Cilgavimab / 8suo

A4DAB064_8suo_I_M | Source PDB: 8suo | Chains: I, M | Done
100
Yes
10 Å
Yes
Avg A4D Score
-0.6978
Max Score
1.2704
Min Score
-3.6017
Total Score
-310.54
Score CDR
-0.4998
Score non-CDR
-0.7305

Calculation Parameters

Chain Sequence(s) EVQLVESGGGLVKPGGSLRLSCAASGFTFRDVWMSWVRQAPGKGLEWVGRIKSKIDGGTTDYAAPVKGRFTISRDDSKNTLYLQMNSLKTEDTAVYYCTTAGSYYYDTVGPGLPEGKFDYWGQGTLVTVSSASTKGPSVFPLAPSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDIVMTQSPDSLAVSLGERATINCKSSQSVLYSSNNKNYLAWYQQKPGQPPKLLMYWASTRESGVPDRFSGSGSGAEFTLTISSLQAEDVAIYYCQQYYSTLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG input.pdb
Selected Chain(s) I (Heavy), M (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.6017
Maximum Score 1.2704
Average Score -0.6978
Total Score -310.5392

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E I -2.6058 Soluble
2 V I 0.0000 Buried
3 Q I -1.4539 Soluble
4 L I 0.0000 Buried
5 V I 1.0401 Aggregation-prone
6 E I 0.1618 Aggregation-prone
7 S I -0.3958 Soluble
8 G I -0.8677 Soluble
9 G I -0.4450 Soluble
11 G I -0.1833 Soluble
12 L I -0.0440 Soluble
13 V I -0.6194 Soluble
14 K I -1.5965 Soluble
15 P I -1.6647 Soluble
16 G I -1.4351 Soluble
17 G I -1.1206 Soluble
18 S I -1.1636 Soluble
19 L I -1.1671 Soluble
20 R I -2.1487 Soluble
21 L I 0.0000 Buried
22 S I -0.4490 Soluble
23 C I 0.0000 Buried
24 A I -0.0524 Soluble
25 A I 0.0000 Buried
26 S I -1.0784 Soluble
27 G I -1.5462 Soluble
28 F I -0.9905 Soluble
29 T I -0.7114 Soluble
30 F I 0.0000 Buried
35 R I -2.4934 Soluble
36 D I -1.2539 Soluble
37 V I 0.0000 Buried
38 W I 0.0000 Buried
39 M I 0.0000 Buried
40 S I 0.0000 Buried
41 W I 0.0000 Buried
42 V I 0.0000 Buried
43 R I 0.0000 Buried
44 Q I -0.8473 Soluble
45 A I -1.2082 Soluble
46 P I -0.9920 Soluble
47 G I -1.5055 Soluble
48 K I -2.2972 Soluble
49 G I -1.4597 Soluble
50 L I 0.0000 Buried
51 E I -1.1675 Soluble
52 W I 0.0000 Buried
53 V I 0.0000 Buried
54 G I 0.0000 Buried
55 R I 0.0000 Buried
56 I I 0.0000 Buried
57 K I -1.0934 Soluble
58 S I 0.0000 Buried
59 K I -1.7511 Soluble
60 I I 0.3167 Aggregation-prone
61 D I -0.5580 Soluble
62 G I -0.8566 Soluble
63 G I -1.0663 Soluble
64 T I -0.9189 Soluble
65 T I -0.5413 Soluble
66 D I -1.0151 Soluble
67 Y I -0.8558 Soluble
68 A I -1.0212 Soluble
69 A I -0.9876 Soluble
70 P I -1.0149 Soluble
71 V I 0.0000 Buried
72 K I -2.1189 Soluble
74 G I -1.5867 Soluble
75 R I -1.3621 Soluble
76 F I 0.0000 Buried
77 T I -0.9670 Soluble
78 I I 0.0000 Buried
79 S I -0.3530 Soluble
80 R I -1.2740 Soluble
81 D I -1.7018 Soluble
82 D I -2.1551 Soluble
83 S I -1.6758 Soluble
84 K I -2.4149 Soluble
85 N I -1.9544 Soluble
86 T I -1.0077 Soluble
87 L I 0.0000 Buried
88 Y I -0.6275 Soluble
89 L I 0.0000 Buried
90 Q I -1.4286 Soluble
91 M I 0.0000 Buried
92 N I -1.3542 Soluble
93 S I -1.2052 Soluble
94 L I 0.0000 Buried
95 K I -2.1579 Soluble
96 T I -1.7298 Soluble
97 E I -2.2593 Soluble
98 D I 0.0000 Buried
99 T I -0.6697 Soluble
100 A I 0.0000 Buried
101 V I 0.1796 Aggregation-prone
102 Y I 0.0000 Buried
103 Y I 0.0000 Buried
104 C I 0.0000 Buried
105 T I 0.0000 Buried
106 T I 0.0000 Buried
107 A I 0.0000 Buried
108 G I 0.0000 Buried
109 S I 0.0000 Buried
110 Y I 0.4800 Aggregation-prone
111 Y I 0.6442 Aggregation-prone
111A Y I 0.5712 Aggregation-prone
111B D I 0.2216 Aggregation-prone
111C T I 0.2053 Aggregation-prone
111D V I -0.0418 Soluble
112E G I -0.3974 Soluble
112D P I -0.6084 Soluble
112C G I -0.8420 Soluble
112B L I -0.7872 Soluble
112A P I -1.5639 Soluble
112 E I -2.4156 Soluble
113 G I -1.5105 Soluble
114 K I -1.1739 Soluble
115 F I -0.2740 Soluble
116 D I 0.0000 Buried
117 Y I 0.0000 Buried
118 W I -0.5087 Soluble
119 G I 0.0000 Buried
120 Q I -1.2586 Soluble
121 G I -0.4148 Soluble
122 T I 0.0065 Aggregation-prone
123 L I 0.2268 Aggregation-prone
124 V I 0.0000 Buried
125 T I -0.3513 Soluble
126 V I 0.0000 Buried
127 S I -0.7541 Soluble
128 S I -0.7608 Soluble
129 A I -0.5280 Soluble
130 S I -0.6004 Soluble
131 T I -0.7894 Soluble
132 K I -1.5246 Soluble
133 G I -1.5052 Soluble
134 P I 0.0000 Buried
135 S I -0.1572 Soluble
136 V I -0.3623 Soluble
137 F I 0.0000 Buried
138 P I -1.0787 Soluble
139 L I 0.0000 Buried
140 A I -1.1621 Soluble
141 P I 0.0000 Buried
142 S I -0.7005 Soluble
143 G I -0.6041 Soluble
144 T I -0.4068 Soluble
145 A I -0.2269 Soluble
146 A I 0.0000 Buried
147 L I 0.0000 Buried
148 G I 0.0000 Buried
149 C I 0.0000 Buried
150 L I 0.0000 Buried
151 V I 0.0000 Buried
152 K I 0.0000 Buried
153 D I -0.2769 Soluble
154 Y I 0.0000 Buried
155 F I 0.0000 Buried
156 P I 0.0000 Buried
157 E I -0.4076 Soluble
158 P I -0.6790 Soluble
159 V I 0.0000 Buried
160 T I -0.6469 Soluble
161 V I -0.3981 Soluble
162 S I -0.3683 Soluble
163 W I 0.0000 Buried
164 N I -0.8261 Soluble
165 S I -0.5380 Soluble
166 G I -0.2743 Soluble
167 A I -0.2313 Soluble
168 L I 0.0000 Buried
169 T I -0.1163 Soluble
170 S I -0.1684 Soluble
171 G I -0.0579 Soluble
172 V I 0.2666 Aggregation-prone
173 H I -0.0960 Soluble
174 T I -0.0327 Soluble
175 F I 0.0000 Buried
176 P I -0.1931 Soluble
177 A I 0.0000 Buried
178 V I 0.2554 Aggregation-prone
179 L I 1.2704 Aggregation-prone
180 Q I 0.2449 Aggregation-prone
181 S I -0.0601 Soluble
182 S I -0.1638 Soluble
183 G I -0.0013 Soluble
184 L I 0.0798 Aggregation-prone
185 Y I 0.2865 Aggregation-prone
186 S I 0.0000 Buried
187 L I 0.0000 Buried
188 S I 0.0000 Buried
189 S I 0.0000 Buried
190 V I 0.0000 Buried
191 V I 0.0000 Buried
192 T I -0.0269 Soluble
193 V I 0.0000 Buried
194 P I -0.3868 Soluble
195 S I -0.4685 Soluble
196 S I -0.5834 Soluble
197 S I -0.6240 Soluble
198 L I -0.7828 Soluble
199 G I -0.9313 Soluble
200 T I -0.7939 Soluble
201 Q I -1.1352 Soluble
202 T I -1.1699 Soluble
203 Y I 0.0000 Buried
204 I I -1.3592 Soluble
205 C I 0.0000 Buried
206 N I -1.4032 Soluble
207 V I 0.0000 Buried
208 N I -1.8656 Soluble
209 H I 0.0000 Buried
210 K I -2.8545 Soluble
211 P I -1.7800 Soluble
212 S I -1.9694 Soluble
213 N I -2.7683 Soluble
214 T I -2.1484 Soluble
215 K I -2.7044 Soluble
216 V I -1.7455 Soluble
217 D I -2.5039 Soluble
218 K I -2.1505 Soluble
219 R I -2.5573 Soluble
220 V I 0.0000 Buried
221 E I -2.7831 Soluble
222 P I -1.8664 Soluble
223 K I -2.1835 Soluble
224 S I -0.9544 Soluble
225 C I -0.0112 Soluble
1 D M -1.5596 Soluble
2 I M 0.0000 Buried
3 V M 0.8582 Aggregation-prone
4 M M 0.0000 Buried
5 T M -0.5463 Soluble
6 Q M 0.0000 Buried
7 S M -1.2517 Soluble
8 P M -1.4118 Soluble
9 D M -2.3776 Soluble
10 S M -1.4920 Soluble
11 L M -0.7617 Soluble
12 A M -0.4522 Soluble
13 V M -0.7509 Soluble
14 S M -0.7579 Soluble
15 L M 0.1342 Aggregation-prone
16 G M -0.8614 Soluble
17 E M -2.1899 Soluble
18 R M -2.4851 Soluble
19 A M 0.0000 Buried
20 T M -0.7777 Soluble
21 I M 0.0000 Buried
22 N M -1.4239 Soluble
23 C M 0.0000 Buried
24 K M -1.5832 Soluble
25 S M -0.8299 Soluble
26 S M -0.8287 Soluble
27 Q M -1.2973 Soluble
28 S M -0.7929 Soluble
29 V M 0.0000 Buried
30 L M -0.0733 Soluble
31 Y M -0.0793 Soluble
32 S M -0.7951 Soluble
33 S M -0.9896 Soluble
34 N M -1.7688 Soluble
35 N M -1.9609 Soluble
36 K M -1.4333 Soluble
37 N M -0.4946 Soluble
38 Y M 0.0000 Buried
39 L M 0.0000 Buried
40 A M 0.0000 Buried
41 W M 0.0000 Buried
42 Y M 0.0000 Buried
43 Q M 0.0000 Buried
44 Q M 0.0000 Buried
45 K M -1.6916 Soluble
46 P M -1.4232 Soluble
47 G M -1.6403 Soluble
48 Q M -2.1175 Soluble
49 P M -1.5080 Soluble
50 P M 0.0000 Buried
51 K M -1.6408 Soluble
52 L M 0.0000 Buried
53 L M 0.0000 Buried
54 M M 0.0000 Buried
55 Y M -0.0503 Soluble
56 W M -0.1416 Soluble
57 A M 0.0000 Buried
65 S M -0.5976 Soluble
66 T M -0.5553 Soluble
67 R M -1.3471 Soluble
68 E M 0.0000 Buried
69 S M -1.0100 Soluble
70 G M -0.9663 Soluble
71 V M -0.8400 Soluble
72 P M -1.2894 Soluble
74 D M -2.1896 Soluble
75 R M -1.4998 Soluble
76 F M 0.0000 Buried
77 S M -0.9143 Soluble
78 G M -0.5193 Soluble
79 S M -0.7564 Soluble
80 G M -1.0679 Soluble
83 S M -1.0330 Soluble
84 G M -0.8601 Soluble
85 A M -1.5606 Soluble
86 E M -2.4244 Soluble
87 F M 0.0000 Buried
88 T M -1.0186 Soluble
89 L M 0.0000 Buried
90 T M -0.6585 Soluble
91 I M 0.0000 Buried
92 S M -1.5783 Soluble
93 S M -1.2552 Soluble
94 L M 0.0000 Buried
95 Q M -0.8470 Soluble
96 A M -1.4365 Soluble
97 E M -2.0387 Soluble
98 D M 0.0000 Buried
99 V M -1.2174 Soluble
100 A M 0.0000 Buried
101 I M -0.7435 Soluble
102 Y M 0.0000 Buried
103 Y M 0.0000 Buried
104 C M 0.0000 Buried
105 Q M 0.0000 Buried
106 Q M 0.0000 Buried
107 Y M 0.0000 Buried
108 Y M 0.5658 Aggregation-prone
114 S M -0.2789 Soluble
115 T M -0.2522 Soluble
116 L M 0.0000 Buried
117 T M -0.1389 Soluble
118 F M 0.0000 Buried
119 G M 0.0000 Buried
120 G M -1.0164 Soluble
121 G M 0.0000 Buried
122 T M 0.0000 Buried
123 K M -1.8301 Soluble
124 V M 0.0000 Buried
125 E M -0.9743 Soluble
126 I M 0.0000 Buried
127 K M -0.9669 Soluble
128 R M -0.7329 Soluble
129 T M 0.1338 Aggregation-prone
130 V M 1.1269 Aggregation-prone
131 A M 0.2472 Aggregation-prone
132 A M 0.0526 Aggregation-prone
133 P M 0.0000 Buried
134 S M -0.1912 Soluble
135 V M 0.0000 Buried
136 F M 0.1030 Aggregation-prone
137 I M 0.1064 Aggregation-prone
138 F M 0.0000 Buried
139 P M -0.4826 Soluble
140 P M -0.7919 Soluble
141 S M -1.6025 Soluble
142 D M -2.8771 Soluble
143 E M -2.7875 Soluble
144 Q M 0.0000 Buried
145 L M -1.9753 Soluble
146 K M -2.6895 Soluble
147 S M -1.6694 Soluble
148 G M -1.3643 Soluble
149 T M -0.8852 Soluble
150 A M 0.0000 Buried
151 S M 0.0000 Buried
152 V M 0.0000 Buried
153 V M 0.0000 Buried
154 C M 0.0000 Buried
155 L M 0.0000 Buried
156 L M 0.0000 Buried
157 N M 0.0000 Buried
158 N M -0.7187 Soluble
159 F M 0.0000 Buried
160 Y M 0.0000 Buried
161 P M -1.3763 Soluble
162 R M -2.5139 Soluble
163 E M -2.9693 Soluble
164 A M -2.2149 Soluble
165 K M -2.2990 Soluble
166 V M -1.2384 Soluble
167 Q M -0.6269 Soluble
168 W M 0.0000 Buried
169 K M -0.6682 Soluble
170 V M 0.0000 Buried
171 D M -1.9718 Soluble
172 N M -1.4508 Soluble
173 A M -0.3684 Soluble
174 L M 0.7016 Aggregation-prone
175 Q M -0.2001 Soluble
176 S M -0.5702 Soluble
177 G M -1.1834 Soluble
178 N M -1.3833 Soluble
179 S M -1.5728 Soluble
180 Q M -1.8996 Soluble
181 E M -2.0617 Soluble
182 S M -0.9116 Soluble
183 V M -0.2903 Soluble
184 T M -1.0884 Soluble
185 E M -2.1445 Soluble
186 Q M 0.0000 Buried
187 D M -2.1449 Soluble
188 S M -2.2818 Soluble
189 K M -2.5622 Soluble
190 D M -1.8845 Soluble
191 S M 0.0000 Buried
192 T M 0.0000 Buried
193 Y M 0.0000 Buried
194 S M 0.0000 Buried
195 L M 0.0000 Buried
196 S M 0.0000 Buried
197 S M 0.0000 Buried
198 T M -0.8370 Soluble
199 L M 0.0000 Buried
200 T M -0.4852 Soluble
201 L M -0.6545 Soluble
202 S M -0.9285 Soluble
203 K M -1.9621 Soluble
204 A M -1.7863 Soluble
205 D M -2.4091 Soluble
206 Y M 0.0000 Buried
207 E M -3.6017 Soluble
208 K M -3.5262 Soluble
209 H M -2.8254 Soluble
210 K M -2.7001 Soluble
211 V M -1.2151 Soluble
212 Y M 0.0000 Buried
213 A M -1.0228 Soluble
214 C M 0.0000 Buried
215 E M -0.9434 Soluble
216 V M 0.0000 Buried
217 T M -1.2394 Soluble
218 H M 0.0000 Buried
219 Q M -1.3316 Soluble
220 G M -0.1872 Soluble
221 L M -0.1503 Soluble
222 S M -0.4731 Soluble
223 S M -0.4370 Soluble
224 P M -0.5859 Soluble
225 V M -0.1215 Soluble
226 T M -0.5837 Soluble
227 K M -0.9210 Soluble
228 S M -0.5642 Soluble
229 F M -0.6505 Soluble
230 N M -1.4720 Soluble
231 R M -1.7696 Soluble
232 G M -1.0698 Soluble

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
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A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.694 2.3065 CSV PDB
4.5 -0.7389 2.2746 CSV PDB
5.0 -0.7922 2.2243 CSV PDB
5.5 -0.8436 2.1642 CSV PDB
6.0 -0.8812 2.1048 CSV PDB
6.5 -0.8944 2.0552 CSV PDB
7.0 -0.8812 2.028 CSV PDB
7.5 -0.8495 2.0421 CSV PDB
8.0 -0.8076 2.0584 CSV PDB
8.5 -0.7585 2.0755 CSV PDB
9.0 -0.7026 2.0928 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH