Calculation Parameters
| Chain Sequence(s) |
VQLVESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSAISGRGYNADYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKLEYFDYWGQGTLVTVSSASTKGPSVFPLASTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVEDIQMTQSPSTLSASVGDRVTITCRASQSISSWLAWYQQKPGKAPKLLIYKASSLESGVPSRFSGSGSGTDFTLTISSLRPEDFATYYCQQYNSYPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR
input.pdb
|
| Selected Chain(s) | B (Heavy), A (Light) |
| Distance of Aggregation | 10 Å |
| FoldX Energy Minimization | Yes |
| pH Calculations | Yes |
| Downloads | Download all data (.tar.gz) |
Aggrescan4D Profile
Per-Residue A4D Scores
Download CSVResidues with A4D score > 0.0 are highlighted as aggregation-prone.
| Index | Residue | Chain | A4D Score | Classification |
|---|---|---|---|---|
| 2 | V | B | 1.0548 | Aggregation-prone |
| 3 | Q | B | -0.3127 | Soluble |
| 4 | L | B | 0.0000 | Buried |
| 5 | V | B | 0.1613 | Aggregation-prone |
| 6 | E | B | 0.0000 | Buried |
| 7 | S | B | -0.4603 | Soluble |
| 8 | G | B | -0.7749 | Soluble |
| 9 | G | B | -0.1017 | Soluble |
| 11 | G | B | 0.4830 | Aggregation-prone |
| 12 | L | B | 0.6450 | Aggregation-prone |
| 13 | V | B | 0.0000 | Buried |
| 14 | Q | B | -1.5584 | Soluble |
| 15 | P | B | -1.6533 | Soluble |
| 16 | G | B | -1.3686 | Soluble |
| 17 | G | B | -1.0162 | Soluble |
| 18 | S | B | -1.1436 | Soluble |
| 19 | L | B | -1.0234 | Soluble |
| 20 | R | B | -2.0810 | Soluble |
| 21 | L | B | 0.0000 | Buried |
| 22 | S | B | -0.4901 | Soluble |
| 23 | C | B | 0.0000 | Buried |
| 24 | A | B | -0.4029 | Soluble |
| 25 | A | B | 0.0000 | Buried |
| 26 | S | B | -0.3850 | Soluble |
| 27 | G | B | 0.0250 | Aggregation-prone |
| 28 | F | B | 0.2125 | Aggregation-prone |
| 29 | T | B | -0.0032 | Soluble |
| 30 | F | B | 0.0000 | Buried |
| 35 | S | B | -0.9150 | Soluble |
| 36 | S | B | -0.3685 | Soluble |
| 37 | Y | B | 0.0764 | Aggregation-prone |
| 38 | A | B | -0.3420 | Soluble |
| 39 | M | B | 0.0000 | Buried |
| 40 | S | B | 0.0000 | Buried |
| 41 | W | B | 0.0000 | Buried |
| 42 | V | B | 0.0000 | Buried |
| 43 | R | B | 0.0000 | Buried |
| 44 | Q | B | -0.6730 | Soluble |
| 45 | A | B | -1.0253 | Soluble |
| 46 | P | B | -0.8391 | Soluble |
| 47 | G | B | -1.4781 | Soluble |
| 48 | K | B | -2.2819 | Soluble |
| 49 | G | B | -1.4455 | Soluble |
| 50 | L | B | 0.0000 | Buried |
| 51 | E | B | -1.0662 | Soluble |
| 52 | W | B | 0.0000 | Buried |
| 53 | V | B | 0.0000 | Buried |
| 54 | S | B | 0.0000 | Buried |
| 55 | A | B | 0.0000 | Buried |
| 56 | I | B | 0.0000 | Buried |
| 57 | S | B | -0.7795 | Soluble |
| 58 | G | B | -0.9716 | Soluble |
| 59 | R | B | -1.9756 | Soluble |
| 62 | G | B | -1.0386 | Soluble |
| 63 | Y | B | 0.0344 | Aggregation-prone |
| 64 | N | B | -1.1551 | Soluble |
| 65 | A | B | -0.6794 | Soluble |
| 66 | D | B | -1.2033 | Soluble |
| 67 | Y | B | -1.1685 | Soluble |
| 68 | A | B | -1.5180 | Soluble |
| 69 | D | B | -2.5603 | Soluble |
| 70 | S | B | -1.8132 | Soluble |
| 71 | V | B | 0.0000 | Buried |
| 72 | K | B | -2.7087 | Soluble |
| 74 | G | B | -1.7348 | Soluble |
| 75 | R | B | -1.2616 | Soluble |
| 76 | F | B | 0.0000 | Buried |
| 77 | T | B | -0.8657 | Soluble |
| 78 | I | B | 0.0000 | Buried |
| 79 | S | B | -0.5410 | Soluble |
| 80 | R | B | -1.2174 | Soluble |
| 81 | D | B | -1.6876 | Soluble |
| 82 | N | B | -1.9709 | Soluble |
| 83 | S | B | -1.5254 | Soluble |
| 84 | K | B | -2.3098 | Soluble |
| 85 | N | B | -1.6321 | Soluble |
| 86 | T | B | -0.9598 | Soluble |
| 87 | L | B | 0.0000 | Buried |
| 88 | Y | B | -0.4537 | Soluble |
| 89 | L | B | 0.0000 | Buried |
| 90 | Q | B | -1.1324 | Soluble |
| 91 | M | B | 0.0000 | Buried |
| 92 | N | B | -1.3317 | Soluble |
| 93 | S | B | -1.1499 | Soluble |
| 94 | L | B | 0.0000 | Buried |
| 95 | R | B | -2.2364 | Soluble |
| 96 | A | B | -1.6781 | Soluble |
| 97 | E | B | -2.2233 | Soluble |
| 98 | D | B | 0.0000 | Buried |
| 99 | T | B | -0.4023 | Soluble |
| 100 | A | B | 0.0000 | Buried |
| 101 | V | B | 0.7505 | Aggregation-prone |
| 102 | Y | B | 0.0000 | Buried |
| 103 | Y | B | 0.0000 | Buried |
| 104 | C | B | 0.0000 | Buried |
| 105 | A | B | 0.0000 | Buried |
| 106 | K | B | 0.0000 | Buried |
| 107 | L | B | 0.1955 | Aggregation-prone |
| 108 | E | B | -0.4863 | Soluble |
| 114 | Y | B | -0.0433 | Soluble |
| 115 | F | B | 0.0000 | Buried |
| 116 | D | B | -0.1890 | Soluble |
| 117 | Y | B | 0.5459 | Aggregation-prone |
| 118 | W | B | -0.1278 | Soluble |
| 119 | G | B | 0.0000 | Buried |
| 120 | Q | B | -1.3777 | Soluble |
| 121 | G | B | -0.4143 | Soluble |
| 122 | T | B | 0.4505 | Aggregation-prone |
| 123 | L | B | 1.4659 | Aggregation-prone |
| 124 | V | B | 0.0000 | Buried |
| 125 | T | B | 0.0171 | Aggregation-prone |
| 126 | V | B | 0.0000 | Buried |
| 127 | S | B | -0.8692 | Soluble |
| 128 | S | B | -0.8043 | Soluble |
| 129 | A | B | -0.5442 | Soluble |
| 130 | S | B | -0.6403 | Soluble |
| 131 | T | B | -0.8878 | Soluble |
| 132 | K | B | -1.5674 | Soluble |
| 133 | G | B | -1.5881 | Soluble |
| 134 | P | B | 0.0000 | Buried |
| 135 | S | B | -0.3591 | Soluble |
| 136 | V | B | 0.0000 | Buried |
| 137 | F | B | 0.0000 | Buried |
| 138 | P | B | -1.2533 | Soluble |
| 139 | L | B | 0.0000 | Buried |
| 140 | A | B | -0.3796 | Soluble |
| 141 | S | B | -0.3659 | Soluble |
| 142 | T | B | -0.3568 | Soluble |
| 143 | A | B | -0.0119 | Soluble |
| 144 | A | B | 0.0095 | Aggregation-prone |
| 145 | L | B | 0.0000 | Buried |
| 146 | G | B | 0.0000 | Buried |
| 147 | C | B | 0.0000 | Buried |
| 148 | L | B | 0.0000 | Buried |
| 149 | V | B | 0.0000 | Buried |
| 150 | K | B | 0.0000 | Buried |
| 151 | D | B | -0.7267 | Soluble |
| 152 | Y | B | 0.0000 | Buried |
| 153 | F | B | 0.0000 | Buried |
| 154 | P | B | -0.7228 | Soluble |
| 155 | E | B | -1.0341 | Soluble |
| 156 | P | B | -1.0677 | Soluble |
| 157 | V | B | -0.7956 | Soluble |
| 158 | T | B | -0.6061 | Soluble |
| 159 | V | B | -0.3476 | Soluble |
| 160 | S | B | -0.4797 | Soluble |
| 161 | W | B | 0.0000 | Buried |
| 162 | N | B | -1.0059 | Soluble |
| 163 | S | B | -0.7734 | Soluble |
| 164 | G | B | -0.5943 | Soluble |
| 165 | A | B | -0.2562 | Soluble |
| 166 | L | B | -0.0890 | Soluble |
| 167 | T | B | -0.2133 | Soluble |
| 168 | S | B | -0.2648 | Soluble |
| 169 | G | B | -0.4637 | Soluble |
| 170 | V | B | 0.1074 | Aggregation-prone |
| 171 | H | B | -0.1729 | Soluble |
| 172 | T | B | 0.0467 | Aggregation-prone |
| 173 | F | B | 0.0000 | Buried |
| 174 | P | B | -0.3159 | Soluble |
| 175 | A | B | 0.1623 | Aggregation-prone |
| 176 | V | B | 0.6035 | Aggregation-prone |
| 177 | L | B | 1.1771 | Aggregation-prone |
| 178 | Q | B | 0.3106 | Aggregation-prone |
| 179 | S | B | -0.0427 | Soluble |
| 180 | S | B | -0.2513 | Soluble |
| 181 | G | B | 0.0036 | Aggregation-prone |
| 182 | L | B | -0.0882 | Soluble |
| 183 | Y | B | 0.3533 | Aggregation-prone |
| 184 | S | B | 0.0000 | Buried |
| 185 | L | B | 0.0000 | Buried |
| 186 | S | B | 0.0000 | Buried |
| 187 | S | B | 0.0000 | Buried |
| 188 | V | B | 0.0000 | Buried |
| 189 | V | B | 0.0000 | Buried |
| 190 | T | B | -0.1423 | Soluble |
| 191 | V | B | 0.0000 | Buried |
| 192 | P | B | -0.2327 | Soluble |
| 193 | S | B | -0.1513 | Soluble |
| 194 | S | B | -0.2889 | Soluble |
| 195 | S | B | 0.0000 | Buried |
| 196 | L | B | -0.0142 | Soluble |
| 197 | G | B | -0.7891 | Soluble |
| 198 | T | B | -0.7820 | Soluble |
| 199 | K | B | -1.7981 | Soluble |
| 200 | T | B | -1.5144 | Soluble |
| 201 | Y | B | 0.0000 | Buried |
| 202 | T | B | -1.9457 | Soluble |
| 203 | C | B | 0.0000 | Buried |
| 204 | N | B | -1.6493 | Soluble |
| 205 | V | B | 0.0000 | Buried |
| 206 | D | B | -1.8304 | Soluble |
| 207 | H | B | 0.0000 | Buried |
| 208 | K | B | -2.7616 | Soluble |
| 209 | P | B | -1.7704 | Soluble |
| 210 | S | B | -1.9230 | Soluble |
| 211 | N | B | -2.5686 | Soluble |
| 212 | T | B | -2.0816 | Soluble |
| 213 | K | B | -2.6369 | Soluble |
| 214 | V | B | -1.5428 | Soluble |
| 215 | D | B | -2.7249 | Soluble |
| 216 | K | B | -2.0872 | Soluble |
| 217 | R | B | -2.8904 | Soluble |
| 218 | V | B | 0.0000 | Buried |
| 219 | E | B | -2.2531 | Soluble |
| 1 | D | A | -2.0803 | Soluble |
| 2 | I | A | -1.5800 | Soluble |
| 3 | Q | A | -2.1174 | Soluble |
| 4 | M | A | 0.0000 | Buried |
| 5 | T | A | -1.3225 | Soluble |
| 6 | Q | A | -1.0067 | Soluble |
| 7 | S | A | -0.7042 | Soluble |
| 8 | P | A | -0.5015 | Soluble |
| 9 | S | A | -0.6535 | Soluble |
| 10 | T | A | -0.4325 | Soluble |
| 11 | L | A | -0.2145 | Soluble |
| 12 | S | A | -0.4914 | Soluble |
| 13 | A | A | 0.0000 | Buried |
| 14 | S | A | -0.4986 | Soluble |
| 15 | V | A | 0.3025 | Aggregation-prone |
| 16 | G | A | -0.7397 | Soluble |
| 17 | D | A | -1.7356 | Soluble |
| 18 | R | A | -2.2816 | Soluble |
| 19 | V | A | 0.0000 | Buried |
| 20 | T | A | -0.5309 | Soluble |
| 21 | I | A | 0.0000 | Buried |
| 22 | T | A | -0.7976 | Soluble |
| 23 | C | A | 0.0000 | Buried |
| 24 | R | A | -2.7481 | Soluble |
| 25 | A | A | 0.0000 | Buried |
| 26 | S | A | -1.9210 | Soluble |
| 27 | Q | A | -2.1450 | Soluble |
| 28 | S | A | -1.3278 | Soluble |
| 29 | I | A | 0.0000 | Buried |
| 36 | S | A | -0.7219 | Soluble |
| 37 | S | A | -0.5879 | Soluble |
| 38 | W | A | -0.1033 | Soluble |
| 39 | L | A | 0.0000 | Buried |
| 40 | A | A | 0.0000 | Buried |
| 41 | W | A | 0.0000 | Buried |
| 42 | Y | A | 0.0000 | Buried |
| 43 | Q | A | 0.0000 | Buried |
| 44 | Q | A | -1.3472 | Soluble |
| 45 | K | A | -1.8494 | Soluble |
| 46 | P | A | -1.5050 | Soluble |
| 47 | G | A | -1.7484 | Soluble |
| 48 | K | A | -2.6722 | Soluble |
| 49 | A | A | -1.6269 | Soluble |
| 50 | P | A | 0.0000 | Buried |
| 51 | K | A | -1.5426 | Soluble |
| 52 | L | A | 0.0000 | Buried |
| 53 | L | A | 0.0000 | Buried |
| 54 | I | A | 0.0000 | Buried |
| 55 | Y | A | -0.1892 | Soluble |
| 56 | K | A | -0.8948 | Soluble |
| 57 | A | A | 0.0000 | Buried |
| 65 | S | A | -0.5297 | Soluble |
| 66 | S | A | -0.3092 | Soluble |
| 67 | L | A | 0.0445 | Aggregation-prone |
| 68 | E | A | -0.5644 | Soluble |
| 69 | S | A | -0.4801 | Soluble |
| 70 | G | A | -0.5347 | Soluble |
| 71 | V | A | -0.3847 | Soluble |
| 72 | P | A | -0.3300 | Soluble |
| 74 | S | A | -0.4259 | Soluble |
| 75 | R | A | -0.8451 | Soluble |
| 76 | F | A | 0.0000 | Buried |
| 77 | S | A | -0.3312 | Soluble |
| 78 | G | A | -0.4073 | Soluble |
| 79 | S | A | -0.7306 | Soluble |
| 80 | G | A | -1.0115 | Soluble |
| 83 | S | A | -0.9848 | Soluble |
| 84 | G | A | -1.0858 | Soluble |
| 85 | T | A | -1.6680 | Soluble |
| 86 | D | A | -1.9822 | Soluble |
| 87 | F | A | 0.0000 | Buried |
| 88 | T | A | -0.7099 | Soluble |
| 89 | L | A | 0.0000 | Buried |
| 90 | T | A | -0.6068 | Soluble |
| 91 | I | A | 0.0000 | Buried |
| 92 | S | A | -1.3769 | Soluble |
| 93 | S | A | -1.1383 | Soluble |
| 94 | L | A | 0.0000 | Buried |
| 95 | R | A | -1.4949 | Soluble |
| 96 | P | A | -1.1221 | Soluble |
| 97 | E | A | -2.1197 | Soluble |
| 98 | D | A | 0.0000 | Buried |
| 99 | F | A | -0.4942 | Soluble |
| 100 | A | A | 0.0000 | Buried |
| 101 | T | A | -0.6084 | Soluble |
| 102 | Y | A | 0.0000 | Buried |
| 103 | Y | A | 0.0000 | Buried |
| 104 | C | A | 0.0000 | Buried |
| 105 | Q | A | 0.0000 | Buried |
| 106 | Q | A | 0.0000 | Buried |
| 107 | Y | A | -0.1565 | Soluble |
| 108 | N | A | -0.5902 | Soluble |
| 109 | S | A | -0.4075 | Soluble |
| 114 | Y | A | -0.1777 | Soluble |
| 115 | P | A | -0.5502 | Soluble |
| 116 | L | A | 0.0000 | Buried |
| 117 | T | A | -0.6336 | Soluble |
| 118 | F | A | -0.3133 | Soluble |
| 119 | G | A | 0.0000 | Buried |
| 120 | G | A | -1.1550 | Soluble |
| 121 | G | A | 0.0000 | Buried |
| 122 | T | A | 0.0000 | Buried |
| 123 | K | A | -0.8845 | Soluble |
| 124 | V | A | 0.0000 | Buried |
| 125 | E | A | 0.0000 | Buried |
| 126 | I | A | -0.0107 | Soluble |
| 127 | K | A | -1.1988 | Soluble |
| 128 | R | A | -0.9957 | Soluble |
| 129 | T | A | -0.0532 | Soluble |
| 130 | V | A | 0.7829 | Aggregation-prone |
| 131 | A | A | 0.3009 | Aggregation-prone |
| 132 | A | A | -0.0170 | Soluble |
| 133 | P | A | 0.0000 | Buried |
| 134 | S | A | -0.1681 | Soluble |
| 135 | V | A | 0.0000 | Buried |
| 136 | F | A | 0.0640 | Aggregation-prone |
| 137 | I | A | 0.1090 | Aggregation-prone |
| 138 | F | A | 0.0000 | Buried |
| 139 | P | A | -0.6651 | Soluble |
| 140 | P | A | 0.0000 | Buried |
| 141 | S | A | -1.7551 | Soluble |
| 142 | D | A | -3.1511 | Soluble |
| 143 | E | A | -3.3353 | Soluble |
| 144 | Q | A | 0.0000 | Buried |
| 145 | L | A | 0.0000 | Buried |
| 146 | K | A | -3.0304 | Soluble |
| 147 | S | A | -1.8776 | Soluble |
| 148 | G | A | -1.3507 | Soluble |
| 149 | T | A | -1.1139 | Soluble |
| 150 | A | A | 0.0000 | Buried |
| 151 | S | A | 0.0000 | Buried |
| 152 | V | A | 0.0000 | Buried |
| 153 | V | A | 0.0000 | Buried |
| 154 | C | A | 0.0000 | Buried |
| 155 | L | A | 0.0000 | Buried |
| 156 | L | A | 0.0000 | Buried |
| 157 | N | A | 0.0000 | Buried |
| 158 | N | A | -0.7148 | Soluble |
| 159 | F | A | 0.0000 | Buried |
| 160 | Y | A | 0.0000 | Buried |
| 161 | P | A | -1.1398 | Soluble |
| 162 | R | A | -1.9087 | Soluble |
| 163 | E | A | -2.5771 | Soluble |
| 164 | A | A | -1.8761 | Soluble |
| 165 | K | A | -2.0327 | Soluble |
| 166 | V | A | -0.9195 | Soluble |
| 167 | Q | A | -0.5990 | Soluble |
| 168 | W | A | 0.0000 | Buried |
| 169 | K | A | -0.6886 | Soluble |
| 170 | V | A | 0.0000 | Buried |
| 171 | D | A | -1.9291 | Soluble |
| 172 | N | A | -1.3901 | Soluble |
| 173 | A | A | -0.3331 | Soluble |
| 174 | L | A | 0.7112 | Aggregation-prone |
| 175 | Q | A | -0.1327 | Soluble |
| 176 | S | A | -0.5107 | Soluble |
| 177 | G | A | -0.9268 | Soluble |
| 178 | N | A | -0.8950 | Soluble |
| 179 | S | A | -1.1225 | Soluble |
| 180 | Q | A | -1.2967 | Soluble |
| 181 | E | A | -1.8399 | Soluble |
| 182 | S | A | -0.7453 | Soluble |
| 183 | V | A | -0.5810 | Soluble |
| 184 | T | A | -1.0165 | Soluble |
| 185 | E | A | -2.1105 | Soluble |
| 186 | Q | A | -1.6572 | Soluble |
| 187 | D | A | -2.0192 | Soluble |
| 188 | S | A | -1.7402 | Soluble |
| 189 | K | A | -2.2678 | Soluble |
| 190 | D | A | -1.5935 | Soluble |
| 191 | S | A | -1.5773 | Soluble |
| 192 | T | A | 0.0000 | Buried |
| 193 | Y | A | 0.0000 | Buried |
| 194 | S | A | 0.0000 | Buried |
| 195 | L | A | 0.0000 | Buried |
| 196 | S | A | 0.0000 | Buried |
| 197 | S | A | 0.0000 | Buried |
| 198 | T | A | -0.6568 | Soluble |
| 199 | L | A | 0.0000 | Buried |
| 200 | T | A | -0.2877 | Soluble |
| 201 | L | A | -0.7671 | Soluble |
| 202 | S | A | -1.1730 | Soluble |
| 203 | K | A | -2.1836 | Soluble |
| 204 | A | A | -2.0716 | Soluble |
| 205 | D | A | -2.9310 | Soluble |
| 206 | Y | A | 0.0000 | Buried |
| 207 | E | A | -3.7722 | Soluble |
| 208 | K | A | -3.7764 | Soluble |
| 209 | H | A | -3.2938 | Soluble |
| 210 | K | A | -3.3673 | Soluble |
| 211 | V | A | -1.8087 | Soluble |
| 212 | Y | A | 0.0000 | Buried |
| 213 | A | A | 0.0000 | Buried |
| 214 | C | A | 0.0000 | Buried |
| 215 | E | A | -1.0596 | Soluble |
| 216 | V | A | 0.0000 | Buried |
| 217 | T | A | -1.1163 | Soluble |
| 218 | H | A | 0.0000 | Buried |
| 219 | Q | A | -1.5605 | Soluble |
| 220 | G | A | -0.3194 | Soluble |
| 221 | L | A | -0.1157 | Soluble |
| 222 | S | A | -0.4210 | Soluble |
| 223 | S | A | -0.3862 | Soluble |
| 224 | P | A | -0.5418 | Soluble |
| 225 | V | A | -0.0327 | Soluble |
| 226 | T | A | -0.5106 | Soluble |
| 227 | K | A | -0.7257 | Soluble |
| 228 | S | A | -0.7988 | Soluble |
| 229 | F | A | -1.1037 | Soluble |
| 230 | N | A | -2.4164 | Soluble |
| 231 | R | A | -2.5563 | Soluble |
3D Structure — colored by A4D score
pH-Dependent Aggregation Profiles
A4D scores calculated across 11 pH conditions (4.0–9.0, step 0.5). Click a row to view the structure at that pH. The input structure is globular — max score is recommended for pH analysis.
| pH | Avg A4D Score | Max A4D Score | Downloads |
|---|---|---|---|
| 4.0 | -0.7549 | 2.1427 | CSV PDB |
| 4.5 | -0.7968 | 2.1427 | CSV PDB |
| 5.0 | -0.8456 | 2.1427 | CSV PDB |
| 5.5 | -0.892 | 2.1427 | CSV PDB |
| 6.0 | -0.925 | 2.1427 | CSV PDB |
| 6.5 | -0.9356 | 2.1427 | CSV PDB |
| 7.0 | -0.9233 | 2.1427 | CSV PDB |
| 7.5 | -0.896 | 2.1427 | CSV PDB |
| 8.0 | -0.8606 | 2.1427 | CSV PDB |
| 8.5 | -0.8191 | 2.1427 | CSV PDB |
| 9.0 | -0.7713 | 2.1427 | CSV PDB |