Sipavibart / 7zr7

A4DAB241_7zr7_D_E | Source PDB: 7zr7 | Chains: D, E | Done
98.29
Yes
10 Å
Yes
Avg A4D Score
-0.6185
Max Score
1.5935
Min Score
-3.2926
Total Score
-142.26
Score CDR
-0.508
Score non-CDR
-0.6533

Calculation Parameters

Chain Sequence(s) EVQLLETGGGLVQSLRLSCAASGFPFDDYAIHWVRLAPGKGLEWVSSISWDSGSIGYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTALYYCAKGAFPGYSSGWYYGLDVWGQGATVTVSSSVVTQPPSASGSLGQSVTISCTGTSSDVGGYNYVSWYQQHPGKAPKLMIFEVSKRPSGVPDRFSGSKSGNTASLTVSGLQAEDEADYYCSSYAGNKGVFGGGTKLTVL input.pdb
Selected Chain(s) D (Heavy), E (Light)
Distance of Aggregation 10 Å
FoldX Energy Minimization Yes
pH Calculations Yes
Downloads Download all data (.tar.gz)

Aggrescan4D Profile

Aggregation-prone (score > 0)
Soluble (score < 0)
Buried (score = 0)

Per-Residue A4D Scores

Download CSV
Minimum Score -3.2926
Maximum Score 1.5935
Average Score -0.6185
Total Score -142.264

Residues with A4D score > 0.0 are highlighted as aggregation-prone.

Index Residue Chain A4D Score Classification
1 E D -1.9443 Soluble
2 V D -0.9550 Soluble
3 Q D -1.0065 Soluble
4 L D 0.0000 Buried
5 L D 0.4177 Aggregation-prone
6 E D 0.0000 Buried
7 T D -0.4194 Soluble
8 G D -0.8153 Soluble
9 G D -0.4416 Soluble
11 G D 0.3520 Aggregation-prone
12 L D 1.1476 Aggregation-prone
13 V D 0.0270 Aggregation-prone
14 Q D -1.1764 Soluble
18 S D -1.2192 Soluble
19 L D -0.9732 Soluble
20 R D -1.8016 Soluble
21 L D 0.0000 Buried
22 S D -0.4402 Soluble
23 C D 0.0000 Buried
24 A D -0.2126 Soluble
25 A D 0.0000 Buried
26 S D -0.9646 Soluble
27 G D -1.1429 Soluble
28 F D -0.9539 Soluble
29 P D -1.3701 Soluble
30 F D 0.0000 Buried
35 D D -3.2926 Soluble
36 D D -2.6092 Soluble
37 Y D -0.8859 Soluble
38 A D 0.0000 Buried
39 I D 0.0000 Buried
40 H D 0.0000 Buried
41 W D 0.0000 Buried
42 V D 0.0000 Buried
43 R D 0.0000 Buried
44 L D -0.3539 Soluble
45 A D -1.0865 Soluble
46 P D -1.1242 Soluble
47 G D -1.3933 Soluble
48 K D -2.2048 Soluble
49 G D -1.2799 Soluble
50 L D 0.0000 Buried
51 E D -0.8126 Soluble
52 W D 0.0000 Buried
53 V D 0.0000 Buried
54 S D 0.0000 Buried
55 S D 0.0000 Buried
56 I D 0.0000 Buried
57 S D 0.0000 Buried
58 W D -1.6065 Soluble
59 D D -2.4199 Soluble
62 S D -0.9783 Soluble
63 G D -0.7577 Soluble
64 S D -0.1321 Soluble
65 I D 0.6163 Aggregation-prone
66 G D -0.3556 Soluble
67 Y D -1.0350 Soluble
68 A D -1.6955 Soluble
69 D D -2.5102 Soluble
70 S D -1.6885 Soluble
71 V D 0.0000 Buried
72 K D -2.6152 Soluble
74 G D -1.8053 Soluble
75 R D -1.7287 Soluble
76 F D 0.0000 Buried
77 T D -0.9050 Soluble
78 I D 0.0000 Buried
79 S D -0.6060 Soluble
80 R D -1.2901 Soluble
81 D D -2.2146 Soluble
82 N D -2.5543 Soluble
83 A D -1.6722 Soluble
84 K D -2.4769 Soluble
85 N D -1.9712 Soluble
86 S D -1.1191 Soluble
87 L D 0.0000 Buried
88 Y D 0.0000 Buried
89 L D 0.0000 Buried
90 Q D -1.6178 Soluble
91 M D 0.0000 Buried
92 N D -2.0764 Soluble
93 S D -1.4073 Soluble
94 L D -1.7568 Soluble
95 R D -2.7199 Soluble
96 A D -1.9157 Soluble
97 E D -2.4184 Soluble
98 D D 0.0000 Buried
99 T D -0.7126 Soluble
100 A D 0.0000 Buried
101 L D 0.0490 Aggregation-prone
102 Y D 0.0000 Buried
103 Y D 0.0000 Buried
104 C D 0.0000 Buried
105 A D 0.0000 Buried
106 K D 0.0000 Buried
107 G D 0.0000 Buried
108 A D 0.8120 Aggregation-prone
109 F D 1.5499 Aggregation-prone
110 P D 0.1629 Aggregation-prone
111 G D 0.3423 Aggregation-prone
111A Y D 0.1951 Aggregation-prone
111B S D -0.2543 Soluble
112C S D 0.0000 Buried
112B G D 0.0000 Buried
112A W D 0.0000 Buried
112 Y D 0.6318 Aggregation-prone
113 Y D 0.4661 Aggregation-prone
114 G D 0.0000 Buried
115 L D 0.0000 Buried
116 D D -0.7427 Soluble
117 V D -0.3822 Soluble
118 W D 0.0000 Buried
119 G D 0.0000 Buried
120 Q D -1.4636 Soluble
121 G D 0.0000 Buried
122 A D 0.0000 Buried
123 T D -0.0645 Soluble
124 V D 0.0000 Buried
125 T D -0.1218 Soluble
126 V D 0.0000 Buried
127 S D -0.8236 Soluble
128 S D -0.6565 Soluble
2 S E 0.4303 Aggregation-prone
3 V E 1.5935 Aggregation-prone
4 V E 0.0000 Buried
5 T E 0.1555 Aggregation-prone
6 Q E 0.0000 Buried
7 P E -0.6666 Soluble
8 P E -1.1355 Soluble
9 S E -1.0936 Soluble
11 A E -0.8833 Soluble
12 S E -0.3355 Soluble
13 G E -0.0344 Soluble
14 S E 0.5320 Aggregation-prone
15 L E 0.8446 Aggregation-prone
16 G E -0.3941 Soluble
17 Q E -1.0811 Soluble
18 S E -0.9282 Soluble
19 V E 0.0000 Buried
20 T E -0.2336 Soluble
21 I E 0.0000 Buried
22 S E -0.2243 Soluble
23 C E 0.0000 Buried
24 T E -0.2967 Soluble
25 G E 0.0000 Buried
26 T E -0.4583 Soluble
27 S E -0.7560 Soluble
28 S E -0.5451 Soluble
29 D E 0.0000 Buried
30 V E 0.0000 Buried
31 G E -1.1944 Soluble
35 G E -0.7966 Soluble
36 Y E -0.5107 Soluble
37 N E -1.3024 Soluble
38 Y E -0.5769 Soluble
39 V E 0.0000 Buried
40 S E 0.0000 Buried
41 W E 0.0000 Buried
42 Y E 0.0000 Buried
43 Q E 0.0000 Buried
44 Q E 0.0000 Buried
45 H E -1.4964 Soluble
46 P E -1.2115 Soluble
47 G E -1.6167 Soluble
48 K E -2.4294 Soluble
49 A E -1.5026 Soluble
50 P E 0.0000 Buried
51 K E -1.2687 Soluble
52 L E -0.7273 Soluble
53 M E 0.0000 Buried
54 I E 0.0000 Buried
55 F E -1.0619 Soluble
56 E E -1.5313 Soluble
57 V E 0.0000 Buried
65 S E -1.8130 Soluble
66 K E -2.5339 Soluble
67 R E -2.5572 Soluble
68 P E -1.2613 Soluble
69 S E -0.9170 Soluble
70 G E -0.9793 Soluble
71 V E 0.0000 Buried
72 P E -1.4533 Soluble
74 D E -2.3148 Soluble
75 R E -1.4428 Soluble
76 F E 0.0000 Buried
77 S E -1.3354 Soluble
78 G E -1.0353 Soluble
79 S E -1.0222 Soluble
80 K E -1.2498 Soluble
83 S E -0.9247 Soluble
84 G E -1.1923 Soluble
85 N E -1.2941 Soluble
86 T E -0.8495 Soluble
87 A E 0.0000 Buried
88 S E -0.3806 Soluble
89 L E 0.0000 Buried
90 T E -0.3340 Soluble
91 V E 0.0000 Buried
92 S E -1.0534 Soluble
93 G E -0.9591 Soluble
94 L E 0.0000 Buried
95 Q E -1.0326 Soluble
96 A E -0.9440 Soluble
97 E E -2.3223 Soluble
98 D E 0.0000 Buried
99 E E -2.0428 Soluble
100 A E 0.0000 Buried
101 D E 0.0000 Buried
102 Y E 0.0000 Buried
103 Y E 0.0000 Buried
104 C E 0.0000 Buried
105 S E 0.0000 Buried
106 S E 0.0000 Buried
107 Y E -0.5561 Soluble
108 A E -0.8297 Soluble
109 G E -1.2028 Soluble
114 N E -1.8058 Soluble
115 K E -1.7848 Soluble
116 G E 0.0000 Buried
117 V E 0.0157 Aggregation-prone
118 F E 0.0000 Buried
119 G E 0.0000 Buried
120 G E -0.7374 Soluble
121 G E -1.1213 Soluble
122 T E 0.0000 Buried
123 K E -2.1160 Soluble
124 L E 0.0000 Buried
125 T E -0.3337 Soluble
126 V E 0.0827 Aggregation-prone
127 L E 1.4891 Aggregation-prone

3D Structure — colored by A4D score

Sequence - click residue to focus in viewer  |  colored by A4D score
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Downloads
Color Legend (B-factor = A4D Score)
Score > 1.5 — highly aggregation-prone
Score 0.5–1.5 — aggregation-prone
Score ≈ 0 — buried
Score −1 to −0.5 — soluble
Score < −2.5 — highly soluble
pH Structure
Load structure at specific pH condition
A4D Score Threshold
Highlight residues > threshold in the sequence panel
CDR Regions
HCDR1
HCDR2
HCDR3
LCDR1
LCDR2
LCDR3
Display Options

pH-Dependent Aggregation Profiles

A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.

pH Avg A4D Score Max A4D Score Downloads
4.0 -0.4887 4.3242 CSV PDB
4.5 -0.5337 4.2695 CSV PDB
5.0 -0.5863 4.2006 CSV PDB
5.5 -0.6386 4.1233 CSV PDB
6.0 -0.6813 4.0427 CSV PDB
6.5 -0.7066 3.9615 CSV PDB
7.0 -0.7137 3.8815 CSV PDB
7.5 -0.7078 3.8055 CSV PDB
8.0 -0.6933 3.7372 CSV PDB
8.5 -0.6714 3.6778 CSV PDB
9.0 -0.6421 3.627 CSV PDB
Average A4D Score vs pH
Max A4D Score vs pH