Cilgavimab

A4DAB064 | Approved
SARS-CoV-2 Spike RBD
G1 / None
AstraZeneca
Approved
Whole mAb
AZD1061 AZD-1061 COV2-2130 AZD7442 (combination of cilgavimab and tixagevimab) AZD-7442 (combination of cilgavimab and tixagevimab) EVUSHELD (combination of cilgavimab and tixagevimab)
—
IMGT PubChem (434321764) PubChem (434370388) PubChem (442064696) PubChem (472423048) PubChem (476262905) PubChem (476269523) PubChem (483928820) PubChem (513907002) Thera-SAbDab YAbS
Avg A4D Score
-0.7102
Score Range
-0.74 to -0.66
Structures
7
Avg. A4D Score per Structure
pH at Min / Max Aggregation Propensity

Associated Structural Profiles Level 2

Structure ID Source PDB Seq. Identity Avg. A4D Score pH (Min Agg.) pH (Max Agg.) Score CDR Score non-CDR
A4DAB064_7l7e_M_N 7l7e 100% -0.7327 6.5 4.0 -0.4847 -0.7727
A4DAB064_8suo_I_M 8suo 100% -0.6978 6.5 4.0 -0.4998 -0.7305
A4DAB064_8d8q_H_L 8d8q 100% -0.6825 6.5 4.0 -0.4785 -0.7535
A4DAB064_7l7e_O_P 7l7e 100% -0.7357 6.5 9.0 -0.5064 -0.7728
A4DAB064_8ekd_E_F 8ekd 98% -0.6632 6.5 4.0 -0.525 -0.7132
A4DAB064_7l7e_C_D 7l7e 100% -0.742 6.5 9.0 -0.4724 -0.7853
A4DAB064_7l7e_E_F 7l7e 100% -0.7175 6.5 9.0 -0.4819 -0.7555