Calculation Parameters
| Chain Sequence(s) |
QVQLVQSGVEVKKPGASVKVSCKASGYTFTNYYMYWVRQAPGQGLEWMGGINPSNGGTNFNEKFKNRVTLTTDSSTTTAYMELKSLQFDDTAVYYCARRDYRFDMGFDYWGQGTTVTVSSASTKGPSVFPLAPCESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSEIVLTQSPATLSLSPGERATLSCRASKGVSTSGYSYLHWYQQKPGQAPRLLIYLASYLESGVPARFSGSGSGTDFTLTISSLEPEDFAVYYCQHSRDLPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
input.pdb
|
| Selected Chain(s) | B (Heavy), A (Light) |
| Distance of Aggregation | 10 Å |
| FoldX Energy Minimization | Yes |
| pH Calculations | Yes |
| Downloads | Download all data (.tar.gz) |
Aggrescan4D Profile
Per-Residue A4D Scores
Download CSVResidues with A4D score > 0.0 are highlighted as aggregation-prone.
| Index | Residue | Chain | A4D Score | Classification |
|---|---|---|---|---|
| 1 | Q | B | -1.2543 | Soluble |
| 2 | V | B | -0.4453 | Soluble |
| 3 | Q | B | -0.5121 | Soluble |
| 4 | L | B | 0.0000 | Buried |
| 5 | V | B | 0.7075 | Aggregation-prone |
| 6 | Q | B | 0.0000 | Buried |
| 7 | S | B | -0.1082 | Soluble |
| 8 | G | B | 0.2794 | Aggregation-prone |
| 9 | V | B | 1.5433 | Aggregation-prone |
| 11 | E | B | 0.3626 | Aggregation-prone |
| 12 | V | B | 0.6067 | Aggregation-prone |
| 13 | K | B | -0.7723 | Soluble |
| 14 | K | B | -1.9189 | Soluble |
| 15 | P | B | -1.5597 | Soluble |
| 16 | G | B | -1.4525 | Soluble |
| 17 | A | B | -1.4938 | Soluble |
| 18 | S | B | -1.8872 | Soluble |
| 19 | V | B | 0.0000 | Buried |
| 20 | K | B | -1.9663 | Soluble |
| 21 | V | B | 0.0000 | Buried |
| 22 | S | B | -0.4466 | Soluble |
| 23 | C | B | 0.0000 | Buried |
| 24 | K | B | -0.5770 | Soluble |
| 25 | A | B | 0.0000 | Buried |
| 26 | S | B | -0.5287 | Soluble |
| 27 | G | B | -0.7760 | Soluble |
| 28 | Y | B | -0.2778 | Soluble |
| 29 | T | B | -0.1447 | Soluble |
| 30 | F | B | 0.0000 | Buried |
| 35 | T | B | -0.2787 | Soluble |
| 36 | N | B | -0.3569 | Soluble |
| 37 | Y | B | 0.1163 | Aggregation-prone |
| 38 | Y | B | 0.1084 | Aggregation-prone |
| 39 | M | B | 0.0000 | Buried |
| 40 | Y | B | 0.0000 | Buried |
| 41 | W | B | 0.0000 | Buried |
| 42 | V | B | 0.0000 | Buried |
| 43 | R | B | 0.0000 | Buried |
| 44 | Q | B | -0.6478 | Soluble |
| 45 | A | B | -1.0385 | Soluble |
| 46 | P | B | -1.0648 | Soluble |
| 47 | G | B | -1.2103 | Soluble |
| 48 | Q | B | -1.7336 | Soluble |
| 49 | G | B | -1.0816 | Soluble |
| 50 | L | B | 0.0000 | Buried |
| 51 | E | B | -0.6227 | Soluble |
| 52 | W | B | 0.0000 | Buried |
| 53 | M | B | 0.0000 | Buried |
| 54 | G | B | 0.0000 | Buried |
| 55 | G | B | 0.0000 | Buried |
| 56 | I | B | 0.0000 | Buried |
| 57 | N | B | -0.7333 | Soluble |
| 58 | P | B | -0.9100 | Soluble |
| 59 | S | B | -1.0891 | Soluble |
| 62 | N | B | -1.6950 | Soluble |
| 63 | G | B | -1.2766 | Soluble |
| 64 | G | B | -1.2166 | Soluble |
| 65 | T | B | -1.2031 | Soluble |
| 66 | N | B | -1.6716 | Soluble |
| 67 | F | B | -1.8864 | Soluble |
| 68 | N | B | -2.2593 | Soluble |
| 69 | E | B | -3.5810 | Soluble |
| 70 | K | B | -3.3322 | Soluble |
| 71 | F | B | 0.0000 | Buried |
| 72 | K | B | -3.6956 | Soluble |
| 74 | N | B | -3.0788 | Soluble |
| 75 | R | B | -2.5521 | Soluble |
| 76 | V | B | 0.0000 | Buried |
| 77 | T | B | -1.2309 | Soluble |
| 78 | L | B | 0.0000 | Buried |
| 79 | T | B | -0.4211 | Soluble |
| 80 | T | B | -0.6893 | Soluble |
| 81 | D | B | -1.0541 | Soluble |
| 82 | S | B | -0.7550 | Soluble |
| 83 | S | B | -0.5821 | Soluble |
| 84 | T | B | -0.6410 | Soluble |
| 85 | T | B | -0.6913 | Soluble |
| 86 | T | B | 0.0000 | Buried |
| 87 | A | B | 0.0000 | Buried |
| 88 | Y | B | -0.5808 | Soluble |
| 89 | M | B | 0.0000 | Buried |
| 90 | E | B | -1.8313 | Soluble |
| 91 | L | B | 0.0000 | Buried |
| 92 | K | B | -2.5368 | Soluble |
| 93 | S | B | -1.6790 | Soluble |
| 94 | L | B | 0.0000 | Buried |
| 95 | Q | B | -1.4955 | Soluble |
| 96 | F | B | 0.1157 | Aggregation-prone |
| 97 | D | B | -1.2698 | Soluble |
| 98 | D | B | 0.0000 | Buried |
| 99 | T | B | -0.2642 | Soluble |
| 100 | A | B | 0.0000 | Buried |
| 101 | V | B | 0.1788 | Aggregation-prone |
| 102 | Y | B | 0.0000 | Buried |
| 103 | Y | B | 0.0000 | Buried |
| 104 | C | B | 0.0000 | Buried |
| 105 | A | B | 0.0000 | Buried |
| 106 | R | B | 0.0000 | Buried |
| 107 | R | B | -0.0204 | Soluble |
| 108 | D | B | -0.0253 | Soluble |
| 109 | Y | B | 0.4434 | Aggregation-prone |
| 110 | R | B | -0.8965 | Soluble |
| 111 | F | B | 0.3074 | Aggregation-prone |
| 112 | D | B | 0.2679 | Aggregation-prone |
| 113 | M | B | 0.4116 | Aggregation-prone |
| 114 | G | B | 0.0000 | Buried |
| 115 | F | B | 0.0000 | Buried |
| 116 | D | B | -0.6885 | Soluble |
| 117 | Y | B | -0.2417 | Soluble |
| 118 | W | B | 0.0000 | Buried |
| 119 | G | B | 0.0000 | Buried |
| 120 | Q | B | -1.1950 | Soluble |
| 121 | G | B | -0.4755 | Soluble |
| 122 | T | B | 0.0000 | Buried |
| 123 | T | B | 0.4914 | Aggregation-prone |
| 124 | V | B | 0.0000 | Buried |
| 125 | T | B | 0.0000 | Buried |
| 126 | V | B | 0.0000 | Buried |
| 127 | S | B | 0.0000 | Buried |
| 128 | S | B | -0.6342 | Soluble |
| 129 | A | B | -0.6379 | Soluble |
| 130 | S | B | -0.7176 | Soluble |
| 131 | T | B | -0.9371 | Soluble |
| 132 | K | B | -1.6243 | Soluble |
| 133 | G | B | -1.6335 | Soluble |
| 134 | P | B | 0.0000 | Buried |
| 135 | S | B | -0.5947 | Soluble |
| 136 | V | B | 0.0000 | Buried |
| 137 | F | B | 0.0000 | Buried |
| 138 | P | B | -1.2373 | Soluble |
| 139 | L | B | 0.0000 | Buried |
| 140 | A | B | -0.3789 | Soluble |
| 141 | P | B | 0.0092 | Aggregation-prone |
| 142 | C | B | 0.3957 | Aggregation-prone |
| 143 | E | B | -2.0051 | Soluble |
| 144 | S | B | -1.2369 | Soluble |
| 145 | T | B | -0.8920 | Soluble |
| 146 | A | B | -0.4316 | Soluble |
| 147 | A | B | 0.0000 | Buried |
| 148 | L | B | 0.0000 | Buried |
| 149 | G | B | 0.0000 | Buried |
| 150 | C | B | 0.0000 | Buried |
| 151 | L | B | 0.0000 | Buried |
| 152 | V | B | 0.0000 | Buried |
| 153 | K | B | -0.4102 | Soluble |
| 154 | D | B | -0.7264 | Soluble |
| 155 | Y | B | 0.0000 | Buried |
| 156 | F | B | 0.0000 | Buried |
| 157 | P | B | -1.0254 | Soluble |
| 158 | E | B | -1.4421 | Soluble |
| 159 | P | B | -1.3366 | Soluble |
| 160 | V | B | 0.0000 | Buried |
| 161 | T | B | -0.7437 | Soluble |
| 162 | V | B | -0.2237 | Soluble |
| 163 | S | B | -0.4998 | Soluble |
| 164 | W | B | 0.0000 | Buried |
| 165 | N | B | -0.9546 | Soluble |
| 166 | S | B | -0.7721 | Soluble |
| 167 | G | B | -0.6108 | Soluble |
| 168 | A | B | -0.2647 | Soluble |
| 169 | L | B | -0.0912 | Soluble |
| 170 | T | B | -0.1879 | Soluble |
| 171 | S | B | -0.2022 | Soluble |
| 172 | G | B | -0.1317 | Soluble |
| 173 | V | B | 0.2170 | Aggregation-prone |
| 174 | H | B | -0.2358 | Soluble |
| 175 | T | B | 0.0716 | Aggregation-prone |
| 176 | F | B | 0.0000 | Buried |
| 177 | P | B | -0.4625 | Soluble |
| 178 | A | B | -0.1366 | Soluble |
| 179 | V | B | -0.0006 | Soluble |
| 180 | L | B | 0.4275 | Aggregation-prone |
| 181 | Q | B | -0.1251 | Soluble |
| 182 | S | B | -0.2074 | Soluble |
| 183 | S | B | -0.3302 | Soluble |
| 184 | G | B | 0.0804 | Aggregation-prone |
| 185 | L | B | -0.3781 | Soluble |
| 186 | Y | B | 0.0000 | Buried |
| 187 | S | B | 0.0000 | Buried |
| 188 | L | B | 0.0000 | Buried |
| 189 | S | B | 0.0000 | Buried |
| 190 | S | B | 0.0000 | Buried |
| 191 | V | B | 0.0000 | Buried |
| 192 | V | B | 0.0000 | Buried |
| 193 | T | B | -0.1422 | Soluble |
| 194 | V | B | 0.0000 | Buried |
| 195 | P | B | -0.6205 | Soluble |
| 196 | S | B | -0.5678 | Soluble |
| 197 | S | B | -0.5820 | Soluble |
| 198 | S | B | -0.3742 | Soluble |
| 199 | L | B | -0.1187 | Soluble |
| 200 | G | B | -0.6516 | Soluble |
| 201 | T | B | -0.6640 | Soluble |
| 202 | K | B | -1.1833 | Soluble |
| 203 | T | B | -1.2246 | Soluble |
| 204 | Y | B | 0.0000 | Buried |
| 205 | T | B | -1.6462 | Soluble |
| 206 | C | B | 0.0000 | Buried |
| 207 | N | B | -1.6616 | Soluble |
| 208 | V | B | 0.0000 | Buried |
| 209 | D | B | -1.9876 | Soluble |
| 210 | H | B | 0.0000 | Buried |
| 211 | K | B | -2.8651 | Soluble |
| 212 | P | B | -1.8299 | Soluble |
| 213 | S | B | -1.9061 | Soluble |
| 214 | N | B | -2.6272 | Soluble |
| 215 | T | B | -2.1311 | Soluble |
| 216 | K | B | -2.7332 | Soluble |
| 217 | V | B | -1.6913 | Soluble |
| 218 | D | B | -2.7203 | Soluble |
| 219 | K | B | -2.4642 | Soluble |
| 220 | R | B | -2.7186 | Soluble |
| 221 | V | B | 0.0000 | Buried |
| 222 | E | B | -2.2334 | Soluble |
| 223 | G | B | -0.9122 | Soluble |
| 224 | G | B | -1.0217 | Soluble |
| 225 | P | B | 0.0000 | Buried |
| 226 | S | B | -0.3047 | Soluble |
| 227 | V | B | 0.0000 | Buried |
| 228 | F | B | 1.0894 | Aggregation-prone |
| 229 | L | B | 0.8707 | Aggregation-prone |
| 230 | F | B | 1.1371 | Aggregation-prone |
| 231 | P | B | -0.1975 | Soluble |
| 232 | P | B | 0.0000 | Buried |
| 233 | K | B | -2.2016 | Soluble |
| 234 | P | B | -1.4371 | Soluble |
| 235 | K | B | -1.2078 | Soluble |
| 236 | D | B | 0.0000 | Buried |
| 237 | T | B | 0.0000 | Buried |
| 238 | L | B | 0.0000 | Buried |
| 239 | M | B | 0.3492 | Aggregation-prone |
| 240 | I | B | 1.5704 | Aggregation-prone |
| 241 | S | B | 0.1761 | Aggregation-prone |
| 242 | R | B | -1.1303 | Soluble |
| 243 | T | B | -0.5966 | Soluble |
| 244 | P | B | 0.0000 | Buried |
| 245 | E | B | -0.9527 | Soluble |
| 246 | V | B | 0.0000 | Buried |
| 247 | T | B | 0.3731 | Aggregation-prone |
| 248 | C | B | 0.0000 | Buried |
| 249 | V | B | 0.5557 | Aggregation-prone |
| 250 | V | B | 0.0000 | Buried |
| 251 | V | B | -0.8987 | Soluble |
| 252 | D | B | -2.0655 | Soluble |
| 253 | V | B | 0.0000 | Buried |
| 254 | S | B | -2.1384 | Soluble |
| 255 | Q | B | -2.6946 | Soluble |
| 256 | E | B | -2.7448 | Soluble |
| 257 | D | B | -1.8039 | Soluble |
| 258 | P | B | -1.7185 | Soluble |
| 259 | E | B | -1.1184 | Soluble |
| 260 | V | B | -0.4640 | Soluble |
| 261 | Q | B | -0.2359 | Soluble |
| 262 | F | B | -0.3266 | Soluble |
| 263 | N | B | -1.0142 | Soluble |
| 264 | W | B | 0.0000 | Buried |
| 265 | Y | B | -1.0108 | Soluble |
| 266 | V | B | -1.0609 | Soluble |
| 267 | D | B | -2.2649 | Soluble |
| 268 | G | B | -1.0839 | Soluble |
| 269 | V | B | 0.1892 | Aggregation-prone |
| 270 | E | B | -1.4754 | Soluble |
| 271 | V | B | -0.8106 | Soluble |
| 272 | H | B | -2.1933 | Soluble |
| 273 | N | B | -2.2439 | Soluble |
| 274 | A | B | -1.8183 | Soluble |
| 275 | K | B | -2.3850 | Soluble |
| 276 | T | B | -1.6287 | Soluble |
| 277 | K | B | -2.3804 | Soluble |
| 278 | P | B | -2.3255 | Soluble |
| 279 | R | B | -3.1372 | Soluble |
| 280 | E | B | -3.8548 | Soluble |
| 281 | E | B | -3.3044 | Soluble |
| 282 | Q | B | -1.5442 | Soluble |
| 283 | F | B | 0.8110 | Aggregation-prone |
| 284 | N | B | -0.9510 | Soluble |
| 285 | S | B | -1.1529 | Soluble |
| 286 | T | B | -2.1863 | Soluble |
| 287 | Y | B | -2.6638 | Soluble |
| 288 | R | B | -2.8149 | Soluble |
| 289 | V | B | 0.0000 | Buried |
| 290 | V | B | -0.7743 | Soluble |
| 291 | S | B | 0.0000 | Buried |
| 292 | V | B | -0.7367 | Soluble |
| 293 | L | B | 0.0000 | Buried |
| 294 | T | B | -0.5438 | Soluble |
| 295 | V | B | 0.0000 | Buried |
| 296 | L | B | 0.9847 | Aggregation-prone |
| 297 | H | B | 0.0340 | Aggregation-prone |
| 298 | Q | B | -0.9788 | Soluble |
| 299 | D | B | -1.1605 | Soluble |
| 300 | W | B | 0.0000 | Buried |
| 301 | L | B | -0.9219 | Soluble |
| 302 | N | B | -1.9506 | Soluble |
| 303 | G | B | -1.8878 | Soluble |
| 304 | K | B | -1.9977 | Soluble |
| 305 | E | B | -2.0654 | Soluble |
| 306 | Y | B | 0.0000 | Buried |
| 307 | K | B | -1.7036 | Soluble |
| 308 | C | B | 0.0000 | Buried |
| 309 | K | B | -1.1353 | Soluble |
| 310 | V | B | 0.0000 | Buried |
| 311 | S | B | 0.0000 | Buried |
| 312 | N | B | 0.0000 | Buried |
| 313 | K | B | -1.1613 | Soluble |
| 314 | G | B | -1.1471 | Soluble |
| 315 | L | B | -0.4969 | Soluble |
| 316 | P | B | -0.5456 | Soluble |
| 317 | S | B | -0.6122 | Soluble |
| 318 | S | B | -0.6882 | Soluble |
| 319 | I | B | -0.5760 | Soluble |
| 320 | E | B | -1.8687 | Soluble |
| 321 | K | B | -1.1779 | Soluble |
| 322 | T | B | -1.0163 | Soluble |
| 323 | I | B | -0.1709 | Soluble |
| 324 | S | B | -1.0447 | Soluble |
| 325 | K | B | 0.0000 | Buried |
| 326 | A | B | -1.1229 | Soluble |
| 327 | K | B | -2.3043 | Soluble |
| 328 | G | B | -1.9462 | Soluble |
| 329 | Q | B | -2.1037 | Soluble |
| 330 | P | B | -1.6898 | Soluble |
| 331 | R | B | -1.9923 | Soluble |
| 332 | E | B | -2.6718 | Soluble |
| 333 | P | B | 0.0000 | Buried |
| 334 | Q | B | -1.4263 | Soluble |
| 335 | V | B | 0.0000 | Buried |
| 336 | Y | B | 0.4663 | Aggregation-prone |
| 337 | T | B | 0.2712 | Aggregation-prone |
| 338 | L | B | 0.5510 | Aggregation-prone |
| 339 | P | B | -0.0256 | Soluble |
| 340 | P | B | -0.7619 | Soluble |
| 341 | S | B | -1.4109 | Soluble |
| 342 | Q | B | -2.2700 | Soluble |
| 343 | E | B | -2.8251 | Soluble |
| 344 | E | B | -2.4441 | Soluble |
| 345 | M | B | -2.1013 | Soluble |
| 346 | T | B | -1.9404 | Soluble |
| 347 | K | B | -3.0465 | Soluble |
| 348 | N | B | -2.8453 | Soluble |
| 349 | Q | B | -2.5616 | Soluble |
| 350 | V | B | 0.0000 | Buried |
| 351 | S | B | -0.8173 | Soluble |
| 352 | L | B | 0.0000 | Buried |
| 353 | T | B | -0.1706 | Soluble |
| 354 | C | B | 0.0000 | Buried |
| 355 | L | B | 0.4385 | Aggregation-prone |
| 356 | V | B | 0.0000 | Buried |
| 357 | K | B | -0.6404 | Soluble |
| 358 | G | B | -1.2754 | Soluble |
| 359 | F | B | 0.0000 | Buried |
| 360 | Y | B | -1.0573 | Soluble |
| 361 | P | B | 0.0000 | Buried |
| 362 | S | B | -0.1140 | Soluble |
| 363 | D | B | -1.3303 | Soluble |
| 364 | I | B | -0.7556 | Soluble |
| 365 | A | B | -0.6851 | Soluble |
| 366 | V | B | 0.0000 | Buried |
| 367 | E | B | -1.8240 | Soluble |
| 368 | W | B | 0.0000 | Buried |
| 369 | E | B | -1.7975 | Soluble |
| 370 | S | B | -1.3274 | Soluble |
| 371 | N | B | -1.8967 | Soluble |
| 372 | G | B | -1.8794 | Soluble |
| 373 | Q | B | -2.2865 | Soluble |
| 374 | P | B | -2.1291 | Soluble |
| 375 | E | B | -2.1376 | Soluble |
| 376 | N | B | -2.6088 | Soluble |
| 377 | N | B | -2.4587 | Soluble |
| 378 | Y | B | -2.3527 | Soluble |
| 379 | K | B | -2.6167 | Soluble |
| 380 | T | B | -1.2406 | Soluble |
| 381 | T | B | -0.3734 | Soluble |
| 382 | P | B | 0.1607 | Aggregation-prone |
| 383 | P | B | 0.6857 | Aggregation-prone |
| 384 | V | B | 1.7395 | Aggregation-prone |
| 385 | L | B | 1.3173 | Aggregation-prone |
| 386 | D | B | -0.6741 | Soluble |
| 387 | S | B | -1.2416 | Soluble |
| 388 | D | B | -2.0400 | Soluble |
| 389 | G | B | -0.9477 | Soluble |
| 390 | S | B | 0.0000 | Buried |
| 391 | F | B | 0.4078 | Aggregation-prone |
| 392 | F | B | 0.7901 | Aggregation-prone |
| 393 | L | B | 0.0000 | Buried |
| 394 | Y | B | 0.3981 | Aggregation-prone |
| 395 | S | B | 0.0000 | Buried |
| 396 | R | B | -2.2194 | Soluble |
| 397 | L | B | 0.0000 | Buried |
| 398 | T | B | -1.5647 | Soluble |
| 399 | V | B | 0.0000 | Buried |
| 400 | D | B | -2.4468 | Soluble |
| 401 | K | B | -2.7577 | Soluble |
| 402 | S | B | -2.2828 | Soluble |
| 403 | R | B | -2.4844 | Soluble |
| 404 | W | B | 0.0000 | Buried |
| 405 | Q | B | -2.0258 | Soluble |
| 406 | Q | B | -2.1513 | Soluble |
| 407 | G | B | -1.2955 | Soluble |
| 408 | N | B | -1.0187 | Soluble |
| 409 | V | B | 0.0447 | Aggregation-prone |
| 410 | F | B | 0.0000 | Buried |
| 411 | S | B | 0.0000 | Buried |
| 412 | C | B | 0.0000 | Buried |
| 413 | S | B | 0.0000 | Buried |
| 414 | V | B | 0.0000 | Buried |
| 415 | M | B | 0.0000 | Buried |
| 416 | H | B | 0.0000 | Buried |
| 417 | E | B | -1.1394 | Soluble |
| 418 | A | B | -1.4166 | Soluble |
| 419 | L | B | -1.3832 | Soluble |
| 420 | H | B | -1.7338 | Soluble |
| 421 | N | B | -1.6479 | Soluble |
| 422 | H | B | -1.1605 | Soluble |
| 423 | Y | B | -0.3532 | Soluble |
| 424 | T | B | -0.7314 | Soluble |
| 425 | Q | B | -1.0377 | Soluble |
| 426 | K | B | -1.1365 | Soluble |
| 427 | S | B | -0.4106 | Soluble |
| 428 | L | B | 0.0000 | Buried |
| 429 | S | B | 0.0510 | Aggregation-prone |
| 430 | L | B | 0.0878 | Aggregation-prone |
| 431 | S | B | -0.0686 | Soluble |
| 1 | E | A | -1.8001 | Soluble |
| 2 | I | A | 0.0000 | Buried |
| 3 | V | A | 0.3989 | Aggregation-prone |
| 4 | L | A | 0.0000 | Buried |
| 5 | T | A | -0.6612 | Soluble |
| 6 | Q | A | 0.0000 | Buried |
| 7 | S | A | -0.6372 | Soluble |
| 8 | P | A | -0.2421 | Soluble |
| 9 | A | A | -0.1663 | Soluble |
| 10 | T | A | -0.0415 | Soluble |
| 11 | L | A | 0.0586 | Aggregation-prone |
| 12 | S | A | -0.2513 | Soluble |
| 13 | L | A | -0.6016 | Soluble |
| 14 | S | A | -1.0568 | Soluble |
| 15 | P | A | -1.4680 | Soluble |
| 16 | G | A | -1.8625 | Soluble |
| 17 | E | A | -2.0630 | Soluble |
| 18 | R | A | -2.4659 | Soluble |
| 19 | A | A | 0.0000 | Buried |
| 20 | T | A | -0.6434 | Soluble |
| 21 | L | A | 0.0000 | Buried |
| 22 | S | A | -0.9294 | Soluble |
| 23 | C | A | 0.0000 | Buried |
| 24 | R | A | -2.5109 | Soluble |
| 25 | A | A | 0.0000 | Buried |
| 26 | S | A | -1.3386 | Soluble |
| 27 | K | A | -2.3738 | Soluble |
| 28 | G | A | -1.7276 | Soluble |
| 29 | V | A | 0.0000 | Buried |
| 30 | S | A | -0.7037 | Soluble |
| 31 | T | A | -0.4229 | Soluble |
| 34 | S | A | -0.3384 | Soluble |
| 35 | G | A | -0.3915 | Soluble |
| 36 | Y | A | 0.0213 | Aggregation-prone |
| 37 | S | A | 0.0000 | Buried |
| 38 | Y | A | -0.3177 | Soluble |
| 39 | L | A | 0.0000 | Buried |
| 40 | H | A | 0.0000 | Buried |
| 41 | W | A | 0.0000 | Buried |
| 42 | Y | A | 0.0000 | Buried |
| 43 | Q | A | 0.0000 | Buried |
| 44 | Q | A | 0.0000 | Buried |
| 45 | K | A | -1.4151 | Soluble |
| 46 | P | A | -1.2349 | Soluble |
| 47 | G | A | -1.3937 | Soluble |
| 48 | Q | A | -2.1038 | Soluble |
| 49 | A | A | -1.4785 | Soluble |
| 50 | P | A | 0.0000 | Buried |
| 51 | R | A | -1.9213 | Soluble |
| 52 | L | A | 0.0000 | Buried |
| 53 | L | A | 0.0000 | Buried |
| 54 | I | A | 0.0000 | Buried |
| 55 | Y | A | 0.5264 | Aggregation-prone |
| 56 | L | A | 0.0000 | Buried |
| 57 | A | A | 0.0000 | Buried |
| 65 | S | A | 0.1421 | Aggregation-prone |
| 66 | Y | A | 0.8745 | Aggregation-prone |
| 67 | L | A | 0.7897 | Aggregation-prone |
| 68 | E | A | -0.1155 | Soluble |
| 69 | S | A | -0.3086 | Soluble |
| 70 | G | A | -0.4389 | Soluble |
| 71 | V | A | -0.2886 | Soluble |
| 72 | P | A | -0.1550 | Soluble |
| 74 | A | A | -0.1068 | Soluble |
| 75 | R | A | -0.6636 | Soluble |
| 76 | F | A | 0.0000 | Buried |
| 77 | S | A | -0.1232 | Soluble |
| 78 | G | A | -0.1223 | Soluble |
| 79 | S | A | -0.6802 | Soluble |
| 80 | G | A | -1.2745 | Soluble |
| 83 | S | A | -1.0745 | Soluble |
| 84 | G | A | -1.2234 | Soluble |
| 85 | T | A | -1.9292 | Soluble |
| 86 | D | A | -2.3929 | Soluble |
| 87 | F | A | 0.0000 | Buried |
| 88 | T | A | -0.8682 | Soluble |
| 89 | L | A | 0.0000 | Buried |
| 90 | T | A | -0.6702 | Soluble |
| 91 | I | A | 0.0000 | Buried |
| 92 | S | A | -1.4319 | Soluble |
| 93 | S | A | -1.6489 | Soluble |
| 94 | L | A | 0.0000 | Buried |
| 95 | E | A | -1.9551 | Soluble |
| 96 | P | A | -1.6811 | Soluble |
| 97 | E | A | -2.2190 | Soluble |
| 98 | D | A | 0.0000 | Buried |
| 99 | F | A | -0.4012 | Soluble |
| 100 | A | A | 0.0000 | Buried |
| 101 | V | A | 0.1745 | Aggregation-prone |
| 102 | Y | A | 0.0000 | Buried |
| 103 | Y | A | 0.0000 | Buried |
| 104 | C | A | 0.0000 | Buried |
| 105 | Q | A | 0.0000 | Buried |
| 106 | H | A | 0.0000 | Buried |
| 107 | S | A | -0.9685 | Soluble |
| 108 | R | A | -2.1061 | Soluble |
| 109 | D | A | -2.3015 | Soluble |
| 114 | L | A | -1.1247 | Soluble |
| 115 | P | A | -1.0236 | Soluble |
| 116 | L | A | 0.0000 | Buried |
| 117 | T | A | -0.3148 | Soluble |
| 118 | F | A | 0.0000 | Buried |
| 119 | G | A | 0.0000 | Buried |
| 120 | G | A | -0.6218 | Soluble |
| 121 | G | A | -0.4647 | Soluble |
| 122 | T | A | 0.0000 | Buried |
| 123 | K | A | -0.1405 | Soluble |
| 124 | V | A | 0.0000 | Buried |
| 125 | E | A | 0.0000 | Buried |
| 126 | I | A | -0.1915 | Soluble |
| 127 | K | A | -0.8660 | Soluble |
| 128 | R | A | -0.7151 | Soluble |
| 129 | T | A | 0.0000 | Buried |
| 130 | V | A | -0.2910 | Soluble |
| 131 | A | A | -0.3352 | Soluble |
| 132 | A | A | -0.3570 | Soluble |
| 133 | P | A | 0.0000 | Buried |
| 134 | S | A | -0.1186 | Soluble |
| 135 | V | A | 0.0000 | Buried |
| 136 | F | A | -0.0345 | Soluble |
| 137 | I | A | 0.0000 | Buried |
| 138 | F | A | 0.0000 | Buried |
| 139 | P | A | -0.2076 | Soluble |
| 140 | P | A | -0.6753 | Soluble |
| 141 | S | A | -1.6747 | Soluble |
| 142 | D | A | -3.0153 | Soluble |
| 143 | E | A | -3.1431 | Soluble |
| 144 | Q | A | 0.0000 | Buried |
| 145 | L | A | -2.1175 | Soluble |
| 146 | K | A | -2.8497 | Soluble |
| 147 | S | A | -1.8088 | Soluble |
| 148 | G | A | -1.2427 | Soluble |
| 149 | T | A | -1.0227 | Soluble |
| 150 | A | A | 0.0000 | Buried |
| 151 | S | A | 0.0000 | Buried |
| 152 | V | A | 0.0000 | Buried |
| 153 | V | A | 0.0000 | Buried |
| 154 | C | A | 0.0000 | Buried |
| 155 | L | A | 0.0000 | Buried |
| 156 | L | A | 0.0000 | Buried |
| 157 | N | A | 0.0000 | Buried |
| 158 | N | A | -0.7392 | Soluble |
| 159 | F | A | 0.0000 | Buried |
| 160 | Y | A | 0.0000 | Buried |
| 161 | P | A | -1.2328 | Soluble |
| 162 | R | A | -1.9473 | Soluble |
| 163 | E | A | -2.3101 | Soluble |
| 164 | A | A | -1.8428 | Soluble |
| 165 | K | A | -1.9983 | Soluble |
| 166 | V | A | 0.0000 | Buried |
| 167 | Q | A | -0.7163 | Soluble |
| 168 | W | A | 0.0000 | Buried |
| 169 | K | A | -0.6055 | Soluble |
| 170 | V | A | 0.0000 | Buried |
| 171 | D | A | -1.6369 | Soluble |
| 172 | N | A | -1.3522 | Soluble |
| 173 | A | A | -0.2391 | Soluble |
| 174 | L | A | 0.7366 | Aggregation-prone |
| 175 | Q | A | -0.0588 | Soluble |
| 176 | S | A | -0.5013 | Soluble |
| 177 | G | A | -0.9355 | Soluble |
| 178 | N | A | -0.8424 | Soluble |
| 179 | S | A | -1.3052 | Soluble |
| 180 | Q | A | -1.8466 | Soluble |
| 181 | E | A | -2.0526 | Soluble |
| 182 | S | A | -0.6929 | Soluble |
| 183 | V | A | -0.2531 | Soluble |
| 184 | T | A | -0.8636 | Soluble |
| 185 | E | A | -2.0907 | Soluble |
| 186 | Q | A | -1.6852 | Soluble |
| 187 | D | A | -1.9557 | Soluble |
| 188 | S | A | -1.6934 | Soluble |
| 189 | K | A | -2.2637 | Soluble |
| 190 | D | A | -1.7203 | Soluble |
| 191 | S | A | -1.4927 | Soluble |
| 192 | T | A | 0.0000 | Buried |
| 193 | Y | A | 0.0000 | Buried |
| 194 | S | A | 0.0000 | Buried |
| 195 | L | A | 0.0000 | Buried |
| 196 | S | A | 0.0000 | Buried |
| 197 | S | A | 0.0000 | Buried |
| 198 | T | A | -0.7865 | Soluble |
| 199 | L | A | 0.0000 | Buried |
| 200 | T | A | -0.4263 | Soluble |
| 201 | L | A | -0.5904 | Soluble |
| 202 | S | A | -0.9849 | Soluble |
| 203 | K | A | -1.9314 | Soluble |
| 204 | A | A | -1.7827 | Soluble |
| 205 | D | A | -2.4133 | Soluble |
| 206 | Y | A | 0.0000 | Buried |
| 207 | E | A | -3.3546 | Soluble |
| 208 | K | A | -3.3771 | Soluble |
| 209 | H | A | -2.7479 | Soluble |
| 210 | K | A | -2.7386 | Soluble |
| 211 | V | A | -1.2299 | Soluble |
| 212 | Y | A | 0.0000 | Buried |
| 213 | A | A | 0.0000 | Buried |
| 214 | C | A | 0.0000 | Buried |
| 215 | E | A | -0.8198 | Soluble |
| 216 | V | A | 0.0000 | Buried |
| 217 | T | A | -1.0819 | Soluble |
| 218 | H | A | 0.0000 | Buried |
| 219 | Q | A | -1.4573 | Soluble |
| 220 | G | A | 0.0000 | Buried |
| 221 | L | A | -0.2123 | Soluble |
| 222 | S | A | -0.4164 | Soluble |
| 223 | S | A | -0.3699 | Soluble |
| 224 | P | A | -0.4840 | Soluble |
| 225 | V | A | 0.0462 | Aggregation-prone |
| 226 | T | A | -0.4932 | Soluble |
| 227 | K | A | -0.7146 | Soluble |
| 228 | S | A | -0.5421 | Soluble |
| 229 | F | A | 0.0000 | Buried |
| 230 | N | A | -1.5136 | Soluble |
| 231 | R | A | -2.0131 | Soluble |
| 232 | G | A | -1.7068 | Soluble |
| 233 | E | A | -1.9770 | Soluble |
| 234 | C | A | -0.2273 | Soluble |
3D Structure — colored by A4D score
pH-Dependent Aggregation Profiles
A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.
| pH | Avg A4D Score | Max A4D Score | Downloads |
|---|---|---|---|
| 4.0 | -0.6595 | 3.3901 | CSV PDB |
| 4.5 | -0.7124 | 3.3746 | CSV PDB |
| 5.0 | -0.7759 | 3.36 | CSV PDB |
| 5.5 | -0.8365 | 3.359 | CSV PDB |
| 6.0 | -0.8803 | 3.3807 | CSV PDB |
| 6.5 | -0.898 | 3.4262 | CSV PDB |
| 7.0 | -0.8893 | 3.4919 | CSV PDB |
| 7.5 | -0.8626 | 3.5699 | CSV PDB |
| 8.0 | -0.8258 | 3.653 | CSV PDB |
| 8.5 | -0.7823 | 3.7374 | CSV PDB |
| 9.0 | -0.7328 | 3.8198 | CSV PDB |