Galegenimab / 7sjo

A4DAB122_7sjo_E_F | Source PDB: 7sjo | Chains: E, F | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.7738
Max Score
1.212
Min Score
-3.4744
Total Score
-334.28
Score CDR
-0.7087
Score non-CDR
-0.7814

Calculation Parameters

Chain Sequence(s) EVQLVQSGAEVKKPGASVKVSCKASGYKFTDSEMHWVRQAPGQGLEWIGGVDPETEGAAYNQKFKGRATITRDTSTSTAYLELSSLRSEDTAVYYCTRGYDYDYALDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSDIQMTQSPSSLSASVGDRVTITCRASSSVEFIHWYQQKPGKAPKPLISATSNLASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQWSSAPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE input.pdb
Selected Chain(s) E (Heavy), F (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.4744
Maximum Score 1.212
Average Score -0.7738
Total Score -334.2766

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E E -2.0706 Soluble
2 V E -1.1531 Soluble
3 Q E -1.3226 Soluble
4 L E 0.0000 Buried
5 V E 0.6661 Aggregation-prone
7 S E -0.5397 Soluble
8 G E -0.2955 Soluble
9 A E 0.1698 Aggregation-prone
11 E E -0.0398 Soluble
12 V E 0.9321 Aggregation-prone
13 K E -0.7343 Soluble
14 K E -2.0721 Soluble
15 P E -1.8559 Soluble
16 G E -1.5816 Soluble
17 A E -1.0136 Soluble
18 S E -0.9852 Soluble
19 V E 0.0000 Buried
20 K E -1.8660 Soluble
21 V E 0.0000 Buried
22 S E -0.3885 Soluble
23 C E 0.0000 Buried
24 K E -0.7964 Soluble
25 A E 0.0000 Buried
26 S E -1.1184 Soluble
27 G E -1.3079 Soluble
28 Y E -1.4079 Soluble
29 K E -2.1999 Soluble
30 F E 0.0000 Buried
35 T E -2.1761 Soluble
36 D E -2.5138 Soluble
37 S E 0.0000 Buried
38 E E -1.3765 Soluble
39 M E 0.0000 Buried
40 H E 0.0000 Buried
41 W E 0.0000 Buried
42 V E 0.0000 Buried
43 R E 0.0000 Buried
44 Q E -0.4798 Soluble
45 A E -0.9786 Soluble
46 P E -0.8371 Soluble
47 G E -1.3969 Soluble
48 Q E -1.8892 Soluble
49 G E -1.3642 Soluble
50 L E 0.0000 Buried
51 E E -0.6454 Soluble
52 W E -0.1913 Soluble
53 I E 0.0000 Buried
54 G E 0.0000 Buried
55 G E 0.0000 Buried
56 V E 0.0000 Buried
57 D E -2.3203 Soluble
58 P E 0.0000 Buried
59 E E -3.2532 Soluble
62 T E -2.1248 Soluble
63 E E -2.9132 Soluble
64 G E -1.6839 Soluble
65 A E -0.5766 Soluble
66 A E -0.3045 Soluble
67 Y E -0.8013 Soluble
68 N E 0.0000 Buried
69 Q E -3.0081 Soluble
70 K E -3.0977 Soluble
71 F E 0.0000 Buried
72 K E -2.9251 Soluble
74 G E -1.8300 Soluble
75 R E -1.5729 Soluble
76 A E 0.0000 Buried
77 T E -0.6397 Soluble
78 I E -0.2220 Soluble
79 T E -0.7406 Soluble
80 R E -1.4531 Soluble
81 D E -1.0910 Soluble
82 T E -1.1343 Soluble
83 S E -0.7751 Soluble
84 T E -0.8780 Soluble
85 S E -1.1121 Soluble
86 T E -0.5929 Soluble
87 A E 0.0000 Buried
88 Y E -0.4247 Soluble
89 L E 0.0000 Buried
90 E E -1.2901 Soluble
91 L E 0.0000 Buried
92 S E -1.0462 Soluble
93 S E -0.9048 Soluble
94 L E 0.0000 Buried
95 R E -2.9636 Soluble
96 S E -2.1297 Soluble
97 E E -2.5930 Soluble
98 D E 0.0000 Buried
99 T E -0.5459 Soluble
100 A E 0.0000 Buried
101 V E 0.3820 Aggregation-prone
102 Y E 0.0000 Buried
103 Y E 0.0000 Buried
104 C E 0.0000 Buried
105 T E 0.0000 Buried
106 R E 0.0000 Buried
107 G E 0.0000 Buried
108 Y E 0.5198 Aggregation-prone
109 D E -0.3810 Soluble
110 Y E 0.2821 Aggregation-prone
112 D E -0.7422 Soluble
113 Y E 0.3854 Aggregation-prone
114 A E 0.0000 Buried
115 L E 0.0000 Buried
116 D E -0.0331 Soluble
117 Y E 0.2660 Aggregation-prone
118 W E -0.2554 Soluble
119 G E 0.0000 Buried
120 Q E -1.3059 Soluble
121 G E -0.4941 Soluble
122 T E 0.0000 Buried
123 L E 0.7544 Aggregation-prone
124 V E 0.0000 Buried
125 T E -0.0371 Soluble
126 V E 0.0000 Buried
127 S E -0.8485 Soluble
128 S E -0.6831 Soluble
129 A E -0.5447 Soluble
130 S E -0.6578 Soluble
131 T E -0.9000 Soluble
132 K E -1.6066 Soluble
133 G E -1.3465 Soluble
134 P E 0.0000 Buried
135 S E -0.6778 Soluble
136 V E 0.0000 Buried
137 F E -0.7782 Soluble
138 P E -1.2436 Soluble
139 L E 0.0000 Buried
140 A E -0.9465 Soluble
141 P E -0.9311 Soluble
142 S E -1.1818 Soluble
143 S E -1.4817 Soluble
144 K E -1.9143 Soluble
145 S E 0.0000 Buried
146 T E -1.0570 Soluble
147 S E -1.0469 Soluble
148 G E -0.8319 Soluble
149 G E -0.8563 Soluble
150 T E -0.5959 Soluble
151 A E 0.0000 Buried
152 A E 0.0000 Buried
153 L E 0.0000 Buried
154 G E 0.0000 Buried
155 C E 0.0000 Buried
156 L E 0.0000 Buried
157 V E 0.0000 Buried
158 K E 0.0000 Buried
159 D E -0.9336 Soluble
160 Y E 0.0000 Buried
161 F E -0.2962 Soluble
162 P E 0.0000 Buried
163 E E -0.2151 Soluble
164 P E -0.7284 Soluble
165 V E -0.4228 Soluble
166 T E -0.5019 Soluble
167 V E -0.2568 Soluble
168 S E -0.3510 Soluble
169 W E 0.0000 Buried
170 N E -0.4832 Soluble
171 S E -0.5435 Soluble
172 G E -0.5438 Soluble
173 A E -0.1317 Soluble
174 L E 0.1655 Aggregation-prone
175 T E -0.0665 Soluble
176 S E -0.2915 Soluble
177 G E -0.2060 Soluble
178 V E 0.2418 Aggregation-prone
179 H E -0.4580 Soluble
180 T E -0.2614 Soluble
181 F E 0.0000 Buried
182 P E -0.3314 Soluble
183 A E 0.0586 Aggregation-prone
184 V E 0.2213 Aggregation-prone
185 L E 0.7311 Aggregation-prone
186 Q E -0.0289 Soluble
187 S E -0.3634 Soluble
188 S E -0.2870 Soluble
189 G E -0.0539 Soluble
190 L E -0.1036 Soluble
191 Y E 0.3136 Aggregation-prone
192 S E 0.0871 Aggregation-prone
193 L E 0.0000 Buried
194 S E -0.0444 Soluble
195 S E 0.0000 Buried
196 V E 0.0000 Buried
197 V E 0.0000 Buried
198 T E -0.1188 Soluble
199 V E 0.0000 Buried
200 P E -0.5074 Soluble
201 S E -0.6769 Soluble
202 S E -0.6375 Soluble
203 S E -0.6722 Soluble
204 L E 0.0000 Buried
205 G E -1.3964 Soluble
206 T E -0.8763 Soluble
207 Q E -1.6165 Soluble
208 T E -1.3154 Soluble
209 Y E 0.0000 Buried
210 I E -0.9424 Soluble
211 C E 0.0000 Buried
212 N E -1.1596 Soluble
213 V E 0.0000 Buried
214 N E -1.8232 Soluble
215 H E 0.0000 Buried
216 K E -2.6732 Soluble
217 P E -1.6201 Soluble
218 S E -1.8917 Soluble
219 N E -2.5052 Soluble
220 T E -2.0736 Soluble
221 K E -2.3837 Soluble
222 V E -1.0830 Soluble
223 D E -1.6631 Soluble
224 K E -2.2574 Soluble
225 K E -2.6390 Soluble
226 V E -1.9345 Soluble
227 E E -2.8749 Soluble
228 P E -1.9662 Soluble
229 K E -2.4012 Soluble
230 S E -1.1983 Soluble
1 D F -2.4131 Soluble
2 I F -1.2390 Soluble
3 Q F -1.6080 Soluble
4 M F -1.3220 Soluble
5 T F -1.1244 Soluble
6 Q F 0.0000 Buried
7 S F -0.8354 Soluble
8 P F -0.6991 Soluble
9 S F -0.7047 Soluble
10 S F -0.6533 Soluble
11 L F -0.1762 Soluble
12 S F -0.4615 Soluble
13 A F -0.6670 Soluble
14 S F 0.0000 Buried
15 V F 0.3069 Aggregation-prone
16 G F -1.1232 Soluble
17 D F -2.5605 Soluble
18 R F -2.7227 Soluble
19 V F 0.0000 Buried
20 T F -0.7757 Soluble
21 I F 0.0000 Buried
22 T F -1.0617 Soluble
23 C F 0.0000 Buried
24 R F -2.5399 Soluble
25 A F -1.5965 Soluble
26 S F -0.9348 Soluble
27 S F -0.7266 Soluble
28 S F -1.2407 Soluble
29 V F 0.0000 Buried
37 E F -1.8828 Soluble
38 F F -0.9722 Soluble
39 I F 0.0000 Buried
40 H F 0.0000 Buried
41 W F 0.0000 Buried
42 Y F 0.0000 Buried
43 Q F 0.0000 Buried
44 Q F 0.0000 Buried
45 K F -2.3595 Soluble
46 P F -1.7026 Soluble
47 G F -1.7859 Soluble
48 K F -2.7204 Soluble
49 A F -1.6365 Soluble
50 P F 0.0000 Buried
51 K F -1.5286 Soluble
52 P F -0.4077 Soluble
53 L F 0.0000 Buried
54 I F 0.0000 Buried
55 S F 0.0000 Buried
56 A F -0.6369 Soluble
57 T F 0.0000 Buried
65 S F -0.8060 Soluble
66 N F -1.1755 Soluble
67 L F -0.2456 Soluble
68 A F -0.0792 Soluble
69 S F -0.4280 Soluble
70 G F -0.4205 Soluble
71 V F -0.1158 Soluble
72 P F -0.3934 Soluble
74 S F -0.4738 Soluble
75 R F -0.7019 Soluble
76 F F 0.0000 Buried
77 S F -0.4965 Soluble
78 G F -0.4821 Soluble
79 S F -0.8770 Soluble
80 G F -1.1906 Soluble
83 S F -1.3148 Soluble
84 G F -1.5385 Soluble
85 T F -1.9865 Soluble
86 D F -2.5923 Soluble
87 F F 0.0000 Buried
88 T F -0.8675 Soluble
89 L F 0.0000 Buried
90 T F -0.6767 Soluble
91 I F 0.0000 Buried
92 S F -1.3876 Soluble
93 S F -1.2318 Soluble
94 L F 0.0000 Buried
95 Q F -0.9593 Soluble
96 P F -0.8623 Soluble
97 E F -2.1377 Soluble
98 D F 0.0000 Buried
99 F F -0.8332 Soluble
100 A F 0.0000 Buried
101 T F 0.0000 Buried
102 Y F 0.0000 Buried
103 Y F 0.0000 Buried
104 C F 0.0000 Buried
105 Q F 0.0000 Buried
106 Q F 0.0000 Buried
107 W F -0.1602 Soluble
108 S F -0.4372 Soluble
109 S F -0.4965 Soluble
114 A F -0.3345 Soluble
115 P F 0.0000 Buried
116 W F -0.0944 Soluble
117 T F -0.5476 Soluble
118 F F 0.0000 Buried
119 G F 0.0000 Buried
120 Q F -1.6830 Soluble
121 G F 0.0000 Buried
122 T F 0.0000 Buried
123 K F -0.9748 Soluble
124 V F 0.0000 Buried
125 E F -0.3112 Soluble
126 I F 0.0291 Aggregation-prone
127 K F 0.0000 Buried
128 R F -1.2508 Soluble
129 T F -0.2330 Soluble
130 V F 1.2120 Aggregation-prone
131 A F 0.4635 Aggregation-prone
132 A F 0.1582 Aggregation-prone
133 P F 0.0000 Buried
134 S F -0.0529 Soluble
135 V F 0.3726 Aggregation-prone
136 F F 0.1969 Aggregation-prone
137 I F 0.0937 Aggregation-prone
138 F F 0.0000 Buried
139 P F -0.8774 Soluble
140 P F -1.0812 Soluble
141 S F -1.8982 Soluble
142 D F -3.3627 Soluble
143 E F -3.2212 Soluble
144 Q F 0.0000 Buried
145 L F 0.0000 Buried
146 K F -3.1136 Soluble
147 S F -1.8424 Soluble
148 G F -1.6644 Soluble
149 T F -1.1376 Soluble
150 A F 0.0000 Buried
151 S F 0.0000 Buried
152 V F 0.0000 Buried
153 V F 0.0000 Buried
154 C F 0.0000 Buried
155 L F 0.0000 Buried
156 L F 0.0000 Buried
157 N F 0.0000 Buried
158 N F -1.1180 Soluble
159 F F 0.0000 Buried
160 Y F -0.5710 Soluble
161 P F -1.0749 Soluble
162 R F -2.1405 Soluble
163 E F -2.5245 Soluble
164 A F -2.0963 Soluble
165 K F -2.3478 Soluble
166 V F -1.3314 Soluble
167 Q F -0.7067 Soluble
168 W F 0.0000 Buried
169 K F -0.9001 Soluble
170 V F -1.0333 Soluble
171 D F -2.1583 Soluble
172 N F -1.7227 Soluble
173 A F -0.5875 Soluble
174 L F 0.6524 Aggregation-prone
175 Q F -0.4734 Soluble
176 S F -0.8037 Soluble
177 G F -1.3242 Soluble
178 N F -1.6932 Soluble
179 S F -1.6411 Soluble
180 Q F -1.8380 Soluble
181 E F -2.0030 Soluble
182 S F -0.8674 Soluble
183 V F -0.9112 Soluble
184 T F -1.2249 Soluble
185 E F -2.4901 Soluble
186 Q F -2.5280 Soluble
187 D F -3.4675 Soluble
188 S F -2.6378 Soluble
189 K F -3.3060 Soluble
190 D F -3.3103 Soluble
191 S F -2.6545 Soluble
192 T F -1.9926 Soluble
193 Y F 0.0000 Buried
194 S F 0.0000 Buried
195 L F 0.0000 Buried
196 S F 0.0000 Buried
197 S F 0.0000 Buried
198 T F -0.9184 Soluble
199 L F 0.0000 Buried
200 T F -0.3386 Soluble
201 L F -0.4616 Soluble
202 S F -1.0035 Soluble
203 K F -2.2522 Soluble
204 A F -1.5515 Soluble
205 D F -2.2941 Soluble
206 Y F -2.2086 Soluble
207 E F -3.4744 Soluble
208 K F -3.2557 Soluble
209 H F -2.5334 Soluble
210 K F -2.3484 Soluble
211 V F -0.3555 Soluble
212 Y F 0.0000 Buried
213 A F -0.5375 Soluble
214 C F 0.0000 Buried
215 E F -0.6843 Soluble
216 V F 0.0000 Buried
217 T F -0.8413 Soluble
218 H F -1.2840 Soluble
219 Q F -0.9979 Soluble
220 G F -0.0534 Soluble
221 L F 0.4892 Aggregation-prone
222 S F -0.0790 Soluble
223 S F -0.2025 Soluble
224 P F -0.1485 Soluble
225 V F 0.1007 Aggregation-prone
226 T F -0.4444 Soluble
227 K F -0.6864 Soluble
228 S F -0.3857 Soluble
229 F F 0.0000 Buried
230 N F -2.2510 Soluble
231 R F -2.8908 Soluble
232 G F -2.3187 Soluble
233 E F -2.6423 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.77 2.0071 CSV PDB
4.5 -0.8235 1.807 CSV PDB
5.0 -0.8874 1.6137 CSV PDB
5.5 -0.95 1.5942 CSV PDB
6.0 -0.9975 1.5999 CSV PDB
6.5 -1.0188 1.6327 CSV PDB
7.0 -1.0119 1.6871 CSV PDB
7.5 -0.9849 1.7539 CSV PDB
8.0 -0.9457 1.8257 CSV PDB
8.5 -0.8974 1.8986 CSV PDB
9.0 -0.8407 1.9697 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH