Orilanolimab / 6nha

A4DAB196_6nha_H_L | Source PDB: 6nha | Chains: H, L | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.7297
Max Score
1.4287
Min Score
-3.7569
Total Score
-308.65
Score CDR
-0.4434
Score non-CDR
-0.7638

Calculation Parameters

Chain Sequence(s) QVQLVQSGAELKKPGASVKLSCKASGYTFTSYGISWVKQATGQGLEWIGEIYPRSGNTYYNEKFKGRATLTADKSTSTAYMELRSLRSEDSAVYFCARSTTVRPPGIWGTGTTVTVSSASTKGPSVFPLAPESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVEDIQMTQSPSSLSASVGDRVTITCKASDHINNWLAWYQQKPGQAPRLLISGATSLETGVPSRFSGSGTGKDYTLTISSLQPEDFATYYCQQYWSTPYTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG input.pdb
Selected Chain(s) H (Heavy), L (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.7569
Maximum Score 1.4287
Average Score -0.7297
Total Score -308.6522

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 Q H -1.2348 Soluble
2 V H -0.3929 Soluble
3 Q H -0.7127 Soluble
4 L H 0.0000 Buried
5 V H 0.8275 Aggregation-prone
6 Q H 0.1190 Aggregation-prone
7 S H -0.4899 Soluble
8 G H -0.5437 Soluble
9 A H -0.5065 Soluble
11 E H -0.9432 Soluble
12 L H -0.6071 Soluble
13 K H -1.7046 Soluble
14 K H -2.5214 Soluble
15 P H -2.3830 Soluble
16 G H -1.8044 Soluble
17 A H -1.4005 Soluble
18 S H -1.6163 Soluble
19 V H 0.0000 Buried
20 K H -2.1384 Soluble
21 L H 0.0000 Buried
22 S H -0.5821 Soluble
23 C H 0.0000 Buried
24 K H -0.8119 Soluble
25 A H 0.0000 Buried
26 S H -0.5291 Soluble
27 G H -0.7051 Soluble
28 Y H -0.1875 Soluble
29 T H -0.1671 Soluble
30 F H 0.0000 Buried
35 T H -1.0439 Soluble
36 S H -0.3605 Soluble
37 Y H -0.0836 Soluble
38 G H 0.0000 Buried
39 I H 0.0000 Buried
40 S H 0.0000 Buried
41 W H 0.0000 Buried
42 V H 0.0000 Buried
43 K H -0.4631 Soluble
44 Q H -0.6496 Soluble
45 A H -0.9175 Soluble
46 T H -0.6877 Soluble
47 G H -1.1396 Soluble
48 Q H -1.6927 Soluble
49 G H -1.0941 Soluble
50 L H 0.0000 Buried
51 E H -0.6957 Soluble
52 W H 0.0000 Buried
53 I H 0.0000 Buried
54 G H 0.0000 Buried
55 E H 0.0000 Buried
56 I H 0.0000 Buried
57 Y H -0.9180 Soluble
58 P H 0.0000 Buried
59 R H -2.4489 Soluble
62 S H -1.7064 Soluble
63 G H -1.5766 Soluble
64 N H -1.6405 Soluble
65 T H -0.3352 Soluble
66 Y H 0.1582 Aggregation-prone
67 Y H -0.4740 Soluble
68 N H 0.0000 Buried
69 E H -3.2461 Soluble
70 K H -3.0096 Soluble
71 F H 0.0000 Buried
72 K H -2.5014 Soluble
74 G H -1.9381 Soluble
75 R H -1.8102 Soluble
76 A H 0.0000 Buried
77 T H -0.8697 Soluble
78 L H 0.0000 Buried
79 T H -0.5831 Soluble
80 A H -1.1497 Soluble
81 D H -1.7061 Soluble
82 K H -2.4488 Soluble
83 S H -1.3074 Soluble
84 T H -1.1022 Soluble
85 S H -1.2885 Soluble
86 T H 0.0000 Buried
87 A H 0.0000 Buried
88 Y H -0.6494 Soluble
89 M H 0.0000 Buried
90 E H -1.5942 Soluble
91 L H 0.0000 Buried
92 R H -1.7268 Soluble
93 S H -1.5713 Soluble
94 L H 0.0000 Buried
95 R H -3.2148 Soluble
96 S H -2.4550 Soluble
97 E H -2.5581 Soluble
98 D H 0.0000 Buried
99 S H -1.0877 Soluble
100 A H 0.0000 Buried
101 V H 0.2255 Aggregation-prone
102 Y H 0.0000 Buried
103 F H 0.0000 Buried
104 C H 0.0000 Buried
105 A H 0.0000 Buried
106 R H -0.2973 Soluble
107 S H 0.0000 Buried
108 T H 0.2193 Aggregation-prone
109 T H 0.6808 Aggregation-prone
110 V H 1.4287 Aggregation-prone
113 R H -0.0256 Soluble
114 P H 0.0000 Buried
115 P H 0.0000 Buried
116 G H -0.7216 Soluble
117 I H -0.0633 Soluble
118 W H -0.1232 Soluble
119 G H 0.0000 Buried
120 T H -0.1820 Soluble
121 G H -0.1628 Soluble
122 T H 0.0000 Buried
123 T H -0.2073 Soluble
124 V H 0.0000 Buried
125 T H -0.9672 Soluble
126 V H 0.0000 Buried
127 S H -1.5229 Soluble
128 S H -0.9702 Soluble
129 A H -0.6364 Soluble
130 S H -0.7130 Soluble
131 T H -0.7421 Soluble
132 K H -1.2550 Soluble
133 G H -1.5171 Soluble
134 P H -0.6627 Soluble
135 S H -0.4578 Soluble
136 V H 0.0000 Buried
137 F H 0.0000 Buried
138 P H -1.2904 Soluble
139 L H 0.0000 Buried
140 A H -0.5606 Soluble
141 P H -0.4027 Soluble
142 E H -2.0028 Soluble
143 S H -1.2472 Soluble
144 T H -0.8507 Soluble
145 A H -0.4987 Soluble
146 A H 0.0000 Buried
147 L H 0.0000 Buried
148 G H 0.0000 Buried
149 C H 0.0000 Buried
150 L H 0.0000 Buried
151 V H 0.0000 Buried
152 K H 0.0000 Buried
153 D H -0.3789 Soluble
154 Y H 0.0000 Buried
155 F H 0.0000 Buried
156 P H -0.7185 Soluble
157 E H -0.8950 Soluble
158 P H -0.9028 Soluble
159 V H -0.9111 Soluble
160 T H -0.7725 Soluble
161 V H -0.4850 Soluble
162 S H -0.5497 Soluble
163 W H 0.0000 Buried
164 N H -0.9799 Soluble
165 S H -0.7533 Soluble
166 G H -0.5426 Soluble
167 A H -0.2514 Soluble
168 L H -0.0957 Soluble
169 T H -0.1842 Soluble
170 S H -0.1863 Soluble
171 G H -0.2485 Soluble
172 V H 0.1500 Aggregation-prone
173 H H -0.2963 Soluble
174 T H -0.1489 Soluble
175 F H 0.0000 Buried
176 P H -0.3322 Soluble
177 A H 0.1874 Aggregation-prone
178 V H 0.5105 Aggregation-prone
179 L H 1.1624 Aggregation-prone
180 Q H 0.2688 Aggregation-prone
181 S H -0.0735 Soluble
182 S H -0.1990 Soluble
183 G H 0.0099 Aggregation-prone
184 L H 0.1150 Aggregation-prone
185 Y H 0.4091 Aggregation-prone
186 S H 0.0000 Buried
187 L H 0.0000 Buried
188 S H 0.0000 Buried
189 S H 0.0000 Buried
190 V H 0.0000 Buried
191 V H 0.0000 Buried
192 T H -0.1120 Soluble
193 V H 0.0000 Buried
194 P H -0.5685 Soluble
195 S H -0.6538 Soluble
196 S H -0.6618 Soluble
197 S H -0.4902 Soluble
198 L H -0.4452 Soluble
199 G H -0.7969 Soluble
200 T H -0.7346 Soluble
201 K H -1.1798 Soluble
202 T H -1.2963 Soluble
203 Y H 0.0000 Buried
204 T H -1.8686 Soluble
205 C H 0.0000 Buried
206 N H -1.7277 Soluble
207 V H 0.0000 Buried
208 D H -2.4278 Soluble
209 H H 0.0000 Buried
210 K H -2.9255 Soluble
211 P H -1.7471 Soluble
212 S H -1.9527 Soluble
213 N H -2.6610 Soluble
214 T H -2.1912 Soluble
215 K H -2.8682 Soluble
216 V H -1.8213 Soluble
217 D H -2.7352 Soluble
218 K H -2.1902 Soluble
219 R H -2.8440 Soluble
220 V H 0.0000 Buried
221 E H -2.2860 Soluble
1 D L -2.3900 Soluble
2 I L -1.6551 Soluble
3 Q L -2.0492 Soluble
4 M L 0.0000 Buried
5 T L -1.0966 Soluble
6 Q L 0.0000 Buried
7 S L -0.7035 Soluble
8 P L -0.5463 Soluble
9 S L -0.7462 Soluble
10 S L -0.7609 Soluble
11 L L -0.5535 Soluble
12 S L -0.9170 Soluble
13 A L 0.0000 Buried
14 S L -0.4426 Soluble
15 V L 0.5293 Aggregation-prone
16 G L -0.5559 Soluble
17 D L -1.4695 Soluble
18 R L -2.2239 Soluble
19 V L 0.0000 Buried
20 T L -0.5436 Soluble
21 I L 0.0000 Buried
22 T L -0.7451 Soluble
23 C L 0.0000 Buried
24 K L -2.6305 Soluble
25 A L 0.0000 Buried
26 S L -2.1898 Soluble
27 D L -2.8226 Soluble
28 H L -2.3213 Soluble
29 I L 0.0000 Buried
36 N L -1.6683 Soluble
37 N L -1.2376 Soluble
38 W L -0.0532 Soluble
39 L L 0.0000 Buried
40 A L 0.0000 Buried
41 W L 0.0000 Buried
42 Y L 0.0000 Buried
43 Q L 0.0000 Buried
44 Q L 0.0000 Buried
45 K L -1.7306 Soluble
46 P L -1.4013 Soluble
47 G L -1.3638 Soluble
48 Q L -1.9038 Soluble
49 A L -1.0597 Soluble
50 P L 0.0000 Buried
51 R L -1.5155 Soluble
52 L L 0.0000 Buried
53 L L 0.0000 Buried
54 I L 0.0000 Buried
55 S L 0.0000 Buried
56 G L -0.2373 Soluble
57 A L 0.0000 Buried
65 T L -0.3213 Soluble
66 S L -0.1783 Soluble
67 L L 0.1033 Aggregation-prone
68 E L -0.5602 Soluble
69 T L -0.3744 Soluble
70 G L -0.4953 Soluble
71 V L -0.2151 Soluble
72 P L -0.3203 Soluble
74 S L -0.3621 Soluble
75 R L -0.7492 Soluble
76 F L 0.0000 Buried
77 S L -0.2744 Soluble
78 G L -0.2864 Soluble
79 S L -0.7062 Soluble
80 G L -1.3159 Soluble
83 T L -1.2824 Soluble
84 G L -1.9555 Soluble
85 K L -2.8461 Soluble
86 D L -2.5129 Soluble
87 Y L 0.0000 Buried
88 T L -0.6816 Soluble
89 L L 0.0000 Buried
90 T L -0.6076 Soluble
91 I L 0.0000 Buried
92 S L -1.2770 Soluble
93 S L -1.0191 Soluble
94 L L 0.0000 Buried
95 Q L -0.9076 Soluble
96 P L -0.8037 Soluble
97 E L -1.8494 Soluble
98 D L 0.0000 Buried
99 F L -0.5402 Soluble
100 A L 0.0000 Buried
101 T L -0.8517 Soluble
102 Y L 0.0000 Buried
103 Y L 0.0000 Buried
104 C L 0.0000 Buried
105 Q L 0.0000 Buried
106 Q L 0.0000 Buried
107 Y L 0.0000 Buried
108 W L 0.3687 Aggregation-prone
109 S L -0.1911 Soluble
114 T L -0.2672 Soluble
115 P L -0.7119 Soluble
116 Y L -0.1028 Soluble
117 T L -0.4336 Soluble
118 F L -0.1667 Soluble
119 G L 0.0000 Buried
120 G L -1.0049 Soluble
121 G L 0.0000 Buried
122 T L 0.0000 Buried
123 K L -1.4461 Soluble
124 V L 0.0000 Buried
125 E L -1.0082 Soluble
126 I L -0.6286 Soluble
127 K L -1.4381 Soluble
128 R L -1.0888 Soluble
129 T L -0.0534 Soluble
130 V L 0.5582 Aggregation-prone
131 A L 0.2434 Aggregation-prone
132 A L -0.0249 Soluble
133 P L 0.0000 Buried
134 S L -0.1779 Soluble
135 V L 0.0000 Buried
136 F L 0.0402 Aggregation-prone
137 I L 0.0457 Aggregation-prone
138 F L 0.0000 Buried
139 P L -0.5593 Soluble
140 P L -0.8958 Soluble
141 S L -1.7701 Soluble
142 D L -3.0507 Soluble
143 E L -3.1994 Soluble
144 Q L 0.0000 Buried
145 L L -2.4164 Soluble
146 K L -2.8731 Soluble
147 S L -1.8500 Soluble
148 G L -1.3532 Soluble
149 T L -1.0275 Soluble
150 A L 0.0000 Buried
151 S L 0.0000 Buried
152 V L 0.0000 Buried
153 V L 0.0000 Buried
154 C L 0.0000 Buried
155 L L 0.0000 Buried
156 L L 0.0000 Buried
157 N L 0.0000 Buried
158 N L -0.9007 Soluble
159 F L 0.0000 Buried
160 Y L 0.0000 Buried
161 P L -1.3855 Soluble
162 R L -2.3754 Soluble
163 E L -2.9173 Soluble
164 A L -2.1735 Soluble
165 K L -2.3249 Soluble
166 V L -1.0352 Soluble
167 Q L -0.4680 Soluble
168 W L 0.0000 Buried
169 K L -0.4656 Soluble
170 V L 0.0000 Buried
171 D L -2.1493 Soluble
172 N L -1.5260 Soluble
173 A L -0.2339 Soluble
174 L L 0.7594 Aggregation-prone
175 Q L -0.0605 Soluble
176 S L -0.4321 Soluble
177 G L -0.8897 Soluble
178 N L -0.7890 Soluble
179 S L -1.1132 Soluble
180 Q L -1.4343 Soluble
181 E L -1.9094 Soluble
182 S L -0.7520 Soluble
183 V L -0.5839 Soluble
184 T L -1.0405 Soluble
185 E L -2.1858 Soluble
186 Q L -1.8604 Soluble
187 D L -1.9938 Soluble
188 S L -1.7548 Soluble
189 K L -2.2894 Soluble
190 D L -1.8377 Soluble
191 S L -1.8002 Soluble
192 T L 0.0000 Buried
193 Y L 0.0000 Buried
194 S L 0.0000 Buried
195 L L 0.0000 Buried
196 S L 0.0000 Buried
197 S L 0.0000 Buried
198 T L -0.6878 Soluble
199 L L 0.0000 Buried
200 T L -0.4765 Soluble
201 L L -0.7820 Soluble
202 S L -1.2699 Soluble
203 K L -2.3335 Soluble
204 A L -2.1611 Soluble
205 D L -3.0655 Soluble
206 Y L 0.0000 Buried
207 E L -3.4539 Soluble
208 K L -3.7569 Soluble
209 H L -3.4203 Soluble
210 K L -3.4481 Soluble
211 V L -1.9514 Soluble
212 Y L 0.0000 Buried
213 A L 0.0000 Buried
214 C L 0.0000 Buried
215 E L -0.7686 Soluble
216 V L 0.0000 Buried
217 T L -1.1863 Soluble
218 H L 0.0000 Buried
219 Q L -1.6428 Soluble
220 G L -0.3472 Soluble
221 L L -0.1292 Soluble
222 S L -0.3883 Soluble
223 S L -0.4135 Soluble
224 P L -0.4896 Soluble
225 V L -0.0274 Soluble
226 T L -0.4981 Soluble
227 K L -0.7294 Soluble
228 S L -0.8387 Soluble
229 F L -1.1163 Soluble
230 N L -2.2803 Soluble
231 R L -2.5958 Soluble
232 G L -1.3648 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.793 2.0828 CSV PDB
4.5 -0.8393 2.0382 CSV PDB
5.0 -0.8922 1.9802 CSV PDB
5.5 -0.9407 1.9186 CSV PDB
6.0 -0.9721 1.8627 CSV PDB
6.5 -0.9773 1.8221 CSV PDB
7.0 -0.9575 1.8002 CSV PDB
7.5 -0.9216 1.7912 CSV PDB
8.0 -0.877 1.788 CSV PDB
8.5 -0.8259 1.787 CSV PDB
9.0 -0.7683 1.7867 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH