Cilgavimab / 7l7e

A4DAB064_7l7e_M_N | Source PDB: 7l7e | Chains: M, N | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.7327
Max Score
1.5283
Min Score
-3.4756
Total Score
-332.66
Score CDR
-0.4847
Score non-CDR
-0.7727

Calculation Parameters

Chain Sequence(s) EVQLVESGGGLVKPGGSLRLSCAASGFTFRDVWMSWVRQAPGKGLEWVGRIKSKIDGGTTDYAAPVKGRFTISRDDSKNTLYLQMNSLKTEDTAVYYCTTAGSYYYDTVGPGLPEGKFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDDIVMTQSPDSLAVSLGERATINCKSSQSVLYSSNNKNYLAWYQQKPGQPPKLLMYWASTRESGVPDRFSGSGSGAEFTLTISSLQAEDVAIYYCQQYYSTLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLRSPVTKSFNRGEC input.pdb
Selected Chain(s) M (Heavy), N (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.4756
Maximum Score 1.5283
Average Score -0.7327
Total Score -332.6599

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E M -2.4927 Soluble
2 V M 0.0000 Buried
3 Q M -1.2307 Soluble
4 L M 0.0000 Buried
5 V M 1.0620 Aggregation-prone
6 E M 0.1933 Aggregation-prone
7 S M -0.3793 Soluble
8 G M -1.0192 Soluble
9 G M -0.4459 Soluble
11 G M -0.2197 Soluble
12 L M -0.0092 Soluble
13 V M -0.7639 Soluble
14 K M -2.0048 Soluble
15 P M -1.8266 Soluble
16 G M -1.4642 Soluble
17 G M -1.2054 Soluble
18 S M -1.2750 Soluble
19 L M -1.1578 Soluble
20 R M -2.1503 Soluble
21 L M 0.0000 Buried
22 S M -0.5145 Soluble
23 C M 0.0000 Buried
24 A M -0.1292 Soluble
25 A M 0.0000 Buried
26 S M -1.0527 Soluble
27 G M -1.5312 Soluble
28 F M -0.9109 Soluble
29 T M -0.6535 Soluble
30 F M 0.0000 Buried
35 R M -2.3425 Soluble
36 D M -1.2639 Soluble
37 V M 0.0000 Buried
38 W M -0.6681 Soluble
39 M M 0.0000 Buried
40 S M 0.0000 Buried
41 W M 0.0000 Buried
42 V M 0.0000 Buried
43 R M 0.0000 Buried
44 Q M -0.8372 Soluble
45 A M -1.2144 Soluble
46 P M -1.0441 Soluble
47 G M -1.4879 Soluble
48 K M -2.2657 Soluble
49 G M -1.4139 Soluble
50 L M 0.0000 Buried
51 E M -1.1960 Soluble
52 W M 0.0000 Buried
53 V M 0.0000 Buried
54 G M 0.0000 Buried
55 R M 0.0000 Buried
56 I M 0.0000 Buried
57 K M -1.3113 Soluble
58 S M 0.0000 Buried
59 K M -1.7761 Soluble
60 I M 0.2075 Aggregation-prone
61 D M -0.6479 Soluble
62 G M -0.9220 Soluble
63 G M -1.0427 Soluble
64 T M -1.0703 Soluble
65 T M -0.8012 Soluble
66 D M -1.3823 Soluble
67 Y M -1.0333 Soluble
68 A M 0.0000 Buried
69 A M -0.9826 Soluble
70 P M -0.8908 Soluble
71 V M 0.0000 Buried
72 K M -2.1346 Soluble
74 G M -1.4870 Soluble
75 R M -1.4163 Soluble
76 F M 0.0000 Buried
77 T M -1.0388 Soluble
78 I M 0.0000 Buried
79 S M -0.3771 Soluble
80 R M -1.2215 Soluble
81 D M -1.3879 Soluble
82 D M 0.0000 Buried
83 S M -1.5633 Soluble
84 K M -2.1822 Soluble
85 N M -1.8848 Soluble
86 T M -1.0122 Soluble
87 L M 0.0000 Buried
88 Y M -0.5975 Soluble
89 L M 0.0000 Buried
90 Q M -1.4541 Soluble
91 M M 0.0000 Buried
92 N M -1.3064 Soluble
93 S M -1.2091 Soluble
94 L M 0.0000 Buried
95 K M -2.2037 Soluble
96 T M -1.8045 Soluble
97 E M -2.2277 Soluble
98 D M 0.0000 Buried
99 T M -0.6906 Soluble
100 A M 0.0000 Buried
101 V M 0.0803 Aggregation-prone
102 Y M 0.0000 Buried
103 Y M 0.0000 Buried
104 C M 0.0000 Buried
105 T M 0.0000 Buried
106 T M 0.0000 Buried
107 A M 0.0000 Buried
108 G M 0.0000 Buried
109 S M 0.0000 Buried
110 Y M 0.5762 Aggregation-prone
111 Y M 0.7469 Aggregation-prone
111A Y M 0.6748 Aggregation-prone
111B D M 0.3241 Aggregation-prone
111C T M 0.3323 Aggregation-prone
111D V M 0.3008 Aggregation-prone
112E G M -0.2896 Soluble
112D P M -0.6015 Soluble
112C G M -0.8801 Soluble
112B L M -0.8425 Soluble
112A P M -1.5056 Soluble
112 E M -2.2838 Soluble
113 G M -1.5817 Soluble
114 K M -1.2951 Soluble
115 F M 0.0000 Buried
116 D M 0.0000 Buried
117 Y M -0.2763 Soluble
118 W M -0.3284 Soluble
119 G M 0.0000 Buried
120 Q M -1.1725 Soluble
121 G M -0.5215 Soluble
122 T M -0.1263 Soluble
123 L M 0.0936 Aggregation-prone
124 V M 0.0000 Buried
125 T M 0.0000 Buried
126 V M 0.0000 Buried
127 S M -1.0680 Soluble
128 S M -0.8573 Soluble
129 A M -0.5188 Soluble
130 S M -0.5487 Soluble
131 T M -0.6245 Soluble
132 K M -1.0475 Soluble
133 G M -1.2929 Soluble
134 P M -0.5250 Soluble
135 S M -0.4329 Soluble
136 V M 0.0000 Buried
137 F M 0.0000 Buried
138 P M -1.2273 Soluble
139 L M 0.0000 Buried
140 A M 0.0000 Buried
141 P M 0.0000 Buried
142 S M 0.0000 Buried
143 S M -0.9435 Soluble
144 K M -0.9392 Soluble
145 S M 0.0000 Buried
146 T M -0.4988 Soluble
147 S M -0.6750 Soluble
148 G M -0.8459 Soluble
149 G M -0.8972 Soluble
150 T M -0.5987 Soluble
151 A M 0.0000 Buried
152 A M 0.0000 Buried
153 L M 0.0000 Buried
154 G M 0.0000 Buried
155 C M 0.0000 Buried
156 L M 0.0000 Buried
157 V M 0.0000 Buried
158 K M 0.0000 Buried
159 D M -0.2202 Soluble
160 Y M 0.0000 Buried
161 F M -0.1075 Soluble
162 P M 0.0000 Buried
163 E M -0.4116 Soluble
164 P M -0.6790 Soluble
165 V M -0.4007 Soluble
166 T M -0.5271 Soluble
167 V M -0.1946 Soluble
168 S M -0.3555 Soluble
169 W M 0.0000 Buried
170 N M -0.7436 Soluble
171 S M -0.6755 Soluble
172 G M -0.5232 Soluble
173 A M -0.1970 Soluble
174 L M -0.0000 Buried
175 T M -0.2376 Soluble
176 S M -0.2612 Soluble
177 G M -0.2932 Soluble
178 V M -0.0731 Soluble
179 H M -0.5247 Soluble
180 T M -0.2192 Soluble
181 F M 0.0000 Buried
182 P M -0.3705 Soluble
183 A M 0.3138 Aggregation-prone
184 V M 0.6959 Aggregation-prone
185 L M 1.5283 Aggregation-prone
186 Q M 0.4589 Aggregation-prone
187 S M -0.0409 Soluble
188 S M -0.2156 Soluble
189 G M 0.0299 Aggregation-prone
190 L M 0.3276 Aggregation-prone
191 Y M 0.6186 Aggregation-prone
192 S M 0.0000 Buried
193 L M 0.1835 Aggregation-prone
194 S M 0.0000 Buried
195 S M 0.0000 Buried
196 V M 0.0000 Buried
197 V M 0.0000 Buried
198 T M -0.2148 Soluble
199 V M 0.0000 Buried
200 P M -0.5651 Soluble
201 S M -0.6379 Soluble
202 S M -0.5558 Soluble
203 S M -0.5672 Soluble
204 L M -0.7546 Soluble
205 G M -0.9915 Soluble
206 T M -0.7334 Soluble
207 Q M -1.2245 Soluble
208 T M -1.0817 Soluble
209 Y M 0.0000 Buried
210 I M -1.1726 Soluble
211 C M 0.0000 Buried
212 N M -1.5807 Soluble
213 V M 0.0000 Buried
214 N M -1.8142 Soluble
215 H M 0.0000 Buried
216 K M -2.6821 Soluble
217 P M -1.5021 Soluble
218 S M -1.7010 Soluble
219 N M -2.5424 Soluble
220 T M -2.0264 Soluble
221 K M -2.7756 Soluble
222 V M -1.9326 Soluble
223 D M -2.6676 Soluble
224 K M -2.3581 Soluble
225 K M -2.6165 Soluble
226 V M 0.0000 Buried
227 E M -2.5482 Soluble
228 P M -1.5265 Soluble
229 K M -1.2494 Soluble
230 S M -1.1765 Soluble
231 C M 0.0000 Buried
232 D M -2.6673 Soluble
1 D N -1.4851 Soluble
2 I N 0.0000 Buried
3 V N 0.8941 Aggregation-prone
4 M N 0.0000 Buried
5 T N -0.4332 Soluble
6 Q N -1.2908 Soluble
7 S N -1.1299 Soluble
8 P N -1.4560 Soluble
9 D N -2.3681 Soluble
10 S N -1.6606 Soluble
11 L N -0.9388 Soluble
12 A N -0.8605 Soluble
13 V N -1.0027 Soluble
14 S N -0.9996 Soluble
15 L N -0.4014 Soluble
16 G N -1.1982 Soluble
17 E N -2.2215 Soluble
18 R N -2.5366 Soluble
19 A N 0.0000 Buried
20 T N -0.6068 Soluble
21 I N 0.0000 Buried
22 N N -1.1535 Soluble
23 C N 0.0000 Buried
24 K N -1.7060 Soluble
25 S N -0.8171 Soluble
26 S N -0.7108 Soluble
27 Q N -1.1283 Soluble
28 S N -0.6669 Soluble
29 V N 0.0000 Buried
30 L N 0.0157 Aggregation-prone
31 Y N -0.0862 Soluble
32 S N -0.6562 Soluble
33 S N -0.8760 Soluble
34 N N -1.5205 Soluble
35 N N -1.8415 Soluble
36 K N -1.4083 Soluble
37 N N 0.0000 Buried
38 Y N 0.0000 Buried
39 L N 0.0000 Buried
40 A N 0.0000 Buried
41 W N 0.0000 Buried
42 Y N 0.0000 Buried
43 Q N 0.0000 Buried
44 Q N 0.0000 Buried
45 K N -1.3843 Soluble
46 P N -1.1742 Soluble
47 G N -1.2033 Soluble
48 Q N -1.5421 Soluble
49 P N -1.2195 Soluble
50 P N 0.0000 Buried
51 K N -1.4950 Soluble
52 L N 0.0000 Buried
53 L N 0.0000 Buried
54 M N 0.0000 Buried
55 Y N -0.0849 Soluble
56 W N -0.1697 Soluble
57 A N 0.0000 Buried
65 S N -0.6721 Soluble
66 T N -0.6285 Soluble
67 R N -1.4499 Soluble
68 E N 0.0000 Buried
69 S N -0.8653 Soluble
70 G N -0.9370 Soluble
71 V N -0.8744 Soluble
72 P N -1.3061 Soluble
74 D N -2.1935 Soluble
75 R N -1.5383 Soluble
76 F N 0.0000 Buried
77 S N -0.9314 Soluble
78 G N -0.5292 Soluble
79 S N -0.7589 Soluble
80 G N -1.1867 Soluble
83 S N -1.1425 Soluble
84 G N -0.9273 Soluble
85 A N -1.4771 Soluble
86 E N -2.5590 Soluble
87 F N 0.0000 Buried
88 T N -0.9482 Soluble
89 L N 0.0000 Buried
90 T N -0.6141 Soluble
91 I N 0.0000 Buried
92 S N -1.6775 Soluble
93 S N -1.6072 Soluble
94 L N 0.0000 Buried
95 Q N -1.4872 Soluble
96 A N -1.7197 Soluble
97 E N -1.8722 Soluble
98 D N 0.0000 Buried
99 V N -1.0929 Soluble
100 A N 0.0000 Buried
101 I N -0.8788 Soluble
102 Y N 0.0000 Buried
103 Y N 0.0000 Buried
104 C N 0.0000 Buried
105 Q N 0.0000 Buried
106 Q N 0.0000 Buried
107 Y N 0.0000 Buried
108 Y N 0.4693 Aggregation-prone
114 S N -0.1955 Soluble
115 T N -0.3747 Soluble
116 L N 0.0000 Buried
117 T N -0.0883 Soluble
118 F N 0.0000 Buried
119 G N 0.0000 Buried
120 G N -1.0325 Soluble
121 G N 0.0000 Buried
122 T N 0.0000 Buried
123 K N -1.9457 Soluble
124 V N 0.0000 Buried
125 E N -1.5088 Soluble
126 I N 0.0000 Buried
127 K N -1.1671 Soluble
128 R N -0.7754 Soluble
129 T N -0.1094 Soluble
130 V N 0.1209 Aggregation-prone
131 A N -0.0889 Soluble
132 A N -0.4804 Soluble
133 P N 0.0000 Buried
134 S N -0.3876 Soluble
135 V N 0.0000 Buried
136 F N -0.1449 Soluble
137 I N 0.0000 Buried
138 F N 0.0000 Buried
139 P N 0.0000 Buried
140 P N 0.0000 Buried
141 S N -1.6887 Soluble
142 D N -2.9880 Soluble
143 E N -3.0931 Soluble
144 Q N 0.0000 Buried
145 L N -2.3300 Soluble
146 K N -2.8731 Soluble
147 S N -1.8430 Soluble
148 G N -1.4361 Soluble
149 T N -1.2593 Soluble
150 A N 0.0000 Buried
151 S N 0.0000 Buried
152 V N 0.0000 Buried
153 V N 0.0000 Buried
154 C N 0.0000 Buried
155 L N 0.0000 Buried
156 L N 0.0000 Buried
157 N N -0.7636 Soluble
158 N N -1.6803 Soluble
159 F N 0.0000 Buried
160 Y N 0.0000 Buried
161 P N -1.7774 Soluble
162 R N -3.0078 Soluble
163 E N -3.1530 Soluble
164 A N -2.3605 Soluble
165 K N -2.4611 Soluble
166 V N -1.3362 Soluble
167 Q N -0.8153 Soluble
168 W N 0.0000 Buried
169 K N -0.6515 Soluble
170 V N 0.0000 Buried
171 D N -1.9438 Soluble
172 N N -1.5735 Soluble
173 A N -0.2926 Soluble
174 L N 0.7067 Aggregation-prone
175 Q N -0.3651 Soluble
176 S N -0.6886 Soluble
177 G N -1.3001 Soluble
178 N N -1.6474 Soluble
179 S N -1.5005 Soluble
180 Q N -1.3654 Soluble
181 E N -1.8552 Soluble
182 S N -0.9717 Soluble
183 V N -0.8028 Soluble
184 T N -1.2442 Soluble
185 E N -2.0734 Soluble
186 Q N 0.0000 Buried
187 D N -2.3295 Soluble
188 S N -2.2782 Soluble
189 K N -2.8272 Soluble
190 D N -2.4883 Soluble
191 S N 0.0000 Buried
192 T N 0.0000 Buried
193 Y N 0.0000 Buried
194 S N 0.0000 Buried
195 L N 0.0000 Buried
196 S N 0.0000 Buried
197 S N 0.0000 Buried
198 T N -0.7629 Soluble
199 L N 0.0000 Buried
200 T N -0.6202 Soluble
201 L N -0.7901 Soluble
202 S N -1.0879 Soluble
203 K N -2.2204 Soluble
204 A N -1.8217 Soluble
205 D N -2.3115 Soluble
206 Y N 0.0000 Buried
207 E N -3.4038 Soluble
208 K N -3.4756 Soluble
209 H N -2.8391 Soluble
210 K N -3.1128 Soluble
211 V N -1.4768 Soluble
212 Y N 0.0000 Buried
213 A N 0.0000 Buried
214 C N 0.0000 Buried
215 E N -0.8405 Soluble
216 V N 0.0000 Buried
217 T N -1.4094 Soluble
218 H N 0.0000 Buried
219 Q N -2.0882 Soluble
220 G N -0.8956 Soluble
221 L N -1.0005 Soluble
222 R N -2.0512 Soluble
223 S N -1.1475 Soluble
224 P N -0.8061 Soluble
225 V N -0.0868 Soluble
226 T N -0.3400 Soluble
227 K N -0.5719 Soluble
228 S N -0.6072 Soluble
229 F N 0.0000 Buried
230 N N -2.0908 Soluble
231 R N -2.4927 Soluble
232 G N -2.3407 Soluble
233 E N -2.9014 Soluble
234 C N -1.7337 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.7208 2.095 CSV PDB
4.5 -0.7684 2.0951 CSV PDB
5.0 -0.8243 2.0954 CSV PDB
5.5 -0.8773 2.0962 CSV PDB
6.0 -0.9146 2.0986 CSV PDB
6.5 -0.9266 2.1046 CSV PDB
7.0 -0.913 2.1156 CSV PDB
7.5 -0.8824 2.1309 CSV PDB
8.0 -0.8427 2.1485 CSV PDB
8.5 -0.7965 2.167 CSV PDB
9.0 -0.7436 2.1857 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH