0000 Buried
142 S O -0.2890 Soluble
143 G O -0.6476 Soluble
144 T O -0.5080 Soluble
145 A O -0.2822 Soluble
146 A O 0.0000 Buried
147 L O 0.0000 Buried
148 G O 0.0000 Buried
149 C O 0.0000 Buried
150 L O 0.0000 Buried
151 V O 0.0000 Buried
152 K O 0.0000 Buried
153 D O -0.5471 Soluble
154 Y O 0.0000 Buried
155 F O 0.0000 Buried
156 P O -0.9254 Soluble
157 E O -1.3507 Soluble
158 P O -1.1600 Soluble
159 V O -0.6454 Soluble
160 T O -0.6538 Soluble
161 V O -0.2026 Soluble
162 S O -0.4290 Soluble
163 W O 0.0000 Buried
164 N O -0.6590 Soluble
165 S O -0.6824 Soluble
166 G O -0.5815 Soluble
167 A O -0.2275 Soluble
168 L O 0.0431 Aggregation-prone
169 T O -0.1368 Soluble
170 S O -0.1510 Soluble
171 G O -0.1586 Soluble
172 V O 0.2163 Aggregation-prone
173 H O -0.2861 Soluble
174 T O 0.0330 Aggregation-prone
175 F O 0.0000 Buried
176 P O -0.4092 Soluble
177 A O 0.0537 Aggregation-prone
178 V O 0.2801 Aggregation-prone
179 L O 0.9024 Aggregation-prone
180 Q O 0.0709 Aggregation-prone
181 S O -0.2072 Soluble
182 S O -0.2580 Soluble
183 G O -0.0270 Soluble
184 L O -0.1597 Soluble
185 Y O 0.0000 Buried
186 S O 0.0000 Buried
187 L O 0.0000 Buried
188 S O 0.0000 Buried
189 S O 0.0000 Buried
190 V O 0.0000 Buried
191 V O 0.0000 Buried
192 T O -0.1347 Soluble
193 V O 0.0000 Buried
194 P O -0.6126 Soluble
195 S O -0.6079 Soluble
196 S O -0.6271 Soluble
197 S O -0.6228 Soluble
198 L O -0.7942 Soluble
199 G O -0.9717 Soluble
200 T O -0.7384 Soluble
201 Q O -1.2568 Soluble
202 T O -1.0094 Soluble
203 Y O 0.0000 Buried
204 I O -1.1315 Soluble
205 C O 0.0000 Buried
206 N O -1.6210 Soluble
207 V O 0.0000 Buried
208 N O -1.9664 Soluble
209 H O 0.0000 Buried
210 K O -2.8190 Soluble
211 P O -1.7646 Soluble
212 S O -1.8938 Soluble
213 N O -2.6617 Soluble
214 T O -2.1034 Soluble
215 K O -2.7890 Soluble
216 V O -1.7349 Soluble
217 D O -2.5992 Soluble
218 K O -2.0875 Soluble
219 K O -2.0020 Soluble
220 V O 0.0000 Buried
221 E O -2.5450 Soluble
222 P O -1.7703 Soluble
223 K O -2.2802 Soluble
224 S O -1.0140 Soluble
225 C O -0.6386 Soluble
1 D P -2.3002 Soluble
2 I P -1.8471 Soluble
3 Q P -2.0139 Soluble
4 M P 0.0000 Buried
5 T P -1.1338 Soluble
6 Q P 0.0000 Buried
7 S P -0.6611 Soluble
8 P P -0.4624 Soluble
9 S P -0.6621 Soluble
10 S P -0.3956 Soluble
11 L P -0.1702 Soluble
12 S P -0.6113 Soluble
13 A P 0.0000 Buried
14 S P -0.5090 Soluble
15 V P 0.3170 Aggregation-prone
16 G P -0.6626 Soluble
17 D P -1.6849 Soluble
18 R P -2.2888 Soluble
19 V P 0.0000 Buried
20 T P -0.4858 Soluble
21 I P 0.0000 Buried
22 T P -0.3936 Soluble
23 C P 0.0000 Buried
24 R P -1.7291 Soluble
25 T P 0.0000 Buried
26 S P -1.8638 Soluble
27 Q P -2.6438 Soluble
28 D P -2.5329 Soluble
29 V P 0.0000 Buried
36 R P -2.5159 Soluble
37 G P -1.3246 Soluble
38 A P -0.7931 Soluble
39 L P 0.0000 Buried
40 A P 0.0000 Buried
41 W P 0.0000 Buried
42 Y P 0.0000 Buried
43 Q P 0.0000 Buried
44 Q P 0.0000 Buried
45 K P -1.7613 Soluble
46 P P -1.4502 Soluble
47 G P -1.6910 Soluble
48 K P -2.6521 Soluble
49 A P -1.7473 Soluble
50 P P 0.0000 Buried
51 K P -1.9183 Soluble
52 L P 0.0000 Buried
53 L P 0.0000 Buried
54 I P 0.0000 Buried
55 F P 0.1966 Aggregation-prone
56 D P -0.3632 Soluble
57 A P -0.5001 Soluble
65 S P -0.3644 Soluble
66 S P -0.0724 Soluble
67 L P 0.2711 Aggregation-prone
68 E P -0.4483 Soluble
69 T P -0.2818 Soluble
70 G P -0.4627 Soluble
71 V P -0.3256 Soluble
72 P P -0.2871 Soluble
74 S P -0.3392 Soluble
75 R P -0.7380 Soluble
76 F P 0.0000 Buried
77 S P -0.2787 Soluble
78 G P -0.3208 Soluble
79 S P -0.4099 Soluble
80 G P -0.3853 Soluble
83 S P -0.9700 Soluble
84 G P -1.5600 Soluble
85 T P -1.3205 Soluble
86 V P -0.4403 Soluble
87 F P 0.0000 Buried
88 T P -0.3143 Soluble
89 L P 0.0000 Buried
90 T P -0.5764 Soluble
91 I P 0.0000 Buried
92 S P -1.3484 Soluble
93 S P -1.0754 Soluble
94 L P 0.0000 Buried
95 Q P -1.0087 Soluble
96 P P -0.9533 Soluble
97 E P -1.9640 Soluble
98 D P 0.0000 Buried
99 F P -0.4257 Soluble
100 A P 0.0000 Buried
101 A P -0.4141 Soluble
102 Y P 0.0000 Buried
103 Y P 0.0000 Buried
104 C P 0.0000 Buried
105 Q P 0.0000 Buried
106 Q P 0.0000 Buried
107 F P 0.0000 Buried
108 L P -0.8362 Soluble
109 D P -1.4129 Soluble
114 F P -0.7660 Soluble
115 P P -0.6205 Soluble
116 F P 0.0000 Buried
117 T P -0.7594 Soluble
118 F P 0.0000 Buried
119 G P 0.0000 Buried
120 Q P -1.6263 Soluble
121 G P -1.0800 Soluble
122 T P 0.0000 Buried
123 R P -0.6977 Soluble
124 L P 0.0000 Buried
125 E P 0.0000 Buried
126 I P -0.3040 Soluble
127 K P -1.3989 Soluble
128 R P -1.1812 Soluble
129 T P -0.2044 Soluble
130 V P 0.3987 Aggregation-prone
131 A P 0.1328 Aggregation-prone
132 A P -0.1066 Soluble
133 P P 0.0000 Buried
134 S P -0.1005 Soluble
135 V P 0.0000 Buried
136 F P 0.1204 Aggregation-prone
137 I P 0.1244 Aggregation-prone
138 F P 0.0000 Buried
139 P P -0.4862 Soluble
140 P P 0.0000 Buried
141 S P -1.5620 Soluble
142 D P -2.8131 Soluble
143 E P -2.7637 Soluble
144 Q P 0.0000 Buried
145 L P -2.2085 Soluble
146 K P -2.7395 Soluble
147 S P -1.7570 Soluble
148 G P -1.3250 Soluble
149 T P -0.8382 Soluble
150 A P 0.0000 Buried
151 S P 0.0000 Buried
152 V P 0.0000 Buried
153 V P 0.0000 Buried
154 C P 0.0000 Buried
155 L P 0.0000 Buried
156 L P 0.0000 Buried
157 N P 0.0000 Buried
158 N P -0.8333 Soluble
159 F P 0.0000 Buried
160 Y P 0.0000 Buried
161 P P -1.3190 Soluble
162 R P -2.0998 Soluble
163 E P -2.7891 Soluble
164 A P -2.1655 Soluble
165 K P -2.6327 Soluble
166 V P 0.0000 Buried
167 Q P -0.9335 Soluble
168 W P 0.0000 Buried
169 K P -0.8087 Soluble
170 V P 0.0000 Buried
171 D P -1.5850 Soluble
172 N P -1.3313 Soluble
173 A P -0.4931 Soluble
174 L P -0.0187 Soluble
175 Q P -0.6312 Soluble
176 S P -0.8630 Soluble
177 G P -1.2010 Soluble
178 N P -1.4374 Soluble
179 S P -1.5323 Soluble
180 Q P -1.7166 Soluble
181 E P -1.9531 Soluble
182 S P -0.6462 Soluble
183 V P -0.3787 Soluble
184 T P -0.9909 Soluble
185 E P -2.1525 Soluble
186 Q P -1.7992 Soluble
187 D P -2.1577 Soluble
188 S P -1.7706 Soluble
189 K P -2.3261 Soluble
190 D P -1.7578 Soluble
191 S P -1.7908 Soluble
192 T P 0.0000 Buried
193 Y P 0.0000 Buried
194 S P 0.0000 Buried
195 L P 0.0000 Buried
196 S P 0.0000 Buried
197 S P 0.0000 Buried
198 T P -0.7902 Soluble
199 L P 0.0000 Buried
200 T P -0.4935 Soluble
201 L P -0.6639 Soluble
202 S P -1.1596 Soluble
203 K P -2.0722 Soluble
204 A P -1.8539 Soluble
205 D P -2.4099 Soluble
206 Y P 0.0000 Buried
207 E P -3.5794 Soluble
208 K P -3.5784 Soluble
209 H P -2.8558 Soluble
210 K P -3.0579 Soluble
211 V P -1.3996 Soluble
212 Y P 0.0000 Buried
213 A P 0.0000 Buried
214 C P 0.0000 Buried
215 E P -0.9460 Soluble
216 V P 0.0000 Buried
217 T P -1.2982 Soluble
218 H P 0.0000 Buried
219 Q P -1.6968 Soluble
220 G P -0.4629 Soluble
221 L P -0.2929 Soluble
222 S P -0.4993 Soluble
223 S P -0.4390 Soluble
224 P P -0.6841 Soluble
225 V P -0.1033 Soluble
226 T P -0.5937 Soluble
227 K P -0.8402 Soluble
228 S P -0.5868 Soluble
229 F P -1.0858 Soluble
230 N P -2.1189 Soluble
231 R P -2.7601 Soluble
232 G P -2.0414 Soluble
233 E P -2.3823 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
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pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.7636 1.8064 CSV PDB
4.5 -0.8087 1.7081 CSV PDB
5.0 -0.8609 1.6582 CSV PDB
5.5 -0.9102 1.6073 CSV PDB
6.0 -0.945 1.5561 CSV PDB
6.5 -0.9557 1.5051 CSV PDB
7.0 -0.9424 1.4545 CSV PDB
7.5 -0.9134 1.4056 CSV PDB
8.0 -0.8758 1.3609 CSV PDB
8.5 -0.8317 1.3249 CSV PDB
9.0 -0.7809 1.3124 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH