Clesrovimab

A4DAB067 | Infectious diseases | Preregistration
RSV gpF
G1 / IgG1
Merck Sharp & Dohme
Preregistration
Whole mAb
MK-1654 MK1654 RB1 RB-1
—
Avg A4D Score
-0.7571
Score Range
-0.78 to -0.73
Structures
8
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB067_6ous_Q_R 6ous 100% -0.7804 6.5 4.0 -0.7974 -0.778
A4DAB067_6ous_O_P 6ous 100% -0.7301 6.5 4.0 -0.665 -0.7393
A4DAB067_6ous_W_X 6ous 100% -0.7499 6.5 4.0 -0.7307 -0.7526
A4DAB067_6ous_U_V 6ous 100% -0.7334 6.5 4.0 -0.7354 -0.7331
A4DAB067_6ous_S_T 6ous 100% -0.7578 6.5 4.0 -0.7972 -0.7523
A4DAB067_9mmv_M_N 9mmv 100% -0.7493 6.5 4.0 -0.7246 -0.7528
A4DAB067_6ous_M_N 6ous 100% -0.7752 6.5 4.0 -0.8045 -0.7711
A4DAB067_9mml_M_N 9mml 100% -0.7809 6.5 4.0 -0.7171 -0.7899